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Study Information
Study Attribute Value
CEBS Accession Number: 002-03184-0002-0000-0
Chemical Name: p-Nitrosodiphenylamine
CASRN: 156-10-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 976337_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 11/18/1986    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 10 0.050 3.0 4 0.020 2.0 5 0.025 1.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 10 0.050 5.0 4 0.020 2.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: p-Nitrosodiphenylamine 
 0.5       
 200 11 0.055 2.5 3 0.015 1.5 8 0.040 1.5 0 0.000 0.0 
1.3       
 200 81 0.405 18.0 24 0.120 8.0 41 0.205 11.5 16 0.080 3.5 
2.5       
 121 92 0.760 28.1 14 0.116 9.0 53 0.438 19.8 25 0.207 5.8 
3.75      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 56 0.560 20.0 21 0.210 19.0 32 0.320 23.0 3 0.030 3.0
Mitomycin-C 
 0.08      
 25 30 1.200 68.0 11 0.440 32.0 19 0.760 48.0 0 0.000 0.0
Trend: 7.327 3.874 6.191  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/18/1986    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 1 0.005 0.5 2 0.010 1.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0 1 0.005 0.5
Test Chemical: p-Nitrosodiphenylamine 
15.1       
 200 56 0.280 17.5 7 0.035 3.5 10 0.050 4.5 39 0.195 10.5 
20.1       
 200 119 0.595 20.0 19 0.095 6.0 30 0.150 9.5 70 0.350 8.0 
50.3       
 30 36 1.200 60.0 9 0.300 20.0 13 0.433 36.7 14 0.467 16.7 
100.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 28 0.140 12.5 4 0.020 2.0 18 0.090 7.5 6 0.030 3.0
Cyclophosphamide 
12.5       
 25 8 0.320 24.0 3 0.120 12.0 4 0.160 12.0 1 0.040 4.0
Trend: 8.587 4.543 7.324  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 12/23/1986    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: p-Nitrosodiphenylamine 
 0.25      
 100 12 0.120 10.0 3 0.030 2.0 7 0.070 7.0 2 0.020 2.0 
 0.5       
 100 80 0.800 34.0 26 0.260 20.0 21 0.210 15.0 33 0.330 6.0 
 0.75      
 20 65 3.250 70.0 5 0.250 25.0 9 0.450 25.0 51 2.550 30.0 
1.25      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 42 0.420 25.0 11 0.110 11.0 31 0.310 18.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 19 0.760 60.0 8 0.320 28.0 11 0.440 40.0 0 0.000 0.0
Trend: 7.816 5.273 4.344  
Probability: 0.000 0.000 0.000