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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Coumarin |
CASRN: | ="91-64-5" |
Study Number: | C07103B |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | GAVAGE |
TDMS Number: | 0509001 |
Sex: | Male |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (MG/KG) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 5 |
5 |
0 |
|
|
|
Day 19 |
182 |
100 |
|
202.3 |
|
Day 20 |
268 |
100 |
|
214.1 |
|
Day 40 |
324 |
100 |
|
298.2 |
|
Day 40 |
339 |
100 |
|
276.7 |
|
Day 49 |
294 |
100 |
|
269.8 |
|
Day 50 |
258 |
0 |
|
324.9 |
|
Day 63 |
133 |
50 |
|
343.4 |
|
Day 70 |
248 |
0 |
|
362.4 |
|
Day 70 |
336 |
100 |
|
302.1 |
|
Day 71 |
307 |
0 |
|
331.4 |
|
Day 83 |
273 |
100 |
|
318.1 |
|
Day 90 |
105 |
25 |
|
355.1 |
|
Day 216 |
245 |
0 |
|
447 |
|
Day 253 |
340 |
100 |
|
372 |
|
Day 274 |
242 |
0 |
|
448 |
|
Day 274 |
243 |
0 |
|
432.3 |
|
Day 274 |
244 |
0 |
|
464.4 |
|
Day 274 |
246 |
0 |
|
383 |
|
Day 274 |
247 |
0 |
|
453.2 |
|
Day 274 |
250 |
0 |
|
427 |
|
Day 274 |
253 |
0 |
|
479.5 |
|
Day 274 |
254 |
0 |
|
485.7 |
|
Day 274 |
256 |
0 |
|
516.5 |
|
Day 274 |
257 |
0 |
|
453.1 |
|
Day 274 |
263 |
100 |
|
322.5 |
|
Day 274 |
265 |
100 |
|
332 |
|
Day 274 |
266 |
100 |
|
395.9 |
|
Day 274 |
269 |
100 |
|
422.3 |
|
Day 274 |
270 |
100 |
|
361.5 |
|
Day 274 |
271 |
100 |
|
424 |
|
Day 274 |
277 |
100 |
|
370.9 |
|
Day 274 |
278 |
100 |
|
375 |
|
Day 275 |
241 |
0 |
|
457.1 |
|
Day 275 |
249 |
0 |
|
489.4 |
|
Day 275 |
251 |
0 |
|
452.9 |
|
Day 275 |
252 |
0 |
|
468.3 |
|
Day 275 |
255 |
0 |
|
463.2 |
|
Day 275 |
259 |
0 |
|
457.4 |
|
Day 275 |
260 |
0 |
|
482.5 |
|
Day 275 |
261 |
100 |
|
389 |
|
Day 275 |
262 |
100 |
|
401.3 |
|
Day 275 |
264 |
100 |
|
395.2 |
|
Day 275 |
267 |
100 |
|
393 |
|
Day 275 |
272 |
100 |
|
426 |
|
Day 275 |
274 |
100 |
|
433.6 |
|
Day 275 |
275 |
100 |
|
416.1 |
|
Day 275 |
276 |
100 |
|
427 |
|
Day 275 |
279 |
100 |
|
442.8 |
|
Day 275 |
280 |
100 |
|
405.3 |
|
Day 307 |
220 |
100 |
|
375.2 |
|
Day 307 |
290 |
100 |
|
281.1 |
|
Day 335 |
48 |
0 |
|
487.1 |
|
Day 337 |
301 |
0 |
|
530.2 |
|
Day 338 |
303 |
0 |
|
507.5 |
|
Day 343 |
89 |
25 |
|
421.3 |
|
Day 352 |
86 |
25 |
|
497.4 |
|
Day 372 |
54 |
0 |
|
353.8 |
|
Day 377 |
119 |
25 |
|
560.1 |
|
Day 380 |
207 |
100 |
|
370.4 |
|
Day 408 |
47 |
0 |
|
604 |
|
Day 408 |
153 |
50 |
|
411.1 |
|
Day 420 |
1 |
0 |
|
331.5 |
|
Day 420 |
197 |
100 |
|
361.8 |
|
Day 426 |
188 |
100 |
|
470.8 |
|
Day 428 |
129 |
50 |
|
480.6 |
|
Day 429 |
140 |
50 |
|
339.5 |
|
Day 453 |
19 |
0 |
|
432.6 |
|
Day 453 |
302 |
0 |
|
523.6 |
|
Day 453 |
309 |
0 |
|
534.3 |
|
Day 453 |
43 |
0 |
|
512.4 |
|
Day 453 |
46 |
0 |
|
473.4 |
|
Day 453 |
102 |
25 |
|
492.4 |
|
Day 453 |
64 |
25 |
|
465.7 |
|
Day 453 |
69 |
25 |
|
525.4 |
|
Day 453 |
93 |
25 |
|
536.7 |
|
Day 453 |
146 |
50 |
|
501.2 |
|
Day 453 |
152 |
50 |
|
442.3 |
|
Day 453 |
164 |
50 |
|
486.6 |
|
Day 453 |
168 |
50 |
|
528.5 |
|
Day 453 |
187 |
100 |
|
439.3 |
|
Day 453 |
191 |
100 |
|
388.1 |
|
Day 453 |
216 |
100 |
|
514.8 |
|
Day 453 |
221 |
100 |
|
456.1 |
|
Day 453 |
313 |
100 |
|
429.2 |
|
Day 453 |
314 |
100 |
|
490.5 |
|
Day 453 |
319 |
100 |
|
461.6 |
|
Day 455 |
25 |
0 |
|
558.6 |
|
Day 455 |
304 |
0 |
|
532.3 |
|
Day 455 |
306 |
0 |
|
521.4 |
|
Day 455 |
308 |
0 |
|
538.6 |
|
Day 455 |
31 |
0 |
|
515.5 |
|
Day 455 |
310 |
0 |
|
534 |
|
Day 455 |
34 |
0 |
|
559.2 |
|
Day 455 |
4 |
0 |
|
577.8 |
|
Day 455 |
45 |
0 |
|
554.9 |
|
Day 455 |
51 |
0 |
|
569.1 |
|
Day 455 |
120 |
25 |
|
501.4 |
|
Day 455 |
87 |
25 |
|
543.6 |
|
Day 455 |
90 |
25 |
|
533.9 |
|
Day 455 |
92 |
25 |
|
539.7 |
|
Day 455 |
136 |
50 |
|
477.1 |
|
Day 455 |
144 |
50 |
|
458.6 |
|
Day 455 |
150 |
50 |
|
515.2 |
|
Day 455 |
157 |
50 |
|
451 |
|
Day 455 |
196 |
100 |
|
489.5 |
|
Day 455 |
217 |
100 |
|
462.8 |
|
Day 455 |
226 |
100 |
|
494.3 |
|
Day 455 |
237 |
100 |
|
405.8 |
|
Day 455 |
311 |
100 |
|
429.7 |
|
Day 455 |
312 |
100 |
|
463.2 |
|
Day 455 |
318 |
100 |
|
514.8 |
|
Day 455 |
320 |
100 |
|
450.6 |
|
Day 456 |
305 |
0 |
|
521.4 |
|
Day 456 |
8 |
0 |
|
518.6 |
|
Day 456 |
115 |
25 |
|
485.2 |
|
Day 456 |
80 |
25 |
|
579.2 |
|
Day 456 |
161 |
50 |
|
493.8 |
|
Day 456 |
199 |
100 |
|
417.8 |
|
Day 456 |
201 |
100 |
|
467.7 |
|
Day 456 |
240 |
100 |
|
474.5 |
|
Day 456 |
315 |
100 |
|
432.6 |
|
Day 456 |
316 |
100 |
|
491.5 |
|
Day 456 |
317 |
100 |
|
454.2 |
|
Day 472 |
50 |
0 |
|
351.6 |
|
Day 473 |
123 |
50 |
|
316.5 |
|
Day 477 |
223 |
100 |
|
331.1 |
|
Day 482 |
61 |
25 |
|
407.5 |
|
Day 485 |
203 |
100 |
|
326.6 |
|
Day 492 |
100 |
25 |
|
465.6 |
|
Day 492 |
224 |
100 |
|
333.9 |
|
Day 496 |
145 |
50 |
|
341.2 |
|
Day 496 |
192 |
100 |
|
356.5 |
|
Day 496 |
206 |
100 |
|
365.8 |
|
Day 496 |
333 |
100 |
|
326 |
|
Day 498 |
175 |
50 |
|
304.1 |
|
Day 499 |
334 |
100 |
|
349.9 |
|
Day 503 |
84 |
25 |
|
362.3 |
|
Day 503 |
202 |
100 |
|
380.5 |
|
Day 506 |
160 |
50 |
|
415.5 |
|
Day 506 |
167 |
50 |
|
377.3 |
|
Day 510 |
183 |
100 |
|
378.7 |
|
Day 511 |
214 |
100 |
|
308.7 |
|
Day 512 |
176 |
50 |
|
362.3 |
|
Day 512 |
225 |
100 |
|
331.1 |
|
Day 513 |
22 |
0 |
|
474.8 |
|
Day 517 |
154 |
50 |
|
393.3 |
|
Day 517 |
229 |
100 |
|
325.4 |
|
Day 518 |
104 |
25 |
|
445.2 |
|
Day 518 |
208 |
100 |
|
347.7 |
|
Day 518 |
231 |
100 |
|
366.2 |
|
Day 520 |
287 |
100 |
|
314.8 |
|
Day 525 |
163 |
50 |
|
382 |
|
Day 525 |
204 |
100 |
|
341.7 |
|
Day 531 |
141 |
50 |
|
337.7 |
|
Day 531 |
173 |
50 |
|
372.5 |
|
Day 533 |
169 |
50 |
|
332.1 |
|
Day 533 |
213 |
100 |
|
327.2 |
|
Day 534 |
209 |
100 |
|
296.5 |
|
Day 539 |
125 |
50 |
|
369.3 |
|
Day 545 |
159 |
50 |
|
318.5 |
|
Day 546 |
126 |
50 |
|
339.4 |
|
Day 548 |
166 |
50 |
|
370.4 |
|
Day 551 |
215 |
100 |
|
308.6 |
|
Day 552 |
211 |
100 |
|
355 |
|
Day 552 |
234 |
100 |
|
360.4 |
|
Day 555 |
149 |
50 |
|
395.3 |
|
Day 556 |
147 |
50 |
|
397.6 |
|
Day 560 |
200 |
100 |
|
340.6 |
|
Day 563 |
184 |
100 |
|
243.8 |
|
Day 565 |
321 |
100 |
|
302.3 |
|
Day 566 |
235 |
100 |
|
298.6 |
|
Day 566 |
325 |
100 |
|
318.5 |
|
Day 567 |
219 |
100 |
|
334.6 |
|
Day 569 |
108 |
25 |
|
361.6 |
|
Day 569 |
143 |
50 |
|
348.4 |
|
Day 572 |
212 |
100 |
|
308.9 |
|
Day 573 |
33 |
0 |
|
442.7 |
|
Day 575 |
139 |
50 |
|
389.6 |
|
Day 577 |
70 |
25 |
|
465.6 |
|
Day 578 |
56 |
0 |
|
346.1 |
|
Day 580 |
121 |
50 |
|
400.1 |
|
Day 580 |
178 |
50 |
|
353.9 |
|
Day 580 |
198 |
100 |
|
370.3 |
|
Day 580 |
227 |
100 |
|
341.3 |
|
Day 583 |
118 |
25 |
|
276.4 |
|
Day 583 |
286 |
100 |
|
411.3 |
|
Day 585 |
337 |
100 |
|
262.5 |
|
Day 586 |
12 |
0 |
|
323.7 |
|
Day 588 |
135 |
50 |
|
339.5 |
|
Day 588 |
293 |
100 |
|
307.5 |
|
Day 588 |
338 |
100 |
|
289.4 |
|
Day 589 |
181 |
100 |
|
302 |
|
Day 593 |
75 |
25 |
|
317.2 |
|
Day 593 |
332 |
100 |
|
324.1 |
|
Day 594 |
130 |
50 |
|
311.7 |
|
Day 595 |
193 |
100 |
|
314.4 |
|
Day 596 |
124 |
50 |
|
374.7 |
|
Day 596 |
142 |
50 |
|
278.7 |
|
Day 600 |
111 |
25 |
|
439.1 |
|
Day 600 |
91 |
25 |
|
518.9 |
|
Day 601 |
57 |
0 |
|
471.6 |
|
Day 601 |
155 |
50 |
|
260.7 |
|
Day 601 |
194 |
100 |
|
291.5 |
|
Day 602 |
134 |
50 |
|
268 |
|
Day 607 |
180 |
50 |
|
310.8 |
|
Day 607 |
210 |
100 |
|
311.9 |
|
Day 609 |
15 |
0 |
|
581.1 |
|
Day 609 |
330 |
100 |
|
302.8 |
|
Day 611 |
41 |
0 |
|
416 |
|
Day 611 |
71 |
25 |
|
372.1 |
|
Day 611 |
230 |
100 |
|
272 |
|
Day 611 |
232 |
100 |
|
272 |
|
Day 613 |
72 |
25 |
|
377.3 |
|
Day 615 |
101 |
25 |
|
328.8 |
|
Day 615 |
165 |
50 |
|
319.2 |
|
Day 615 |
170 |
50 |
|
274.5 |
|
Day 615 |
205 |
100 |
|
290.3 |
|
Day 618 |
190 |
100 |
|
285.5 |
|
Day 618 |
228 |
100 |
|
316.3 |
|
Day 618 |
282 |
100 |
|
257.5 |
|
Day 618 |
331 |
100 |
|
315.7 |
|
Day 618 |
335 |
100 |
|
290.9 |
|
Day 619 |
291 |
100 |
|
369 |
|
Day 622 |
60 |
0 |
|
575.9 |
|
Day 622 |
68 |
25 |
|
365.5 |
|
Day 622 |
128 |
50 |
|
340.7 |
|
Day 622 |
131 |
50 |
|
322 |
|
Day 622 |
151 |
50 |
|
373 |
|
Day 623 |
27 |
0 |
|
276.3 |
|
Day 623 |
328 |
100 |
|
371.8 |
|
Day 625 |
73 |
25 |
|
400.8 |
|
Day 625 |
76 |
25 |
|
394.7 |
|
Day 625 |
122 |
50 |
|
297.1 |
|
Day 628 |
132 |
50 |
|
373.7 |
|
Day 630 |
174 |
50 |
|
281 |
|
Day 630 |
189 |
100 |
|
289.6 |
|
Day 631 |
107 |
25 |
|
315 |
|
Day 631 |
127 |
50 |
|
286.2 |
|
Day 631 |
195 |
100 |
|
328.6 |
|
Day 636 |
94 |
25 |
|
326 |
|
Day 636 |
186 |
100 |
|
282.6 |
|
Day 638 |
238 |
100 |
|
279.6 |
|
Day 639 |
65 |
25 |
|
291.8 |
|
Day 639 |
323 |
100 |
|
328.4 |
|
Day 639 |
327 |
100 |
|
278.7 |
|
Day 643 |
148 |
50 |
|
289.3 |
|
Day 643 |
162 |
50 |
|
234 |
|
Day 643 |
233 |
100 |
|
291.8 |
|
Day 645 |
67 |
25 |
|
307 |
|
Day 645 |
85 |
25 |
|
322.4 |
|
Day 645 |
156 |
50 |
|
302.6 |
|
Day 646 |
239 |
100 |
|
293.3 |
|
Day 650 |
236 |
100 |
|
274.8 |
|
Day 652 |
77 |
25 |
|
319.1 |
|
Day 654 |
218 |
100 |
|
310.5 |
|
Day 657 |
98 |
25 |
|
276.6 |
|
Day 657 |
172 |
50 |
|
304.1 |
|
Day 660 |
11 |
0 |
|
582.5 |
|
Day 660 |
103 |
25 |
|
324 |
|
Day 660 |
222 |
100 |
|
332.6 |
|
Day 661 |
78 |
25 |
|
350.3 |
|
Day 663 |
117 |
25 |
|
354.9 |
|
Day 666 |
99 |
25 |
|
504.7 |
|
Day 666 |
137 |
50 |
|
295.5 |
|
Day 671 |
32 |
0 |
|
292 |
|
Day 671 |
116 |
25 |
|
336 |
|
Day 671 |
81 |
25 |
|
340.3 |
|
Day 673 |
62 |
25 |
|
417.7 |
|
Day 675 |
79 |
25 |
|
356.5 |
|
Day 675 |
97 |
25 |
|
321.6 |
|
Day 678 |
138 |
50 |
|
329.2 |
|
Day 679 |
171 |
50 |
|
278.3 |
|
Day 680 |
96 |
25 |
|
314.1 |
|
Day 680 |
289 |
100 |
|
313.5 |
|
Day 680 |
295 |
100 |
|
228.7 |
|
Day 680 |
298 |
100 |
|
282 |
|
Day 688 |
292 |
100 |
|
259.6 |
|
Day 692 |
106 |
25 |
|
347.5 |
|
Day 694 |
14 |
0 |
|
433.4 |
|
Day 694 |
88 |
25 |
|
320.1 |
|
Day 694 |
158 |
50 |
|
355.5 |
|
Day 698 |
113 |
25 |
|
337.5 |
|
Day 698 |
185 |
100 |
|
273.7 |
|
Day 699 |
29 |
0 |
|
295.1 |
|
Day 704 |
28 |
0 |
|
346.7 |
|
Day 719 |
95 |
25 |
|
318.6 |
|
Day 720 |
39 |
0 |
|
366.6 |
|
Day 726 |
326 |
100 |
|
269.3 |
|
Day 728 |
40 |
0 |
|
411.3 |
|
Day 729 |
10 |
0 |
|
420.7 |
|
Day 729 |
13 |
0 |
|
422.7 |
|
Day 729 |
16 |
0 |
|
509.5 |
|
Day 729 |
17 |
0 |
|
441 |
|
Day 729 |
2 |
0 |
|
452.5 |
|
Day 729 |
20 |
0 |
|
526.1 |
|
Day 729 |
23 |
0 |
|
422 |
|
Day 729 |
24 |
0 |
|
460.2 |
|
Day 729 |
3 |
0 |
|
464.2 |
|
Day 729 |
30 |
0 |
|
530.6 |
|
Day 729 |
35 |
0 |
|
443.5 |
|
Day 729 |
36 |
0 |
|
415.4 |
|
Day 729 |
37 |
0 |
|
463.8 |
|
Day 729 |
42 |
0 |
|
480.1 |
|
Day 729 |
44 |
0 |
|
523 |
|
Day 729 |
52 |
0 |
|
473.5 |
|
Day 729 |
53 |
0 |
|
478.4 |
|
Day 729 |
55 |
0 |
|
472.7 |
|
Day 729 |
59 |
0 |
|
464.5 |
|
Day 729 |
7 |
0 |
|
472.4 |
|
Day 729 |
9 |
0 |
|
446 |
|
Day 729 |
110 |
25 |
|
395.8 |
|
Day 729 |
112 |
25 |
|
309.5 |
|
Day 729 |
114 |
25 |
|
426 |
|
Day 729 |
66 |
25 |
|
372 |
|
Day 729 |
74 |
25 |
|
450.3 |
|
Day 729 |
82 |
25 |
|
448 |
|
Day 729 |
83 |
25 |
|
399.5 |
|
Day 729 |
177 |
50 |
|
335 |
|
Day 729 |
281 |
100 |
|
300.6 |
|
Day 729 |
283 |
100 |
|
335.4 |
|
Day 729 |
284 |
100 |
|
403.3 |
|
Day 729 |
296 |
100 |
|
368.6 |
|
Day 729 |
297 |
100 |
|
339.1 |
|
Day 729 |
299 |
100 |
|
421.9 |
|
Day 729 |
300 |
100 |
|
360.9 |
|
Day 729 |
322 |
100 |
|
298.2 |
|
Day 729 |
329 |
100 |
|
346.3 |
|
Day 730 |
18 |
0 |
|
460.1 |
|
Day 730 |
21 |
0 |
|
394.7 |
|
Day 730 |
26 |
0 |
|
440.2 |
|
Day 730 |
38 |
0 |
|
434.3 |
|
Day 730 |
49 |
0 |
|
401.5 |
|
Day 730 |
58 |
0 |
|
484.6 |
|
Day 730 |
6 |
0 |
|
529.7 |
|
Day 730 |
109 |
25 |
|
342.4 |
|
Day 730 |
63 |
25 |
|
410.5 |
|
Day 730 |
179 |
50 |
|
404 |
|
Day 730 |
285 |
100 |
|
434.4 |
|
Day 730 |
288 |
100 |
|
401.1 |
|
Abbreviations: |
NA: Not Available
|