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Study Information
Study Attribute Value
CEBS Accession Number: 002-03183-0002-0000-9
Chemical Name: p-Nitrophenol
CASRN: 100-02-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333983_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 02/12/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Nitrophenol 
100         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
250         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 12 0.120 12.0 5 0.050 5.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 8 0.320 28.0 4 0.160 16.0 4 0.160 16.0 0 0.000 0.0
Trend: 1.095 0.009 1.331  
Probability: 0.137 0.497 0.092  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/12/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Nitrophenol 
1250         
 100 8 0.080 5.0 4 0.040 2.0 4 0.040 3.0 0 0.000 0.0 
1500         
 50 25 0.500 22.0 17 0.340 16.0 8 0.160 12.0 0 0.000 0.0 
1750         
 50 49 0.980 32.0 18 0.360 18.0 20 0.400 24.0 11 0.220 4.0 
2000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 11 0.110 10.0 5 0.050 5.0 6 0.060 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 18 0.720 44.0 12 0.480 32.0 6 0.240 24.0 0 0.000 0.0
Trend: 6.074 4.760 5.275  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/24/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: p-Nitrophenol 
100         
 100 5 0.050 4.0 3 0.030 2.0 2 0.020 2.0 0 0.000 0.0 
250         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 50 5 0.100 10.0 2 0.040 4.0 3 0.060 6.0 0 0.000 0.0
Trend: -0.294 -0.692 0.187  
Probability: 0.616 0.755 0.426  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/24/1985    Harvest Time: 21.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 9 0.090 7.0 1 0.010 1.0 8 0.080 6.0 0 0.000 0.0
Test Chemical: p-Nitrophenol 
1500         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
1750         
 100 13 0.130 8.0 8 0.080 5.0 5 0.050 3.0 0 0.000 0.0 
2000         
 20 11 0.550 30.0 0 0.000 0.0 11 0.550 30.0 0 0.000 0.0 
2500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 18 0.180 15.0 2 0.020 2.0 16 0.160 13.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 23 0.920 48.0 10 0.400 32.0 13 0.520 32.0 0 0.000 0.0
Trend: 2.052 1.214 1.610  
Probability: 0.020 0.112 0.054