| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03205-0021-0000-5 |
| Chemical Name: | t-Butylhydroquinone |
| CASRN: | 1948-33-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | A73022_CA |
| Study Result: | Negative |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|
| CA | 11/10/93 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.7447 |
| Test Group | Dose (mg/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Dimethylbenzanthracene | 200 | 8 | 8.25 ± 1.53 | 0.0006 |
| Test Chemical | t-Butylhydroquinone | 100 | 8 | 2.25 ± 0.45 | 0.7465 |
150 | 8 | 1.75 ± 0.59 | 0.8772 | ||
200 | 8 | 2.25 ± 0.59 | 0.7465 | ||
250 | 2 | 3.00 ± 1.00 | 0.5000 | ||
| Vehicle Control | No Stressor | 0 | 8 | 3.00 ± 0.76 | 0.0000 |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|
| CA | 03/16/94 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.0001 |
| Test Group | Dose (mg/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Dimethylbenzanthracene | 200 | 8 | 11.75 ± 1.91 | 0.0000 |
| Test Chemical | t-Butylhydroquinone | 50 | 8 | 1.50 ± 0.73 | 0.6101 |
100 | 8 | 3.00 ± 1.00 | 0.1228 | ||
150 | 8 | 3.25 ± 1.73 | 0.0871 | ||
200 | 8 | 6.00 ± 2.95 | 0.0009 | ||
| Vehicle Control | No Stressor | 0 | 8 | 1.75 ± 0.59 | 0.0000 |
Footnotes: IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed
INHAL: Inhalation
n: Number of animals analyzed