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Chemical Name: | 2-Methylimidazole |
---|---|
CASRN: | ="693-98-1" |
Study Number: | C92012 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | FEED |
TDMS Number: | 9201204.ss |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Hematology Individual Animal Data | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | HCT (spun) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Retics (million/uL) | Platelet (1000/mL) | Leukocytes (1000/mL) | Seg Neut (1000/mL) | Band Neut (1000/mL) | Lymph (1000/mL) | Mono (1000/mL) | EOS (1000/mL) | NRBC (per 100 WC) |
Day 93 | 0001 | 0 | U | 9.72 | 15.6 | 51 | 52 | 52.5 | 16 | 30.6 | 0.107 | 937 | 6.7 | 0.268 | 0.134 | 6.03 | 0.201 | 0.067 | 0 |
Day 93 | 0002 | 0 | U | 9.47 | 15.2 | 48.9 | 50.5 | 51.6 | 16.1 | 31.1 | 0.152 | 1012 | 4.2 | 0.588 | 0.084 | 3.276 | 0.126 | 0.126 | 1 |
Day 93 | 0003 | 0 | U | 8.78 | 14.7 | 44 | 47 | 50.1 | 16.7 | 33.4 | 0.132 | 888 | 3.2 | 0.416 | 0 | 2.528 | 0.224 | 0.032 | 0 |
Day 93 | 0004 | 0 | U | 10.38 | 16.7 | 53 | 55 | 51.1 | 16.1 | 31.5 | 0.218 | 867 | 4.8 | 0.672 | 0.096 | 3.888 | 0.096 | 0 | 0 |
Day 93 | 0005 | 0 | U | 9.2 | 15.9 | 49.6 | 50.5 | 53.9 | 17.3 | 32.1 | 0.202 | 938 | 6.8 | 0.816 | 0.136 | 5.576 | 0.272 | 0 | 0 |
Day 93 | 0006 | 0 | U | 9.86 | 15.9 | 49.6 | 49 | 50.3 | 16.1 | 32.1 | 0.177 | 755 | 6.4 | 0.832 | 0 | 5.312 | 0.192 | 0.064 | 0 |
Day 93 | 0007 | 0 | U | 9.92 | 16.2 | 52.5 | 51.5 | 52.9 | 16.3 | 30.9 | 0.188 | 985 | 8.3 | 0.581 | 0.332 | 6.723 | 0.581 | 0.083 | 0 |
Day 93 | 0008 | 0 | U | 9.5 | 15.2 | 47.6 | 49.5 | 50.1 | 16 | 31.9 | 0.181 | 940 | 2.3 | 0.437 | 0.046 | 1.61 | 0.092 | 0.092 | 0 |
Day 93 | 0009 | 0 | U | 9 | 15.2 | 46.1 | 48 | 51.2 | 16.9 | 33 | 0.126 | 978 | 1.9 | 0.361 | 0.038 | 1.406 | 0.038 | 0.038 | 0 |
Day 93 | 0010 | 0 | U | 9.98 | 15.8 | 49.6 | 51 | 49.7 | 15.8 | 31.9 | 0.19 | 718 | 5.7 | 0.684 | 0 | 4.845 | 0.114 | 0 | 0 |
Day 93 | 0011 | 625 | 9.25 | 15.7 | 48.7 | 49.5 | 52.7 | 17 | 32.2 | 0.287 | 974 | 3.2 | 0.448 | 0.032 | 2.528 | 0.16 | 0.032 | 0 | |
Day 93 | 0012 | 625 | 9.06 | 15.4 | 48.5 | 49.5 | 53.5 | 17 | 31.8 | 0.19 | 921 | 1.6 | 0.32 | 0 | 1.28 | 0 | 0 | 0 | |
Day 93 | 0013 | 625 | 9.2 | 14.6 | 45.9 | 48 | 49.9 | 15.9 | 31.8 | 0.184 | 835 | 4.1 | 0.697 | 0 | 3.198 | 0.123 | 0.082 | 0 | |
Day 93 | 0014 | 625 | 8.28 | 14.8 | 42.8 | 50 | 51.7 | 17.9 | 34.6 | 0.083 | 856 | 2.2 | 0.528 | 0 | 1.628 | 0.044 | 0 | 1 | |
Day 93 | 0015 | 625 | 9.07 | 15.1 | 46.6 | 49 | 51.4 | 16.6 | 32.4 | 0.154 | 917 | 2.4 | 0.504 | 0.024 | 1.704 | 0.144 | 0.024 | 0 | |
Day 93 | 0016 | 625 | 8.71 | 15.1 | 45.1 | 48 | 51.8 | 17.3 | 33.5 | 0.165 | 955 | 2.8 | 0.224 | 0 | 2.576 | 0 | 0 | 0 | |
Day 93 | 0017 | 625 | 8.81 | 14.7 | 45.1 | 49 | 51.2 | 16.7 | 32.6 | 0.106 | 926 | 2.6 | 0.078 | 0 | 2.522 | 0 | 0 | 1 | |
Day 93 | 0018 | 625 | 9.21 | 15.2 | 48.9 | 50 | 53.1 | 16.5 | 31.1 | 0.175 | 978 | 2.6 | 0.208 | 0 | 2.262 | 0.052 | 0.078 | 0 | |
Day 93 | 0019 | 625 | 9.37 | 15.2 | 48.2 | 48 | 51.4 | 16.2 | 31.5 | 0.122 | 929 | 3.6 | 0.396 | 0 | 3.132 | 0.072 | 0 | 0 | |
Day 93 | 0020 | 625 | 9.45 | 15.7 | 49 | 50.5 | 51.8 | 16.6 | 32 | 0.255 | 1050 | 4.3 | 0.172 | 0 | 4.042 | 0.086 | 0 | 0 | |
Day 93 | 0021 | 1250 | 8.29 | 14.3 | 43.4 | 47 | 52.4 | 17.2 | 32.9 | 0.332 | 967 | 4.1 | 0.369 | 0 | 3.69 | 0 | 0.041 | 0 | |
Day 93 | 0022 | 1250 | 8.8 | 15.1 | 46.3 | 48.5 | 52.6 | 17.2 | 32.6 | 0.246 | 1076 | 3.4 | 0.204 | 0.034 | 3.026 | 0.136 | 0 | 0 | |
Day 93 | 0023 | 1250 | 7.98 | 14.3 | 41.7 | 45 | 52.3 | 17.9 | 34.3 | 0.327 | 981 | 2.5 | 0.15 | 0 | 2.325 | 0.025 | 0 | 1 | |
Day 93 | 0024 | 1250 | 8.23 | 14.2 | 42.9 | 45 | 52.1 | 17.3 | 33.1 | 0.346 | 972 | 5.7 | 1.083 | 0.057 | 4.047 | 0.456 | 0 | 0 | |
Day 93 | 0025 | 1250 | 7.92 | 13.9 | 41.4 | 43.5 | 52.3 | 17.6 | 33.6 | 0.293 | 948 | 4.1 | 0.656 | 0 | 3.198 | 0.123 | 0.082 | 0 | |
Day 93 | 0026 | 1250 | 8.21 | 14.9 | 42.8 | 45 | 52.1 | 18.1 | 34.8 | 0.246 | 1008 | 3.9 | 0.078 | 0 | 3.393 | 0.429 | 0 | 0 | |
Day 93 | 0027 | 1250 | 6.13 | 10.8 | 31.9 | 35.5 | 52 | 17.6 | 33.9 | 0.159 | 756 | 8.4 | 5.208 | 0 | 3.024 | 0 | 0.168 | 0 | |
Day 93 | 0028 | 1250 | 8.5 | 15.2 | 44.7 | 46 | 52.6 | 17.9 | 34 | 0.391 | 803 | 3.7 | 1.221 | 0.111 | 1.998 | 0.37 | 0 | 0 | |
Day 93 | 0029 | 1250 | 7.65 | 14.2 | 40.4 | 45 | 52.8 | 18.6 | 35.1 | 0.513 | 938 | 3.3 | 0.627 | 0 | 2.475 | 0.165 | 0.033 | 0 | |
Day 93 | 0030 | 1250 | 8.49 | 14.5 | 43.9 | 47 | 51.7 | 17.1 | 33 | 0.212 | 1031 | 2.2 | 0.352 | 0 | 1.65 | 0.198 | 0 | 0 | |
Day 93 | 0031 | 2500 | 7.19 | 13.5 | 38.9 | 41 | 54.1 | 18.8 | 34.7 | 0.467 | 1169 | 2.8 | 0.336 | 0.056 | 2.268 | 0.14 | 0 | 0 | |
Day 93 | 0032 | 2500 | 6.54 | 12.1 | 35.7 | 41 | 54.6 | 18.5 | 33.9 | 0.549 | 1049 | 5.9 | 1.534 | 0 | 4.13 | 0.236 | 0 | 0 | |
Day 93 | 0033 | 2500 | 7.13 | 12.9 | 38.2 | 42 | 53.6 | 18.1 | 33.8 | 0.513 | 1138 | 4.2 | 0.546 | 0 | 3.57 | 0 | 0.042 | 0 | |
Day 93 | 0034 | 2500 | 6.67 | 12.1 | 35.6 | 38 | 53.4 | 18.1 | 34 | 0.727 | 1217 | 3.4 | 0.17 | 0 | 3.23 | 0 | 0 | 0 | |
Day 93 | 0035 | 2500 | 6.95 | 12.5 | 37.7 | 39.5 | 54.2 | 18 | 33.2 | 0.417 | 1274 | 4.4 | 1.452 | 0 | 2.816 | 0.044 | 0.088 | 0 | |
Day 93 | 0036 | 2500 | 6.64 | 12.1 | 35.5 | 38.5 | 53.4 | 18.2 | 34.1 | 0.319 | 1231 | 4.5 | 0.45 | 0 | 3.825 | 0.225 | 0 | 0 | |
Day 93 | 0037 | 2500 | 6.88 | 12.8 | 37.4 | 39 | 54.3 | 18.6 | 34.2 | 0.378 | 1196 | 2.4 | 0.264 | 0 | 2.088 | 0.048 | 0 | 0 | |
Day 93 | 0038 | 2500 | 6.83 | 12.4 | 36.5 | 39.5 | 53.5 | 18.2 | 34 | 0.587 | 1198 | 4.2 | 0.252 | 0 | 3.906 | 0.042 | 0 | 0 | |
Day 93 | 0039 | 2500 | 6.63 | 12.5 | 36.3 | 40 | 54.8 | 18.9 | 34.4 | 0.517 | 1139 | 5.4 | 0.54 | 0 | 4.158 | 0.648 | 0.054 | 0 | |
Day 93 | 0040 | 2500 | 6.82 | 12.3 | 36.8 | 40 | 53.9 | 18 | 33.4 | 0.737 | 1224 | 4.4 | 0.748 | 0 | 3.3 | 0.22 | 0.044 | 0 | |
Day 93 | 0041 | 5000 | 5.67 | 11.5 | 32.4 | 37 | 57.2 | 20.3 | 35.5 | 0.641 | 1292 | 5.7 | 0.684 | 0 | 4.902 | 0.114 | 0 | 0 | |
Day 93 | 0042 | 5000 | 5.99 | 11.8 | 34.4 | 36 | 57.5 | 19.7 | 34.3 | 0.443 | 1213 | 5.2 | 0.676 | 0 | 4.368 | 0.156 | 0 | 0 | |
Day 93 | 0043 | 5000 | 6.71 | 12.4 | 36.6 | 40 | 54.5 | 18.5 | 33.9 | 0.376 | 1058 | 7 | 0.91 | 0 | 5.74 | 0.35 | 0 | 0 | |
Day 93 | 0044 | 5000 | 6.06 | 12.1 | 35 | 40 | 57.8 | 20 | 34.6 | 0.642 | 1164 | 4.2 | 0.336 | 0 | 3.864 | 0 | 0 | 0 | |
Day 93 | 0045 | 5000 | 6.08 | 12.1 | 34.6 | 38.5 | 56.9 | 19.9 | 35 | 1.003 | 1181 | 6.1 | 0.305 | 0 | 5.673 | 0.122 | 0 | 1 | |
Day 93 | 0046 | 5000 | 5.57 | 10.9 | 31.9 | 34 | 57.3 | 19.6 | 34.2 | 0.785 | 1222 | 8 | 3.12 | 0.08 | 4.72 | 0.08 | 0 | 0 | |
Day 93 | 0047 | 5000 | 5.78 | 11.3 | 33.4 | 35 | 57.7 | 19.6 | 33.8 | 0.89 | 1117 | 9.6 | 0.864 | 0 | 7.968 | 0.768 | 0 | 0 | |
Day 93 | 0048 | 5000 | 6.57 | 12.6 | 37.2 | 40.5 | 56.6 | 19.2 | 33.9 | 1.202 | 1158 | 8 | 1.12 | 0.08 | 6.56 | 0.16 | 0.08 | 0 | |
Day 93 | 0049 | 5000 | 5.83 | 11.5 | 33.7 | 38 | 57.8 | 19.7 | 34.1 | 0.542 | 1346 | 7.6 | 0.608 | 0 | 6.992 | 0 | 0 | 1 | |
Day 93 | 0050 | 5000 | 5.42 | 11.4 | 31.5 | 32.5 | 58.1 | 21 | 36.2 | 0.976 | 1684 | 12.7 | 0.889 | 0.127 | 11.684 | 0 | 0 | 0 | |
Day 93 | 0051 | 10000 | 5.81 | 11.9 | 34.6 | 38 | 59.5 | 20.5 | 34.4 | 0.854 | 1240 | 15.9 | 1.59 | 0 | 13.833 | 0.477 | 0 | 0 | |
Day 93 | 0052 | 10000 | 6.03 | 11.8 | 35.2 | 39 | 58.4 | 19.6 | 33.5 | 0.856 | 1214 | 4.9 | 0.098 | 0 | 4.802 | 0 | 0 | 0 | |
Day 93 | 0053 | 10000 | 5.93 | 12.1 | 34 | 36 | 57.4 | 20.4 | 35.6 | 0.741 | 1401 | 5.1 | 0.714 | 0 | 4.233 | 0.153 | 0 | 0 | |
Day 93 | 0054 | 10000 | 6.87 | 12.9 | 39.6 | 43 | 57.7 | 18.8 | 32.6 | 0.872 | 928 | 6.3 | 0.693 | 0 | 5.355 | 0.252 | 0 | 0 | |
Day 93 | 0055 | 10000 | 6.18 | 12.4 | 35.1 | 37 | 56.8 | 20.1 | 35.3 | 0.754 | 1316 | 4 | 0.84 | 0 | 3.12 | 0.04 | 0 | 0 | |
Day 93 | 0056 | 10000 | 5.96 | 12 | 35.2 | 37.5 | 59 | 20.1 | 34.1 | 0.817 | 1229 | 14.9 | 4.321 | 0 | 9.536 | 0.447 | 0.298 | 0 | |
Day 93 | 0057 | 10000 | 5.78 | 12.3 | 34.4 | 38 | 59.6 | 21.3 | 35.8 | 1.092 | 1069 | 21.5 | 2.365 | 0 | 17.845 | 1.075 | 0 | 0 | |
Day 93 | 0058 | 10000 | 5.81 | 11.7 | 33.4 | 35.5 | 57.5 | 20.1 | 35 | 1.081 | 1369 | 7.5 | 0.375 | 0 | 6.75 | 0.3 | 0.075 | 0 | |
Day 93 | 0059 | 10000 | 4.94 | 11.1 | 30 | 32.5 | 60.8 | 22.5 | 37 | 0.919 | 1622 | 14.5 | 0.725 | 0 | 13.195 | 0.58 | 0 | 0 | |
Day 93 | 0060 | 10000 | 5.71 | 11.9 | 34.5 | 38 | 60.4 | 20.8 | 34.5 | 1.096 | 1089 | 17.8 | 1.78 | 0 | 15.842 | 0.178 | 0 | 0 | |
Abbreviations: | |||||||||||||||||||
NA: Not Available, U: Untreated Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, HCT (spun): Hematocrit Manual, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Seg Neut: Segmented Neutrophil Count, Band Neut: Band Neutrophil Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, NRBC: Nucleated Rbc Per 100 Wbc |