Alimentary System |
Esophagus |
Epithelium |
8 MG/KG |
1 |
237 |
237 |
4 |
1 |
Hyperplasia |
Mild, Diffuse |
Dosing Accident |
Alimentary System |
Esophagus |
Muscularis, Periesoph Tiss |
8 MG/KG |
1 |
237 |
237 |
4 |
1 |
Inflammation |
Marked, Focal, Chronic Active |
Dosing Accident |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
15 |
213 |
213 |
277 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
15 |
216 |
216 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
15 |
218 |
218 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
8 MG/KG |
15 |
228 |
228 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
15 |
218 |
218 |
277 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
8 MG/KG |
15 |
226 |
226 |
277 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Vacuolization Cytoplasmic |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
Serosa |
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Mineralization |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
8 MG/KG |
15 |
227 |
227 |
277 |
1 |
Tension Lipidosis |
|
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
15 |
220 |
220 |
277 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
213 |
213 |
277 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
214 |
214 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
215 |
215 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
216 |
216 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
217 |
217 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
218 |
218 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
220 |
220 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
221 |
221 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
222 |
222 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
223 |
223 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
224 |
224 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
225 |
225 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
226 |
226 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
227 |
227 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
228 |
228 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
231 |
231 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
232 |
232 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
233 |
233 |
277 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
234 |
234 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
236 |
236 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
238 |
238 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
239 |
239 |
277 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
240 |
240 |
277 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
213 |
213 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
214 |
214 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
215 |
215 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
216 |
216 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
217 |
217 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
218 |
218 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
220 |
220 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
221 |
221 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
223 |
223 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
15 |
225 |
225 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
226 |
226 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
227 |
227 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
228 |
228 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
231 |
231 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
232 |
232 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
233 |
233 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
234 |
234 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
236 |
236 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
238 |
238 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
239 |
239 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
8 MG/KG |
15 |
240 |
240 |
277 |
1 |
Hypertrophy |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Ectopic Thymus |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
2 |
216 |
216 |
277 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
2 |
222 |
222 |
277 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
8 MG/KG |
2 |
229 |
229 |
277 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
8 MG/KG |
2 |
235 |
235 |
277 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
8 MG/KG |
2 |
229 |
229 |
277 |
1 |
Infiltration Cellular |
Minimal, Focal, Lymphocyte |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Degeneration |
Marked, Focal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
15 |
216 |
216 |
277 |
1 |
Degeneration |
Marked, Focal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Degeneration |
Marked, Focal |
Dosing Accident |
Genital System |
Testes |
Germinal Epith |
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Degeneration |
Mild, Focal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Atrophy |
Mild |
Dosing Accident |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
213 |
213 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
214 |
214 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
215 |
215 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
216 |
216 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
217 |
217 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
218 |
218 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
220 |
220 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
221 |
221 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
222 |
222 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
223 |
223 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
224 |
224 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
225 |
225 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
226 |
226 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
227 |
227 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
228 |
228 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
231 |
231 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
233 |
233 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
234 |
234 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
236 |
236 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
238 |
238 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
239 |
239 |
277 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
240 |
240 |
277 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
213 |
213 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
215 |
215 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
219 |
219 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
220 |
220 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
221 |
221 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
222 |
222 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
223 |
223 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
224 |
224 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
15 |
225 |
225 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
227 |
227 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
228 |
228 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
231 |
231 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
232 |
232 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
233 |
233 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
234 |
234 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
236 |
236 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
8 MG/KG |
15 |
239 |
239 |
277 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
15 |
221 |
221 |
277 |
1 |
Atrophy |
Mild, Focal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
15 |
225 |
225 |
277 |
1 |
Atrophy |
Minimal, Focal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Atrophy |
Moderate, Diffuse |
Dosing Accident |
Hematopoietic System |
Thymus |
|
8 MG/KG |
15 |
231 |
231 |
277 |
1 |
Atrophy |
Minimal, Focal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
8 MG/KG |
15 |
232 |
232 |
277 |
1 |
Atrophy |
Minimal, Focal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Atrophy |
Mild, Focal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
8 MG/KG |
15 |
230 |
230 |
277 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Integumentary System |
Skin |
Subcut Tiss |
Vehicle Control |
15 |
212 |
212 |
277 |
1 |
Inflammation |
Moderate, Focal, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
Subcut Tiss |
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Inflammation |
Marked, Focal, Chronic Active |
Dosing Accident |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
15 |
211 |
211 |
277 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
8 MG/KG |
15 |
229 |
229 |
277 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Respiratory System |
Lung |
Mediastinum |
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Inflammation |
Marked, Focal, Acute |
Dosing Accident |
Respiratory System |
Lung |
Perivascular |
8 MG/KG |
15 |
235 |
235 |
277 |
1 |
Infiltration Cellular |
Minimal, Focal, Lymphocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
8 MG/KG |
15 |
237 |
237 |
4 |
1 |
Hemorrhage |
Minimal, Focal |
Dosing Accident |
Urinary System |
Kidney |
Renal Tubule |
8 MG/KG |
15 |
226 |
226 |
277 |
1 |
Degeneration |
Minimal, Focal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
15 |
214 |
214 |
277 |
1 |
Dilatation |
Minimal, Focal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
15 |
222 |
222 |
277 |
1 |
Dilatation |
Minimal, Diffuse |
Terminal Sacrifice |