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Study Information
Study Attribute Value
CEBS Accession Number: 002-03222-0012-0000-4
Chemical Name: tris(2-Ethylhexyl)phosphate
CASRN: 78-42-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 135008_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/09/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2844
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 17.00 ± 2.10 0.0000
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 8 1.50 ± 0.50 0.8899
  
2500         
 8 1.75 ± 0.70 0.8299
  
5000         
 8 3.00 ± 0.65 0.4162
Vehicle Control No Stressor 
 0         
 8 2.75 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/29/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3057
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 10.50 ± 1.59 0.0000
Test Chemical tris(2-Ethylhexyl)phosphate 
1250         
 8 1.00 ± 0.76 0.6313
  
2500         
 8 1.75 ± 0.59 0.2804
  
5000         
 8 1.50 ± 0.63 0.3807
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.65 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed