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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Codeine |
CASRN: | ="76-57-3" |
Study Number: | C61541C |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | DOSED FEED |
TDMS Number: | 0506810 |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight (g) |
Day 8 |
346 |
750 |
|
13.8 |
Day 8 |
348 |
750 |
|
10.9 |
Day 8 |
402 |
1500 |
|
11.6 |
Day 8 |
458 |
3000 |
|
10.9 |
Day 8 |
472 |
3000 |
|
10.3 |
Day 9 |
257 |
0 |
|
12.3 |
Day 272 |
293 |
0 |
|
24.7 |
Day 323 |
390 |
1500 |
|
23.5 |
Day 329 |
396 |
1500 |
|
19.7 |
Day 348 |
350 |
750 |
|
38.7 |
Day 359 |
334 |
750 |
|
50.9 |
Day 388 |
343 |
750 |
|
46.8 |
Day 397 |
466 |
3000 |
|
40.8 |
Day 430 |
465 |
3000 |
|
36.8 |
Day 457 |
247 |
0 |
|
47.7 |
Day 457 |
254 |
0 |
|
54.9 |
Day 457 |
260 |
0 |
|
59.9 |
Day 457 |
263 |
0 |
|
60 |
Day 457 |
265 |
0 |
|
61.1 |
Day 457 |
272 |
0 |
|
58 |
Day 457 |
273 |
0 |
|
56.8 |
Day 457 |
277 |
0 |
|
51.3 |
Day 457 |
292 |
0 |
|
44.3 |
Day 457 |
295 |
0 |
|
56.9 |
Day 457 |
307 |
750 |
|
59.7 |
Day 457 |
315 |
750 |
|
58.2 |
Day 457 |
330 |
750 |
|
52.2 |
Day 457 |
333 |
750 |
|
60.4 |
Day 457 |
338 |
750 |
|
49 |
Day 457 |
341 |
750 |
|
55.9 |
Day 457 |
353 |
750 |
|
52.8 |
Day 457 |
355 |
750 |
|
53.8 |
Day 457 |
356 |
750 |
|
62.4 |
Day 457 |
362 |
1500 |
|
41.9 |
Day 457 |
367 |
1500 |
|
66.2 |
Day 457 |
370 |
1500 |
|
58.9 |
Day 457 |
376 |
1500 |
|
43.3 |
Day 457 |
388 |
1500 |
|
44.1 |
Day 457 |
394 |
1500 |
|
54.2 |
Day 457 |
401 |
1500 |
|
44.9 |
Day 457 |
414 |
1500 |
|
48.9 |
Day 457 |
419 |
1500 |
|
55.5 |
Day 457 |
427 |
3000 |
|
53.2 |
Day 457 |
432 |
3000 |
|
41.7 |
Day 457 |
437 |
3000 |
|
41.1 |
Day 457 |
445 |
3000 |
|
49.1 |
Day 457 |
447 |
3000 |
|
38.1 |
Day 457 |
457 |
3000 |
|
42.6 |
Day 457 |
460 |
3000 |
|
45 |
Day 457 |
475 |
3000 |
|
52.7 |
Day 457 |
480 |
3000 |
|
48.4 |
Day 479 |
323 |
750 |
|
40.9 |
Day 497 |
290 |
0 |
|
50.6 |
Day 506 |
434 |
3000 |
|
45.7 |
Day 512 |
345 |
750 |
|
30.4 |
Day 530 |
250 |
0 |
|
35.2 |
Day 539 |
332 |
750 |
|
26 |
Day 544 |
266 |
0 |
|
31.6 |
Day 556 |
428 |
3000 |
|
36.7 |
Day 565 |
275 |
0 |
|
42.3 |
Day 570 |
288 |
0 |
|
23.3 |
Day 582 |
283 |
0 |
|
36.9 |
Day 591 |
259 |
0 |
|
50.6 |
Day 598 |
430 |
3000 |
|
39.2 |
Day 616 |
339 |
750 |
|
43.9 |
Day 619 |
424 |
3000 |
|
45.7 |
Day 625 |
352 |
750 |
|
45 |
Day 631 |
444 |
3000 |
|
31.4 |
Day 633 |
325 |
750 |
|
28.7 |
Day 643 |
386 |
1500 |
|
39.6 |
Day 647 |
327 |
750 |
|
33.7 |
Day 651 |
285 |
0 |
|
33.8 |
Day 659 |
251 |
0 |
|
37.8 |
Day 664 |
342 |
750 |
|
38.7 |
Day 672 |
311 |
750 |
|
45.1 |
Day 677 |
328 |
750 |
|
23.6 |
Day 680 |
423 |
3000 |
|
46.6 |
Day 695 |
249 |
0 |
|
28.1 |
Day 703 |
397 |
1500 |
|
41.5 |
Day 711 |
421 |
3000 |
|
37.1 |
Day 711 |
439 |
3000 |
|
36.8 |
Day 713 |
243 |
0 |
|
55.8 |
Day 720 |
451 |
3000 |
|
36.4 |
Day 722 |
256 |
0 |
|
26 |
Day 722 |
463 |
3000 |
|
30.3 |
Day 724 |
383 |
1500 |
|
38 |
Day 727 |
392 |
1500 |
|
49.6 |
Day 727 |
405 |
1500 |
|
41.1 |
Day 727 |
454 |
3000 |
|
47.6 |
Day 728 |
452 |
3000 |
|
27.9 |
Day 731 |
278 |
0 |
|
45.2 |
Day 731 |
304 |
750 |
|
49.1 |
Day 731 |
412 |
1500 |
|
33.6 |
Day 731 |
467 |
3000 |
|
32.9 |
Day 732 |
286 |
0 |
|
44.2 |
Day 734 |
242 |
0 |
|
35.3 |
Day 734 |
245 |
0 |
|
57 |
Day 734 |
246 |
0 |
|
56.7 |
Day 734 |
248 |
0 |
|
51.6 |
Day 734 |
264 |
0 |
|
61.5 |
Day 734 |
269 |
0 |
|
54.6 |
Day 734 |
270 |
0 |
|
56 |
Day 734 |
284 |
0 |
|
49.2 |
Day 734 |
291 |
0 |
|
45.6 |
Day 734 |
301 |
750 |
|
50 |
Day 734 |
302 |
750 |
|
63.3 |
Day 734 |
308 |
750 |
|
40.6 |
Day 734 |
312 |
750 |
|
48.7 |
Day 734 |
316 |
750 |
|
43.3 |
Day 734 |
317 |
750 |
|
33.9 |
Day 734 |
322 |
750 |
|
52.9 |
Day 734 |
324 |
750 |
|
53.3 |
Day 734 |
331 |
750 |
|
70 |
Day 734 |
335 |
750 |
|
58.9 |
Day 734 |
336 |
750 |
|
43.7 |
Day 734 |
337 |
750 |
|
53.4 |
Day 734 |
340 |
750 |
|
59.9 |
Day 734 |
347 |
750 |
|
60.7 |
Day 734 |
349 |
750 |
|
29.6 |
Day 734 |
351 |
750 |
|
44.5 |
Day 734 |
354 |
750 |
|
58.5 |
Day 734 |
361 |
1500 |
|
51.2 |
Day 734 |
365 |
1500 |
|
55.4 |
Day 734 |
373 |
1500 |
|
55.3 |
Day 734 |
374 |
1500 |
|
40.5 |
Day 734 |
378 |
1500 |
|
58.9 |
Day 734 |
382 |
1500 |
|
53 |
Day 734 |
384 |
1500 |
|
57.1 |
Day 734 |
385 |
1500 |
|
47.7 |
Day 734 |
389 |
1500 |
|
36.3 |
Day 734 |
400 |
1500 |
|
52.8 |
Day 734 |
403 |
1500 |
|
39.7 |
Day 734 |
411 |
1500 |
|
43.3 |
Day 734 |
416 |
1500 |
|
56.2 |
Day 734 |
418 |
1500 |
|
51.8 |
Day 734 |
433 |
3000 |
|
37.2 |
Day 734 |
435 |
3000 |
|
35.3 |
Day 734 |
436 |
3000 |
|
39.5 |
Day 734 |
438 |
3000 |
|
37.1 |
Day 734 |
441 |
3000 |
|
55.1 |
Day 734 |
443 |
3000 |
|
34.1 |
Day 734 |
446 |
3000 |
|
44.3 |
Day 734 |
449 |
3000 |
|
34.3 |
Day 734 |
450 |
3000 |
|
50.2 |
Day 734 |
455 |
3000 |
|
39.3 |
Day 734 |
461 |
3000 |
|
49.1 |
Day 734 |
462 |
3000 |
|
38.2 |
Day 734 |
469 |
3000 |
|
52.4 |
Day 734 |
470 |
3000 |
|
56.3 |
Day 734 |
471 |
3000 |
|
43.5 |
Day 734 |
474 |
3000 |
|
35.3 |
Day 734 |
476 |
3000 |
|
49.6 |
Day 734 |
477 |
3000 |
|
36.6 |
Day 734 |
478 |
3000 |
|
35.5 |
Day 734 |
479 |
3000 |
|
37.2 |
Day 735 |
244 |
0 |
|
47.9 |
Day 735 |
255 |
0 |
|
44.4 |
Day 735 |
258 |
0 |
|
45.6 |
Day 735 |
267 |
0 |
|
51.5 |
Day 735 |
271 |
0 |
|
38.8 |
Day 735 |
274 |
0 |
|
36.9 |
Day 735 |
276 |
0 |
|
50 |
Day 735 |
279 |
0 |
|
57.6 |
Day 735 |
281 |
0 |
|
48 |
Day 735 |
282 |
0 |
|
51.3 |
Day 735 |
287 |
0 |
|
50 |
Day 735 |
296 |
0 |
|
45.2 |
Day 735 |
297 |
0 |
|
49.3 |
Day 735 |
298 |
0 |
|
54.5 |
Day 735 |
299 |
0 |
|
46.7 |
Day 735 |
303 |
750 |
|
46.3 |
Day 735 |
305 |
750 |
|
53.9 |
Day 735 |
306 |
750 |
|
56.7 |
Day 735 |
309 |
750 |
|
42.8 |
Day 735 |
310 |
750 |
|
48.7 |
Day 735 |
313 |
750 |
|
53.7 |
Day 735 |
314 |
750 |
|
35.8 |
Day 735 |
318 |
750 |
|
54.8 |
Day 735 |
319 |
750 |
|
59.7 |
Day 735 |
321 |
750 |
|
36.1 |
Day 735 |
326 |
750 |
|
51.9 |
Day 735 |
329 |
750 |
|
52.8 |
Day 735 |
357 |
750 |
|
46.1 |
Day 735 |
358 |
750 |
|
50.8 |
Day 735 |
359 |
750 |
|
56.7 |
Day 735 |
360 |
750 |
|
46.6 |
Day 735 |
364 |
1500 |
|
61.3 |
Day 735 |
368 |
1500 |
|
55.5 |
Day 735 |
371 |
1500 |
|
55.1 |
Day 735 |
372 |
1500 |
|
33 |
Day 735 |
377 |
1500 |
|
36.6 |
Day 735 |
380 |
1500 |
|
49.3 |
Day 735 |
381 |
1500 |
|
32.8 |
Day 735 |
387 |
1500 |
|
55.1 |
Day 735 |
391 |
1500 |
|
49.8 |
Day 735 |
393 |
1500 |
|
51.2 |
Day 735 |
395 |
1500 |
|
56.5 |
Day 735 |
399 |
1500 |
|
59.9 |
Day 735 |
404 |
1500 |
|
44.6 |
Day 735 |
406 |
1500 |
|
55.4 |
Day 735 |
407 |
1500 |
|
56 |
Day 735 |
408 |
1500 |
|
53.7 |
Day 735 |
409 |
1500 |
|
48.6 |
Day 735 |
413 |
1500 |
|
64.7 |
Day 735 |
417 |
1500 |
|
60.1 |
Day 735 |
425 |
3000 |
|
35.1 |
Day 735 |
429 |
3000 |
|
39 |
Day 735 |
431 |
3000 |
|
35.7 |
Day 735 |
442 |
3000 |
|
42.6 |
Day 735 |
448 |
3000 |
|
37.2 |
Day 735 |
453 |
3000 |
|
35.1 |
Day 735 |
456 |
3000 |
|
44.2 |
Day 735 |
459 |
3000 |
|
45.4 |
Day 735 |
468 |
3000 |
|
47.1 |
Day 735 |
473 |
3000 |
|
42.1 |
Day 736 |
241 |
0 |
|
35.4 |
Day 736 |
252 |
0 |
|
50 |
Day 736 |
253 |
0 |
|
59.1 |
Day 736 |
261 |
0 |
|
44.6 |
Day 736 |
262 |
0 |
|
47.5 |
Day 736 |
268 |
0 |
|
57.5 |
Day 736 |
280 |
0 |
|
53.7 |
Day 736 |
289 |
0 |
|
46.4 |
Day 736 |
294 |
0 |
|
62.8 |
Day 736 |
300 |
0 |
|
51.7 |
Day 736 |
320 |
750 |
|
64.3 |
Day 736 |
344 |
750 |
|
49.7 |
Day 736 |
363 |
1500 |
|
53 |
Day 736 |
366 |
1500 |
|
41.4 |
Day 736 |
369 |
1500 |
|
49.2 |
Day 736 |
375 |
1500 |
|
41.8 |
Day 736 |
379 |
1500 |
|
37.7 |
Day 736 |
398 |
1500 |
|
41.2 |
Day 736 |
410 |
1500 |
|
34.2 |
Day 736 |
415 |
1500 |
|
48.5 |
Day 736 |
420 |
1500 |
|
51.4 |
Day 736 |
422 |
3000 |
|
43.1 |
Day 736 |
426 |
3000 |
|
33.3 |
Day 736 |
440 |
3000 |
|
55.3 |
Day 736 |
464 |
3000 |
|
35.3 |
Abbreviations: |
NA: Not Available
|