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Chemical Name: | Dicyclohexylcarbodiimide |
---|---|
CASRN: | ="538-75-0" |
Study Number: | C93021 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | SP |
TDMS Number: | 9302104.ss |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Hematology Individual Animal Data | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | HCT (spun) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Retics (%) | Platelet (1000/mL) | Leukocytes (1000/mL) | Neut (%) | Band (%) | Lymph (%) | Mono (%) | EOS (%) | NRBC (per 100 WC) |
Day 93 | 0061 | 0 | V | 10.88 | 17.4 | 55.4 | 55.0 | 50.9 | 16.0 | 31.4 | 0.163 | 435 | 3.0 | 0.210 | 0.000 | 2.700 | 0.000 | 0.090 | 0 |
Day 93 | 0062 | 0 | V | 9.97 | 16.5 | 50.9 | 50.0 | 51.1 | 16.5 | 32.4 | 0.110 | 621 | 4.0 | 0.400 | 0.000 | 3.520 | 0.080 | 0.000 | 0 |
Day 93 | 0063 | 0 | V | 9.64 | 16.0 | 49.4 | 50.0 | 51.2 | 16.6 | 32.4 | 0.202 | 601 | 4.1 | 0.369 | 0.000 | 3.567 | 0.123 | 0.041 | 0 |
Day 93 | 0064 | 0 | V | 10.19 | 16.7 | 51.8 | 52.0 | 50.8 | 16.4 | 32.2 | 0.194 | 490 | 3.8 | 0.532 | 0.000 | 3.154 | 0.076 | 0.038 | 0 |
Day 93 | 0065 | 0 | V | 9.80 | 15.9 | 50.8 | 50.0 | 51.8 | 16.2 | 31.3 | 0.196 | 816 | 2.9 | 0.203 | 0.000 | 2.610 | 0.058 | 0.029 | 0 |
Day 93 | 0066 | 0 | V | 9.91 | 16.0 | 50.7 | 50.0 | 51.2 | 16.1 | 31.6 | 0.218 | 726 | 6.8 | 0.476 | 0.000 | 6.188 | 0.068 | 0.068 | 1 |
Day 93 | 0067 | 0 | V | 9.35 | 15.5 | 47.5 | 47.5 | 50.8 | 16.6 | 32.6 | 0.262 | 619 | 5.2 | 0.364 | 0.000 | 4.628 | 0.104 | 0.104 | 0 |
Day 93 | 0068 | 0 | V | 9.65 | 16.1 | 49.1 | 50.0 | 50.9 | 16.7 | 32.8 | 0.241 | 621 | 4.4 | 0.352 | 0.000 | 3.960 | 0.088 | 0.000 | 0 |
Day 93 | 0069 | 0 | V | 10.38 | 16.7 | 53.0 | 55.0 | 51.1 | 16.1 | 31.5 | 0.145 | 600 | 2.6 | 0.390 | 0.000 | 2.210 | 0.000 | 0.000 | 0 |
Day 93 | 0070 | 0 | V | 9.86 | 16.3 | 50.6 | 51.0 | 51.3 | 16.5 | 32.2 | 0.168 | 550 | 3.7 | 0.333 | 0.000 | 3.330 | 0.037 | 0.000 | 0 |
Day 93 | 0071 | 1.5 | 10.58 | 16.7 | 53.5 | 52.0 | 50.6 | 15.8 | 31.2 | 0.254 | 587 | 4.7 | 0.517 | 0.000 | 4.136 | 0.047 | 0.000 | 0 | |
Day 93 | 0072 | 1.5 | 9.28 | 15.4 | 48.2 | 50.0 | 51.9 | 16.6 | 32.0 | 0.195 | 793 | 5.7 | 0.741 | 0.000 | 4.902 | 0.057 | 0.000 | 0 | |
Day 93 | 0073 | 1.5 | 10.16 | 16.4 | 52.4 | 52.0 | 51.6 | 16.1 | 31.3 | 0.274 | 631 | 4.1 | 0.328 | 0.000 | 3.608 | 0.082 | 0.082 | 0 | |
Day 93 | 0074 | 1.5 | 10.02 | 16.6 | 51.0 | 53.0 | 50.9 | 16.6 | 32.5 | 0.321 | 590 | 3.9 | 0.468 | 0.000 | 3.393 | 0.039 | 0.000 | 0 | |
Day 93 | 0075 | 1.5 | 9.88 | 16.4 | 50.6 | 51.0 | 51.2 | 16.6 | 32.4 | 0.247 | 543 | 3.8 | 0.532 | 0.000 | 3.116 | 0.114 | 0.038 | 0 | |
Day 93 | 0076 | 1.5 | 10.07 | 16.7 | 52.0 | 51.0 | 51.6 | 16.6 | 32.1 | 0.302 | 668 | 4.0 | 0.440 | 0.000 | 3.480 | 0.040 | 0.040 | 0 | |
Day 93 | 0077 | 1.5 | 10.00 | 16.3 | 50.8 | 51.0 | 50.8 | 16.3 | 32.1 | 0.260 | 629 | 3.8 | 0.456 | 0.038 | 3.192 | 0.038 | 0.076 | 0 | |
Day 93 | 0078 | 1.5 | 9.26 | 15.5 | 47.7 | 49.0 | 51.5 | 16.7 | 32.5 | 0.157 | 757 | 2.7 | 0.432 | 0.027 | 2.187 | 0.027 | 0.027 | 0 | |
Day 93 | 0079 | 1.5 | 9.91 | 16.4 | 50.4 | 50.0 | 50.9 | 16.5 | 32.5 | 0.198 | 605 | 3.8 | 0.228 | 0.000 | 3.458 | 0.076 | 0.038 | 0 | |
Day 93 | 0080 | 1.5 | 9.99 | 16.5 | 51.6 | 53.0 | 51.7 | 16.5 | 32.0 | 0.250 | 569 | 5.1 | 0.153 | 0.000 | 4.896 | 0.051 | 0.000 | 0 | |
Day 93 | 0081 | 3.0 | 9.58 | 15.8 | 49.6 | 49.0 | 51.8 | 16.5 | 31.9 | 0.125 | 597 | 3.1 | 0.217 | 0.000 | 2.821 | 0.062 | 0.000 | 0 | |
Day 93 | 0082 | 3.0 | 9.75 | 16.3 | 49.8 | 52.0 | 51.1 | 16.7 | 32.7 | 0.166 | 667 | 3.4 | 0.204 | 0.000 | 3.128 | 0.034 | 0.034 | 0 | |
Day 93 | 0083 | 3.0 | 10.16 | 16.4 | 51.9 | 51.5 | 51.1 | 16.1 | 31.6 | 0.163 | 681 | 5.1 | 0.408 | 0.000 | 4.590 | 0.102 | 0.000 | 0 | |
Day 93 | 0084 | 3.0 | 9.18 | 15.7 | 47.8 | 50.0 | 52.1 | 17.1 | 32.8 | 0.275 | 743 | 4.9 | 0.392 | 0.000 | 4.410 | 0.098 | 0.000 | 0 | |
Day 93 | 0085 | 3.0 | 9.89 | 16.4 | 50.8 | 51.0 | 51.4 | 16.6 | 32.3 | 0.227 | 524 | 5.5 | 0.220 | 0.000 | 5.170 | 0.110 | 0.000 | 0 | |
Day 93 | 0086 | 3.0 | 9.70 | 15.5 | 48.2 | 48.0 | 49.7 | 16.0 | 32.2 | 0.204 | 763 | 5.5 | 0.330 | 0.000 | 4.950 | 0.165 | 0.055 | 1 | |
Day 93 | 0087 | 3.0 | 10.28 | 16.5 | 52.0 | 53.0 | 50.6 | 16.1 | 31.7 | 0.278 | 549 | 4.3 | 0.559 | 0.000 | 3.612 | 0.043 | 0.086 | 0 | |
Day 93 | 0088 | 3.0 | 10.26 | 16.3 | 51.8 | 52.0 | 50.5 | 15.9 | 31.5 | 0.257 | 645 | 3.5 | 0.315 | 0.000 | 3.080 | 0.105 | 0.000 | 0 | |
Day 93 | 0089 | 3.0 | 10.26 | 16.9 | 52.7 | 54.0 | 51.4 | 16.5 | 32.1 | 0.123 | 485 | 3.8 | 0.380 | 0.000 | 3.344 | 0.076 | 0.000 | 0 | |
Day 93 | 0090 | 3.0 | 10.27 | 16.7 | 52.3 | 53.0 | 50.9 | 16.3 | 31.9 | 0.205 | 511 | 4.7 | 0.517 | 0.000 | 4.136 | 0.047 | 0.000 | 0 | |
Day 93 | 0091 | 6.0 | 9.42 | 15.7 | 48.6 | 50.0 | 51.6 | 16.7 | 32.3 | 0.132 | 692 | 3.8 | 0.342 | 0.000 | 3.344 | 0.114 | 0.000 | 0 | |
Day 93 | 0092 | 6.0 | 9.15 | 15.6 | 46.3 | 48.0 | 50.6 | 17.0 | 33.7 | 0.357 | 619 | 4.0 | 0.560 | 0.000 | 3.320 | 0.080 | 0.040 | 0 | |
Day 93 | 0093 | 6.0 | 8.99 | 14.9 | 45.8 | 46.0 | 51.0 | 16.6 | 32.5 | 0.279 | 912 | 4.5 | 0.585 | 0.000 | 3.780 | 0.090 | 0.045 | 0 | |
Day 93 | 0094 | 6.0 | 9.25 | 15.1 | 46.5 | 47.0 | 50.3 | 16.3 | 32.5 | 0.167 | 814 | 4.5 | 0.720 | 0.000 | 3.645 | 0.090 | 0.045 | 0 | |
Day 93 | 0095 | 6.0 | 10.17 | 16.4 | 51.8 | 51.0 | 50.9 | 16.1 | 31.7 | 0.275 | 549 | 3.4 | 0.272 | 0.000 | 3.060 | 0.000 | 0.068 | 0 | |
Day 93 | 0096 | 6.0 | 10.53 | 17.0 | 53.5 | 53.0 | 50.8 | 16.1 | 31.8 | 0.221 | 610 | 4.1 | 0.574 | 0.041 | 3.321 | 0.041 | 0.123 | 0 | |
Day 93 | 0097 | 6.0 | 9.45 | 15.5 | 48.9 | 47.5 | 51.7 | 16.4 | 31.7 | 0.189 | 701 | 4.7 | 0.423 | 0.000 | 4.183 | 0.094 | 0.000 | 0 | |
Day 93 | 0098 | 6.0 | 10.07 | 16.5 | 51.2 | 51.0 | 50.8 | 16.4 | 32.2 | 0.262 | 532 | 3.9 | 0.117 | 0.000 | 3.588 | 0.078 | 0.117 | 0 | |
Day 93 | 0099 | 6.0 | 9.00 | 15.1 | 46.4 | 47.5 | 51.5 | 16.8 | 32.5 | 0.288 | 715 | 6.2 | 0.372 | 0.000 | 5.828 | 0.000 | 0.000 | 0 | |
Day 93 | 0100 | 6.0 | 9.42 | 15.7 | 47.9 | 49.0 | 50.9 | 16.7 | 32.8 | 0.217 | 725 | 5.1 | 1.071 | 0.000 | 3.876 | 0.051 | 0.051 | 0 | |
Day 93 | 0101 | 12.0 | 9.24 | 15.4 | 46.8 | 49.0 | 50.7 | 16.7 | 32.9 | 0.166 | 815 | 5.6 | 1.344 | 0.056 | 4.032 | 0.112 | 0.056 | 0 | |
Day 93 | 0102 | 12.0 | 9.10 | 15.3 | 46.6 | 48.0 | 51.2 | 16.8 | 32.8 | 0.300 | 1001 | 7.4 | 1.924 | 0.000 | 5.180 | 0.148 | 0.074 | 0 | |
Day 93 | 0103 | 12.0 | 9.77 | 16.0 | 50.4 | 51.0 | 51.6 | 16.4 | 31.7 | 0.244 | 719 | 3.9 | 0.429 | 0.039 | 3.237 | 0.078 | 0.117 | 0 | |
Day 93 | 0104 | 12.0 | 9.29 | 15.8 | 47.5 | 48.5 | 51.1 | 17.0 | 33.3 | 0.177 | 767 | 5.4 | 0.540 | 0.000 | 4.752 | 0.108 | 0.000 | 0 | |
Day 93 | 0105 | 12.0 | 9.87 | 16.1 | 49.9 | 51.0 | 50.6 | 16.3 | 32.3 | 0.188 | 527 | 5.2 | 0.676 | 0.000 | 4.316 | 0.156 | 0.052 | 0 | |
Day 93 | 0106 | 12.0 | 8.83 | 15.4 | 45.9 | 48.5 | 52.0 | 17.4 | 33.6 | 0.256 | 754 | 4.7 | 0.658 | 0.000 | 3.948 | 0.094 | 0.000 | 0 | |
Day 93 | 0107 | 12.0 | 9.08 | 15.2 | 46.3 | 47.5 | 51.0 | 16.7 | 32.8 | 0.236 | 824 | 8.3 | 2.573 | 0.000 | 5.478 | 0.083 | 0.083 | 0 | |
Day 93 | 0108 | 12.0 | 9.37 | 15.4 | 47.8 | 48.0 | 51.0 | 16.4 | 32.2 | 0.141 | 719 | 6.0 | 0.600 | 0.000 | 5.280 | 0.060 | 0.060 | 0 | |
Day 93 | 0109 | 12.0 | 9.73 | 16.3 | 49.5 | 48.0 | 50.9 | 16.8 | 32.9 | 0.165 | 627 | 4.2 | 0.588 | 0.000 | 3.486 | 0.042 | 0.084 | 0 | |
Day 93 | 0110 | 12.0 | 9.71 | 16.1 | 50.5 | 50.0 | 52.0 | 16.6 | 31.9 | 0.146 | 759 | 6.9 | 1.173 | 0.069 | 5.451 | 0.207 | 0.000 | 0 | |
Abbreviations: | |||||||||||||||||||
NA: Not Available, V: Vehicle Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, HCT (spun): Hematocrit Manual, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Percentage, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Neut: Neutrophil Percentage, Band: Band Neutrophil Percentage, Lymph: Lymphocyte Percentage, Mono: Monocyte Percentage, EOS: Eosinophil Percentage, NRBC: Nucleated Rbc Per 100 Wbc |