COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0001-0000-2
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 980274_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1017 393 0.386 7.86 26.0 0.000
Test Chemical tris(2-Ethylhexyl)phosphate 
 0.5       
 50 1017 421 0.414 8.42 26.0 7.125 
1.67      
 50 1015 416 0.410 8.32 26.0 6.061 
5         
 50 1023 415 0.406 8.30 26.0 4.979 
16.7       
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 621 0.611 12.42 20.0 58.171
Mitomycin-C 
 0.01      
 5 105 212 2.019 42.40 26.0 422.486
Trend: 0.607        
Probability: 0.272        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1004 362 0.361 7.24 26.0 -33.154
Ethanol 
0         
 50 1003 541 0.539 10.82 26.0 0.000
Test Chemical tris(2-Ethylhexyl)phosphate 
50         
 50 1030 602 0.584 12.04 26.0 8.358 
167         
 50 1043 558 0.535 11.16 26.0 -0.813 
500         
 50 998 570 0.571 11.40 26.0 5.888 
1670         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1031 631 0.612 12.62 26.0 13.468
Cyclophosphamide 
2         
 5 105 161 1.533 32.20 26.0 184.276
Trend: 0.397        
Probability: 0.346        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/24/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1008 536 0.532 10.72 26.0 0.000
Negative (Not Specified) 
0         
 50 1001 391 0.391 7.82 26.0 -26.542
Test Chemical tris(2-Ethylhexyl)phosphate 
167.9       
 50 1020 546 0.535 10.92 26.0 0.667 
419.7       
 50 1009 541 0.536 10.82 26.0 0.833 
839         
 50 998 587 0.588 11.74 26.0 10.612 
1253         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 996 557 0.559 11.14 26.0 5.170
Cyclophosphamide 
2         
 5 100 182 1.820 36.40 26.0 242.269
Trend: 1.598        
Probability: 0.055