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Study Information
Study Attribute Value
CEBS Accession Number: 002-03183-0001-0000-8
Chemical Name: p-Nitrophenol
CASRN: 100-02-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333983_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/11/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 528 0.520 10.56 26.0 0.000
Test Chemical p-Nitrophenol 
 0.167     
 50 1014 558 0.550 11.16 31.5 5.890 
 0.5       
 50 1019 618 0.606 12.36 31.5 16.701 
1.7       
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 583 0.574 11.66 26.0 10.417
Mitomycin-C 
 0.01      
 5 106 171 1.613 34.20 26.0 210.420
Trend: 2.611        
Probability: 0.005        

Trial #: 2    Activation: No Activation    Date: 01/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 490 0.482 9.80 26.0 0.000
Test Chemical p-Nitrophenol 
5         
 50 1017 536 0.527 10.72 33.5 9.388 
10         
 50 1023 529 0.517 10.58 33.5 7.326 
25         
 50 1002 529 0.528 10.58 33.5 9.575
Positive Control Mitomycin-C 
 0.001     
 50 1024 626 0.611 12.52 26.0 26.882
Mitomycin-C 
 0.01      
 5 104 219 2.106 43.80 26.0 337.055
Trend: 1.283        
Probability: 0.100        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/11/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 508 0.500 10.16 26.0 0.000
Test Chemical p-Nitrophenol 
50         
 50 1037 500 0.482 10.00 26.0 -3.568 
167         
 50 1028 521 0.507 10.42 31.5 1.362 
500         
 50 1030 620 0.602 12.40 31.5 20.388 
1700         
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1023 774 0.757 15.48 26.0 51.320
Cyclophosphamide 
2         
 5 103 250 2.427 50.00 26.0 385.437
Trend: 3.242        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 475 0.463 9.50 26.0 0.000
Test Chemical p-Nitrophenol 
1000         
 50 1023 458 0.448 9.16 26.0 -3.296 
1300         
 50 1026 500 0.487 10.00 26.0 5.263 
1500         
 50 1022 518 0.507 10.36 33.5 9.479 
2000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1032 785 0.761 15.70 26.0 64.302
Cyclophosphamide 
2         
 5 104 184 1.769 36.80 26.0 282.154
Trend: 1.745        
Probability: 0.041