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Study Information
Study Attribute Value
CEBS Accession Number: 002-03181-0001-0000-6
Chemical Name: p-Nitrohippuric acid
CASRN: 2645-07-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 037964_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/17/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 398 0.389 7.96 25.5 0.000
Test Chemical p-Nitrohippuric acid 
166.7       
 50 1029 418 0.406 8.36 25.5 4.311 
500         
 50 1018 461 0.453 9.22 25.5 16.284 
1666.7       
 50 1025 440 0.429 8.80 25.5 10.229 
5000         
 0 0 0 0.000 0.00 38.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1009 574 0.569 11.48 25.5 46.079
Mitomycin-C 
 0.01      
 5 99 193 1.949 38.60 25.5 400.599
Trend: 1.805        
Probability: 0.036        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/17/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1021 391 0.383 7.82 25.5 0.000
Test Chemical p-Nitrohippuric acid 
500         
 50 1033 396 0.383 7.92 25.5 0.102 
1666.7       
 50 1031 404 0.392 8.08 25.5 2.323 
5000         
 50 1016 408 0.402 8.16 25.5 4.861
Positive Control Cyclophosphamide 
 0.4       
 50 1019 575 0.564 11.50 25.5 47.347
Cyclophosphamide 
2         
 5 105 188 1.790 37.60 25.5 367.539
Trend: 0.734        
Probability: 0.231