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Study Information
Study Attribute Value
CEBS Accession Number: 002-03208-0001-0000-6
Chemical Name: tert-Butyl perbenzoate
CASRN: 614-45-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096324_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/18/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 456 0.435 9.12 26.5 0.000
Test Chemical tert-Butyl perbenzoate 
 0.16      
 50 1050 468 0.446 9.36 26.5 2.534 
 0.5       
 50 1052 423 0.402 8.46 26.5 -7.501 
1.6       
 50 1049 618 0.589 12.36 26.5 35.526 
5         
 50 1048 1066 1.017 21.32 26.5 133.995 
16         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 585 0.558 11.70 26.5 28.289
Mitomycin-C 
 0.01      
 10 209 473 2.263 47.30 26.5 420.626
Trend: 17.625        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/28/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 473 0.451 9.46 27.5 0.000
Test Chemical tert-Butyl perbenzoate 
1         
 50 1049 584 0.557 11.68 27.5 23.467 
2.5       
 50 1048 749 0.715 14.98 27.5 58.502 
5         
 50 1049 1618 1.542 32.36 27.5 242.072
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 648 0.621 12.96 27.5 37.786
Mitomycin-C 
 0.005     
 10 210 329 1.567 32.90 27.5 247.449
Trend: 26.884        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/18/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 370 0.357 7.40 26.0 0.000
Test Chemical tert-Butyl perbenzoate 
 0.5       
 50 1045 368 0.352 7.36 26.0 -1.302 
1.6       
 50 1045 378 0.362 7.56 26.0 1.380 
5         
 50 1037 341 0.329 6.82 26.0 -7.838 
16         
 50 1039 434 0.418 8.68 26.0 17.072 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1042 646 0.620 12.92 26.0 73.757
Cyclophosphamide 
 0.6       
 50 1038 807 0.777 16.14 26.0 117.898
Trend: 1.673        
Probability: 0.047        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/28/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 413 0.395 8.26 26.5 0.000
Test Chemical tert-Butyl perbenzoate 
1         
 50 1051 400 0.381 8.00 26.5 -3.608 
5         
 50 1050 429 0.409 8.58 26.5 3.478 
10         
 50 1048 439 0.419 8.78 26.5 6.093
Positive Control Cyclophosphamide 
 0.3       
 50 1048 549 0.524 10.98 26.5 32.676
Trend: 1.159        
Probability: 0.123