Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03207-0002-0000-6 |
Chemical Name: | tert-Butyl hydroperoxide |
CASRN: | 75-91-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 389785_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Medium | 0 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | tert-Butyl hydroperoxide | 8 | 100 | 50 | 0.500 | 29.0 | 24 | 0.240 | 19.0 | 26 | 0.260 | 16.0 | 0 | 0.000 | 0.0 |
9 | 100 | 77 | 0.770 | 44.0 | 34 | 0.340 | 27.0 | 43 | 0.430 | 28.0 | 0 | 0.000 | 0.0 | ||
10.1 | 100 | 76 | 0.760 | 49.0 | 39 | 0.390 | 34.0 | 37 | 0.370 | 24.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 50 | 19 | 0.380 | 26.0 | 11 | 0.220 | 18.0 | 8 | 0.160 | 5.0 | 0 | 0.000 | 0.0 |
Trend: | 7.548 | 5.762 | 5.009 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Medium | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | tert-Butyl hydroperoxide | 24.8 | 100 | 21 | 0.210 | 17.0 | 16 | 0.160 | 15.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 |
49.6 | 100 | 35 | 0.350 | 23.0 | 26 | 0.260 | 20.0 | 9 | 0.090 | 7.0 | 0 | 0.000 | 0.0 | ||
75.2 | 56 | 39 | 0.696 | 34.0 | 24 | 0.429 | 30.0 | 15 | 0.268 | 16.0 | 0 | 0.000 | 0.0 | ||
100.2 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 75 | 50 | 9 | 0.180 | 16.0 | 6 | 0.120 | 12.0 | 3 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
Trend: | 5.680 | 5.252 | 4.008 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |