Alimentary System |
Esophagus |
Periesoph Tiss |
25 MG/KG |
50 |
18 |
86 |
352 |
1 |
Hemorrhage |
Marked |
Gavage Death |
Alimentary System |
Esophagus |
|
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Alimentary System |
Intestine Large |
Colon |
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Intestine Large |
Rectum |
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Intestine Small |
Duodenum |
Vehicle Control |
59 |
3 |
15 |
609 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Intestine Small |
Duodenum |
25 MG/KG |
50 |
16 |
79 |
675 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Intestine Small |
Duodenum |
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Intestine Small |
Duodenum |
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Intestine Small |
Duodenum |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Intestine Small |
Duodenum |
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Intestine Small |
Duodenum |
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Intestine Small |
Jejunum |
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
12 |
56 |
578 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
6 |
29 |
699 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
8 |
40 |
728 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Hyperplasia |
Minimal |
Gavage Death |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
61 |
302 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
61 |
304 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
62 |
308 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
62 |
309 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
10 |
62 |
310 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
49 |
243 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
50 |
246 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
50 |
247 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
50 |
250 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
51 |
252 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
20 |
52 |
260 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
1 |
4 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
10 |
46 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
11 |
51 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
2 |
8 |
456 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
7 |
31 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
9 |
43 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
10 |
50 |
472 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
3 |
11 |
660 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
7 |
33 |
573 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
1 |
2 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
10 |
49 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
11 |
53 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
11 |
55 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
12 |
59 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
2 |
10 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
2 |
6 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
2 |
7 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
3 |
13 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
5 |
21 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
5 |
24 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
6 |
26 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
7 |
35 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
8 |
36 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
8 |
37 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
9 |
42 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
15 |
75 |
593 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
16 |
78 |
661 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
19 |
91 |
600 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
22 |
108 |
569 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
24 |
119 |
377 |
1 |
Hyperplasia |
Minimal |
Gavage Death |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
14 |
69 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
16 |
80 |
456 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
18 |
87 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
19 |
92 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
19 |
93 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
21 |
102 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
23 |
115 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
24 |
120 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
13 |
62 |
673 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
14 |
67 |
645 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
14 |
68 |
622 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
15 |
71 |
611 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
15 |
73 |
625 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
16 |
76 |
625 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
16 |
77 |
652 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
16 |
79 |
675 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
17 |
81 |
671 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
17 |
85 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
18 |
88 |
694 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
19 |
94 |
636 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
19 |
95 |
719 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
20 |
100 |
492 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
20 |
96 |
680 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
20 |
97 |
675 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
20 |
98 |
657 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
20 |
99 |
666 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
21 |
103 |
660 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
21 |
104 |
518 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
22 |
106 |
692 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
22 |
107 |
631 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
23 |
113 |
698 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
24 |
116 |
671 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
24 |
117 |
663 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
24 |
118 |
583 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
13 |
63 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
14 |
66 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
15 |
74 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
17 |
82 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
17 |
83 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
22 |
109 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
22 |
110 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
23 |
112 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
25 MG/KG |
60 |
23 |
114 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
26 |
126 |
546 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
26 |
128 |
622 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
26 |
130 |
594 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
28 |
140 |
429 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
29 |
141 |
531 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
30 |
147 |
556 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
30 |
148 |
643 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
31 |
154 |
517 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
31 |
155 |
601 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
35 |
173 |
531 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
36 |
178 |
580 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
28 |
136 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
29 |
144 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
30 |
146 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
30 |
150 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
31 |
152 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
32 |
157 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
33 |
161 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
33 |
164 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
34 |
168 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
25 |
122 |
625 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
25 |
124 |
596 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
25 |
125 |
539 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
26 |
127 |
631 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
27 |
131 |
622 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
27 |
134 |
602 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
27 |
135 |
588 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
28 |
137 |
666 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
28 |
139 |
575 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
29 |
142 |
596 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
29 |
145 |
496 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
30 |
149 |
555 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
31 |
151 |
622 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
32 |
156 |
645 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
32 |
158 |
694 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
32 |
159 |
545 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
32 |
160 |
506 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
33 |
162 |
643 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
33 |
163 |
525 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
33 |
165 |
615 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
34 |
166 |
548 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
34 |
167 |
506 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
34 |
169 |
533 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
34 |
170 |
615 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
35 |
171 |
679 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
35 |
172 |
657 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
35 |
174 |
630 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
36 |
180 |
607 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
36 |
177 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
58 |
286 |
583 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
59 |
291 |
619 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Hyperplasia |
Minimal |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
46 |
229 |
517 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
38 |
188 |
426 |
1 |
Hyperplasia |
Mild |
Gavage Death |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
63 |
311 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
63 |
312 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
63 |
313 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
63 |
314 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
63 |
315 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
64 |
316 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
64 |
317 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
64 |
318 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
10 |
64 |
320 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
53 |
261 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
53 |
262 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
53 |
263 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
53 |
264 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
54 |
266 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
54 |
269 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
55 |
272 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
56 |
277 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
38 |
187 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
39 |
191 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
40 |
196 |
455 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
40 |
199 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
44 |
217 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
45 |
221 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
48 |
237 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
48 |
240 |
456 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
57 |
282 |
618 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
58 |
287 |
520 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
60 |
298 |
680 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
65 |
323 |
639 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
67 |
333 |
496 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
67 |
334 |
499 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
68 |
337 |
585 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
68 |
338 |
588 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
40 |
197 |
420 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
42 |
207 |
380 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Hyperplasia |
Marked |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
44 |
220 |
307 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
57 |
281 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
57 |
284 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
60 |
296 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
60 |
299 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
65 |
322 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
53 |
261 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
53 |
262 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
53 |
263 |
274 |
1 |
Cytomegaly |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
53 |
264 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
54 |
266 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
54 |
269 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
54 |
270 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
55 |
272 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
56 |
277 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Cytomegaly |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
16 |
80 |
456 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
18 |
87 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
18 |
90 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
19 |
92 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
21 |
102 |
453 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
23 |
115 |
456 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
24 |
120 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 MG/KG |
60 |
23 |
114 |
729 |
1 |
Degeneration |
Mild, Granular |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
29 |
144 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
30 |
146 |
453 |
1 |
Degeneration |
Moderate, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
30 |
150 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
31 |
152 |
453 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
32 |
157 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
33 |
161 |
456 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
33 |
164 |
453 |
1 |
Degeneration |
Moderate, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
60 |
34 |
168 |
453 |
1 |
Degeneration |
Moderate, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
63 |
311 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
63 |
313 |
453 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
63 |
314 |
453 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
63 |
315 |
456 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
64 |
317 |
456 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
64 |
318 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
64 |
320 |
455 |
1 |
Degeneration |
Mild, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
38 |
187 |
453 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
39 |
191 |
453 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
44 |
217 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
48 |
237 |
455 |
1 |
Degeneration |
Minimal, Granular |
Interval Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Degeneration |
Minimal, Granular |
Moribund |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
60 |
44 |
220 |
307 |
1 |
Degeneration |
Moderate, Granular |
Moribund |
Alimentary System |
Liver |
Periductular |
25 MG/KG |
60 |
16 |
76 |
625 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
Periductular |
100 MG/KG |
20 |
67 |
333 |
496 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
8 |
40 |
728 |
1 |
Basophilic Focus |
|
Dead |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Basophilic Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
3 |
11 |
660 |
1 |
Basophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
11 |
55 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
3 |
13 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
16 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Basophilic Focus |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
5 |
24 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
6 |
26 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
13 |
64 |
453 |
1 |
Basophilic Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
13 |
63 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
66 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
74 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
22 |
109 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
177 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Basophilic Focus |
|
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Basophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Basophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Basophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Basophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
60 |
299 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
306 |
455 |
1 |
Clear Cell Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
20 |
49 |
241 |
275 |
1 |
Clear Cell Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
2 |
7 |
729 |
1 |
Clear Cell Focus |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
16 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
5 |
21 |
730 |
1 |
Clear Cell Focus |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
9 |
42 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Clear Cell Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Clear Cell Focus |
|
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Clear Cell Focus |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Cyst |
Moderate |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
126 |
546 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
128 |
622 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
122 |
625 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
124 |
596 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
125 |
539 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
127 |
631 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
131 |
622 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
135 |
588 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
137 |
666 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
138 |
678 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
139 |
575 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
142 |
596 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
156 |
645 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
159 |
545 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
162 |
643 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
163 |
525 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
165 |
615 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
166 |
548 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
167 |
506 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
169 |
533 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
170 |
615 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
171 |
679 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
174 |
630 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
180 |
607 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Cytologic Alterations |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Cytologic Alterations |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Cytologic Alterations |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Cytologic Alterations |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
207 |
380 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Cytologic Alterations |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Cytologic Alterations |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Cytologic Alterations |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Cytologic Alterations |
Moderate |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Developmental Malformation |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
22 |
110 |
729 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Developmental Malformation |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Developmental Malformation |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Developmental Malformation |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Developmental Malformation |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
57 |
284 |
729 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
11 |
55 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
12 |
59 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
2 |
6 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
18 |
88 |
694 |
1 |
Eosinophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Eosinophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Eosinophilic Focus |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Eosinophilic Focus |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Fatty Change |
Mild |
Dead |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
301 |
337 |
1 |
Fatty Change |
Minimal |
Gavage Death |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
308 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
20 |
51 |
252 |
275 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
20 |
52 |
259 |
275 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
20 |
52 |
260 |
275 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
11 |
54 |
372 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
70 |
577 |
1 |
Fatty Change |
Minimal |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
18 |
86 |
352 |
1 |
Fatty Change |
Minimal |
Gavage Death |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
16 |
80 |
456 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
18 |
87 |
455 |
1 |
Fatty Change |
Moderate |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
18 |
90 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
19 |
92 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
19 |
93 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
102 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
23 |
115 |
456 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
24 |
120 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
68 |
622 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
73 |
625 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
104 |
518 |
1 |
Fatty Change |
Mild |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
22 |
106 |
692 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
141 |
531 |
1 |
Fatty Change |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
173 |
531 |
1 |
Fatty Change |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
129 |
428 |
1 |
Fatty Change |
Minimal |
Gavage Death |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
136 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
144 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
146 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
150 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
157 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
161 |
456 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
164 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
168 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Fatty Change |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Fatty Change |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
123 |
473 |
1 |
Fatty Change |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
311 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
312 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
313 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
314 |
453 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
315 |
456 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
64 |
316 |
456 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
64 |
317 |
456 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
64 |
318 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
64 |
320 |
455 |
1 |
Fatty Change |
Moderate |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
40 |
196 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
217 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Fatty Change |
Mild |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
237 |
455 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
240 |
456 |
1 |
Fatty Change |
Minimal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Fatty Change |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Fatty Change |
Marked |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
57 |
281 |
729 |
1 |
Fatty Change |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
57 |
283 |
729 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
16 |
77 |
652 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
24 |
118 |
583 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
126 |
546 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
128 |
622 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
130 |
594 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
140 |
429 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
141 |
531 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
147 |
556 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
148 |
643 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
31 |
155 |
601 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
173 |
531 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
178 |
580 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
122 |
625 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
124 |
596 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
125 |
539 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
127 |
631 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
131 |
622 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
134 |
602 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
135 |
588 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
137 |
666 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
138 |
678 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
139 |
575 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
142 |
596 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
145 |
496 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
149 |
555 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
156 |
645 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
159 |
545 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
160 |
506 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
162 |
643 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
163 |
525 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
165 |
615 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
166 |
548 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
167 |
506 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
169 |
533 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
170 |
615 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
171 |
679 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
172 |
657 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
174 |
630 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
180 |
607 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Fibrosis |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
229 |
517 |
1 |
Fibrosis |
Mild |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Fibrosis |
Minimal |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Fibrosis |
Minimal |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Hemorrhage |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Hemorrhage |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Hemorrhage |
Moderate |
Dead |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
7 |
32 |
671 |
1 |
Hyperplasia |
Minimal |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
2 |
10 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
72 |
613 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
75 |
593 |
1 |
Hyperplasia |
Moderate |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Hyperplasia |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
60 |
296 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Infiltration Cellular |
Mild, Lymphocyte |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Infiltration Cellular |
Mild, Lymphocyte |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
3 |
13 |
729 |
1 |
Infiltration Cellular |
Mild, Lymphocyte |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
20 |
100 |
492 |
1 |
Infiltration Cellular |
Mild, Lymphocyte |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Inflammation |
Minimal, Chronic |
Interval Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Inflammation |
Minimal, Chronic |
Interval Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
70 |
577 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
19 |
94 |
636 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
22 |
107 |
631 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
178 |
580 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
166 |
548 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
180 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
54 |
268 |
20 |
1 |
Inflammation |
Mild, Chronic |
Gavage Death |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Inflammation |
Minimal, Focal, Chronic |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
7 |
35 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
66 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
14 |
70 |
577 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
75 |
593 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
16 |
78 |
661 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
13 |
65 |
639 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
71 |
611 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
15 |
73 |
625 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
16 |
76 |
625 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
17 |
81 |
671 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
19 |
94 |
636 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
20 |
96 |
680 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
21 |
104 |
518 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
60 |
22 |
106 |
692 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
126 |
546 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
128 |
622 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
130 |
594 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
140 |
429 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
141 |
531 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
147 |
556 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
148 |
643 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
31 |
154 |
517 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
31 |
155 |
601 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
178 |
580 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
124 |
596 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
25 |
125 |
539 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
26 |
127 |
631 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
131 |
622 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
134 |
602 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
27 |
135 |
588 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
137 |
666 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
138 |
678 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
28 |
139 |
575 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
142 |
596 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
30 |
149 |
555 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
31 |
151 |
622 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
156 |
645 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
159 |
545 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
32 |
160 |
506 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
163 |
525 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
33 |
165 |
615 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
167 |
506 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
169 |
533 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
34 |
170 |
615 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
171 |
679 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
172 |
657 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
35 |
174 |
630 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
58 |
286 |
583 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Necrosis |
Minimal, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
229 |
517 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
312 |
455 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
63 |
315 |
456 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
53 |
261 |
275 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
53 |
262 |
275 |
1 |
Necrosis |
Minimal, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
53 |
263 |
274 |
1 |
Necrosis |
Minimal, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
53 |
264 |
275 |
1 |
Necrosis |
Mild, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
54 |
266 |
274 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
54 |
270 |
274 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
272 |
275 |
1 |
Necrosis |
Mild, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
56 |
277 |
274 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Necrosis |
Mild, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Necrosis |
Minimal, Multifocal |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Necrosis |
Minimal, Coagulative |
Interval Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
12 |
57 |
601 |
1 |
Hemorrhage |
Marked |
Dead |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
1 |
50 |
250 |
274 |
1 |
Inflammation |
Moderate, Chronic |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
3 |
61 |
302 |
453 |
1 |
Inflammation |
Moderate, Chronic |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
10 |
47 |
408 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
11 |
52 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
13 |
64 |
453 |
1 |
Inflammation |
Mild, Suppurative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
16 |
77 |
652 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
17 |
85 |
645 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
19 |
94 |
636 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
21 |
103 |
660 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
35 |
171 |
679 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
43 |
215 |
551 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
4 |
67 |
331 |
618 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
42 |
209 |
534 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
42 |
210 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
7 |
57 |
281 |
729 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
7 |
57 |
283 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
8 |
40 |
728 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
3 |
62 |
306 |
455 |
1 |
Necrosis |
Marked, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
3 |
62 |
309 |
453 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
2 |
8 |
456 |
1 |
Necrosis |
Marked, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
9 |
43 |
453 |
1 |
Necrosis |
Marked, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
10 |
50 |
472 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
3 |
12 |
586 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
3 |
14 |
694 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
9 |
41 |
611 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
12 |
58 |
730 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
12 |
59 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
2 |
10 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
2 |
9 |
729 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
6 |
30 |
729 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
6 |
30 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
8 |
38 |
730 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
21 |
9 |
44 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
16 |
78 |
661 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
19 |
91 |
600 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
13 |
64 |
453 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
13 |
62 |
673 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
16 |
76 |
625 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
21 |
103 |
660 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
15 |
74 |
729 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
25 MG/KG |
12 |
22 |
110 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
26 |
128 |
622 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
35 |
173 |
531 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
30 |
146 |
453 |
1 |
Necrosis |
Mild, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
30 |
150 |
455 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
32 |
157 |
455 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
25 |
124 |
596 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
26 |
127 |
631 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
27 |
131 |
622 |
1 |
Necrosis |
Minimal, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
27 |
132 |
628 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
27 |
135 |
588 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
28 |
139 |
575 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
29 |
143 |
569 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
33 |
165 |
615 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
35 |
171 |
679 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
25 |
123 |
473 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Fat |
50 MG/KG |
18 |
36 |
179 |
730 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
4 |
66 |
326 |
726 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
37 |
184 |
563 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
45 |
223 |
477 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
1 |
53 |
262 |
275 |
1 |
Necrosis |
Marked, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
1 |
64 |
317 |
456 |
1 |
Necrosis |
Moderate, Coagulative |
Interval Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
4 |
67 |
335 |
618 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
8 |
39 |
195 |
631 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
4 |
66 |
329 |
729 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
7 |
57 |
285 |
730 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
100 MG/KG |
7 |
58 |
288 |
730 |
1 |
Necrosis |
Moderate, Coagulative |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
50 MG/KG |
18 |
35 |
171 |
679 |
1 |
Ectopic Tissue |
|
Moribund |
Alimentary System |
Pancreas |
Acinar Cell |
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
25 MG/KG |
50 |
20 |
97 |
675 |
1 |
Hyperplasia |
Moderate |
Moribund |
Alimentary System |
Pancreas |
Vein |
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Dilatation |
Moderate |
Moribund |
Alimentary System |
Pancreas |
|
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Atrophy |
Mild |
Dead |
Alimentary System |
Pancreas |
|
Vehicle Control |
20 |
50 |
248 |
70 |
1 |
Atrophy |
Moderate |
Gavage Death |
Alimentary System |
Pancreas |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
Vehicle Control |
59 |
10 |
49 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
23 |
111 |
600 |
1 |
Atrophy |
Mild |
Dead |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
13 |
62 |
673 |
1 |
Atrophy |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
16 |
76 |
625 |
1 |
Atrophy |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
16 |
79 |
675 |
1 |
Atrophy |
Marked |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
17 |
81 |
671 |
1 |
Atrophy |
Minimal |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
24 |
117 |
663 |
1 |
Atrophy |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
17 |
83 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
50 MG/KG |
51 |
26 |
130 |
594 |
1 |
Atrophy |
Mild |
Dead |
Alimentary System |
Pancreas |
|
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Atrophy |
Moderate |
Moribund |
Alimentary System |
Pancreas |
|
100 MG/KG |
20 |
59 |
291 |
619 |
1 |
Atrophy |
Mild |
Dead |
Alimentary System |
Pancreas |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Atrophy |
Moderate |
Dead |
Alimentary System |
Pancreas |
|
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Atrophy |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Atrophy |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
50 MG/KG |
51 |
28 |
138 |
678 |
1 |
Fibrosis |
Moderate |
Moribund |
Alimentary System |
Pancreas |
|
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Fibrosis |
Mild |
Moribund |
Alimentary System |
Pancreas |
|
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Infiltration Cellular |
Minimal, Lymphocyte |
Moribund |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Alimentary System |
Pancreas |
|
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Alimentary System |
Pancreas |
|
100 MG/KG |
10 |
63 |
312 |
455 |
1 |
Inflammation |
Mild, Chronic |
Interval Sacrifice |
Alimentary System |
Salivary Glands |
|
25 MG/KG |
50 |
16 |
79 |
675 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Salivary Glands |
|
50 MG/KG |
51 |
35 |
173 |
531 |
1 |
Necrosis |
Marked, Caseous |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Cyst Epithelial Inclusion |
|
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
75 |
593 |
1 |
Hyperkeratosis |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
13 |
63 |
730 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
22 |
109 |
730 |
1 |
Hyperkeratosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
26 |
130 |
594 |
1 |
Hyperkeratosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
25 |
122 |
625 |
1 |
Hyperkeratosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
27 |
134 |
602 |
1 |
Hyperkeratosis |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
34 |
166 |
548 |
1 |
Hyperkeratosis |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Hyperkeratosis |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
57 |
283 |
729 |
1 |
Hyperkeratosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Hyperplasia |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
14 |
70 |
577 |
1 |
Inflammation |
Marked, Chronic |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
73 |
625 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
17 |
85 |
645 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
19 |
94 |
636 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
22 |
106 |
692 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
22 |
107 |
631 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
26 |
130 |
594 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
25 |
124 |
596 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
34 |
166 |
548 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
34 |
170 |
615 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
174 |
630 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Inflammation |
Moderate, Chronic |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
57 |
282 |
618 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
58 |
287 |
520 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
67 |
333 |
496 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
68 |
337 |
585 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Mineralization |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Ulcer |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
3 |
12 |
586 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
7 |
33 |
573 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
14 |
70 |
577 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
72 |
613 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
75 |
593 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
16 |
78 |
661 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
22 |
108 |
569 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
13 |
65 |
639 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
14 |
68 |
622 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
71 |
611 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
15 |
73 |
625 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
16 |
77 |
652 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
16 |
79 |
675 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
18 |
88 |
694 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
19 |
94 |
636 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
19 |
95 |
719 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
20 |
96 |
680 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
20 |
97 |
675 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
20 |
98 |
657 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
21 |
101 |
615 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
21 |
103 |
660 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
21 |
104 |
518 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
24 |
117 |
663 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
24 |
118 |
583 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
22 |
109 |
730 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
51 |
23 |
112 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
26 |
126 |
546 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
26 |
128 |
622 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
30 |
147 |
556 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
30 |
148 |
643 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
31 |
154 |
517 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
173 |
531 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
175 |
498 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
36 |
178 |
580 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
25 |
125 |
539 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
26 |
127 |
631 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
27 |
131 |
622 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
27 |
132 |
628 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
27 |
135 |
588 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
28 |
137 |
666 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
28 |
138 |
678 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
28 |
139 |
575 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
29 |
142 |
596 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
29 |
143 |
569 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
29 |
145 |
496 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
30 |
149 |
555 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
32 |
159 |
545 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
33 |
162 |
643 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
33 |
163 |
525 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
33 |
165 |
615 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
34 |
169 |
533 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
171 |
679 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
172 |
657 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
35 |
174 |
630 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
36 |
176 |
512 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
51 |
25 |
123 |
473 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
59 |
291 |
619 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
57 |
281 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
57 |
283 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
68 |
338 |
588 |
1 |
Dilatation |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
14 |
68 |
622 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
18 |
88 |
694 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
20 |
98 |
657 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
25 |
122 |
625 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
35 |
174 |
630 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
15 |
72 |
613 |
1 |
Mineralization |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
20 |
96 |
680 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
22 |
107 |
631 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
24 |
116 |
671 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Mineralization |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
27 |
132 |
628 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
33 |
162 |
643 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
35 |
171 |
679 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Mineralization |
Marked |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Mineralization |
Moderate |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Mineralization |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Mineralization |
Marked |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
65 |
323 |
639 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Mineralization |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Mineralization |
Marked |
Moribund |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Ulcer |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
59 |
7 |
33 |
573 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
15 |
75 |
593 |
1 |
Ulcer |
Moderate |
Dead |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
15 |
71 |
611 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
16 |
77 |
652 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
17 |
85 |
645 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
51 |
24 |
118 |
583 |
1 |
Ulcer |
Marked |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
25 |
125 |
539 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
27 |
134 |
602 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
27 |
135 |
588 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
28 |
137 |
666 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
33 |
165 |
615 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
51 |
34 |
169 |
533 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Ulcer |
Marked |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Ulcer |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Ulcer |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Ulcer |
Mild |
Dead |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
20 |
68 |
337 |
585 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Ulcer |
Moderate |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Ulcer |
Mild |
Moribund |
Alimentary System |
Tongue |
|
100 MG/KG |
1 |
47 |
233 |
643 |
1 |
Necrosis |
Mild, Zenkers |
Moribund |
Cardiovascular System |
Blood Vessel |
Aorta |
25 MG/KG |
4 |
22 |
107 |
631 |
1 |
Mineralization |
Moderate |
Moribund |
Cardiovascular System |
Blood Vessel |
Aorta |
100 MG/KG |
1 |
41 |
205 |
615 |
1 |
Mineralization |
Moderate |
Dead |
Cardiovascular System |
Blood Vessel |
Aorta |
100 MG/KG |
1 |
66 |
326 |
726 |
1 |
Mineralization |
Mild |
Dead |
Cardiovascular System |
Blood Vessel |
Aorta |
100 MG/KG |
1 |
59 |
295 |
680 |
1 |
Mineralization |
Marked |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
25 MG/KG |
4 |
21 |
101 |
615 |
1 |
Arteriosclerosis |
Marked |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
100 MG/KG |
1 |
59 |
295 |
680 |
1 |
Mineralization |
Marked |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
50 MG/KG |
2 |
25 |
122 |
625 |
1 |
Polyarteritis |
Marked |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
50 MG/KG |
2 |
28 |
138 |
678 |
1 |
Polyarteritis |
Marked |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
50 MG/KG |
2 |
28 |
138 |
678 |
1 |
Thrombosis |
Marked |
Moribund |
Cardiovascular System |
Heart |
Av Valve |
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
6 |
29 |
699 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
8 |
40 |
728 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
61 |
301 |
337 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
50 |
248 |
70 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
10 |
48 |
335 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
61 |
302 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
61 |
304 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
62 |
306 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
62 |
308 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
62 |
309 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
49 |
242 |
274 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
49 |
243 |
274 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
50 |
249 |
275 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
51 |
251 |
275 |
1 |
Cardiomyopathy |
Moderate |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
51 |
253 |
274 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
51 |
254 |
274 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
51 |
255 |
275 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
52 |
257 |
274 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
20 |
52 |
260 |
275 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
1 |
4 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
10 |
46 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
11 |
51 |
455 |
1 |
Cardiomyopathy |
Moderate |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
2 |
8 |
456 |
1 |
Cardiomyopathy |
Moderate |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
5 |
25 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
7 |
31 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
7 |
34 |
455 |
1 |
Cardiomyopathy |
Moderate |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
9 |
43 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
12 |
60 |
622 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
3 |
11 |
660 |
1 |
Cardiomyopathy |
Minimal |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
3 |
12 |
586 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
7 |
32 |
671 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
11 |
53 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
2 |
6 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
2 |
7 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
3 |
13 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
5 |
21 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
5 |
24 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
8 |
37 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
59 |
9 |
42 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
16 |
78 |
661 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
19 |
91 |
600 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
18 |
86 |
352 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
21 |
105 |
90 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
24 |
119 |
377 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
13 |
61 |
482 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
13 |
62 |
673 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
13 |
65 |
639 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
14 |
67 |
645 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
14 |
68 |
622 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
15 |
73 |
625 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
16 |
76 |
625 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
16 |
77 |
652 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
16 |
79 |
675 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
17 |
85 |
645 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
18 |
88 |
694 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
18 |
89 |
343 |
1 |
Cardiomyopathy |
Minimal |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
20 |
97 |
675 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
20 |
99 |
666 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
21 |
104 |
518 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
22 |
107 |
631 |
1 |
Cardiomyopathy |
Marked |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
23 |
113 |
698 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
24 |
117 |
663 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
24 |
118 |
583 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
13 |
63 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
14 |
66 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
15 |
74 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
22 |
110 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
23 |
112 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
23 |
114 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
26 |
128 |
622 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
28 |
140 |
429 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
31 |
154 |
517 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
35 |
173 |
531 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
35 |
175 |
498 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
26 |
129 |
428 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
27 |
133 |
63 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
25 |
124 |
596 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
27 |
131 |
622 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
28 |
137 |
666 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
28 |
138 |
678 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
33 |
162 |
643 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
34 |
169 |
533 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
34 |
170 |
615 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
35 |
172 |
657 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
35 |
174 |
630 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
36 |
177 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
36 |
179 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
58 |
286 |
583 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Cardiomyopathy |
Marked |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Cardiomyopathy |
Moderate |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Cardiomyopathy |
Mild |
Dead |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
59 |
294 |
49 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
68 |
339 |
40 |
1 |
Cardiomyopathy |
Minimal |
Gavage Death |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
38 |
188 |
426 |
1 |
Cardiomyopathy |
Mild |
Gavage Death |
Cardiovascular System |
Heart |
|
100 MG/KG |
10 |
63 |
314 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
10 |
64 |
317 |
456 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
10 |
64 |
318 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
10 |
64 |
320 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
54 |
270 |
274 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Cardiomyopathy |
Minimal |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
38 |
187 |
453 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
40 |
196 |
455 |
1 |
Cardiomyopathy |
Mild |
Interval Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
57 |
282 |
618 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Cardiomyopathy |
Marked |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
60 |
298 |
680 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
67 |
333 |
496 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
68 |
338 |
588 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
40 |
197 |
420 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Cardiomyopathy |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Cardiomyopathy |
Minimal |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Cardiomyopathy |
Mild |
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
57 |
284 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Fibrosis |
Moderate |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
51 |
30 |
148 |
643 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Cardiovascular System |
Heart |
|
25 MG/KG |
50 |
23 |
113 |
698 |
1 |
Thrombosis |
|
Moribund |
Cardiovascular System |
Heart |
|
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Thrombosis |
Marked |
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
25 MG/KG |
50 |
15 |
74 |
729 |
1 |
Clear Cell Focus |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
51 |
28 |
138 |
678 |
1 |
Clear Cell Focus |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Cortex |
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Clear Cell Focus |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Clear Cell Focus |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Cortex |
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Congestion |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
25 MG/KG |
50 |
13 |
63 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Hypertrophy |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Medulla |
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Basophilic Focus |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
50 |
13 |
65 |
639 |
1 |
Basophilic Focus |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Congestion |
Moderate |
Dead |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
50 |
17 |
81 |
671 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
50 |
20 |
96 |
680 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
50 |
20 |
97 |
675 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
50 |
24 |
117 |
663 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
59 |
3 |
15 |
609 |
1 |
Hyperplasia |
Minimal |
Moribund |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
14 |
68 |
622 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
15 |
71 |
611 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
15 |
73 |
625 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
16 |
76 |
625 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
16 |
77 |
652 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
17 |
85 |
645 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
18 |
88 |
694 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
19 |
94 |
636 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
20 |
96 |
680 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
21 |
101 |
615 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
21 |
104 |
518 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
22 |
107 |
631 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
23 |
113 |
698 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
24 |
117 |
663 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
24 |
118 |
583 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
25 MG/KG |
50 |
22 |
109 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
26 |
128 |
622 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
31 |
154 |
517 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
35 |
175 |
498 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
25 |
122 |
625 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
26 |
127 |
631 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
27 |
131 |
622 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
27 |
134 |
602 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
27 |
135 |
588 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
28 |
137 |
666 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
28 |
138 |
678 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
29 |
142 |
596 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
29 |
143 |
569 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
29 |
145 |
496 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
30 |
149 |
555 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
32 |
160 |
506 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
33 |
162 |
643 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
33 |
163 |
525 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
33 |
165 |
615 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
34 |
166 |
548 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
34 |
170 |
615 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
35 |
171 |
679 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
35 |
172 |
657 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
35 |
174 |
630 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
36 |
176 |
512 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
50 MG/KG |
51 |
36 |
177 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Hyperplasia |
Marked |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Hyperplasia |
Moderate |
Dead |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
58 |
287 |
520 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
60 |
298 |
680 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
100 MG/KG |
20 |
65 |
322 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
20 |
60 |
299 |
729 |
1 |
Congestion |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
59 |
5 |
21 |
730 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
25 MG/KG |
50 |
13 |
62 |
673 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
25 MG/KG |
50 |
13 |
65 |
639 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
25 MG/KG |
50 |
20 |
99 |
666 |
1 |
Cyst |
Moderate |
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Cyst |
Mild |
Dead |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Cyst |
Mild |
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Cyst |
Moderate |
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
10 |
62 |
308 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
20 |
50 |
250 |
274 |
1 |
Hyperplasia |
Moderate |
Interval Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 MG/KG |
20 |
58 |
287 |
520 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
10 |
61 |
304 |
455 |
1 |
Hypertrophy |
Moderate |
Interval Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
25 MG/KG |
50 |
22 |
107 |
631 |
1 |
Hypertrophy |
Mild |
Moribund |
Endocrine System |
Pituitary Gland |
Pars Intermed |
Vehicle Control |
59 |
2 |
6 |
730 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
2 |
7 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
25 MG/KG |
50 |
16 |
78 |
661 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Thyroid Gland |
C Cell |
25 MG/KG |
50 |
23 |
113 |
698 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
C Cell |
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
C Cell |
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
C Cell |
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
Follicle |
Vehicle Control |
59 |
3 |
15 |
609 |
1 |
Cyst |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
Follicular Cel |
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Cyst |
Moderate |
Moribund |
General Body System |
Tissue NOS |
|
100 MG/KG |
4 |
43 |
215 |
551 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Genital System |
Preputial Gland |
Duct |
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Dilatation |
Mild |
Moribund |
Genital System |
Preputial Gland |
Duct |
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Dilatation |
Marked |
Moribund |
Genital System |
Preputial Gland |
Duct |
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Preputial Gland |
Duct |
50 MG/KG |
51 |
36 |
178 |
580 |
1 |
Dilatation |
Marked |
Dead |
Genital System |
Preputial Gland |
Duct |
50 MG/KG |
51 |
30 |
149 |
555 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Preputial Gland |
Duct |
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Preputial Gland |
Duct |
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Preputial Gland |
Duct |
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Preputial Gland |
|
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Preputial Gland |
|
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Hemorrhage |
Mild |
Dead |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Inflammation |
Marked, Suppurative |
Interval Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Inflammation |
Moderate, Suppurative |
Interval Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
7 |
32 |
671 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
1 |
2 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
11 |
55 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
15 |
72 |
613 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
16 |
78 |
661 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
23 |
111 |
600 |
1 |
Inflammation |
Moderate, Chronic |
Dead |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
13 |
62 |
673 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
14 |
68 |
622 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
16 |
77 |
652 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
17 |
81 |
671 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
25 MG/KG |
50 |
18 |
89 |
343 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
51 |
29 |
142 |
596 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
51 |
31 |
153 |
408 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
51 |
34 |
166 |
548 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Preputial Gland |
|
100 MG/KG |
60 |
45 |
221 |
453 |
1 |
Inflammation |
Moderate, Suppurative |
Interval Sacrifice |
Genital System |
Preputial Gland |
|
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Preputial Gland |
|
100 MG/KG |
20 |
65 |
322 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Prostate |
|
50 MG/KG |
51 |
36 |
178 |
580 |
1 |
Edema |
Moderate |
Dead |
Genital System |
Prostate |
|
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Hemorrhage |
Moderate |
Moribund |
Genital System |
Prostate |
|
Vehicle Control |
59 |
7 |
35 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
25 MG/KG |
50 |
22 |
109 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
50 MG/KG |
51 |
26 |
127 |
631 |
1 |
Hyperplasia |
Mild |
Moribund |
Genital System |
Prostate |
|
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
100 MG/KG |
20 |
60 |
299 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Prostate |
|
Vehicle Control |
59 |
10 |
50 |
472 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Prostate |
|
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Genital System |
Prostate |
|
25 MG/KG |
50 |
15 |
71 |
611 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
50 |
17 |
85 |
645 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
50 |
22 |
106 |
692 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
50 |
13 |
63 |
730 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Genital System |
Prostate |
|
25 MG/KG |
50 |
15 |
74 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Genital System |
Prostate |
|
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Prostate |
|
50 MG/KG |
51 |
25 |
125 |
539 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
50 MG/KG |
51 |
27 |
134 |
602 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
50 MG/KG |
51 |
28 |
137 |
666 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Prostate |
|
50 MG/KG |
51 |
36 |
180 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Prostate |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Genital System |
Prostate |
|
100 MG/KG |
20 |
68 |
339 |
40 |
1 |
Inflammation |
Mild, Chronic |
Gavage Death |
Genital System |
Prostate |
|
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Inflammation |
Mild, Suppurative |
Interval Sacrifice |
Genital System |
Prostate |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Prostate |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Genital System |
Prostate |
|
100 MG/KG |
60 |
42 |
207 |
380 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Genital System |
Prostate |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Atrophy |
Moderate |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Hyperplasia |
Minimal |
Gavage Death |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
49 |
241 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
49 |
242 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
50 |
246 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
50 |
247 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
50 |
249 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
51 |
251 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
51 |
253 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
52 |
256 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
20 |
52 |
257 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
59 |
1 |
4 |
455 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
59 |
11 |
51 |
455 |
1 |
Hyperplasia |
Moderate |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
25 MG/KG |
59 |
18 |
89 |
343 |
1 |
Hyperplasia |
Mild |
Moribund |
Genital System |
Testes |
Interstit Cell |
25 MG/KG |
59 |
20 |
100 |
492 |
1 |
Hyperplasia |
Mild |
Moribund |
Genital System |
Testes |
Interstit Cell |
50 MG/KG |
59 |
35 |
175 |
498 |
1 |
Hyperplasia |
Mild |
Dead |
Genital System |
Testes |
Interstit Cell |
50 MG/KG |
59 |
31 |
153 |
408 |
1 |
Hyperplasia |
Moderate |
Moribund |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Hyperplasia |
Mild |
Dead |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
53 |
262 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
53 |
263 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
54 |
266 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
54 |
269 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
55 |
272 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
56 |
277 |
274 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Hyperplasia |
Minimal |
Interval Sacrifice |
Genital System |
Testes |
Interstit Cell |
100 MG/KG |
60 |
44 |
216 |
453 |
1 |
Hyperplasia |
Mild |
Interval Sacrifice |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Atrophy |
Marked |
Interval Sacrifice |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Atrophy |
Moderate |
Moribund |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Atrophy |
Marked |
Moribund |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
59 |
6 |
26 |
730 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
50 MG/KG |
59 |
34 |
168 |
453 |
1 |
Atrophy |
Marked |
Interval Sacrifice |
Genital System |
Testes |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Atrophy |
Moderate |
Dead |
Genital System |
Testes |
|
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Atrophy |
Moderate |
Interval Sacrifice |
Genital System |
Testes |
|
100 MG/KG |
20 |
57 |
283 |
729 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
100 MG/KG |
20 |
65 |
323 |
639 |
1 |
Infarct |
Marked |
Moribund |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Hyperplasia |
Moderate, Mononuclear Cl |
Moribund |
Hematopoietic System |
Bone Marrow |
|
25 MG/KG |
50 |
13 |
61 |
482 |
1 |
Hyperplasia |
Moderate, Neutrophil |
Moribund |
Hematopoietic System |
Bone Marrow |
|
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Hyperplasia |
Mild, Mononuclear Cl |
Moribund |
Hematopoietic System |
Lymph Node |
Lumbar |
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Hemorrhage |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Lumbar |
50 MG/KG |
51 |
35 |
172 |
657 |
1 |
Hemorrhage |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Lumbar |
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Hemorrhage |
Moderate |
Dead |
Hematopoietic System |
Lymph Node |
Lumbar |
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Hemorrhage |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Lumbar |
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Hemorrhage |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
59 |
6 |
29 |
699 |
1 |
Congestion |
Moderate |
Dead |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Congestion |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
61 |
301 |
337 |
1 |
Edema |
Moderate |
Gavage Death |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Edema |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
50 |
13 |
63 |
730 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
51 |
33 |
165 |
615 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Hyperplasia |
Mild, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Hyperplasia |
Marked, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Dead |
Hematopoietic System |
Lymph Node |
Mediastinal |
25 MG/KG |
50 |
14 |
67 |
645 |
1 |
Hemorrhage |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mediastinal |
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Hemorrhage |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mediastinal |
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Hemorrhage |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mediastinal |
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Pigmentation |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Congestion |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
50 |
14 |
67 |
645 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund |
Hematopoietic System |
Lymph Node |
Renal |
25 MG/KG |
50 |
14 |
67 |
645 |
1 |
Hemorrhage |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Amyloid Deposition |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Congestion |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Congestion |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Congestion |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Congestion |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
1 |
2 |
729 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
7 |
35 |
729 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Ectopic Tissue |
Moderate |
Interval Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
32 |
157 |
455 |
1 |
Fibrosis |
Mild |
Interval Sacrifice |
Hematopoietic System |
Spleen |
|
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Fibrosis |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
19 |
91 |
600 |
1 |
Hemorrhage |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
17 |
81 |
671 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
20 |
98 |
657 |
1 |
Hyperplasia |
Moderate, Histiocytic |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
32 |
158 |
694 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Hypoplasia |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
20 |
96 |
680 |
1 |
Infarct |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
22 |
109 |
730 |
1 |
Infarct |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
19 |
94 |
636 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
36 |
178 |
580 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
34 |
166 |
548 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
35 |
173 |
531 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Hematopoietic System |
Spleen |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Necrosis |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
52 |
26 |
127 |
631 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund |
Hematopoietic System |
Spleen |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund |
Hematopoietic System |
Spleen |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Pigmentation |
Mild, Hemosiderin |
Moribund |
Hematopoietic System |
Spleen |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Thrombosis |
Marked |
Moribund |
Hematopoietic System |
Thymus |
|
50 MG/KG |
51 |
26 |
129 |
428 |
1 |
Ectopic Tissue |
|
Gavage Death |
Hematopoietic System |
Thymus |
|
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Integumentary System |
Mammary Gland |
|
Vehicle Control |
59 |
3 |
12 |
586 |
1 |
Galactocele |
Moderate |
Moribund |
Integumentary System |
Mammary Gland |
|
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Galactocele |
Mild |
Moribund |
Integumentary System |
Mammary Gland |
|
50 MG/KG |
51 |
29 |
141 |
531 |
1 |
Galactocele |
Moderate |
Dead |
Integumentary System |
Mammary Gland |
|
50 MG/KG |
51 |
25 |
124 |
596 |
1 |
Galactocele |
Moderate |
Moribund |
Integumentary System |
Skin |
Sebaceous Gl |
25 MG/KG |
50 |
24 |
116 |
671 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Acanthosis |
Moderate |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Cyst Epithelial Inclusion |
|
Gavage Death |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Cyst Epithelial Inclusion |
|
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
4 |
16 |
729 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
5 |
24 |
729 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Cyst Epithelial Inclusion |
Marked |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
33 |
165 |
615 |
1 |
Cyst Epithelial Inclusion |
Marked |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
34 |
167 |
506 |
1 |
Cyst Epithelial Inclusion |
Moderate |
Moribund |
Integumentary System |
Skin |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Cyst Epithelial Inclusion |
Moderate |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
31 |
153 |
408 |
1 |
Degeneration |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Hemorrhage |
Moderate |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
18 |
86 |
352 |
1 |
Hemorrhage |
Minimal |
Gavage Death |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Hyperkeratosis |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
13 |
61 |
482 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
16 |
76 |
625 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
18 |
89 |
343 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
50 |
24 |
118 |
583 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
32 |
156 |
645 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
51 |
32 |
158 |
694 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Musculoskeletal System |
Bone |
Cranium |
25 MG/KG |
50 |
23 |
114 |
729 |
1 |
Proliferation |
Mild |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
50 MG/KG |
51 |
31 |
151 |
622 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Musculoskeletal System |
Bone |
|
Vehicle Control |
59 |
10 |
46 |
453 |
1 |
Necrosis |
Moderate |
Interval Sacrifice |
Musculoskeletal System |
Skeletal Muscle |
|
50 MG/KG |
2 |
33 |
163 |
525 |
1 |
Inflammation |
Marked, Chronic |
Moribund |
Musculoskeletal System |
Skeletal Muscle |
|
50 MG/KG |
2 |
36 |
180 |
607 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Musculoskeletal System |
Skeletal Muscle |
|
100 MG/KG |
1 |
44 |
218 |
654 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Nervous System |
Brain |
Cerebellum |
Vehicle Control |
59 |
7 |
32 |
671 |
1 |
Developmental Malformation |
|
Moribund |
Nervous System |
Brain |
Cerebellum |
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Hemorrhage |
Moderate |
Moribund |
Nervous System |
Brain |
Cerebrum |
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Hemorrhage |
Moderate |
Moribund |
Nervous System |
Brain |
Cerebrum |
100 MG/KG |
20 |
65 |
322 |
729 |
1 |
Infarct |
Moderate |
Terminal Sacrifice |
Nervous System |
Brain |
Hypothalamus |
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Compression |
Moderate |
Moribund |
Nervous System |
Brain |
Meninges |
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Hemorrhage |
Moderate |
Dead |
Respiratory System |
Larynx |
|
25 MG/KG |
1 |
18 |
86 |
352 |
1 |
Hemorrhage |
Marked |
Gavage Death |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
59 |
12 |
56 |
578 |
1 |
Hyperplasia |
Moderate |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
59 |
10 |
50 |
472 |
1 |
Hyperplasia |
Moderate |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Hyperplasia |
Minimal |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
59 |
8 |
36 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
59 |
8 |
37 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
16 |
79 |
675 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
52 |
33 |
163 |
525 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Hyperplasia |
Minimal |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Hyperplasia |
Moderate |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
100 MG/KG |
20 |
57 |
284 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
52 |
31 |
153 |
408 |
1 |
Atelectasis |
Mild |
Moribund |
Respiratory System |
Lung |
|
Vehicle Control |
20 |
49 |
245 |
216 |
1 |
Congestion |
Marked |
Dead |
Respiratory System |
Lung |
|
Vehicle Control |
20 |
50 |
248 |
70 |
1 |
Congestion |
Marked |
Gavage Death |
Respiratory System |
Lung |
|
Vehicle Control |
20 |
52 |
258 |
50 |
1 |
Congestion |
Marked |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
54 |
268 |
20 |
1 |
Congestion |
Moderate |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
55 |
273 |
83 |
1 |
Congestion |
Moderate |
Gavage Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Edema |
Mild |
Gavage Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
62 |
307 |
71 |
1 |
Edema |
Mild |
Gavage Death |
Respiratory System |
Lung |
|
50 MG/KG |
52 |
27 |
133 |
63 |
1 |
Edema |
Minimal |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
59 |
294 |
49 |
1 |
Emphysema |
Mild |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Fibrosis |
Mild |
Moribund |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
65 |
324 |
40 |
1 |
Foreign Body |
Minimal |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
68 |
336 |
70 |
1 |
Foreign Body |
Minimal |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
68 |
339 |
40 |
1 |
Foreign Body |
Minimal |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
60 |
37 |
182 |
19 |
1 |
Foreign Body |
Minimal |
Gavage Death |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
18 |
86 |
352 |
1 |
Hemorrhage |
Mild |
Gavage Death |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Hemorrhage |
Mild |
Dead |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Hemorrhage |
Moderate |
Interval Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
24 |
118 |
583 |
1 |
Hyperplasia |
Mild, Macrophage |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
17 |
82 |
729 |
1 |
Hyperplasia |
Minimal, Macrophage |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Hyperplasia |
Mild, Macrophage |
Moribund |
Respiratory System |
Lung |
|
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Lung |
|
Vehicle Control |
20 |
50 |
250 |
274 |
1 |
Inflammation |
Moderate, Granulomatous |
Interval Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
20 |
52 |
259 |
275 |
1 |
Inflammation |
Minimal, Granulomatous |
Interval Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
19 |
94 |
636 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
52 |
35 |
173 |
531 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
52 |
29 |
145 |
496 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Lung |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
20 |
100 |
492 |
1 |
Mineralization |
Minimal |
Moribund |
Respiratory System |
Nose |
Nasolacrim Dct |
100 MG/KG |
2 |
54 |
268 |
20 |
1 |
Inflammation |
Mild |
Gavage Death |
Respiratory System |
Nose |
Nasolacrim Dct |
100 MG/KG |
2 |
55 |
273 |
83 |
1 |
Inflammation |
Mild |
Gavage Death |
Respiratory System |
Nose |
Olfactory Epi |
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Degeneration |
Mild |
Dead |
Respiratory System |
Nose |
Respirat Epith |
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Hyperplasia |
Marked |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
3 |
52 |
258 |
50 |
1 |
Congestion |
Marked |
Gavage Death |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
11 |
54 |
372 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
12 |
60 |
622 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
17 |
84 |
503 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
21 |
101 |
615 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
26 |
126 |
546 |
1 |
Fungus |
Marked |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
27 |
131 |
622 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
29 |
145 |
496 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
33 |
162 |
643 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Fungus |
Moderate |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Fungus |
Marked |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Fungus |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
18 |
86 |
352 |
1 |
Hemorrhage |
Mild |
Gavage Death |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Hemorrhage |
Moderate |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
12 |
57 |
601 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
6 |
29 |
699 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Inflammation |
Minimal, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
7 |
34 |
455 |
1 |
Inflammation |
Minimal, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
11 |
54 |
372 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
12 |
60 |
622 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
1 |
2 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
4 |
16 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
14 |
70 |
577 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
16 |
78 |
661 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
22 |
108 |
569 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
13 |
62 |
673 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
13 |
65 |
639 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
14 |
68 |
622 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
15 |
71 |
611 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
16 |
76 |
625 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
17 |
84 |
503 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
19 |
94 |
636 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
19 |
95 |
719 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
20 |
96 |
680 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
20 |
97 |
675 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
21 |
101 |
615 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
21 |
103 |
660 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
24 |
117 |
663 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
24 |
118 |
583 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
22 |
109 |
730 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
22 |
110 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
23 |
114 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
25 |
121 |
580 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
26 |
126 |
546 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
26 |
130 |
594 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
29 |
141 |
531 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
35 |
175 |
498 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
28 |
136 |
455 |
1 |
Inflammation |
Moderate, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
27 |
131 |
622 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
27 |
132 |
628 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
27 |
134 |
602 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
28 |
137 |
666 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
28 |
138 |
678 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
28 |
139 |
575 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
29 |
143 |
569 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
29 |
145 |
496 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
32 |
156 |
645 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
32 |
158 |
694 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
32 |
159 |
545 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
33 |
162 |
643 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
33 |
163 |
525 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
34 |
166 |
548 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
34 |
167 |
506 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
34 |
169 |
533 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
34 |
170 |
615 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
35 |
174 |
630 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
36 |
176 |
512 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
36 |
180 |
607 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
25 |
123 |
473 |
1 |
Inflammation |
Mild, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
50 MG/KG |
52 |
36 |
177 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
58 |
290 |
307 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
46 |
229 |
517 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
38 |
188 |
426 |
1 |
Inflammation |
Mild, Suppurative |
Gavage Death |
Respiratory System |
Nose |
|
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Inflammation |
Moderate, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
38 |
187 |
453 |
1 |
Inflammation |
Minimal, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
40 |
199 |
456 |
1 |
Inflammation |
Minimal, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Inflammation |
Minimal, Suppurative |
Interval Sacrifice |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
57 |
282 |
618 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
42 |
207 |
380 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
44 |
220 |
307 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
50 |
21 |
101 |
615 |
1 |
Metaplasia |
Moderate, Squamous |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Metaplasia |
Mild, Squamous |
Moribund |
Respiratory System |
Nose |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Respiratory System |
Trachea |
|
50 MG/KG |
51 |
31 |
155 |
601 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Trachea |
|
100 MG/KG |
20 |
65 |
323 |
639 |
1 |
Metaplasia |
Mild, Squamous |
Moribund |
Special Senses System |
Eye |
Cornea |
50 MG/KG |
4 |
26 |
129 |
428 |
1 |
Edema |
Mild |
Gavage Death |
Special Senses System |
Eye |
Postr Chamber |
100 MG/KG |
1 |
65 |
325 |
566 |
1 |
Hemorrhage |
Moderate |
Moribund |
Special Senses System |
Eye |
Retina |
100 MG/KG |
1 |
38 |
186 |
636 |
1 |
Degeneration |
Moderate |
Moribund |
Special Senses System |
Eye |
|
50 MG/KG |
4 |
30 |
147 |
556 |
1 |
Cataract |
Mild |
Dead |
Special Senses System |
Eye |
|
100 MG/KG |
1 |
38 |
186 |
636 |
1 |
Cataract |
Moderate |
Moribund |
Special Senses System |
Eye |
|
100 MG/KG |
1 |
57 |
282 |
618 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Special Senses System |
Eye |
|
50 MG/KG |
4 |
29 |
144 |
455 |
1 |
Pigmentation |
Mild |
Interval Sacrifice |
Special Senses System |
Zymbal's Gland |
|
50 MG/KG |
1 |
36 |
178 |
580 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Urinary System |
Kidney |
Cortex |
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Cyst |
Marked |
Moribund |
Urinary System |
Kidney |
Cortex |
25 MG/KG |
60 |
17 |
85 |
645 |
1 |
Cyst |
|
Moribund |
Urinary System |
Kidney |
Cortex |
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Cyst |
Moderate |
Moribund |
Urinary System |
Kidney |
Cortex |
25 MG/KG |
60 |
24 |
116 |
671 |
1 |
Cyst |
Moderate |
Moribund |
Urinary System |
Kidney |
Cortex |
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Cyst |
Mild |
Dead |
Urinary System |
Kidney |
Cortex |
50 MG/KG |
60 |
28 |
138 |
678 |
1 |
Cyst |
Moderate |
Moribund |
Urinary System |
Kidney |
Cortex |
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Cyst |
Moderate |
Moribund |
Urinary System |
Kidney |
Cortex |
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Cyst |
Moderate |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Hyperplasia |
Minimal |
Dead |
Urinary System |
Kidney |
Renal Tubule |
25 MG/KG |
60 |
16 |
77 |
652 |
1 |
Hyperplasia |
Marked |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
25 MG/KG |
60 |
18 |
88 |
694 |
1 |
Hyperplasia |
Mild |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
25 MG/KG |
60 |
24 |
118 |
583 |
1 |
Hyperplasia |
Moderate |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Hyperplasia |
Minimal |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Hyperplasia |
Minimal |
Moribund |
Urinary System |
Kidney |
Renal Tubule |
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
54 |
372 |
1 |
Congestion |
Mild |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Hydronephrosis |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
12 |
56 |
578 |
1 |
Nephropathy |
Minimal |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
6 |
27 |
623 |
1 |
Nephropathy |
Mild |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
6 |
28 |
704 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
6 |
29 |
699 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
8 |
40 |
728 |
1 |
Nephropathy |
Minimal |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
301 |
337 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
303 |
338 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
10 |
48 |
335 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
302 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
304 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
305 |
456 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
62 |
306 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
62 |
308 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
62 |
309 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
62 |
310 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
49 |
241 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
49 |
242 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
49 |
243 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
49 |
244 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
50 |
246 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
50 |
247 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
50 |
249 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
50 |
250 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
51 |
251 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
51 |
252 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
51 |
253 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
51 |
254 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
51 |
255 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
52 |
256 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
52 |
257 |
274 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
52 |
259 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
20 |
52 |
260 |
275 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
1 |
4 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
10 |
46 |
453 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
51 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
2 |
8 |
456 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
4 |
19 |
453 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
5 |
25 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
7 |
31 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
7 |
34 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
9 |
43 |
453 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
9 |
45 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
10 |
47 |
408 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
10 |
50 |
472 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
54 |
372 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
12 |
60 |
622 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
3 |
11 |
660 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
3 |
12 |
586 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
3 |
14 |
694 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
3 |
15 |
609 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
5 |
22 |
513 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
7 |
32 |
671 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
7 |
33 |
573 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
8 |
39 |
720 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
9 |
41 |
611 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
1 |
2 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
1 |
3 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
10 |
49 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
52 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
53 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
11 |
55 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
12 |
58 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
12 |
59 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
2 |
10 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
2 |
6 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
2 |
7 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
2 |
9 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
3 |
13 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
4 |
16 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
4 |
17 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
4 |
18 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
4 |
20 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
5 |
21 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
5 |
23 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
5 |
24 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
6 |
26 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
6 |
30 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
7 |
35 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
8 |
36 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
8 |
37 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
8 |
38 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
9 |
42 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
59 |
9 |
44 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
14 |
70 |
577 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
15 |
72 |
613 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
15 |
75 |
593 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
16 |
78 |
661 |
1 |
Nephropathy |
Mild |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
19 |
91 |
600 |
1 |
Nephropathy |
Mild |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
22 |
108 |
569 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
23 |
111 |
600 |
1 |
Nephropathy |
Mild |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
18 |
86 |
352 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
24 |
119 |
377 |
1 |
Nephropathy |
Mild |
Gavage Death |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
13 |
64 |
453 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
14 |
69 |
453 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
16 |
80 |
456 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
18 |
87 |
455 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
18 |
90 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
19 |
92 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
19 |
93 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
21 |
102 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
23 |
115 |
456 |
1 |
Nephropathy |
Minimal |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
24 |
120 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
13 |
61 |
482 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
13 |
62 |
673 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
13 |
65 |
639 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
14 |
67 |
645 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
14 |
68 |
622 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
15 |
71 |
611 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
15 |
73 |
625 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
16 |
76 |
625 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
16 |
77 |
652 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
16 |
79 |
675 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
17 |
81 |
671 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
17 |
84 |
503 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
17 |
85 |
645 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
18 |
88 |
694 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
18 |
89 |
343 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
19 |
94 |
636 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
20 |
100 |
492 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
20 |
96 |
680 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
20 |
97 |
675 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
20 |
98 |
657 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
20 |
99 |
666 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
21 |
101 |
615 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
21 |
103 |
660 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
21 |
104 |
518 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
22 |
106 |
692 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
22 |
107 |
631 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
23 |
113 |
698 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
24 |
116 |
671 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
24 |
117 |
663 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
24 |
118 |
583 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
13 |
63 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
14 |
66 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
15 |
74 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
17 |
82 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
17 |
83 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
22 |
109 |
730 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
22 |
110 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
23 |
112 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
60 |
23 |
114 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
25 |
121 |
580 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
26 |
126 |
546 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
26 |
128 |
622 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
26 |
130 |
594 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
28 |
140 |
429 |
1 |
Nephropathy |
Minimal |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
29 |
141 |
531 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
30 |
147 |
556 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
30 |
148 |
643 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
31 |
154 |
517 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
31 |
155 |
601 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
35 |
173 |
531 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
35 |
175 |
498 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
36 |
178 |
580 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
26 |
129 |
428 |
1 |
Nephropathy |
Mild |
Gavage Death |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
28 |
136 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
29 |
144 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
30 |
146 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
30 |
150 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
31 |
152 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
32 |
157 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
33 |
161 |
456 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
33 |
164 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
34 |
168 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
25 |
122 |
625 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
25 |
124 |
596 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
25 |
125 |
539 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
26 |
127 |
631 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
27 |
131 |
622 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
27 |
132 |
628 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
27 |
134 |
602 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
27 |
135 |
588 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
28 |
137 |
666 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
28 |
138 |
678 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
28 |
139 |
575 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
29 |
142 |
596 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
29 |
143 |
569 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
29 |
145 |
496 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
30 |
149 |
555 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
31 |
151 |
622 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
31 |
153 |
408 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
32 |
156 |
645 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
32 |
158 |
694 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
32 |
159 |
545 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
32 |
160 |
506 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
33 |
162 |
643 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
33 |
163 |
525 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
33 |
165 |
615 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
34 |
166 |
548 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
34 |
167 |
506 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
34 |
169 |
533 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
34 |
170 |
615 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
35 |
171 |
679 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
35 |
172 |
657 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
35 |
174 |
630 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
36 |
176 |
512 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
36 |
180 |
607 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
25 |
123 |
473 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
36 |
177 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
60 |
36 |
179 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
58 |
286 |
583 |
1 |
Nephropathy |
Mild |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
58 |
290 |
307 |
1 |
Nephropathy |
Minimal |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
59 |
291 |
619 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
59 |
293 |
588 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
60 |
297 |
729 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
66 |
326 |
726 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
66 |
328 |
623 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
37 |
184 |
563 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
38 |
189 |
630 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
39 |
192 |
496 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
41 |
201 |
456 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
41 |
202 |
503 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
41 |
205 |
615 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
42 |
208 |
518 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
43 |
211 |
552 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
43 |
213 |
533 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
43 |
215 |
551 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
44 |
218 |
654 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
44 |
219 |
567 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
45 |
223 |
477 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
46 |
228 |
618 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
46 |
229 |
517 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
47 |
234 |
552 |
1 |
Nephropathy |
Moderate |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
47 |
235 |
566 |
1 |
Nephropathy |
Marked |
Dead |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
55 |
273 |
83 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
59 |
294 |
49 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
65 |
324 |
40 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
68 |
336 |
70 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
68 |
339 |
40 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
37 |
182 |
19 |
1 |
Nephropathy |
Minimal |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
38 |
188 |
426 |
1 |
Nephropathy |
Moderate |
Gavage Death |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
63 |
311 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
63 |
312 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
63 |
313 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
63 |
314 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
63 |
315 |
456 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
316 |
456 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
317 |
456 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
318 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
319 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
10 |
64 |
320 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
53 |
261 |
275 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
53 |
262 |
275 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
53 |
263 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
53 |
264 |
275 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
53 |
265 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
54 |
266 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
54 |
267 |
275 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
54 |
269 |
274 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
54 |
270 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
55 |
271 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
55 |
272 |
275 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
55 |
275 |
275 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
56 |
277 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
56 |
278 |
274 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
56 |
279 |
275 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
56 |
280 |
275 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
38 |
187 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
39 |
191 |
453 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
40 |
196 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
40 |
199 |
456 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
44 |
216 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
44 |
217 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
45 |
221 |
453 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
46 |
226 |
455 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
48 |
237 |
455 |
1 |
Nephropathy |
Mild |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
48 |
240 |
456 |
1 |
Nephropathy |
Moderate |
Interval Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
57 |
282 |
618 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
58 |
287 |
520 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
59 |
292 |
688 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
59 |
295 |
680 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
60 |
298 |
680 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
65 |
321 |
565 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
65 |
323 |
639 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
65 |
325 |
566 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
66 |
327 |
639 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
66 |
330 |
609 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
67 |
331 |
618 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
67 |
332 |
593 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
67 |
333 |
496 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
67 |
334 |
499 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
67 |
335 |
618 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
68 |
337 |
585 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
68 |
338 |
588 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
37 |
181 |
589 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
37 |
183 |
510 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
37 |
185 |
698 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
38 |
186 |
636 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
38 |
190 |
618 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
39 |
193 |
595 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
39 |
194 |
601 |
1 |
Nephropathy |
Moderate |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
39 |
195 |
631 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
40 |
197 |
420 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
40 |
198 |
580 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
40 |
200 |
560 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
41 |
203 |
485 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
41 |
204 |
525 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
42 |
206 |
496 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
42 |
207 |
380 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
42 |
209 |
534 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
42 |
210 |
607 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
43 |
212 |
572 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
43 |
214 |
511 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
44 |
220 |
307 |
1 |
Nephropathy |
Minimal |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
45 |
222 |
660 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
45 |
224 |
492 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
45 |
225 |
512 |
1 |
Nephropathy |
Mild |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
46 |
227 |
580 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
46 |
230 |
611 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
47 |
231 |
518 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
47 |
232 |
611 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
47 |
233 |
643 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
48 |
236 |
650 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
48 |
238 |
638 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Nephropathy |
Marked |
Moribund |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
57 |
281 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
57 |
283 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
57 |
284 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
57 |
285 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
58 |
288 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
60 |
296 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
60 |
299 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
60 |
300 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
65 |
322 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 MG/KG |
20 |
66 |
329 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
Lumen |
100 MG/KG |
20 |
68 |
340 |
253 |
1 |
Hemorrhage |
Mild |
Moribund |
Urinary System |
Urinary Bladder |
|
100 MG/KG |
20 |
55 |
274 |
275 |
1 |
Calculus Gross Observation |
|
Interval Sacrifice |
Urinary System |
Urinary Bladder |
|
100 MG/KG |
20 |
56 |
276 |
275 |
1 |
Calculus Gross Observation |
|
Interval Sacrifice |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
59 |
1 |
1 |
420 |
1 |
Hyperplasia |
Mild |
Moribund |
Urinary System |
Urinary Bladder |
|
100 MG/KG |
20 |
58 |
289 |
680 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Urinary System |
Urinary Bladder |
|
100 MG/KG |
60 |
48 |
239 |
646 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |