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Study Information
Study Attribute Value
CEBS Accession Number: 002-03239-0003-0000-2
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 097978_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/01/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.75 ± 2.15 0.0000
Test Chemical DL-menthol 
225         
 8 2.50 ± 1.05 0.3168
  
450         
 8 4.00 ± 0.76 0.0487
  
900         
 8 7.75 ± 1.67 0.0001
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/15/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9794
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 8.50 ± 1.76 0.0157
Test Chemical DL-menthol 
450         
 8 2.50 ± 0.73 0.9391
  
675         
 8 2.75 ± 0.65 0.9092
  
900         
 8 2.00 ± 0.85 0.9770
Vehicle Control No Stressor 
 0         
 7 4.57 ± 1.43 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/12/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0191
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 21.50 ± 2.35 0.0000
Test Chemical DL-menthol 
225         
 8 1.25 ± 0.65 0.3687
  
450         
 8 1.50 ± 0.63 0.2622
  
900         
 8 2.75 ± 0.75 0.0340
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.38 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/09/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0319
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 24.50 ± 1.72 0.0000
Test Chemical DL-menthol 
225         
 8 2.75 ± 0.65 0.7874
  
450         
 8 3.25 ± 1.06 0.6498
  
900         
 7 6.00 ± 0.87 0.0752
Vehicle Control No Stressor 
 0         
 8 3.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed