Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
133 |
133 |
89 |
1 |
Inflammation |
Minimal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
129 |
129 |
57 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
130 |
130 |
87 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
131 |
131 |
89 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
133 |
133 |
89 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
134 |
134 |
58 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
136 |
136 |
89 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
137 |
137 |
87 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
138 |
138 |
33 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
200 MG/KG |
32 |
171 |
171 |
86 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
200 MG/KG |
32 |
184 |
184 |
86 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
200 MG/KG |
32 |
191 |
191 |
32 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
130 |
130 |
87 |
1 |
Tension Lipidosis |
Mild |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
200 MG/KG |
32 |
167 |
167 |
87 |
1 |
Tension Lipidosis |
Mild |
Scheduled Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
129 |
129 |
57 |
1 |
Fibrosis |
Mild |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
162 |
162 |
88 |
1 |
Hyperplasia, Grade 1 |
Multifocal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
163 |
163 |
85 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
164 |
164 |
57 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
165 |
165 |
58 |
1 |
Hyperplasia, Grade 1 |
Multifocal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
167 |
167 |
87 |
1 |
Hyperplasia, Grade 1 |
Multifocal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
169 |
169 |
87 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
170 |
170 |
88 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
179 |
179 |
88 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
181 |
181 |
58 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
182 |
182 |
89 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
183 |
183 |
89 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
185 |
185 |
85 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
187 |
187 |
32 |
1 |
Hyperplasia, Grade 3 |
Focal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
188 |
188 |
86 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
190 |
190 |
33 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
200 MG/KG |
32 |
191 |
191 |
32 |
1 |
Hyperplasia, Grade 3 |
Focal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Anterior Lobe |
Vehicle Control |
10 |
130 |
130 |
87 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Genital System |
Prostate |
Dorsal Lobe |
Vehicle Control |
10 |
130 |
130 |
87 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Dorsal Lobe |
200 MG/KG |
32 |
187 |
187 |
32 |
1 |
Hyperplasia, Grade 3 |
Multifocal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Dorsal Lobe |
200 MG/KG |
32 |
191 |
191 |
32 |
1 |
Hyperplasia, Grade 3 |
Multifocal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
Vehicle Control |
10 |
132 |
132 |
87 |
1 |
Hyperplasia, Grade 2 |
Focal, Grade 2 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
Vehicle Control |
10 |
134 |
134 |
58 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
200 MG/KG |
32 |
176 |
176 |
87 |
1 |
Hyperplasia, Grade 1 |
Focal, Grade 1 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
200 MG/KG |
32 |
187 |
187 |
32 |
1 |
Hyperplasia, Grade 3 |
Multifocal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
200 MG/KG |
32 |
191 |
191 |
32 |
1 |
Hyperplasia, Grade 3 |
Focal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Lateral Lobe |
Vehicle Control |
10 |
132 |
132 |
87 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Genital System |
Prostate |
Ventral Lobe |
200 MG/KG |
32 |
187 |
187 |
32 |
1 |
Hyperplasia, Grade 3 |
Focal, Grade 3 |
Scheduled Sacrifice |
Genital System |
Prostate |
Ventral Lobe |
200 MG/KG |
32 |
191 |
191 |
32 |
1 |
Hyperplasia, Grade 2 |
Focal, Grade 2 |
Scheduled Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
10 |
129 |
129 |
57 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
10 |
130 |
130 |
87 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Genital System |
Testes |
Germinal Epith |
200 MG/KG |
32 |
161 |
161 |
89 |
1 |
Syncytial Alteration |
Minimal |
Scheduled Sacrifice |
Genital System |
Testes |
Germinal Epith |
200 MG/KG |
32 |
180 |
180 |
87 |
1 |
Syncytial Alteration |
Minimal |
Scheduled Sacrifice |
Genital System |
Testes |
Germinal Epith |
200 MG/KG |
32 |
161 |
161 |
89 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Scheduled Sacrifice |
Genital System |
Testes |
Germinal Epith |
200 MG/KG |
32 |
176 |
176 |
87 |
1 |
Vacuolization Cytoplasmic |
Mild |
Scheduled Sacrifice |
Genital System |
Testes |
Germinal Epith |
200 MG/KG |
32 |
182 |
182 |
89 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Scheduled Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
10 |
133 |
133 |
89 |
1 |
Atrophy |
Minimal |
Scheduled Sacrifice |
Genital System |
Testes |
|
200 MG/KG |
32 |
186 |
186 |
33 |
1 |
Atrophy |
Minimal |
Scheduled Sacrifice |
Hematopoietic System |
Spleen |
|
200 MG/KG |
32 |
161 |
161 |
89 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Scheduled Sacrifice |
Hematopoietic System |
Spleen |
|
200 MG/KG |
32 |
175 |
175 |
89 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Scheduled Sacrifice |
Hematopoietic System |
Spleen |
|
200 MG/KG |
32 |
182 |
182 |
89 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Scheduled Sacrifice |
Urinary System |
Kidney |
Cortex, Renal Tubule |
200 MG/KG |
32 |
171 |
171 |
86 |
1 |
Dilatation |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Cortex, Renal Tubule |
200 MG/KG |
32 |
180 |
180 |
87 |
1 |
Dilatation |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Cortex, Renal Tubule |
200 MG/KG |
32 |
169 |
169 |
87 |
1 |
Regeneration |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Cortex, Renal Tubule |
200 MG/KG |
32 |
186 |
186 |
33 |
1 |
Regeneration |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Medulla, Renal Tubule |
Vehicle Control |
10 |
137 |
137 |
87 |
1 |
Dilatation |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Medulla, Renal Tubule |
200 MG/KG |
32 |
183 |
183 |
89 |
1 |
Dilatation |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Medulla, Renal Tubule |
200 MG/KG |
32 |
185 |
185 |
85 |
1 |
Dilatation |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
137 |
137 |
87 |
1 |
Casts Protein |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
200 MG/KG |
32 |
170 |
170 |
88 |
1 |
Casts Protein |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
200 MG/KG |
32 |
171 |
171 |
86 |
1 |
Casts Protein |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
200 MG/KG |
32 |
186 |
186 |
33 |
1 |
Inflammation |
Minimal, Focal |
Scheduled Sacrifice |
Urinary System |
Kidney |
|
200 MG/KG |
32 |
166 |
166 |
33 |
1 |
Hydronephrosis |
Mild |
Scheduled Sacrifice |
Urinary System |
Urinary Bladder |
Serosa |
Vehicle Control |
10 |
134 |
134 |
58 |
1 |
Mineralization |
Mild, Focal |
Scheduled Sacrifice |