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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Acetaminophen (4-hydroxyacetanilide) |
CASRN: | ="103-90-2" |
Study Number: | C55801 |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | DOSED FEED |
TDMS Number: | 0503503 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (%) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 245 |
187 |
0.6 |
|
240.4 |
|
Day 308 |
238 |
0.6 |
|
151.8 |
|
Day 354 |
239 |
0.6 |
|
284.8 |
|
Day 372 |
171 |
0.3 |
|
254.4 |
|
Day 380 |
32 |
0 |
|
257.4 |
|
Day 396 |
34 |
0 |
|
303.2 |
|
Day 456 |
148 |
0.3 |
|
273.2 |
|
Day 463 |
13 |
0 |
|
307.4 |
|
Day 463 |
43 |
0 |
|
310.6 |
|
Day 463 |
44 |
0 |
|
320.2 |
|
Day 463 |
6 |
0 |
|
334.6 |
|
Day 463 |
8 |
0 |
|
294 |
|
Day 463 |
103 |
0.06 |
|
343.8 |
|
Day 463 |
70 |
0.06 |
|
328.4 |
|
Day 463 |
76 |
0.06 |
|
341.4 |
|
Day 463 |
77 |
0.06 |
|
283.6 |
|
Day 463 |
97 |
0.06 |
|
345.8 |
|
Day 463 |
133 |
0.3 |
|
351.8 |
|
Day 463 |
137 |
0.3 |
|
295.4 |
|
Day 463 |
144 |
0.3 |
|
277.6 |
|
Day 463 |
165 |
0.3 |
|
333.6 |
|
Day 463 |
178 |
0.3 |
|
334.4 |
|
Day 463 |
186 |
0.6 |
|
334.6 |
|
Day 463 |
207 |
0.6 |
|
289.8 |
|
Day 463 |
210 |
0.6 |
|
301.6 |
|
Day 463 |
216 |
0.6 |
|
285.6 |
|
Day 463 |
223 |
0.6 |
|
341.2 |
|
Day 464 |
16 |
0 |
|
302.4 |
|
Day 464 |
18 |
0 |
|
302.4 |
|
Day 464 |
19 |
0 |
|
297.6 |
|
Day 464 |
25 |
0 |
|
340.2 |
|
Day 464 |
60 |
0 |
|
369 |
|
Day 464 |
109 |
0.06 |
|
388.2 |
|
Day 464 |
110 |
0.06 |
|
300.2 |
|
Day 464 |
65 |
0.06 |
|
260 |
|
Day 464 |
69 |
0.06 |
|
345.6 |
|
Day 464 |
87 |
0.06 |
|
304.8 |
|
Day 464 |
129 |
0.3 |
|
297.4 |
|
Day 464 |
130 |
0.3 |
|
243.4 |
|
Day 464 |
140 |
0.3 |
|
276.8 |
|
Day 464 |
160 |
0.3 |
|
289.2 |
|
Day 464 |
176 |
0.3 |
|
274.5 |
|
Day 464 |
188 |
0.6 |
|
313.2 |
|
Day 464 |
201 |
0.6 |
|
289.8 |
|
Day 464 |
218 |
0.6 |
|
326.2 |
|
Day 464 |
230 |
0.6 |
|
341.6 |
|
Day 464 |
233 |
0.6 |
|
301.2 |
|
Day 471 |
215 |
0.6 |
|
267.4 |
|
Day 485 |
180 |
0.3 |
|
288 |
|
Day 499 |
91 |
0.06 |
|
238.8 |
|
Day 501 |
23 |
0 |
|
293.4 |
|
Day 501 |
108 |
0.06 |
|
325.4 |
|
Day 506 |
139 |
0.3 |
|
307.4 |
|
Day 517 |
20 |
0 |
|
267.8 |
|
Day 519 |
179 |
0.3 |
|
272.6 |
|
Day 519 |
199 |
0.6 |
|
254.4 |
|
Day 534 |
141 |
0.3 |
|
322.6 |
|
Day 554 |
237 |
0.6 |
|
239 |
|
Day 562 |
63 |
0.06 |
|
323.4 |
|
Day 570 |
158 |
0.3 |
|
282.2 |
|
Day 574 |
57 |
0 |
|
323 |
|
Day 575 |
36 |
0 |
|
314.4 |
|
Day 576 |
114 |
0.06 |
|
354.6 |
|
Day 578 |
39 |
0 |
|
288.2 |
|
Day 581 |
101 |
0.06 |
|
283.2 |
|
Day 585 |
196 |
0.6 |
|
262.2 |
|
Day 585 |
240 |
0.6 |
|
253.6 |
|
Day 590 |
169 |
0.3 |
|
284.4 |
|
Day 591 |
155 |
0.3 |
|
256.2 |
|
Day 596 |
24 |
0 |
|
272 |
|
Day 607 |
40 |
0 |
|
295.4 |
|
Day 611 |
150 |
0.3 |
|
259 |
|
Day 611 |
212 |
0.6 |
|
258 |
|
Day 613 |
154 |
0.3 |
|
296.4 |
|
Day 614 |
184 |
0.6 |
|
308.8 |
|
Day 618 |
116 |
0.06 |
|
304.2 |
|
Day 625 |
35 |
0 |
|
317.4 |
|
Day 626 |
120 |
0.06 |
|
283 |
|
Day 627 |
106 |
0.06 |
|
334.4 |
|
Day 628 |
209 |
0.6 |
|
247 |
|
Day 639 |
214 |
0.6 |
|
249.2 |
|
Day 640 |
194 |
0.6 |
|
277 |
|
Day 640 |
197 |
0.6 |
|
289.6 |
|
Day 644 |
37 |
0 |
|
358.4 |
|
Day 644 |
118 |
0.06 |
|
249.4 |
|
Day 644 |
161 |
0.3 |
|
258 |
|
Day 652 |
10 |
0 |
|
305.6 |
|
Day 652 |
204 |
0.6 |
|
217.8 |
|
Day 655 |
67 |
0.06 |
|
241.4 |
|
Day 662 |
182 |
0.6 |
|
266 |
|
Day 664 |
22 |
0 |
|
382 |
|
Day 668 |
21 |
0 |
|
252.4 |
|
Day 668 |
50 |
0 |
|
229.4 |
|
Day 668 |
232 |
0.6 |
|
214 |
|
Day 670 |
82 |
0.06 |
|
287.4 |
|
Day 672 |
229 |
0.6 |
|
296.8 |
|
Day 676 |
146 |
0.3 |
|
243.4 |
|
Day 678 |
192 |
0.6 |
|
265 |
|
Day 679 |
11 |
0 |
|
258.8 |
|
Day 683 |
31 |
0 |
|
246.6 |
|
Day 689 |
102 |
0.06 |
|
349.2 |
|
Day 689 |
86 |
0.06 |
|
257.6 |
|
Day 689 |
173 |
0.3 |
|
319.8 |
|
Day 690 |
236 |
0.6 |
|
294.4 |
|
Day 693 |
195 |
0.6 |
|
266.6 |
|
Day 694 |
75 |
0.06 |
|
340 |
|
Day 697 |
47 |
0 |
|
340.4 |
|
Day 704 |
41 |
0 |
|
232 |
|
Day 708 |
193 |
0.6 |
|
305.8 |
|
Day 710 |
78 |
0.06 |
|
234.8 |
|
Day 715 |
131 |
0.3 |
|
249.6 |
|
Day 716 |
100 |
0.06 |
|
253.6 |
|
Day 718 |
168 |
0.3 |
|
277.4 |
|
Day 724 |
33 |
0 |
|
243 |
|
Day 729 |
27 |
0 |
|
248.6 |
|
Day 729 |
181 |
0.6 |
|
295.6 |
|
Day 729 |
183 |
0.6 |
|
337.2 |
|
Day 729 |
185 |
0.6 |
|
335.6 |
|
Day 729 |
189 |
0.6 |
|
275 |
|
Day 729 |
190 |
0.6 |
|
312 |
|
Day 729 |
234 |
0.6 |
|
315.2 |
|
Day 730 |
9 |
0 |
|
242.8 |
|
Day 730 |
200 |
0.6 |
|
289.2 |
|
Day 730 |
221 |
0.6 |
|
360 |
|
Day 730 |
222 |
0.6 |
|
328.2 |
|
Day 730 |
224 |
0.6 |
|
326.8 |
|
Day 730 |
225 |
0.6 |
|
370.2 |
|
Day 730 |
226 |
0.6 |
|
347.2 |
|
Day 730 |
227 |
0.6 |
|
297.4 |
|
Day 730 |
228 |
0.6 |
|
357.2 |
|
Day 730 |
231 |
0.6 |
|
358.4 |
|
Day 730 |
235 |
0.6 |
|
288.2 |
|
Day 731 |
191 |
0.6 |
|
287.8 |
|
Day 731 |
198 |
0.6 |
|
316.4 |
|
Day 731 |
203 |
0.6 |
|
367 |
|
Day 731 |
213 |
0.6 |
|
263.4 |
|
Day 732 |
132 |
0.3 |
|
353.8 |
|
Day 732 |
134 |
0.3 |
|
267.4 |
|
Day 732 |
135 |
0.3 |
|
323 |
|
Day 732 |
162 |
0.3 |
|
357.8 |
|
Day 732 |
164 |
0.3 |
|
341 |
|
Day 732 |
202 |
0.6 |
|
379.6 |
|
Day 732 |
205 |
0.6 |
|
319.6 |
|
Day 732 |
206 |
0.6 |
|
349 |
|
Day 732 |
208 |
0.6 |
|
353 |
|
Day 732 |
211 |
0.6 |
|
323.8 |
|
Day 732 |
217 |
0.6 |
|
346 |
|
Day 732 |
219 |
0.6 |
|
226 |
|
Day 732 |
220 |
0.6 |
|
336.6 |
|
Day 735 |
117 |
0.06 |
|
298 |
|
Day 735 |
61 |
0.06 |
|
428 |
|
Day 735 |
62 |
0.06 |
|
360.8 |
|
Day 735 |
64 |
0.06 |
|
315.4 |
|
Day 735 |
66 |
0.06 |
|
293 |
|
Day 735 |
74 |
0.06 |
|
401.2 |
|
Day 735 |
121 |
0.3 |
|
269.2 |
|
Day 735 |
122 |
0.3 |
|
340.8 |
|
Day 735 |
123 |
0.3 |
|
338.4 |
|
Day 735 |
124 |
0.3 |
|
316.2 |
|
Day 735 |
125 |
0.3 |
|
330.4 |
|
Day 735 |
126 |
0.3 |
|
349.8 |
|
Day 735 |
127 |
0.3 |
|
364.8 |
|
Day 735 |
128 |
0.3 |
|
376.4 |
|
Day 735 |
136 |
0.3 |
|
314.8 |
|
Day 735 |
138 |
0.3 |
|
372.2 |
|
Day 735 |
142 |
0.3 |
|
289.2 |
|
Day 735 |
143 |
0.3 |
|
367.2 |
|
Day 735 |
145 |
0.3 |
|
353 |
|
Day 735 |
147 |
0.3 |
|
383.2 |
|
Day 735 |
149 |
0.3 |
|
340 |
|
Day 735 |
151 |
0.3 |
|
272.4 |
|
Day 735 |
152 |
0.3 |
|
|
|
Day 735 |
153 |
0.3 |
|
363.6 |
|
Day 735 |
156 |
0.3 |
|
359.4 |
|
Day 735 |
157 |
0.3 |
|
371.2 |
|
Day 735 |
159 |
0.3 |
|
364.6 |
|
Day 735 |
163 |
0.3 |
|
337.4 |
|
Day 735 |
166 |
0.3 |
|
340.4 |
|
Day 735 |
167 |
0.3 |
|
211.6 |
|
Day 735 |
170 |
0.3 |
|
340 |
|
Day 735 |
172 |
0.3 |
|
327.4 |
|
Day 735 |
174 |
0.3 |
|
358.2 |
|
Day 735 |
175 |
0.3 |
|
374.8 |
|
Day 735 |
177 |
0.3 |
|
339.6 |
|
Day 736 |
1 |
0 |
|
334.8 |
|
Day 736 |
2 |
0 |
|
342.4 |
|
Day 736 |
3 |
0 |
|
341.4 |
|
Day 736 |
4 |
0 |
|
270.8 |
|
Day 736 |
104 |
0.06 |
|
328.8 |
|
Day 736 |
105 |
0.06 |
|
338.4 |
|
Day 736 |
107 |
0.06 |
|
385.2 |
|
Day 736 |
111 |
0.06 |
|
289.6 |
|
Day 736 |
112 |
0.06 |
|
294 |
|
Day 736 |
113 |
0.06 |
|
329.8 |
|
Day 736 |
115 |
0.06 |
|
366.6 |
|
Day 736 |
119 |
0.06 |
|
253.8 |
|
Day 736 |
68 |
0.06 |
|
321.8 |
|
Day 736 |
71 |
0.06 |
|
300.6 |
|
Day 736 |
72 |
0.06 |
|
331.2 |
|
Day 736 |
73 |
0.06 |
|
310 |
|
Day 736 |
79 |
0.06 |
|
346.8 |
|
Day 736 |
80 |
0.06 |
|
330.6 |
|
Day 736 |
81 |
0.06 |
|
245.4 |
|
Day 736 |
83 |
0.06 |
|
339.4 |
|
Day 736 |
84 |
0.06 |
|
337.2 |
|
Day 736 |
85 |
0.06 |
|
373 |
|
Day 736 |
88 |
0.06 |
|
366.4 |
|
Day 736 |
89 |
0.06 |
|
382.6 |
|
Day 736 |
90 |
0.06 |
|
303.6 |
|
Day 736 |
92 |
0.06 |
|
331.4 |
|
Day 736 |
93 |
0.06 |
|
351 |
|
Day 736 |
94 |
0.06 |
|
315.6 |
|
Day 736 |
95 |
0.06 |
|
310.6 |
|
Day 736 |
96 |
0.06 |
|
343 |
|
Day 736 |
98 |
0.06 |
|
332 |
|
Day 736 |
99 |
0.06 |
|
338 |
|
Day 737 |
12 |
0 |
|
390 |
|
Day 737 |
14 |
0 |
|
362.6 |
|
Day 737 |
15 |
0 |
|
327.2 |
|
Day 737 |
17 |
0 |
|
365.8 |
|
Day 737 |
26 |
0 |
|
347 |
|
Day 737 |
28 |
0 |
|
317.8 |
|
Day 737 |
29 |
0 |
|
358.2 |
|
Day 737 |
30 |
0 |
|
338.8 |
|
Day 737 |
38 |
0 |
|
352.6 |
|
Day 737 |
42 |
0 |
|
363 |
|
Day 737 |
45 |
0 |
|
335.4 |
|
Day 737 |
46 |
0 |
|
366.4 |
|
Day 737 |
48 |
0 |
|
276.2 |
|
Day 737 |
49 |
0 |
|
383.4 |
|
Day 737 |
5 |
0 |
|
354.2 |
|
Day 737 |
51 |
0 |
|
301.6 |
|
Day 737 |
52 |
0 |
|
355 |
|
Day 737 |
53 |
0 |
|
383 |
|
Day 737 |
54 |
0 |
|
354.2 |
|
Day 737 |
55 |
0 |
|
346 |
|
Day 737 |
56 |
0 |
|
316.4 |
|
Day 737 |
58 |
0 |
|
301 |
|
Day 737 |
59 |
0 |
|
321 |
|
Day 737 |
7 |
0 |
|
334.8 |
|
Abbreviations: |
NA: Not Available
|