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Study Information
Study Attribute Value
CEBS Accession Number: 002-03178-0001-0000-2
Chemical Name: p-Nitrobenzoic acid
CASRN: 62-23-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 195725_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/07/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 398 0.381 7.96 25.7 0.000
Test Chemical p-Nitrobenzoic acid 
58.3       
 50 1031 382 0.371 7.64 25.7 -2.717 
175         
 50 1041 429 0.412 8.58 25.7 8.203 
583         
 50 1033 570 0.552 11.40 31.3 44.880 
1750         
 0 0 0 0.000 0.00 31.3 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 584 0.556 11.68 25.7 46.035
Mitomycin-C 
 0.01      
 5 105 245 2.333 49.00 25.7 512.647
Trend: 6.140        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/07/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 380 0.364 7.60 25.5 0.000
Test Chemical p-Nitrobenzoic acid 
498         
 50 1034 505 0.488 10.10 32.4 34.180 
753         
 50 1045 604 0.578 12.08 32.4 58.795 
1000         
 50 1049 629 0.600 12.58 32.4 64.737 
1510         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1042 580 0.557 11.60 25.5 52.925
Mitomycin-C 
 0.01      
 5 105 251 2.390 50.20 25.5 556.752
Trend: 8.201        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/07/1985    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 379 0.361 7.58 25.6 0.000
Test Chemical p-Nitrobenzoic acid 
175         
 0 0 0 0.000 0.00 0.0 N/A 
583         
 0 0 0 0.000 0.00 0.0 N/A 
1750         
 50 1051 433 0.412 8.66 25.6 14.139
Positive Control Cyclophosphamide 
 0.4       
 50 1044 608 0.582 12.16 25.6 61.344
Cyclophosphamide 
2         
 5 105 184 1.752 36.80 25.6 385.488
Trend: 1.881        
Probability: 0.030        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/07/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 346 0.332 6.92 25.5 0.000
Test Chemical p-Nitrobenzoic acid 
175         
 50 1044 393 0.376 7.86 25.5 13.257 
583         
 50 1037 328 0.316 6.56 25.5 -4.837 
1750         
 50 1027 364 0.354 7.28 25.5 6.636
Positive Control Cyclophosphamide 
 0.4       
 25 519 312 0.601 12.48 25.5 80.868
Cyclophosphamide 
2         
 5 105 157 1.495 31.40 25.5 349.868
Trend: 0.038        
Probability: 0.485