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Chemical Name: | 4-Methylimidazole |
---|---|
CASRN: | ="822-36-6" |
Study Number: | C92013 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | FEED |
TDMS Number: | 9201304.ss |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Clinical Chemistry Individual Animal Data | ||||||
---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | T3 (ng per dL) | T4 (ug per dL) | TSH (ng per dL) |
Day 8 | 0431 | 0 | U | 146 | 7.8 | 24.00 |
Day 8 | 0432 | 0 | U | 140 | 8.9 | 7.00 |
Day 8 | 0433 | 0 | U | 165 | 7.4 | 14.00 |
Day 8 | 0434 | 0 | U | QNS | 9 | 11.00 |
Day 8 | 0435 | 0 | U | QNS | 7.2 | 20.0 |
Day 8 | 0436 | 0 | U | QNS | 6.9 | 29.00 |
Day 8 | 0437 | 0 | U | QNS | 6.1 | 240.0 |
Day 8 | 0438 | 0 | U | 129 | 7.3 | 21.00 |
Day 8 | 0439 | 0 | U | 135 | 4.7 | 13.00 |
Day 8 | 0440 | 0 | U | 119 | 6.1 | 14.00 |
Day 8 | 0441 | 625 | 138 | 6.4 | 9.00 | |
Day 8 | 0442 | 625 | 144 | 8.8 | 13.00 | |
Day 8 | 0443 | 625 | QNS | 6.7 | 16.00 | |
Day 8 | 0444 | 625 | 133 | 5.7 | 17.00 | |
Day 8 | 0445 | 625 | 119 | 7.9 | 18.00 | |
Day 8 | 0446 | 625 | 129 | 7.3 | 28.00 | |
Day 8 | 0447 | 625 | QNS | 7.3 | 20.0 | |
Day 8 | 0448 | 625 | 143 | 6.8 | 13.00 | |
Day 8 | 0449 | 625 | QNS | 5.6 | 22.00 | |
Day 8 | 0450 | 625 | QNS | 7.4 | 15.00 | |
Day 8 | 0451 | 1250 | 129 | 5.8 | 14.00 | |
Day 8 | 0452 | 1250 | 134 | 7.6 | 4.00 | |
Day 8 | 0453 | 1250 | 118 | 6 | 10.0 | |
Day 8 | 0454 | 1250 | 122 | 6.4 | 14.00 | |
Day 8 | 0455 | 1250 | 126 | 6.9 | 8.00 | |
Day 8 | 0456 | 1250 | QNS | 8.2 | 16.00 | |
Day 8 | 0457 | 1250 | 121 | 7.3 | 7.00 | |
Day 8 | 0458 | 1250 | QNS | 8.3 | 15.00 | |
Day 8 | 0459 | 1250 | 118 | 8.2 | 18.00 | |
Day 8 | 0460 | 1250 | QNS | 8.3 | 19.00 | |
Day 8 | 0461 | 2500 | 133 | 6.5 | 14.00 | |
Day 8 | 0462 | 2500 | 130 | 6.4 | 17.00 | |
Day 8 | 0463 | 2500 | 136 | 7.8 | 16.00 | |
Day 8 | 0464 | 2500 | 130 | 8.1 | 18.00 | |
Day 8 | 0465 | 2500 | 148 | 8.5 | 30.0 | |
Day 8 | 0466 | 2500 | 133 | 7.6 | 9.00 | |
Day 8 | 0467 | 2500 | 121 | 7.8 | 13.00 | |
Day 8 | 0468 | 2500 | 144 | 6.9 | 16.00 | |
Day 8 | 0469 | 2500 | QNS | 9.1 | 14.00 | |
Day 8 | 0470 | 2500 | 120 | 9.1 | 6.00 | |
Day 8 | 0471 | 5000 | QNS | 6.4 | 14.00 | |
Day 8 | 0472 | 5000 | QNS | 5.6 | 22.00 | |
Day 8 | 0473 | 5000 | QNS | 6.5 | 11.00 | |
Day 8 | 0474 | 5000 | QNS | 6.6 | 14.00 | |
Day 8 | 0475 | 5000 | QNS | 8 | 15.00 | |
Day 8 | 0476 | 5000 | 116 | 6.9 | 15.00 | |
Day 8 | 0477 | 5000 | 154 | 6.5 | 14.00 | |
Day 8 | 0478 | 5000 | QNS | 6.6 | 414.00 | |
Day 8 | 0479 | 5000 | 138 | 8.8 | 12.00 | |
Day 8 | 0480 | 5000 | QNS | 10 | 6.00 | |
Day 8 | 0481 | 10000 | QNS | 6.3 | 16.00 | |
Day 8 | 0483 | 10000 | QNS | 7.8 | 26.00 | |
Day 8 | 0484 | 10000 | QNS | 6.5 | 12.00 | |
Day 8 | 0485 | 10000 | QNS | 7.6 | 8.00 | |
Day 8 | 0486 | 10000 | QNS | 5.9 | 12.00 | |
Day 8 | 0487 | 10000 | QNS | 5.6 | 16.00 | |
Day 8 | 0488 | 10000 | QNS | 4 | 25.00 | |
Day 8 | 0489 | 10000 | QNS | 7.7 | 18.00 | |
Day 8 | 0490 | 10000 | QNS | 7.6 | 15.00 | |
Day 29 | 0311 | 0 | U | 118 | 7.4 | 2.00 |
Day 29 | 0312 | 0 | U | 149 | 6.7 | 43.00 |
Day 29 | 0313 | 0 | U | 120 | 7 | 0 |
Day 29 | 0314 | 0 | U | 131 | 6.9 | 72.00 |
Day 29 | 0315 | 0 | U | 145 | 6.4 | 65.00 |
Day 29 | 0316 | 0 | U | 130 | 6.6 | 0 |
Day 29 | 0317 | 0 | U | 135 | 7.7 | 0 |
Day 29 | 0318 | 0 | U | 132 | 7.6 | 87.00 |
Day 29 | 0319 | 0 | U | 115 | 6.3 | 10.0 |
Day 29 | 0320 | 0 | U | 133 | 7.2 | 1.00 |
Day 29 | 0321 | 625 | 123 | 6.3 | 0 | |
Day 29 | 0322 | 625 | QNS | 6.4 | 0 | |
Day 29 | 0323 | 625 | 121 | 6.7 | 1.00 | |
Day 29 | 0324 | 625 | 153 | 7 | 33.00 | |
Day 29 | 0325 | 625 | QNS | 7.5 | 0 | |
Day 29 | 0326 | 625 | 149 | 7.6 | 0 | |
Day 29 | 0327 | 625 | 131 | 6.6 | 0 | |
Day 29 | 0328 | 625 | 113 | 6.6 | 0 | |
Day 29 | 0329 | 625 | 128 | 6.3 | 65.00 | |
Day 29 | 0330 | 625 | 142 | 6.6 | 68.00 | |
Day 29 | 0331 | 1250 | 148 | 7.6 | 0 | |
Day 29 | 0332 | 1250 | 126 | 6.9 | 0 | |
Day 29 | 0333 | 1250 | 137 | 6.6 | 34.00 | |
Day 29 | 0334 | 1250 | 136 | 6.7 | 28.00 | |
Day 29 | 0335 | 1250 | 136 | 7.5 | 0 | |
Day 29 | 0336 | 1250 | 124 | 7.1 | 0 | |
Day 29 | 0337 | 1250 | 117 | 7.9 | 7.00 | |
Day 29 | 0338 | 1250 | 133 | 7.3 | 0 | |
Day 29 | 0339 | 1250 | 132 | 6.3 | 55.00 | |
Day 29 | 0340 | 1250 | 119 | 8 | 0 | |
Day 29 | 0341 | 2500 | QNS | 7 | 5.00 | |
Day 29 | 0342 | 2500 | QNS | 7.2 | 22.00 | |
Day 29 | 0343 | 2500 | 133 | 6.6 | 7.00 | |
Day 29 | 0344 | 2500 | 159 | 7.9 | 0 | |
Day 29 | 0345 | 2500 | 140 | 7 | 0 | |
Day 29 | 0346 | 2500 | 166 | 7.1 | 0 | |
Day 29 | 0347 | 2500 | QNS | 6.5 | 0 | |
Day 29 | 0348 | 2500 | 146 | 6 | 58.00 | |
Day 29 | 0349 | 2500 | 116 | 6.5 | 7.00 | |
Day 29 | 0350 | 2500 | 126 | 6.2 | 3.00 | |
Day 29 | 0351 | 5000 | QNS | 7.4 | 3.00 | |
Day 29 | 0352 | 5000 | 173 | 7.3 | 5.00 | |
Day 29 | 0353 | 5000 | 159 | 9.1 | 26.00 | |
Day 29 | 0354 | 5000 | 139 | 8.1 | 0 | |
Day 29 | 0355 | 5000 | 159 | 9.2 | 65.00 | |
Day 29 | 0356 | 5000 | 139 | 6.6 | 66.00 | |
Day 29 | 0357 | 5000 | 153 | 8 | 58.00 | |
Day 29 | 0358 | 5000 | QNS | 5.6 | 0 | |
Day 29 | 0359 | 5000 | 156 | 6.7 | 66.00 | |
Day 29 | 0360 | 5000 | 129 | 7.1 | 29.00 | |
Day 29 | 0361 | 10000 | 141 | 5.7 | 0 | |
Day 29 | 0363 | 10000 | QNS | 5.3 | 0 | |
Day 29 | 0367 | 10000 | QNS | 6 | 1.00 | |
Day 29 | 0368 | 10000 | 156 | 5.2 | 90.0 | |
Day 29 | 0369 | 10000 | QNS | 5.6 | 10.0 | |
Day 86 | 0191 | 0 | U | QNS | 5.5 | 10.0 |
Day 86 | 0192 | 0 | U | QNS | 6.6 | 28.00 |
Day 86 | 0193 | 0 | U | 103 | 6.8 | 0 |
Day 86 | 0194 | 0 | U | QNS | 5.8 | 33.00 |
Day 86 | 0195 | 0 | U | 121 | 8.1 | 8.00 |
Day 86 | 0196 | 0 | U | 138 | 7.6 | 9.00 |
Day 86 | 0197 | 0 | U | 132 | 6.8 | 18.00 |
Day 86 | 0198 | 0 | U | 135 | 5.9 | 18.00 |
Day 86 | 0199 | 0 | U | 141 | 9.8 | 18.00 |
Day 86 | 0200 | 0 | U | 127 | 6.6 | 16.00 |
Day 86 | 0201 | 625 | 109 | 7.1 | 32.00 | |
Day 86 | 0202 | 625 | 105 | 6.4 | 0 | |
Day 86 | 0203 | 625 | 102 | 6.1 | 11.00 | |
Day 86 | 0204 | 625 | 126 | 6.4 | 5.00 | |
Day 86 | 0205 | 625 | QNS | 6.3 | 27.00 | |
Day 86 | 0206 | 625 | 124 | 6.7 | 14.00 | |
Day 86 | 0207 | 625 | 131 | 6.3 | 17.00 | |
Day 86 | 0208 | 625 | 124 | 6.9 | 28.00 | |
Day 86 | 0209 | 625 | 111 | 6.9 | 10.0 | |
Day 86 | 0210 | 625 | 115 | 5.4 | 19.00 | |
Day 86 | 0211 | 1250 | 154 | 7.4 | 11.00 | |
Day 86 | 0212 | 1250 | 123 | 6.1 | 21.00 | |
Day 86 | 0213 | 1250 | 134 | 6.6 | 12.00 | |
Day 86 | 0214 | 1250 | 127 | 6.2 | 16.00 | |
Day 86 | 0215 | 1250 | 143 | 7.5 | 24.00 | |
Day 86 | 0216 | 1250 | 137 | 5.6 | 0 | |
Day 86 | 0217 | 1250 | 117 | 6.5 | 16.00 | |
Day 86 | 0218 | 1250 | 120 | 6.3 | 6.00 | |
Day 86 | 0219 | 1250 | 123 | 7.4 | 18.00 | |
Day 86 | 0220 | 1250 | 130 | 5.7 | 12.00 | |
Day 86 | 0221 | 2500 | 152 | 6.9 | 4.00 | |
Day 86 | 0222 | 2500 | QNS | 7.6 | 14.00 | |
Day 86 | 0223 | 2500 | 163 | 6.6 | 3.00 | |
Day 86 | 0224 | 2500 | QNS | 7.1 | 10.0 | |
Day 86 | 0225 | 2500 | 134 | 6.5 | 30.0 | |
Day 86 | 0226 | 2500 | QNS | 7.5 | 22.00 | |
Day 86 | 0227 | 2500 | QNS | 6.2 | 13.00 | |
Day 86 | 0228 | 2500 | QNS | 8 | 22.00 | |
Day 86 | 0229 | 2500 | QNS | 7 | 12.00 | |
Day 86 | 0230 | 2500 | QNS | 5.7 | 14.00 | |
Day 86 | 0231 | 5000 | 129 | 6 | 46.00 | |
Day 86 | 0232 | 5000 | QNS | 6.7 | 34.00 | |
Day 86 | 0233 | 5000 | QNS | 5.4 | 14.00 | |
Day 86 | 0234 | 5000 | 122 | 4.8 | 3.00 | |
Day 86 | 0235 | 5000 | QNS | 5.4 | 24.00 | |
Day 86 | 0236 | 5000 | 155 | 6.9 | 4.00 | |
Day 86 | 0237 | 5000 | QNS | 6.4 | 35.00 | |
Day 86 | 0238 | 5000 | 134 | 5 | 13.00 | |
Day 86 | 0239 | 5000 | 165 | 7.3 | 7.00 | |
Day 86 | 0240 | 5000 | QNS | 5.1 | 12.00 | |
Day 86 | 0244 | 10000 | QNS | 5.8 | 14.00 | |
Day 86 | 0250 | 10000 | QNS | 4.7 | 42.00 | |
Abbreviations: | ||||||
NA: Not Available, U: Untreated Control, T3: Triiodothyronine, T4: Thyroxine, TSH: Thyroid Stimulating Hormone |