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Study Information
Study Attribute Value
CEBS Accession Number: 002-03208-0002-0000-7
Chemical Name: tert-Butyl perbenzoate
CASRN: 614-45-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 096324_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 08/09/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: tert-Butyl perbenzoate 
5         
 100 9 0.090 9.0 3 0.030 3.0 6 0.060 6.0 0 0.000 0.0 
10         
 100 42 0.420 31.0 26 0.260 23.0 16 0.160 13.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 33 0.330 27.0 22 0.220 20.0 11 0.110 11.0 0 0.000 0.0
Mitomycin-C 
1         
 50 32 0.640 50.0 27 0.540 42.0 5 0.100 10.0 0 0.000 0.0
Trend: 6.180 6.240 3.110  
Probability: 0.000 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/08/1984    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: tert-Butyl perbenzoate 
10         
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
16         
 100 9 0.090 9.0 3 0.030 3.0 5 0.050 5.0 1 0.010 1.0 
30         
 100 15 0.150 14.0 10 0.100 9.0 5 0.050 5.0 0 0.000 0.0 
50         
 100 22 0.220 20.0 14 0.140 13.0 8 0.080 8.0 0 0.000 0.0 
100         
 34 26 0.765 26.0 13 0.382 21.0 2 0.059 6.0 11 0.324 2.0
Positive Control: Cyclophosphamide 
15         
 100 45 0.450 38.0 32 0.320 27.0 13 0.130 13.0 0 0.000 0.0
Trend: 5.612 5.518 2.119  
Probability: 0.000 0.000 0.017  


Trial #:2   Activation: No Activation    Date: 03/13/1985    Harvest Time: 17.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: tert-Butyl perbenzoate 
5         
 100 26 0.260 23.0 5 0.050 5.0 20 0.200 18.0 1 0.010 1.0 
10         
 100 38 0.380 32.0 24 0.240 20.0 14 0.140 14.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 26 0.260 21.0 11 0.110 9.0 15 0.150 14.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 22.0 14 0.280 18.0 5 0.100 8.0 0 0.000 0.0
Trend: 3.928 4.934 1.030  
Probability: 0.000 0.000 0.151