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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | 2,4-Decadienal |
CASRN: | ="25152-84-5" |
Study Number: | C93022B |
Exposure Route: | GAVAGE |
TDMS Number: | 9302203 |
Sex: | Male |
Strain and Species: | F 344/N Rats |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Intestine Small |
Duodenum |
800 MG/KG/DY |
10 |
11 |
54 |
94 |
1 |
Erosion |
Mild, Focal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum |
800 MG/KG/DY |
10 |
11 |
54 |
94 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
9 |
94 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
7 |
94 |
1 |
Infiltration Cellular |
Mild, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Infiltration Cellular |
Mild, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
400 MG/KG/DY |
10 |
10 |
46 |
94 |
1 |
Edema |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
400 MG/KG/DY |
10 |
10 |
49 |
94 |
1 |
Edema |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
400 MG/KG/DY |
10 |
10 |
49 |
94 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
400 MG/KG/DY |
10 |
9 |
41 |
94 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
800 MG/KG/DY |
10 |
11 |
53 |
94 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
400 MG/KG/DY |
10 |
10 |
46 |
94 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
52 |
94 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
53 |
94 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
54 |
94 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
55 |
94 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
400 MG/KG/DY |
10 |
10 |
46 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
400 MG/KG/DY |
10 |
10 |
50 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
400 MG/KG/DY |
10 |
9 |
42 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
400 MG/KG/DY |
10 |
9 |
43 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
52 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
54 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
11 |
55 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
12 |
56 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
800 MG/KG/DY |
10 |
12 |
59 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
2 |
94 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
3 |
94 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
8 |
94 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
2 |
10 |
94 |
1 |
Accessory Adrenal Cortical Nodule |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
10 |
1 |
5 |
94 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
800 MG/KG/DY |
10 |
12 |
60 |
94 |
1 |
Ultimobranchial Cyst |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
1 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
2 |
94 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
3 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
4 |
94 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
10 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
7 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
9 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
800 MG/KG/DY |
10 |
11 |
52 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
800 MG/KG/DY |
10 |
11 |
53 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
800 MG/KG/DY |
10 |
11 |
55 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
800 MG/KG/DY |
10 |
12 |
59 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
1 |
4 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
400 MG/KG/DY |
1 |
9 |
44 |
94 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Hemorrhage |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
800 MG/KG/DY |
10 |
12 |
60 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Integumentary System |
Skin |
|
400 MG/KG/DY |
1 |
10 |
46 |
94 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
1 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
4 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
10 |
94 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
6 |
94 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
800 MG/KG/DY |
10 |
11 |
51 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
800 MG/KG/DY |
10 |
12 |
58 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
800 MG/KG/DY |
10 |
12 |
60 |
94 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
6 |
94 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
800 MG/KG/DY |
10 |
12 |
60 |
94 |
1 |
Metaplasia, Osseous |
Minimal, Osseous |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
200 MG/KG/DY |
9 |
8 |
39 |
94 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
400 MG/KG/DY |
10 |
9 |
41 |
94 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
800 MG/KG/DY |
10 |
12 |
57 |
94 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
800 MG/KG/DY |
10 |
12 |
58 |
94 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
800 MG/KG/DY |
10 |
12 |
59 |
94 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
800 MG/KG/DY |
10 |
12 |
60 |
94 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
200 MG/KG/DY |
9 |
8 |
39 |
94 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
800 MG/KG/DY |
10 |
12 |
56 |
94 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Sinus |
200 MG/KG/DY |
9 |
8 |
39 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
200 MG/KG/DY |
9 |
8 |
39 |
94 |
1 |
Osteofibrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
400 MG/KG/DY |
10 |
9 |
41 |
94 |
1 |
Osteofibrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
800 MG/KG/DY |
10 |
11 |
53 |
94 |
1 |
Osteofibrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
800 MG/KG/DY |
10 |
11 |
55 |
94 |
1 |
Osteofibrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
800 MG/KG/DY |
10 |
12 |
59 |
94 |
1 |
Osteofibrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
400 MG/KG/DY |
10 |
9 |
41 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
400 MG/KG/DY |
10 |
9 |
45 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
11 |
53 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
11 |
54 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
12 |
56 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
12 |
57 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
12 |
58 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
12 |
59 |
94 |
1 |
Exudate |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
2 |
10 |
94 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Nose |
|
800 MG/KG/DY |
10 |
12 |
56 |
94 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |