Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03222-0002-0000-3 |
Chemical Name: | tris(2-Ethylhexyl)phosphate |
CASRN: | 78-42-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 980274_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 1.0 | 6 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Ethanol | 0 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | tris(2-Ethylhexyl)phosphate | 25.1 | 200 | 5 | 0.025 | 3.0 | 1 | 0.005 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
37.5 | 200 | 8 | 0.040 | 4.0 | 1 | 0.005 | 1.0 | 7 | 0.035 | 4.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 100 | 45 | 0.450 | 23.0 | 25 | 0.250 | 19.0 | 20 | 0.200 | 16.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 18 | 0.720 | 44.0 | 10 | 0.400 | 28.0 | 8 | 0.320 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.567 | 0.470 | 0.746 | ||||||||||||
Probability: | 0.285 | 0.319 | 0.228 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Ethanol | 0 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | tris(2-Ethylhexyl)phosphate | 839 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 |
1253 | 200 | 8 | 0.040 | 4.0 | 1 | 0.005 | 1.0 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 | ||
1670 | 200 | 7 | 0.035 | 4.0 | 2 | 0.010 | 1.0 | 5 | 0.025 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 19 | 0.095 | 9.0 | 11 | 0.055 | 6.0 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 10 | 0.400 | 36.0 | 6 | 0.240 | 20.0 | 4 | 0.160 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.152 | 0.390 | 1.099 | ||||||||||||
Probability: | 0.125 | 0.348 | 0.136 |