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Study Information
Study Attribute Value
CEBS Accession Number: 002-03176-0003-0000-2
Chemical Name: p-Nitroaniline
CASRN: 100-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 786885_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 444 0.425 8.88 26.0 0.000
Test Chemical p-Nitroaniline 
16         
 50 1040 448 0.431 8.96 26.0 1.386 
50         
 50 1048 457 0.436 9.14 26.0 2.633 
160         
 58 1213 534 0.440 9.21 26.0 3.613
Positive Control Mitomycin-C 
 0.005     
 25 524 572 1.092 22.88 26.0 156.920
Trend: 0.581        
Probability: 0.281        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/16/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 469 0.447 9.38 26.0 0.000
Test Chemical p-Nitroaniline 
160         
 50 1048 457 0.436 9.14 26.0 -2.466 
500         
 50 1045 488 0.467 9.76 26.0 4.449 
1600         
 50 1046 563 0.538 11.26 26.0 20.387
Positive Control Cyclophosphamide 
1         
 25 523 490 0.937 19.60 26.0 109.555
Trend: 3.209        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/31/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 515 0.491 10.30 26.0 0.000
Test Chemical p-Nitroaniline 
2000         
 50 1037 721 0.695 14.42 26.0 41.485 
2500         
 50 1050 694 0.661 13.88 28.0 34.501 
3000         
 50 1048 702 0.670 14.04 28.0 36.311
Positive Control Cyclophosphamide 
1         
 50 1051 900 0.856 18.00 26.0 74.258
Trend: 4.589        
Probability: 0.000