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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0002-0000-3
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 980274_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/06/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 3.0 1 0.005 1.0 6 0.030 2.0 0 0.000 0.0
Ethanol 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: tris(2-Ethylhexyl)phosphate 
25.1       
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
37.5       
 200 8 0.040 4.0 1 0.005 1.0 7 0.035 4.0 0 0.000 0.0 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 45 0.450 23.0 25 0.250 19.0 20 0.200 16.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 18 0.720 44.0 10 0.400 28.0 8 0.320 32.0 0 0.000 0.0
Trend: 0.567 0.470 0.746  
Probability: 0.285 0.319 0.228  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/15/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Ethanol 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: tris(2-Ethylhexyl)phosphate 
839         
 200 2 0.010 1.0 0 0.000 0.0 1 0.005 1.0 1 0.005 1.0 
1253         
 200 8 0.040 4.0 1 0.005 1.0 7 0.035 3.0 0 0.000 0.0 
1670         
 200 7 0.035 4.0 2 0.010 1.0 5 0.025 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 19 0.095 9.0 11 0.055 6.0 8 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 10 0.400 36.0 6 0.240 20.0 4 0.160 16.0 0 0.000 0.0
Trend: 1.152 0.390 1.099  
Probability: 0.125 0.348 0.136