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Study Information
Study Attribute Value
CEBS Accession Number: 002-03169-0002-0000-3
Chemical Name: p-Isopropoxydiphenylamine
CASRN: 101-73-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 843024_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 02/20/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: p-Isopropoxydiphenylamine 
1.5       
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
4.98      
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
15         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
49.8       
 28 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 67 0.335 21.5 26 0.130 10.5 41 0.205 13.0 0 0.000 0.0
Mitomycin-C 
5         
 50 35 0.700 40.0 9 0.180 16.0 26 0.520 30.0 0 0.000 0.0
Trend: -1.100 0.000 -1.100  
Probability: 0.864 0.000 0.864  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/16/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Test Chemical: p-Isopropoxydiphenylamine 
10.1       
 200 7 0.035 2.5 1 0.005 0.5 6 0.030 2.5 0 0.000 0.0 
20.2       
 200 20 0.100 6.5 7 0.035 2.5 13 0.065 5.0 0 0.000 0.0 
30.3       
 200 17 0.085 7.5 6 0.030 3.0 11 0.055 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 36 0.720 38.0 12 0.240 20.0 14 0.280 22.0 10 0.200 1.0
Trend: 2.117 2.416 1.178  
Probability: 0.017 0.008 0.119  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/20/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 24 0.120 8.0 4 0.020 2.0 19 0.095 6.0 1 0.005 1.0
Negative (Not Specified) 
0         
 200 9 0.045 4.5 0 0.000 0.0 8 0.040 4.0 1 0.005 1.0
Test Chemical: p-Isopropoxydiphenylamine 
1.5       
 200 29 0.145 8.5 1 0.005 0.5 17 0.085 7.0 11 0.055 2.0 
4.98      
 200 22 0.110 9.0 6 0.030 3.0 15 0.075 5.5 1 0.005 1.0 
15         
 200 26 0.130 7.5 2 0.010 1.0 14 0.070 6.0 10 0.050 1.0 
29.9       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 54 1.080 60.0 19 0.380 30.0 34 0.680 40.0 1 0.020 1.0
Trend: -0.120 -0.074 -0.217  
Probability: 0.548 0.529 0.586  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 04/22/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 14 0.070 4.0 5 0.025 1.5 9 0.045 3.5 0 0.000 0.0
Test Chemical: p-Isopropoxydiphenylamine 
15         
 200 29 0.145 8.0 9 0.045 4.5 9 0.045 4.0 11 0.055 2.0 
20         
 200 61 0.305 17.5 20 0.100 8.0 21 0.105 9.0 20 0.100 2.0 
30         
 200 38 0.190 8.5 6 0.030 3.0 12 0.060 6.0 20 0.100 2.0
Positive Control: Cyclophosphamide 
50         
 50 24 0.480 28.0 12 0.240 20.0 12 0.240 16.0 0 0.000 0.0
Trend: 2.220 1.070 1.582  
Probability: 0.013 0.142 0.057