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Study Information
Study Attribute Value
CEBS Accession Number: 002-03176-0004-0000-3
Chemical Name: p-Nitroaniline
CASRN: 100-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 786885_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/16/1981    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Nitroaniline 
50         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0 
1600         
 100 11 0.110 10.0 1 0.010 1.0 10 0.100 10.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 21 0.210 17.0 4 0.040 4.0 17 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.15      
 100 24 0.240 22.0 9 0.090 8.0 15 0.150 14.0 0 0.000 0.0
Trend: 2.263 0.000 2.706  
Probability: 0.012 0.500 0.003  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/16/1981    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: p-Nitroaniline 
160         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
500         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0 
1600         
 100 26 0.260 20.0 2 0.020 2.0 24 0.240 18.0 0 0.000 0.0 
5000         
 100 31 0.310 22.0 6 0.060 6.0 25 0.250 17.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
150         
 100 22 0.220 18.0 11 0.110 9.0 11 0.110 11.0 0 0.000 0.0
Trend: 4.871 1.724 4.666  
Probability: 0.000 0.042 0.000