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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | 2,3 butanedione |
CASRN: | ="431-03-8" |
Study Number: | I20606 |
Exposure Route: | RESPIRATORY EXPOSURE WHOLE BODY |
TDMS Number: | 2060699 |
Sex: | Female |
Strain and Species: | BALB/C Mice |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
1 |
6 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
3 |
9 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
4 |
20 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
5 |
35 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 ppm |
5 |
37 |
16 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 ppm |
5 |
39 |
33 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 ppm |
5 |
40 |
45 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 ppm |
5 |
41 |
56 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 ppm |
6 |
25 |
2 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 ppm |
6 |
26 |
14 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 ppm |
6 |
27 |
43 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 ppm |
6 |
28 |
52 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 ppm |
6 |
30 |
84 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 ppm |
6 |
13 |
22 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 ppm |
6 |
16 |
40 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 ppm |
6 |
17 |
46 |
25 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Follicles, Germ center |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Increased Number |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Follicles, Germ center |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Increased Number |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Marginal Zone |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Marginal Zone |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Marginal Zone |
100 ppm |
6 |
15 |
27 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Marginal Zone |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Increased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Marginal Zone |
100 ppm |
6 |
17 |
46 |
25 |
1 |
Increased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
25 ppm |
5 |
38 |
31 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Decreased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
28 |
52 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Decreased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
17 |
46 |
25 |
1 |
Decreased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Decreased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
PeriLympSheath |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Number |
Minimal, Pig Macrophag |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
50 ppm |
6 |
28 |
52 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
100 ppm |
6 |
17 |
46 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Number |
Minimal, Hemat Cells |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Red Pulp |
50 ppm |
6 |
27 |
43 |
25 |
1 |
Increased Number |
Mild, Hemat Cells |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
38 |
31 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Decreased Number |
Mild, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
15 |
27 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Decreased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Decreased Size |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Decreased Size |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
15 |
27 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
17 |
46 |
25 |
1 |
Decreased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Extramedullary Hematopoiesis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
37 |
16 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
37 |
16 |
25 |
1 |
Increased Number |
Minimal, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
38 |
31 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Number |
Mild, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Increased Number |
Minimal, Lymphoblasts |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Increased Number |
Minimal, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
27 |
43 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
27 |
43 |
25 |
1 |
Increased Number |
Minimal, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
28 |
52 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
29 |
64 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
29 |
64 |
25 |
1 |
Increased Number |
Minimal, Lymphoblasts |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
29 |
64 |
25 |
1 |
Increased Number |
Minimal, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Number |
Minimal, Ting Body Macr |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Increased Number |
Mild, Lymphoblasts |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Increased Number |
Minimal, Apoptotic Cel |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Increased Number |
Minimal, Lymphoblasts |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
Vehicle Control |
5 |
3 |
9 |
25 |
1 |
Extramedullary Hematopoiesis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Number |
Mild, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
50 ppm |
6 |
27 |
43 |
25 |
1 |
Increased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Increased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Increased Number |
Mild, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
15 |
27 |
25 |
1 |
Increased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Increased Number |
Mild, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
17 |
46 |
25 |
1 |
Increased Number |
Mild, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Increased Number |
Minimal, Lymphocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
25 ppm |
5 |
41 |
56 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Medulla |
100 ppm |
6 |
15 |
27 |
25 |
1 |
Increased Size |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
50 ppm |
6 |
25 |
2 |
25 |
1 |
Decreased Cortex Medulla Ratio |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
50 ppm |
6 |
25 |
2 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
50 ppm |
6 |
28 |
52 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
50 ppm |
6 |
29 |
64 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
50 ppm |
6 |
30 |
84 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
50 ppm |
6 |
26 |
14 |
25 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
100 ppm |
6 |
13 |
22 |
25 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
100 ppm |
6 |
14 |
25 |
25 |
1 |
Regeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
100 ppm |
6 |
16 |
40 |
25 |
1 |
Regeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
100 ppm |
6 |
18 |
63 |
25 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |