Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03181-0002-0000-7 |
Chemical Name: | p-Nitrohippuric acid |
CASRN: | 2645-07-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 037964_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 2.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | p-Nitrohippuric acid | 2513 | 200 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 |
3750 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 1.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 64 | 0.320 | 20.0 | 27 | 0.135 | 12.0 | 37 | 0.185 | 12.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 29 | 1.160 | 56.0 | 10 | 0.400 | 32.0 | 19 | 0.760 | 40.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.126 | -0.072 | 2.002 | ||||||||||||
Probability: | 0.130 | 0.529 | 0.023 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 6 | 0.030 | 3.0 | 1 | 0.005 | 1.0 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | p-Nitrohippuric acid | 2513 | 200 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
3750 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 21 | 0.105 | 10.0 | 3 | 0.015 | 2.0 | 18 | 0.090 | 8.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 13 | 0.520 | 32.0 | 8 | 0.320 | 28.0 | 5 | 0.200 | 12.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.000 | -0.809 | 0.000 | ||||||||||||
Probability: | 0.500 | 0.791 | 0.500 |