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Study Information
Study Attribute Value
CEBS Accession Number: 002-03207-0001-0000-5
Chemical Name: tert-Butyl hydroperoxide
CASRN: 75-91-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 389785_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/13/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1028 417 0.406 8.34 25.5 0.000
Test Chemical tert-Butyl hydroperoxide 
1         
 50 1032 528 0.512 10.56 25.5 26.128 
3         
 50 1025 1135 1.107 22.70 25.5 172.979 
5         
 50 1025 1457 1.421 29.14 32.3 250.423 
7         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 564 0.551 11.28 25.5 35.780
Mitomycin-C 
 0.01      
 5 102 164 1.608 32.80 25.5 296.370
Trend: 28.518        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1027 456 0.444 9.12 25.7 0.000
Test Chemical tert-Butyl hydroperoxide 
15.9       
 50 1026 803 0.783 16.06 25.7 76.268 
17.9       
 50 1023 805 0.787 16.10 25.7 77.225 
19.9       
 50 1024 990 0.967 19.80 25.7 117.741
Positive Control Cyclophosphamide 
 0.3       
 50 1037 590 0.569 11.80 25.7 28.138
Cyclophosphamide 
2         
 5 104 182 1.750 36.40 25.7 294.134
Trend: 13.013        
Probability: 0.000