COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03176-0004-0000-3
Chemical Name: p-Nitroaniline
CASRN: 100-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 786885_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/16/1981    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Nitroaniline 
50         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0 
1600         
 100 11 0.110 10.0 1 0.010 1.0 10 0.100 10.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 21 0.210 17.0 4 0.040 4.0 17 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.15      
 100 24 0.240 22.0 9 0.090 8.0 15 0.150 14.0 0 0.000 0.0
Trend: 2.263 0.000 2.706  
Probability: 0.012 0.500 0.003  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/16/1981    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: p-Nitroaniline 
160         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
500         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0 
1600         
 100 26 0.260 20.0 2 0.020 2.0 24 0.240 18.0 0 0.000 0.0 
5000         
 100 31 0.310 22.0 6 0.060 6.0 25 0.250 17.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
150         
 100 22 0.220 18.0 11 0.110 9.0 11 0.110 11.0 0 0.000 0.0
Trend: 4.871 1.724 4.666  
Probability: 0.000 0.042 0.000