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Study Information
Study Attribute Value
CEBS Accession Number: 002-03205-0001-0000-3
Chemical Name: t-Butylhydroquinone
CASRN: 1948-33-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 089956_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/12/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1014 477 0.470 9.54 25.5 0.000
Test Chemical t-Butylhydroquinone 
 0.5       
 50 1024 441 0.431 8.82 25.5 -8.450 
1.7       
 50 1020 566 0.555 11.32 25.5 17.960 
5         
 50 1029 490 0.476 9.80 25.5 1.228 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 996 566 0.568 11.32 25.5 20.803
Mitomycin-C 
 0.01      
 5 100 138 1.380 27.60 25.5 193.358
Trend: 1.531        
Probability: 0.063        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/12/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 409 0.397 8.18 25.5 0.000
Test Chemical t-Butylhydroquinone 
5         
 50 1031 494 0.479 9.88 25.5 20.548 
16.7       
 50 1016 598 0.589 11.96 25.5 48.081 
50         
 50 1033 603 0.584 12.06 25.5 46.862 
166.7       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1019 706 0.693 14.12 25.5 74.310
Cyclophosphamide 
2         
 5 105 210 2.000 42.00 25.5 403.178
Trend: 6.737        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 523 208 0.398 8.32 25.5 0.000
Test Chemical t-Butylhydroquinone 
49.8       
 25 514 318 0.619 12.72 25.5 55.562 
100.5       
 25 516 352 0.682 14.08 30.5 71.527 
150         
 25 521 359 0.689 14.36 30.5 73.259
Positive Control Cyclophosphamide 
 0.4       
 25 517 278 0.538 11.12 25.5 35.205
Cyclophosphamide 
2         
 5 102 168 1.647 33.60 25.5 314.140
Trend: 6.310        
Probability: 0.000