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Chemical Name: | Diisopropylcarbodiimide |
---|---|
CASRN: | ="693-13-0" |
Study Number: | C93020 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | SP |
TDMS Number: | 9302003.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | BUN (mg_dL) | Creat (U per L) | TP (g_dL) | ALB (g_dL) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | ALP (IU_L) | TBA (umol per g) |
Day 3 | 0121 | 0 | V | 18 | 0.3 | 5.4 | 4.5 | 205 | 52 | 20.0 | 700 | 10.7 |
Day 3 | 0122 | 0 | V | 22 | 0.2 | 5.7 | 4.8 | 229 | 52 | 18.8 | 720 | 5.4 |
Day 3 | 0123 | 0 | V | 21 | 0.3 | 5.4 | 4.6 | 363 | 50 | 22.8 | 657 | 62.1 |
Day 3 | 0124 | 0 | V | 19 | 0.2 | 5.8 | 4.6 | 420 | 49 | 19.4 | 763 | 19.4 |
Day 3 | 0125 | 0 | V | 21 | 0.3 | 5.7 | 4.7 | 426 | 52 | 24.4 | 803 | 18.5 |
Day 3 | 0126 | 0 | V | 19 | 0.2 | 5.3 | 4.4 | 396 | 46 | 24.6 | 732 | 56.6 |
Day 3 | 0127 | 0 | V | 24 | 0.3 | 5.8 | 4.9 | 394 | 48 | 20.3 | 708 | 33.4 |
Day 3 | 0128 | 0 | V | 22 | 0.2 | 5.6 | 4.4 | 1384* | 48 | 13.5 | 649 | 14.5 |
Day 3 | 0129 | 0 | V | 20 | 0.3 | 5.8 | 4.7 | 364 | 51 | 21.2 | 716 | 14.4 |
Day 3 | 0130 | 0 | V | 19 | 0.2 | 5.6 | 4.6 | 416 | 50 | 19.9 | 739 | 60.1 |
Day 3 | 0131 | 10 | 20 | 0.3 | 5.9 | 5 | 311 | 55 | 22.1 | 727 | 21.4 | |
Day 3 | 0132 | 10 | 22 | 0.2 | 5.3 | 4.3 | 508 | 53 | 17.4 | 728 | 37.0 | |
Day 3 | 0133 | 10 | 23 | 0.2 | 5.4 | 4.6 | 406 | 46 | 21.8 | 633 | 29.4 | |
Day 3 | 0134 | 10 | 24 | 0.2 | 5.6 | 4.7 | 309 | 52 | 22.1 | 708 | 16.4 | |
Day 3 | 0135 | 10 | 19 | 0.3 | 6.0 | 4.6 | 455 | 47 | 22.1 | 697 | 48.9 | |
Day 3 | 0136 | 10 | 19 | 0.2 | 5.5 | 4.4 | 495 | 58 | 15.4 | 694 | 34.0 | |
Day 3 | 0137 | 10 | 23 | 0.2 | 5.4 | 4.5 | 369 | 56 | 18.1 | 685 | 23.9 | |
Day 3 | 0138 | 10 | 21 | 0.3 | 6.1 | 4.9 | 177 | 48 | 20.3 | 777 | 43.1 | |
Day 3 | 0139 | 10 | 21 | 0.2 | 5.8 | 4.6 | 420 | 51 | 24.1 | 731 | 17.8 | |
Day 3 | 0140 | 10 | 21 | 0.3 | 5.7 | 4.8 | 460 | 48 | 24.9 | 722 | 38.4 | |
Day 3 | 0141 | 20 | 17 | 0.2 | 5.2 | 4.4 | 348 | 43 | 17.7 | 716 | 13.0 | |
Day 3 | 0142 | 20 | 19 | 0.3 | 5.4 | 4.5 | 486 | 52 | 19.6 | 721 | 54.5 | |
Day 3 | 0143 | 20 | 21 | 0.3 | 6.1 | 4.8 | 192 | 44 | 19.7 | 729 | 49.6 | |
Day 3 | 0144 | 20 | 24 | 0.3 | 6.0 | 4.9 | 352 | 52 | 24.4 | 735 | 15.5 | |
Day 3 | 0145 | 20 | 20 | 0.2 | 5.5 | 4.6 | 314 | 45 | 23.3 | 766 | 19.7 | |
Day 3 | 0146 | 20 | 20 | 0.1 | 5.8 | 4.7 | 633 | 61 | 21.3 | 653 | 48.4 | |
Day 3 | 0147 | 20 | 17 | 0.2 | 5.7 | 4.5 | 409 | 54 | 21.9 | 757 | 29.3 | |
Day 3 | 0148 | 20 | 20 | 0.3 | 5.7 | 4.8 | 232 | 57 | 22.5 | 747 | 45.3 | |
Day 3 | 0149 | 20 | 22 | 0.3 | 5.8 | 4.7 | 732 | 66 | 57.7 | 690 | 26.7 | |
Day 3 | 0150 | 20 | 21 | 0.3 | 5.7 | 4.8 | 351 | 46 | 22.8 | 717 | 50.2 | |
Day 3 | 0151 | 40 | 22 | 0.2 | 5.6 | 4.7 | 439 | 60 | 23.8 | 768 | 21.2 | |
Day 3 | 0152 | 40 | 23 | 0.3 | 5.3 | 4.4 | 319 | 45 | 19.6 | 624 | 21.9 | |
Day 3 | 0153 | 40 | 22 | 0.3 | 5.2 | 4.4 | 865 | 56 | 15.2 | 711 | 55.1 | |
Day 3 | 0154 | 40 | 22 | 0.2 | 5.7 | 4.6 | 842 | 49 | 19.0 | 775 | 33.9 | |
Day 3 | 0155 | 40 | 22 | 0.2 | 6.4 | 4.8 | 264 | 49 | 24.5 | 730 | 12.9 | |
Day 3 | 0156 | 40 | 20 | 0.3 | 5.5 | 4.5 | 574 | 52 | 22.2 | 764 | 35.6 | |
Day 3 | 0157 | 40 | 20 | 0.3 | 5.7 | 4.7 | 365 | 47 | 22.4 | 677 | 18.8 | |
Day 3 | 0158 | 40 | 24 | 0.2 | 5.8 | 5 | 410 | 73 | 23.1 | 817 | 27.7 | |
Day 3 | 0159 | 40 | 21 | 0.3 | 5.5 | 4.5 | 323 | 47 | 18.5 | 653 | 18.4 | |
Day 3 | 0160 | 40 | 22 | 0.3 | 5.8 | 4.7 | 367 | 50 | 23.3 | 775 | 26.2 | |
Day 3 | 0161 | 80 | 21 | 0.2 | 5.5 | 4.5 | 460 | 48 | 22.3 | 620 | 28.9 | |
Day 3 | 0162 | 80 | 19 | 0.2 | 5.7 | 4.7 | 351 | 49 | 22.6 | 707 | 15.4 | |
Day 3 | 0163 | 80 | 20 | 0.3 | 6.0 | 4.9 | 779 | 48 | 22.2 | 669 | 39.4 | |
Day 3 | 0164 | 80 | 24 | 0.3 | 5.4 | 4.5 | 4471* | 74 | 23.0 | 760 | 25.1 | |
Day 3 | 0165 | 80 | 24 | 0.2 | 5.5 | 4.7 | 297 | 45 | 22.3 | 725 | 12.2 | |
Day 3 | 0166 | 80 | 19 | 0.2 | 5.8 | 4.7 | 233 | 50 | 20.0 | 755 | 18.0 | |
Day 3 | 0167 | 80 | 22 | 0.3 | 6.0 | 5 | 324 | 52 | 25.4 | 719 | 34.9 | |
Day 3 | 0168 | 80 | 16 | 0.2 | 5.3 | 4.3 | 328 | 42 | 17.5 | 617 | 32.3 | |
Day 3 | 0169 | 80 | 21 | 0.3 | 5.9 | 4.9 | 627 | 63 | 29.2 | 713 | 20.1 | |
Day 3 | 0170 | 80 | 20 | 0.3 | 5.7 | 4.5 | 251 | 52 | 21.3 | 677 | 26.8 | |
Day 3 | 0171 | 160 | 21 | 0.3 | 5.9 | 4.8 | 384 | 63 | 19.2 | 574 | 42.2 | |
Day 3 | 0172 | 160 | 21 | 0.2 | 5.8 | 4.8 | 280 | 61 | 19.6 | 632 | 61.2 | |
Day 3 | 0173 | 160 | 20 | 0.2 | 5.4 | 4.3 | 498 | 55 | 20.8 | 637 | 30.3 | |
Day 3 | 0174 | 160 | 21 | 0.2 | 6.3 | 4.9 | 556 | 56 | 19.5 | 688 | 41.3 | |
Day 3 | 0175 | 160 | 18 | 0.2 | 5.7 | 4.4 | 285 | 71 | 19.5 | 636 | 20.2 | |
Day 3 | 0176 | 160 | 23 | 0.3 | 6.0 | 5 | 395 | 74 | 21.1 | 726 | 23.4 | |
Day 3 | 0177 | 160 | 18 | 0.2 | 5.5 | 4.7 | 595 | 58 | 19.9 | 691 | 29.0 | |
Day 3 | 0178 | 160 | 22 | 0.3 | 5.7 | 4.7 | 337 | 60 | 23.9 | 671 | 19.3 | |
Day 3 | 0179 | 160 | 20 | 0.3 | 5.8 | 4.7 | 478 | 70 | 21.5 | 697 | 44.9 | |
Day 3 | 0180 | 160 | 23 | 0.3 | 5.5 | 4.5 | 539 | 67 | 17.7 | 639 | 53.4 | |
Day 22 | 0121 | 0 | V | 23 | 0.3 | 5.7 | 4.6 | 353 | 55 | 18.5 | 502 | 10.0 |
Day 22 | 0122 | 0 | V | 22 | 0.2 | 5.3 | 4.3 | 391 | 47 | 20.1 | 464 | 25.1 |
Day 22 | 0123 | 0 | V | 23 | 0.3 | 5.8 | 4.6 | 618 | 51 | 20.4 | 504 | 56.1 |
Day 22 | 0124 | 0 | V | 24 | 0.3 | 6.3 | 4.9 | 562 | 50 | 17.5 | 505 | 15.4 |
Day 22 | 0125 | 0 | V | 20 | 0.3 | 6.0 | 4.7 | 356 | 47 | 20.4 | 481 | 47.7 |
Day 22 | 0126 | 0 | V | 23 | 0.3 | 5.9 | 4.5 | 314 | 42 | 23.2 | 497 | 24.3 |
Day 22 | 0127 | 0 | V | 23 | 0.3 | 5.6 | 4.5 | 671 | 47 | 16.0 | 512 | 5.1 |
Day 22 | 0128 | 0 | V | 24 | 0.3 | 6.5 | 5.0 | 537 | 49 | 15.5 | 500 | 46.9 |
Day 22 | 0129 | 0 | V | 25 | 0.3 | 6.0 | 4.8 | 463 | 49 | 19.8 | 526 | 59.1 |
Day 22 | 0130 | 0 | V | 26 | 0.3 | 5.8 | 4.9 | 891 | 56 | 18.2 | 551 | 17.6 |
Day 22 | 0131 | 10 | 27 | 0.3 | 5.8 | 4.7 | 597 | 48 | 21.0 | 456 | 20.9 | |
Day 22 | 0132 | 10 | 26 | 0.3 | 5.7 | 4.4 | 914 | 54 | 18.7 | 472 | 53.2 | |
Day 22 | 0133 | 10 | 26 | 0.3 | 6.3 | 4.8 | 448 | 49 | 20.2 | 457 | 14.6 | |
Day 22 | 0134 | 10 | 25 | 0.3 | 6.1 | 5.2 | 395 | 47 | 18.4 | 542 | 27.9 | |
Day 22 | 0135 | 10 | 27 | 0.3 | 6.0 | 4.8 | 968 | 52 | 13.1 | 522 | 15.5 | |
Day 22 | 0136 | 10 | 24 | 0.3 | 6.0 | 4.7 | 387 | 41 | 17.5 | 463 | 38.2 | |
Day 22 | 0137 | 10 | 26 | 0.3 | 4.7 | 4.1 | 643 | 55 | 31.3 | 455 | 39.5 | |
Day 22 | 0138 | 10 | 25 | 0.3 | 6.1 | 4.9 | 326 | 43 | 21.2 | 483 | 18.7 | |
Day 22 | 0139 | 10 | 22 | 0.3 | 6.0 | 4.9 | 520 | 58 | 19.8 | 499 | 27.2 | |
Day 22 | 0140 | 10 | 22 | 0.3 | 6.3 | 4.8 | 496 | 51 | 18.4 | 459 | 49.4 | |
Day 22 | 0141 | 20 | 25 | 0.3 | 6.3 | 4.8 | 442 | 53 | 18.6 | 524 | 14.8 | |
Day 22 | 0142 | 20 | 28 | 0.3 | 6.6 | 5.2 | 600 | 49 | 14.8 | 502 | 36.2 | |
Day 22 | 0143 | 20 | 25 | 0.3 | 6.0 | 4.6 | 403 | 39 | 17.3 | 452 | 13.3 | |
Day 22 | 0144 | 20 | 22 | 0.2 | 5.6 | 4.5 | 336 | 50 | 19.4 | 442 | 12.2 | |
Day 22 | 0145 | 20 | 24 | 0.3 | 6.0 | 4.7 | 482 | 48 | 15.8 | 513 | 17.6 | |
Day 22 | 0146 | 20 | 26 | 0.3 | 6.4 | 5.0 | 925 | 60 | 19.2 | 540 | 15.2 | |
Day 22 | 0147 | 20 | 23 | 0.2 | 5.4 | 4.6 | 695 | 48 | 16.0 | 466 | 63.3 | |
Day 22 | 0148 | 20 | 19 | 0.3 | 5.8 | 4.5 | 463 | 47 | 18.2 | 461 | 19.1 | |
Day 22 | 0149 | 20 | 23 | 0.3 | 6.1 | 4.8 | 559 | 44 | 20.0 | 494 | 49.5 | |
Day 22 | 0150 | 20 | 25 | 0.3 | 6.0 | 4.8 | 408 | 55 | 19.6 | 460 | 14.4 | |
Day 22 | 0151 | 40 | 24 | 0.3 | 5.3 | 4.3 | 1311 | 52 | 16.6 | 412 | 93.9 | |
Day 22 | 0152 | 40 | 24 | 0.3 | 5.6 | 4.5 | 252 | 48 | 16.7 | 453 | 22.2 | |
Day 22 | 0153 | 40 | 28 | 0.4 | 5.5 | 4.5 | 1363 | 64 | 26.8 | 497 | 47.3 | |
Day 22 | 0154 | 40 | 23 | 0.2 | 6.3 | 4.9 | 805 | 53 | 17.9 | 492 | 41.2 | |
Day 22 | 0155 | 40 | 23 | 0.3 | 6.1 | 5.1 | 483 | 42 | 15.1 | 444 | 16.2 | |
Day 22 | 0156 | 40 | 23 | 0.3 | 5.8 | 4.8 | 477 | 52 | 20.2 | 487 | 64.9 | |
Day 22 | 0157 | 40 | 21 | 0.3 | 5.8 | 4.6 | 375 | 40 | 16.1 | 481 | 45.8 | |
Day 22 | 0158 | 40 | 20 | 0.3 | 5.9 | 4.6 | 322 | 41 | 20.0 | 526 | 36.4 | |
Day 22 | 0159 | 40 | 27 | 0.3 | 6.3 | 5.1 | 1024 | 57 | 15.1 | 493 | 21.0 | |
Day 22 | 0160 | 40 | 24 | 0.3 | 5.9 | 4.7 | 870 | 45 | 15.6 | 445 | 56.3 | |
Day 22 | 0161 | 80 | 26 | 0.3 | 6.0 | 4.9 | 844 | 41 | 17.8 | 486 | 11.1 | |
Day 22 | 0162 | 80 | 20 | 0.3 | 5.7 | 4.7 | 363 | 43 | 20.0 | 411 | 42.5 | |
Day 22 | 0163 | 80 | 22 | 0.3 | 5.7 | 4.7 | 335 | 50 | 20.0 | 401 | 35.8 | |
Day 22 | 0164 | 80 | 24 | 0.4 | 5.5 | 4.6 | 3692* | 65 | 4.8* | 34* | 39.0 | |
Day 22 | 0165 | 80 | 23 | 0.3 | 5.5 | 4.5 | 414 | 45 | 20.3 | 403 | 40.9 | |
Day 22 | 0166 | 80 | 21 | 0.3 | 6.2 | 4.6 | 596 | 46 | 17.7 | 393 | 43.0 | |
Day 22 | 0167 | 80 | 24 | 0.3 | 5.8 | 4.7 | 479 | 50 | 16.5 | 454 | 26.6 | |
Day 22 | 0169 | 80 | 23 | 0.3 | 5.5 | 4.2 | 625 | 52 | 18.5 | 382 | 124.7 | |
Day 22 | 0170 | 80 | 20 | 0.3 | 6.1 | 4.6 | 618 | 42 | 17.2 | 437 | 40.1 | |
Day 93 | 0001 | 0 | V | 19 | 0.4 | 6.8 | 4.9 | 135 | 51 | 17.1 | 250 | 14.0 |
Day 93 | 0002 | 0 | V | 19 | 0.3 | 6.7 | 4.6 | 163 | 56 | 16.0 | 279 | 14.2 |
Day 93 | 0003 | 0 | V | 19 | 0.4 | 6.8 | 5.2 | 146 | 55 | 20.3 | 256 | 10.5 |
Day 93 | 0004 | 0 | V | 17 | 0.4 | 6.5 | 4.9 | 82 | 55 | 14.5 | 265 | 11.8 |
Day 93 | 0005 | 0 | V | 22 | 0.3 | 7.1 | 5.0 | 161 | 62 | 20.2 | 264 | 18.5 |
Day 93 | 0006 | 0 | V | 22 | 0.4 | 6.8 | 4.9 | 300 | 57 | 16.5 | 341 | 24.0 |
Day 93 | 0007 | 0 | V | 18 | 0.3 | 6.6 | 4.7 | 475 | 53 | 18.9 | 274 | 11.9 |
Day 93 | 0008 | 0 | V | 20 | 0.4 | 6.5 | 4.9 | 257 | 58 | 18.0 | 238 | 13.2 |
Day 93 | 0009 | 0 | V | 19 | 0.4 | 6.6 | 4.6 | 125 | 62 | 18.8 | 279 | 25.2 |
Day 93 | 0010 | 0 | V | 20 | 0.4 | 6.9 | 5.1 | 76 | 48 | 16.2 | 271 | 30.6 |
Day 93 | 0011 | 10 | 19 | 0.3 | 6.1 | 4.4 | 180 | 69 | 17.8 | 266 | 7.0 | |
Day 93 | 0012 | 10 | 23 | 0.4 | 7.0 | 4.5 | 173 | 61 | 17.7 | 270 | 15.7 | |
Day 93 | 0013 | 10 | 22 | 0.4 | 6.7 | 4.6 | 335 | 65 | 16.1 | 292 | 15.3 | |
Day 93 | 0014 | 10 | 19 | 0.4 | 6.5 | 4.8 | 124 | 55 | 15.8 | 275 | 12.4 | |
Day 93 | 0015 | 10 | 22 | 0.4 | 6.5 | 4.9 | 302 | 54 | 16.5 | 243 | 9.0 | |
Day 93 | 0016 | 10 | 19 | 0.3 | 6.3 | 4.8 | 139 | 55 | 15.0 | 273 | 18.9 | |
Day 93 | 0017 | 10 | 21 | 0.4 | 6.3 | 4.7 | 287 | 65 | 19.9 | 257 | 16.0 | |
Day 93 | 0018 | 10 | 19 | 0.3 | 6.3 | 5.0 | 239 | 53 | 14.9 | 265 | 14.9 | |
Day 93 | 0019 | 10 | 19 | 0.4 | 6.4 | 4.7 | 276 | 46 | 15.9 | 269 | 12.4 | |
Day 93 | 0020 | 10 | 23 | 0.4 | 7.1 | 5.3 | 377 | 71 | 18.7 | 287 | 12.8 | |
Day 93 | 0021 | 20 | 19 | 0.4 | 6.7 | 5.0 | 190 | 53 | 20.4 | 254 | 27.6 | |
Day 93 | 0022 | 20 | 20 | 0.3 | 6.1 | 4.7 | 305 | 42 | 15.0 | 260 | 28.1 | |
Day 93 | 0023 | 20 | 20 | 0.4 | 6.5 | 4.8 | 329 | 56 | 16.6 | 245 | 28.1 | |
Day 93 | 0024 | 20 | 22 | 0.3 | 6.4 | 4.9 | 526 | 60 | 21.7 | 266 | 29.2 | |
Day 93 | 0025 | 20 | 20 | 0.3 | 6.5 | 4.9 | 243 | 47 | 17.1 | 267 | 14.5 | |
Day 93 | 0026 | 20 | 23 | 0.4 | 6.6 | 4.8 | 251 | 64 | 17.9 | 248 | 42.3 | |
Day 93 | 0027 | 20 | 21 | 0.4 | 6.5 | 4.8 | 290 | 49 | 16.9 | 277 | 16.0 | |
Day 93 | 0028 | 20 | 21 | 0.4 | 6.5 | 4.9 | 266 | 52 | 18.0 | 250 | 15.2 | |
Day 93 | 0029 | 20 | 21 | 0.4 | 6.6 | 4.9 | 193 | 54 | 19.7 | 269 | 19.5 | |
Day 93 | 0030 | 20 | 20 | 0.4 | 7.4 | 5.3 | 80 | 57 | 16.6 | 276 | 22.0 | |
Day 93 | 0031 | 40 | 23 | 0.3 | 6.2 | 4.7 | 233 | 50 | 17.6 | 273 | 15.7 | |
Day 93 | 0032 | 40 | 20 | 0.3 | 6.4 | 4.7 | 246 | 47 | 17.8 | 282 | 24.6 | |
Day 93 | 0033 | 40 | 19 | 0.4 | 7.0 | 5.0 | 104 | 56 | 15.7 | 225 | 25.8 | |
Day 93 | 0034 | 40 | 19 | 0.3 | 6.4 | 4.7 | 95 | 50 | 19.5 | 252 | 13.3 | |
Day 93 | 0035 | 40 | 19 | 0.4 | 6.6 | 4.7 | 228 | 56 | 18.8 | 280 | 17.6 | |
Day 93 | 0036 | 40 | 20 | 0.3 | 6.1 | 4.6 | 147 | 57 | 16.3 | 267 | 12.8 | |
Day 93 | 0037 | 40 | 19 | 0.3 | 6.3 | 4.7 | 105 | 51 | 15.3 | 219 | 24.3 | |
Day 93 | 0038 | 40 | 23 | 0.4 | 6.3 | 4.8 | 413 | 77 | 37.9 | 280 | 19.0 | |
Day 93 | 0039 | 40 | 20 | 0.3 | 6.2 | 4.6 | 79 | 50 | 15.4 | 232 | 35.2 | |
Day 93 | 0040 | 40 | 19 | 0.4 | 6.7 | 4.8 | 189 | 46 | 18.4 | 262 | 36.7 | |
Abbreviations: | ||||||||||||
NA: Not Available, V: Vehicle Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue |