Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03205-0001-0000-3 |
Chemical Name: | t-Butylhydroquinone |
CASRN: | 1948-33-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 089956_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1014 | 477 | 0.470 | 9.54 | 25.5 | 0.000 |
Test Chemical | t-Butylhydroquinone | 0.5 | 50 | 1024 | 441 | 0.431 | 8.82 | 25.5 | -8.450 |
1.7 | 50 | 1020 | 566 | 0.555 | 11.32 | 25.5 | 17.960 | ||
5 | 50 | 1029 | 490 | 0.476 | 9.80 | 25.5 | 1.228 | ||
16.7 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 996 | 566 | 0.568 | 11.32 | 25.5 | 20.803 |
Mitomycin-C | 0.01 | 5 | 100 | 138 | 1.380 | 27.60 | 25.5 | 193.358 | |
Trend: | 1.531 | ||||||||
Probability: | 0.063 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1029 | 409 | 0.397 | 8.18 | 25.5 | 0.000 |
Test Chemical | t-Butylhydroquinone | 5 | 50 | 1031 | 494 | 0.479 | 9.88 | 25.5 | 20.548 |
16.7 | 50 | 1016 | 598 | 0.589 | 11.96 | 25.5 | 48.081 | ||
50 | 50 | 1033 | 603 | 0.584 | 12.06 | 25.5 | 46.862 | ||
166.7 | 0 | 0 | 0 | 0.000 | 0.00 | 25.5 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1019 | 706 | 0.693 | 14.12 | 25.5 | 74.310 |
Cyclophosphamide | 2 | 5 | 105 | 210 | 2.000 | 42.00 | 25.5 | 403.178 | |
Trend: | 6.737 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 25 | 523 | 208 | 0.398 | 8.32 | 25.5 | 0.000 |
Test Chemical | t-Butylhydroquinone | 49.8 | 25 | 514 | 318 | 0.619 | 12.72 | 25.5 | 55.562 |
100.5 | 25 | 516 | 352 | 0.682 | 14.08 | 30.5 | 71.527 | ||
150 | 25 | 521 | 359 | 0.689 | 14.36 | 30.5 | 73.259 | ||
Positive Control | Cyclophosphamide | 0.4 | 25 | 517 | 278 | 0.538 | 11.12 | 25.5 | 35.205 |
Cyclophosphamide | 2 | 5 | 102 | 168 | 1.647 | 33.60 | 25.5 | 314.140 | |
Trend: | 6.310 | ||||||||
Probability: | 0.000 |