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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0011-0000-3
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 135008_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/26/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.73 ± 0.205
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 4 7.13 ± 0.915
  
2500         
 4 7.02 ± 0.818
  
5000         
 4 7.21 ± 0.259
Positive Control Dimethylbenzanthracene 
2.5       
 4 14.04 ± 0.641


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/12/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.36 ± 0.253
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 4 4.56 ± 0.448
  
2500         
 4 5.47 ± 0.521
  
5000         
 4 5.27 ± 0.188
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.30 ± 0.248


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/05/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.54 ± 0.247
Test Chemical tris(2-Ethylhexyl)phosphate 
3750         
 4 3.96 ± 0.275
  
5000         
 4 3.70 ± 0.373
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.57 ± 1.101


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed