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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0001-0000-2
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 980274_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1017 393 0.386 7.86 26.0 0.000
Test Chemical tris(2-Ethylhexyl)phosphate 
 0.5       
 50 1017 421 0.414 8.42 26.0 7.125 
1.67      
 50 1015 416 0.410 8.32 26.0 6.061 
5         
 50 1023 415 0.406 8.30 26.0 4.979 
16.7       
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 621 0.611 12.42 20.0 58.171
Mitomycin-C 
 0.01      
 5 105 212 2.019 42.40 26.0 422.486
Trend: 0.607        
Probability: 0.272        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1004 362 0.361 7.24 26.0 -33.154
Ethanol 
0         
 50 1003 541 0.539 10.82 26.0 0.000
Test Chemical tris(2-Ethylhexyl)phosphate 
50         
 50 1030 602 0.584 12.04 26.0 8.358 
167         
 50 1043 558 0.535 11.16 26.0 -0.813 
500         
 50 998 570 0.571 11.40 26.0 5.888 
1670         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1031 631 0.612 12.62 26.0 13.468
Cyclophosphamide 
2         
 5 105 161 1.533 32.20 26.0 184.276
Trend: 0.397        
Probability: 0.346        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/24/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1008 536 0.532 10.72 26.0 0.000
Negative (Not Specified) 
0         
 50 1001 391 0.391 7.82 26.0 -26.542
Test Chemical tris(2-Ethylhexyl)phosphate 
167.9       
 50 1020 546 0.535 10.92 26.0 0.667 
419.7       
 50 1009 541 0.536 10.82 26.0 0.833 
839         
 50 998 587 0.588 11.74 26.0 10.612 
1253         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 996 557 0.559 11.14 26.0 5.170
Cyclophosphamide 
2         
 5 100 182 1.820 36.40 26.0 242.269
Trend: 1.598        
Probability: 0.055