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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Acrolein |
CASRN: | ="107-02-8" |
Study Number: | C02802C |
Exposure Route: | GAVAGE |
TDMS Number: | 0280202 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Esophagus |
Periesoph Tiss |
1.25 MG/KG |
1 |
1019 |
1019 |
55 |
1 |
Inflammation |
Marked, Chronic Active |
Dosing Accident |
Alimentary System |
Esophagus |
Periesoph Tiss |
5 MG/KG |
1 |
1039 |
1039 |
54 |
1 |
Inflammation |
Marked, Chronic Active |
Dosing Accident |
Alimentary System |
Esophagus |
|
5 MG/KG |
1 |
1039 |
1039 |
54 |
1 |
Hemorrhage |
Mild |
Dosing Accident |
Alimentary System |
Esophagus |
|
1.25 MG/KG |
1 |
1019 |
1019 |
55 |
1 |
Perforation |
|
Dosing Accident |
Alimentary System |
Esophagus |
|
5 MG/KG |
1 |
1039 |
1039 |
54 |
1 |
Perforation |
|
Dosing Accident |
Alimentary System |
Intestine Small |
Jejunum, Peyers Patch |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1002 |
1002 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1003 |
1003 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1005 |
1005 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1006 |
1006 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1009 |
1009 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1010 |
1010 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.25 MG/KG |
10 |
1011 |
1011 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.25 MG/KG |
10 |
1012 |
1012 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.5 MG/KG |
10 |
1029 |
1029 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
5 MG/KG |
10 |
1031 |
1031 |
92 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
5 MG/KG |
10 |
1032 |
1032 |
92 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
5 MG/KG |
10 |
1034 |
1034 |
92 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
5 MG/KG |
10 |
1035 |
1035 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 MG/KG |
10 |
1045 |
1045 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 MG/KG |
10 |
1046 |
1046 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 MG/KG |
10 |
1048 |
1048 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
10 |
1005 |
1005 |
92 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
5 MG/KG |
10 |
1032 |
1032 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1.25 MG/KG |
10 |
1013 |
1013 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1.25 MG/KG |
10 |
1016 |
1016 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1023 |
1023 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1024 |
1024 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1026 |
1026 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1028 |
1028 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1029 |
1029 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
2.5 MG/KG |
10 |
1030 |
1030 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1031 |
1031 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1032 |
1032 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1033 |
1033 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1034 |
1034 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1035 |
1035 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1036 |
1036 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
1038 |
1038 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Hyperplasia |
Moderate, Squamous |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1041 |
1041 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1042 |
1042 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1043 |
1043 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1045 |
1045 |
92 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1046 |
1046 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1047 |
1047 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1048 |
1048 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1049 |
1049 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1050 |
1050 |
92 |
1 |
Hyperplasia |
Mild, Squamous |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1053 |
1053 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1055 |
1055 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1056 |
1056 |
2 |
1 |
Hemorrhage |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1057 |
1057 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1058 |
1058 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1059 |
1059 |
1 |
1 |
Hemorrhage |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular |
20 MG/KG |
10 |
1060 |
1060 |
1 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
1004 |
1004 |
92 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
20 MG/KG |
10 |
1060 |
1060 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
20 MG/KG |
10 |
1056 |
1056 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
20 MG/KG |
10 |
1057 |
1057 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1056 |
1056 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1057 |
1057 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1058 |
1058 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
20 MG/KG |
10 |
1059 |
1059 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
1.25 MG/KG |
1 |
1019 |
1019 |
55 |
1 |
Depletion Cellular |
Mild |
Dosing Accident |
Hematopoietic System |
Spleen |
Lymph Follic |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1053 |
1053 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1055 |
1055 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1056 |
1056 |
2 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1057 |
1057 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1058 |
1058 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1059 |
1059 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
20 MG/KG |
10 |
1060 |
1060 |
1 |
1 |
Depletion Cellular |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
5 MG/KG |
1 |
1039 |
1039 |
54 |
1 |
Atrophy |
Moderate |
Dosing Accident |
Hematopoietic System |
Thymus |
Thymocyte |
1.25 MG/KG |
1 |
1019 |
1019 |
55 |
1 |
Necrosis |
Mild |
Dosing Accident |
Hematopoietic System |
Thymus |
Thymocyte |
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1052 |
1052 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1053 |
1053 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1054 |
1054 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1055 |
1055 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1056 |
1056 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1057 |
1057 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1058 |
1058 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1059 |
1059 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
20 MG/KG |
10 |
1060 |
1060 |
1 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
5 MG/KG |
1 |
1039 |
1039 |
54 |
1 |
Hemorrhage |
Mild |
Dosing Accident |
Respiratory System |
Nose |
|
10 MG/KG |
10 |
1044 |
1044 |
8 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
1002 |
1002 |
92 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
1006 |
1006 |
92 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
1010 |
1010 |
92 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1.25 MG/KG |
1 |
1019 |
1019 |
55 |
1 |
Regeneration |
Minimal |
Dosing Accident |
Urinary System |
Kidney |
Renal Tubule |
20 MG/KG |
10 |
1051 |
1051 |
1 |
1 |
Regeneration |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1007 |
1007 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
10 MG/KG |
10 |
1046 |
1046 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |