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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Acetaminophen (4-hydroxyacetanilide) |
CASRN: | ="103-90-2" |
Study Number: | C55801 |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | DOSED FEED |
TDMS Number: | 0503503 |
Sex: | Male |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (%) |
Control Code |
Final Body Weight (g) |
Day 305 |
218 |
0.6 |
|
383 |
Day 441 |
137 |
0.3 |
|
444.4 |
Day 442 |
225 |
0.6 |
|
430.4 |
Day 460 |
57 |
0 |
|
329.6 |
Day 464 |
10 |
0 |
|
463 |
Day 464 |
12 |
0 |
|
501.4 |
Day 464 |
2 |
0 |
|
426.2 |
Day 464 |
35 |
0 |
|
440.2 |
Day 464 |
48 |
0 |
|
421.8 |
Day 464 |
51 |
0 |
|
431.2 |
Day 464 |
56 |
0 |
|
504.4 |
Day 464 |
104 |
0.06 |
|
440.2 |
Day 464 |
105 |
0.06 |
|
449.8 |
Day 464 |
112 |
0.06 |
|
446.4 |
Day 464 |
69 |
0.06 |
|
466.6 |
Day 464 |
90 |
0.06 |
|
472.2 |
Day 464 |
145 |
0.3 |
|
453.4 |
Day 464 |
151 |
0.3 |
|
448.6 |
Day 464 |
181 |
0.6 |
|
500.2 |
Day 464 |
185 |
0.6 |
|
464.4 |
Day 464 |
227 |
0.6 |
|
496.8 |
Day 464 |
232 |
0.6 |
|
432.2 |
Day 464 |
234 |
0.6 |
|
483 |
Day 464 |
239 |
0.6 |
|
462.2 |
Day 465 |
13 |
0 |
|
519.6 |
Day 465 |
54 |
0 |
|
476.2 |
Day 465 |
59 |
0 |
|
486.8 |
Day 465 |
61 |
0.06 |
|
487.6 |
Day 465 |
64 |
0.06 |
|
457.4 |
Day 465 |
70 |
0.06 |
|
449.6 |
Day 465 |
78 |
0.06 |
|
454.8 |
Day 465 |
87 |
0.06 |
|
470 |
Day 465 |
121 |
0.3 |
|
446.8 |
Day 465 |
135 |
0.3 |
|
450 |
Day 465 |
139 |
0.3 |
|
524.8 |
Day 465 |
143 |
0.3 |
|
440.6 |
Day 465 |
149 |
0.3 |
|
423.2 |
Day 465 |
162 |
0.3 |
|
492.8 |
Day 465 |
164 |
0.3 |
|
468.2 |
Day 465 |
168 |
0.3 |
|
505.6 |
Day 465 |
186 |
0.6 |
|
422.6 |
Day 465 |
201 |
0.6 |
|
468.2 |
Day 465 |
203 |
0.6 |
|
422.8 |
Day 465 |
231 |
0.6 |
|
460 |
Day 471 |
174 |
0.3 |
|
364.6 |
Day 478 |
148 |
0.3 |
|
420.6 |
Day 484 |
133 |
0.3 |
|
352.8 |
Day 506 |
95 |
0.06 |
|
530 |
Day 514 |
29 |
0 |
|
589 |
Day 521 |
125 |
0.3 |
|
410.8 |
Day 533 |
222 |
0.6 |
|
380.6 |
Day 549 |
109 |
0.06 |
|
413 |
Day 560 |
180 |
0.3 |
|
425.8 |
Day 564 |
217 |
0.6 |
|
454 |
Day 568 |
4 |
0 |
|
418.7 |
Day 568 |
42 |
0 |
|
373 |
Day 577 |
205 |
0.6 |
|
491.4 |
Day 577 |
220 |
0.6 |
|
403.8 |
Day 579 |
5 |
0 |
|
360.4 |
Day 579 |
99 |
0.06 |
|
374.8 |
Day 579 |
210 |
0.6 |
|
401.6 |
Day 582 |
17 |
0 |
|
361.4 |
Day 582 |
167 |
0.3 |
|
489.6 |
Day 585 |
79 |
0.06 |
|
357.2 |
Day 585 |
189 |
0.6 |
|
362.2 |
Day 586 |
224 |
0.6 |
|
435.4 |
Day 591 |
190 |
0.6 |
|
442 |
Day 600 |
107 |
0.06 |
|
447.6 |
Day 603 |
73 |
0.06 |
|
430.4 |
Day 606 |
236 |
0.6 |
|
326.2 |
Day 612 |
37 |
0 |
|
426.6 |
Day 613 |
75 |
0.06 |
|
362.8 |
Day 613 |
219 |
0.6 |
|
367.6 |
Day 619 |
71 |
0.06 |
|
371.2 |
Day 619 |
240 |
0.6 |
|
421.2 |
Day 620 |
144 |
0.3 |
|
344.8 |
Day 624 |
113 |
0.06 |
|
386.4 |
Day 624 |
155 |
0.3 |
|
376 |
Day 627 |
156 |
0.3 |
|
505.8 |
Day 627 |
166 |
0.3 |
|
369.6 |
Day 631 |
26 |
0 |
|
495.4 |
Day 632 |
38 |
0 |
|
366.4 |
Day 632 |
39 |
0 |
|
334.2 |
Day 635 |
11 |
0 |
|
378.6 |
Day 635 |
84 |
0.06 |
|
409.4 |
Day 635 |
177 |
0.3 |
|
359.8 |
Day 638 |
142 |
0.3 |
|
359.2 |
Day 640 |
33 |
0 |
|
308.2 |
Day 641 |
43 |
0 |
|
372.4 |
Day 642 |
140 |
0.3 |
|
425.6 |
Day 643 |
204 |
0.6 |
|
339.4 |
Day 644 |
213 |
0.6 |
|
359.6 |
Day 648 |
165 |
0.3 |
|
341.4 |
Day 652 |
9 |
0 |
|
323.4 |
Day 652 |
77 |
0.06 |
|
426.6 |
Day 654 |
214 |
0.6 |
|
308.8 |
Day 655 |
146 |
0.3 |
|
482.6 |
Day 657 |
187 |
0.6 |
|
330.6 |
Day 661 |
1 |
0 |
|
313.4 |
Day 661 |
7 |
0 |
|
403.2 |
Day 661 |
126 |
0.3 |
|
355.6 |
Day 669 |
92 |
0.06 |
|
337.4 |
Day 669 |
208 |
0.6 |
|
335 |
Day 670 |
16 |
0 |
|
373 |
Day 670 |
101 |
0.06 |
|
331.6 |
Day 670 |
169 |
0.3 |
|
434.6 |
Day 671 |
88 |
0.06 |
|
391.6 |
Day 682 |
60 |
0 |
|
396 |
Day 687 |
66 |
0.06 |
|
349.2 |
Day 687 |
93 |
0.06 |
|
485.8 |
Day 691 |
86 |
0.06 |
|
338.2 |
Day 692 |
132 |
0.3 |
|
317.6 |
Day 695 |
192 |
0.6 |
|
359.8 |
Day 695 |
198 |
0.6 |
|
337.8 |
Day 698 |
170 |
0.3 |
|
364.8 |
Day 701 |
199 |
0.6 |
|
297.2 |
Day 703 |
53 |
0 |
|
358.4 |
Day 703 |
128 |
0.3 |
|
392 |
Day 703 |
150 |
0.3 |
|
408 |
Day 704 |
183 |
0.6 |
|
353.2 |
Day 704 |
206 |
0.6 |
|
343.6 |
Day 708 |
23 |
0 |
|
439.6 |
Day 710 |
123 |
0.3 |
|
289.4 |
Day 712 |
24 |
0 |
|
310.8 |
Day 714 |
58 |
0 |
|
283 |
Day 714 |
141 |
0.3 |
|
277.2 |
Day 715 |
96 |
0.06 |
|
329.2 |
Day 715 |
122 |
0.3 |
|
269 |
Day 718 |
45 |
0 |
|
439.2 |
Day 718 |
97 |
0.06 |
|
307.4 |
Day 718 |
196 |
0.6 |
|
303.6 |
Day 719 |
158 |
0.3 |
|
339 |
Day 719 |
194 |
0.6 |
|
308.6 |
Day 723 |
111 |
0.06 |
|
336.8 |
Day 723 |
80 |
0.06 |
|
284.8 |
Day 723 |
211 |
0.6 |
|
334.8 |
Day 725 |
65 |
0.06 |
|
310.2 |
Day 725 |
129 |
0.3 |
|
323.4 |
Day 729 |
182 |
0.6 |
|
379 |
Day 729 |
184 |
0.6 |
|
379.4 |
Day 729 |
188 |
0.6 |
|
428.4 |
Day 729 |
191 |
0.6 |
|
412.4 |
Day 729 |
193 |
0.6 |
|
411 |
Day 729 |
195 |
0.6 |
|
443.2 |
Day 729 |
197 |
0.6 |
|
307.4 |
Day 729 |
200 |
0.6 |
|
436 |
Day 729 |
202 |
0.6 |
|
383 |
Day 730 |
215 |
0.6 |
|
415 |
Day 730 |
221 |
0.6 |
|
396.4 |
Day 730 |
223 |
0.6 |
|
418 |
Day 730 |
226 |
0.6 |
|
406.4 |
Day 730 |
228 |
0.6 |
|
406.2 |
Day 730 |
229 |
0.6 |
|
389.8 |
Day 730 |
230 |
0.6 |
|
405.2 |
Day 730 |
233 |
0.6 |
|
339.4 |
Day 730 |
235 |
0.6 |
|
372.2 |
Day 730 |
237 |
0.6 |
|
439 |
Day 730 |
238 |
0.6 |
|
354.6 |
Day 731 |
124 |
0.3 |
|
395.4 |
Day 731 |
127 |
0.3 |
|
369.2 |
Day 731 |
130 |
0.3 |
|
467.6 |
Day 731 |
131 |
0.3 |
|
397 |
Day 731 |
134 |
0.3 |
|
411.8 |
Day 731 |
136 |
0.3 |
|
435.8 |
Day 731 |
138 |
0.3 |
|
377 |
Day 731 |
147 |
0.3 |
|
414 |
Day 731 |
207 |
0.6 |
|
411.8 |
Day 731 |
209 |
0.6 |
|
432.2 |
Day 731 |
212 |
0.6 |
|
429 |
Day 731 |
216 |
0.6 |
|
413.2 |
Day 732 |
106 |
0.06 |
|
409.2 |
Day 732 |
108 |
0.06 |
|
363 |
Day 732 |
110 |
0.06 |
|
436.6 |
Day 732 |
116 |
0.06 |
|
384.8 |
Day 732 |
117 |
0.06 |
|
437 |
Day 732 |
118 |
0.06 |
|
435 |
Day 732 |
119 |
0.06 |
|
367.6 |
Day 732 |
120 |
0.06 |
|
392 |
Day 732 |
62 |
0.06 |
|
430.2 |
Day 732 |
63 |
0.06 |
|
424.6 |
Day 732 |
152 |
0.3 |
|
429.2 |
Day 732 |
153 |
0.3 |
|
442.6 |
Day 732 |
154 |
0.3 |
|
407 |
Day 732 |
161 |
0.3 |
|
392.2 |
Day 732 |
163 |
0.3 |
|
389 |
Day 732 |
171 |
0.3 |
|
407.2 |
Day 732 |
172 |
0.3 |
|
395.4 |
Day 732 |
173 |
0.3 |
|
403.4 |
Day 732 |
175 |
0.3 |
|
383.2 |
Day 732 |
176 |
0.3 |
|
411 |
Day 732 |
178 |
0.3 |
|
358 |
Day 732 |
179 |
0.3 |
|
380.8 |
Day 733 |
68 |
0.06 |
|
308.8 |
Day 733 |
157 |
0.3 |
|
422.4 |
Day 733 |
159 |
0.3 |
|
433.8 |
Day 733 |
160 |
0.3 |
|
471 |
Day 735 |
102 |
0.06 |
|
396.4 |
Day 735 |
103 |
0.06 |
|
448.4 |
Day 735 |
67 |
0.06 |
|
392.4 |
Day 735 |
72 |
0.06 |
|
424 |
Day 735 |
74 |
0.06 |
|
469 |
Day 735 |
76 |
0.06 |
|
454 |
Day 736 |
19 |
0 |
|
432.4 |
Day 736 |
25 |
0 |
|
441.4 |
Day 736 |
27 |
0 |
|
379 |
Day 736 |
28 |
0 |
|
424.4 |
Day 736 |
30 |
0 |
|
398.4 |
Day 736 |
36 |
0 |
|
455.2 |
Day 736 |
40 |
0 |
|
426.4 |
Day 736 |
52 |
0 |
|
399.8 |
Day 736 |
55 |
0 |
|
398.8 |
Day 736 |
6 |
0 |
|
391.8 |
Day 736 |
8 |
0 |
|
379.8 |
Day 737 |
41 |
0 |
|
331.6 |
Day 737 |
81 |
0.06 |
|
405.4 |
Day 737 |
82 |
0.06 |
|
423.2 |
Day 737 |
83 |
0.06 |
|
396.6 |
Day 737 |
85 |
0.06 |
|
397.6 |
Day 737 |
89 |
0.06 |
|
397.8 |
Day 737 |
91 |
0.06 |
|
423 |
Day 737 |
94 |
0.06 |
|
389.8 |
Day 738 |
14 |
0 |
|
386 |
Day 738 |
15 |
0 |
|
418.2 |
Day 738 |
18 |
0 |
|
398.2 |
Day 738 |
20 |
0 |
|
390.2 |
Day 738 |
21 |
0 |
|
443.6 |
Day 738 |
22 |
0 |
|
436 |
Day 738 |
3 |
0 |
|
419.8 |
Day 738 |
31 |
0 |
|
308.2 |
Day 738 |
32 |
0 |
|
420.8 |
Day 738 |
34 |
0 |
|
342.6 |
Day 738 |
44 |
0 |
|
401.4 |
Day 738 |
46 |
0 |
|
398.8 |
Day 738 |
47 |
0 |
|
379.2 |
Day 738 |
49 |
0 |
|
420.4 |
Day 738 |
50 |
0 |
|
353.8 |
Day 738 |
100 |
0.06 |
|
403.8 |
Day 738 |
114 |
0.06 |
|
434.4 |
Day 738 |
115 |
0.06 |
|
317.4 |
Day 738 |
98 |
0.06 |
|
438.8 |
Abbreviations: |
NA: Not Available
|