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Study Information
Study Attribute Value
CEBS Accession Number: 002-03221-0001-0000-1
Chemical Name: tris(2-Ethylhexyl) ester phosphorous acid
CASRN: 301-13-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 560845_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/05/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1033 438 0.424 8.76 26.0 0.000
Test Chemical tris(2-Ethylhexyl) ester phosphorous acid 
50         
 50 1012 456 0.451 9.12 26.0 6.270 
167         
 50 1032 413 0.400 8.26 26.0 -5.616 
500         
 50 1026 445 0.434 8.90 32.0 2.291 
1670         
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1029 571 0.555 11.42 26.0 30.872
Mitomycin-C 
 0.01      
 5 99 160 1.616 32.00 26.0 281.163
Trend: -0.255        
Probability: 0.601        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/05/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1007 538 0.534 10.76 26.0 0.000
Test Chemical tris(2-Ethylhexyl) ester phosphorous acid 
500         
 50 1017 585 0.575 11.70 26.0 7.667 
1670         
 50 1006 533 0.530 10.66 26.0 -0.831 
5000         
 50 1025 509 0.497 10.18 26.0 -7.052
Positive Control Cyclophosphamide 
 0.4       
 50 1023 672 0.657 13.44 26.0 22.953
Cyclophosphamide 
2         
 5 99 181 1.828 36.20 26.0 242.208
Trend: -1.552        
Probability: 0.940