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Chemical Name: | Gallium Arsenide |
---|---|
CASRN: | ="1303-00-0" |
Study Number: | C62033 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | INHAL |
TDMS Number: | 0518004.ss |
Sex: | Female |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/m3) | Control Code | BUN (mg_dL) | Creat (U per L) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | Iron (ug per dL) | TIBC (ug per dL) | UIBC (ug per dL) | T3 (ng per dL) | T4 (ug per dL) | Free T4 (ng per dL) | TSH (ng per dL) |
Week 3 | 0111 | 0 | U | 14 | 0.6 | 419 | 36 | 13 | 201 | 549 | 348 | ||||
Week 3 | 0112 | 0 | U | 12 | 0.6 | 427 | 46 | 10 | 237 | 550 | 313 | ||||
Week 3 | 0113 | 0 | U | 14 | 0.5 | 247 | 39 | 10 | 222 | 526 | 304 | ||||
Week 3 | 0114 | 0 | U | 13 | 0.5 | 457 | 41 | 8 | 281 | 553 | 272 | ||||
Week 3 | 0115 | 0 | U | 14 | 0.6 | 228 | 35 | 11 | 307 | 554 | 247 | ||||
Week 3 | 0116 | 0 | U | 14 | 0.4 | 245 | 39 | 8 | 259 | 525 | 266 | ||||
Week 3 | 0117 | 0 | U | 13 | 0.5 | 439 | 39 | 8 | 284 | 543 | 259 | ||||
Week 3 | 0118 | 0 | U | 13 | 0.5 | 200 | 33 | 9 | 413 | ||||||
Week 3 | 0119 | 0 | U | 15 | 0.5 | 178 | 34 | 7 | 227 | ||||||
Week 3 | 0120 | 0 | U | 14 | 0.5 | 200 | 36 | 7 | 192 | ||||||
Week 3 | 0311 | 0.1 | 16 | 0.5 | 249 | 33 | |||||||||
Week 3 | 0312 | 0.1 | 15 | 0.6 | 293 | 36 | |||||||||
Week 3 | 0313 | 0.1 | 14 | 0.5 | 290 | 31 | |||||||||
Week 3 | 0314 | 0.1 | 14 | 0.5 | 571 | 34 | |||||||||
Week 3 | 0315 | 0.1 | 17 | 0.5 | 192 | 25 | |||||||||
Week 3 | 0316 | 0.1 | 15 | 0.5 | 342 | 32 | |||||||||
Week 3 | 0317 | 0.1 | 14 | 0.5 | 266 | 36 | |||||||||
Week 3 | 0318 | 0.1 | 14 | 0.5 | 322 | 37 | |||||||||
Week 3 | 0319 | 0.1 | 15 | 0.5 | 279 | 40 | |||||||||
Week 3 | 0320 | 0.1 | 15 | 0.6 | 548 | 36 | |||||||||
Week 3 | 0511 | 1 | 15 | 0.5 | 372 | 36 | |||||||||
Week 3 | 0512 | 1 | 16 | 0.5 | 321 | 35 | |||||||||
Week 3 | 0513 | 1 | 16 | 0.5 | 208 | 31 | |||||||||
Week 3 | 0514 | 1 | 15 | 0.6 | 178 | 30 | |||||||||
Week 3 | 0515 | 1 | 17 | 0.5 | 219 | 34 | |||||||||
Week 3 | 0516 | 1 | 15 | 0.6 | 284 | 34 | |||||||||
Week 3 | 0517 | 1 | 16 | 0.5 | 555 | 33 | |||||||||
Week 3 | 0518 | 1 | 17 | 0.6 | 429 | 34 | |||||||||
Week 3 | 0519 | 1 | 17 | 0.5 | 254 | 40 | |||||||||
Week 3 | 0520 | 1 | 19 | 0.5 | 779 | 41 | |||||||||
Week 3 | 0711 | 10 | 17 | 0.6 | 252 | 30 | 8 | 166 | 513 | 347 | |||||
Week 3 | 0712 | 10 | 19 | 0.5 | 501 | 29 | 9 | 176 | 481 | 305 | |||||
Week 3 | 0713 | 10 | 16 | 0.6 | 519 | 30 | 13 | 289 | 533 | 244 | |||||
Week 3 | 0714 | 10 | 18 | 0.5 | 495 | 32 | 10 | 382 | 532 | 150 | |||||
Week 3 | 0715 | 10 | 16 | 0.6 | 621 | 36 | 10 | 167 | 497 | 330 | |||||
Week 3 | 0716 | 10 | 16 | 0.5 | 314 | 35 | 8 | 190 | 491 | 301 | |||||
Week 3 | 0717 | 10 | 17 | 0.5 | 344 | 30 | 9 | 311 | 520 | 209 | |||||
Week 3 | 0718 | 10 | 17 | 0.6 | 270 | 31 | 9 | 197 | 523 | 326 | |||||
Week 3 | 0719 | 10 | 17 | 0.6 | 207 | 31 | 7 | 180 | 528 | 348 | |||||
Week 3 | 0720 | 10 | 16 | 0.5 | 390 | 34 | 8 | 177 | 480 | 303 | |||||
Week 3 | 0911 | 37 | 17 | 0.6 | 1815 | 38 | 8 | 201 | 558 | 357 | |||||
Week 3 | 0912 | 37 | 15 | 0.6 | 263 | 28 | 13 | 333 | 559 | 226 | |||||
Week 3 | 0913 | 37 | 16 | 0.6 | 262 | 28 | 10 | 265 | 524 | 259 | |||||
Week 3 | 0914 | 37 | 17 | 0.6 | 306 | 33 | 13 | 321 | 550 | 229 | |||||
Week 3 | 0915 | 37 | 17 | 0.6 | 653 | 34 | 10 | 163 | 521 | 358 | |||||
Week 3 | 0916 | 37 | 18 | 0.6 | 472 | 29 | 10 | 258 | 511 | 253 | |||||
Week 3 | 0917 | 37 | 18 | 0.5 | 201 | 29 | 9 | 180 | 497 | 317 | |||||
Week 3 | 0918 | 37 | 15 | 0.5 | 261 | 26 | 3 | 245 | 514 | 269 | |||||
Week 3 | 0919 | 37 | 18 | 0.7 | 356 | 36 | 11 | 155 | 511 | 356 | |||||
Week 3 | 0920 | 37 | 14 | 0.6 | 169 | 30 | 7 | 186 | 503 | 317 | |||||
Week 3 | 1111 | 75 | 14 | 0.6 | 327 | 28 | 10 | 168 | 488 | 320 | |||||
Week 3 | 1112 | 75 | 18 | 0.6 | 478 | 26 | 10 | 166 | 457 | 291 | |||||
Week 3 | 1113 | 75 | 14 | 0.7 | 1138 | 30 | 11 | 133 | 453 | 320 | |||||
Week 3 | 1114 | 75 | 16 | 0.6 | 253 | 29 | 11 | 209 | 503 | 294 | |||||
Week 3 | 1115 | 75 | 20 | 0.6 | 214 | 34 | 10 | 176 | 488 | 312 | |||||
Week 3 | 1116 | 75 | 16 | 0.6 | 292 | 25 | 10 | 228 | 480 | 252 | |||||
Week 3 | 1117 | 75 | 16 | 0.6 | 186 | 29 | 8 | 150 | 485 | 335 | |||||
Week 3 | 1118 | 75 | 19 | 0.6 | 228 | 30 | 10 | 267 | 504 | 237 | |||||
Week 3 | 1119 | 75 | 18 | 0.6 | 160 | 25 | 9 | 148 | 231 | 83* | |||||
Week 3 | 1120 | 75 | 18 | 0.6 | 218 | 40 | 9 | 159 | 470 | 311 | |||||
Week 13 | 0101 | 0 | U | 20 | 0.6 | 116 | 42 | 14 | 219 | 512 | 293 | 124 | 4.5 | 2.21 | 134.00 |
Week 13 | 0102 | 0 | U | 19 | 0.6 | 174 | 56 | 17 | 247 | 620 | 373 | 132 | 4.7 | 2.46 | 66.00 |
Week 13 | 0103 | 0 | U | 21 | 0.6 | 213 | 47 | 15 | 184 | 542 | 358 | 98 | 3.8 | 2.24 | 100 |
Week 13 | 0104 | 0 | U | 21 | 0.6 | 114 | 45 | 15 | 243 | 562 | 319 | 83 | 2.1 | 1.11 | 136.00 |
Week 13 | 0105 | 0 | U | 21 | 0.6 | 270 | 54 | 16 | 208 | 565 | 357 | 87 | 2.8 | 1.71 | 53.00 |
Week 13 | 0106 | 0 | U | 17 | 0.6 | 148 | 49 | 18 | 241 | 579 | 338 | 133 | 4.8 | 2.41 | 72.00 |
Week 13 | 0107 | 0 | U | 20 | 0.6 | 104 | 44 | 17 | 263 | 605 | 342 | 150 | 5.3 | 2.77 | 110.0 |
Week 13 | 0108 | 0 | U | 19 | 0.6 | 276 | 45 | 16 | 234 | 557 | 323 | 160 | 4.9 | 2.59 | 72.00 |
Week 13 | 0109 | 0 | U | 15 | 0.6 | 176 | 60 | 21 | 262 | 533 | 271 | 143 | 4.5 | 2.15 | 88.00 |
Week 13 | 0110 | 0 | U | 21 | 0.7 | 158 | 43 | 17 | 228 | 594 | 366 | 87 | 3.2 | 1.81 | 143.00 |
Week 13 | 0302 | 0.1 | 25 | 0.8 | 387 | 59 | 134 | 4 | 2.06 | 97.00 | |||||
Week 13 | 0303 | 0.1 | 19 | 0.6 | 105 | 39 | 127 | 4.1 | 2.21 | 192.00 | |||||
Week 13 | 0304 | 0.1 | 23 | 0.6 | 126 | 47 | 121 | 4.2 | 2.13 | 100 | |||||
Week 13 | 0305 | 0.1 | 22 | 0.6 | 95 | 43 | 133 | 4.3 | 2.58 | 202.00 | |||||
Week 13 | 0306 | 0.1 | 22 | 0.6 | 192 | 46 | 132 | 8.7 | 2.75 | 156.00 | |||||
Week 13 | 0307 | 0.1 | 20 | 0.6 | 247 | 40 | 155 | 4.6 | 2.65 | 236.00 | |||||
Week 13 | 0308 | 0.1 | 20 | 0.7 | 135 | 69 | 148 | 3.9 | 2.01 | 99.00 | |||||
Week 13 | 0309 | 0.1 | 24 | 0.6 | 95 | 44 | 90 | 3.1 | 1.84 | 85.00 | |||||
Week 13 | 0310 | 0.1 | 24 | 0.6 | 84 | 31 | 115 | 5 | 2.47 | 142.00 | |||||
Week 13 | 0501 | 1 | 22 | 0.6 | 219 | 45 | 99 | 3.2 | 1.7 | 140.0 | |||||
Week 13 | 0502 | 1 | 27 | 0.8 | 221 | 46 | 96 | 2.4 | 1.46 | 66.00 | |||||
Week 13 | 0503 | 1 | 24 | 0.6 | 95 | 44 | 137 | 3.5 | 1.79 | 120.0 | |||||
Week 13 | 0504 | 1 | 25 | 0.7 | 106 | 72 | 93 | 3 | 2.03 | 92.00 | |||||
Week 13 | 0505 | 1 | 28 | 0.7 | 132 | 60 | 97 | 2 | 1.4 | 78.00 | |||||
Week 13 | 0506 | 1 | 21 | 0.6 | 184 | 53 | 119 | 3.5 | 2.05 | 137.00 | |||||
Week 13 | 0507 | 1 | 18 | 0.6 | 107 | 47 | 118 | 4.5 | 2.59 | 52.00 | |||||
Week 13 | 0508 | 1 | 19 | 0.6 | 111 | 62 | 185 | 5.2 | 3 | 140.0 | |||||
Week 13 | 0509 | 1 | 21 | 0.7 | 184 | 52 | 116 | 3.8 | 2.3 | 116.00 | |||||
Week 13 | 0510 | 1 | 17 | 0.5 | 130 | 47 | 121 | 5 | 2.66 | 117.00 | |||||
Week 13 | 0701 | 10 | 25 | 0.8 | 187 | 86 | 32 | 244 | 623 | 379 | 118 | 3.6 | 1.85 | 66.00 | |
Week 13 | 0702 | 10 | 23 | 0.7 | 204 | 44 | 18 | 245 | 591 | 346 | 148 | 3.7 | 2.33 | 144.00 | |
Week 13 | 0703 | 10 | 17 | 0.6 | 130 | 40 | 15 | 255 | 546 | 291 | 137 | 6.3 | 3.09 | 84.00 | |
Week 13 | 0704 | 10 | 21 | 0.5 | 212 | 37 | 15 | 216 | 498 | 282 | 118 | 4.6 | 2.42 | 281.00 | |
Week 13 | 0705 | 10 | 25 | 0.6 | 107 | 50 | 21 | 193 | 535 | 342 | 100 | 3.5 | 2.35 | 91.00 | |
Week 13 | 0706 | 10 | 30 | 0.7 | 191 | 39 | 15 | 293 | 589 | 296 | 106 | 3.8 | 2.57 | 145.00 | |
Week 13 | 0707 | 10 | 24 | 0.7 | 186 | 45 | 17 | 295 | 617 | 322 | 120 | 4 | 2.59 | 102.00 | |
Week 13 | 0708 | 10 | 21 | 0.6 | 100 | 57 | 22 | 213 | 552 | 339 | 121 | 4 | 2.29 | 131.00 | |
Week 13 | 0709 | 10 | 16 | 0.6 | 221 | 43 | 18 | 243 | 542 | 299 | 113 | 4.5 | 2.48 | 79.00 | |
Week 13 | 0710 | 10 | 22 | 0.6 | 131 | 51 | 20 | 182 | 596 | 414 | 97 | 3.4 | 2.35 | 98.00 | |
Week 13 | 0901 | 37 | 19 | 0.6 | 142 | 64 | 21 | 250 | 535 | 285 | 120 | 4.1 | 2.53 | 120.0 | |
Week 13 | 0902 | 37 | 21 | 0.6 | 176 | 59 | 22 | 235 | 528 | 293 | 149 | 4.4 | 2.23 | 128.00 | |
Week 13 | 0903 | 37 | 26 | 0.7 | 80 | 47 | 18 | 162 | 492 | 330 | 93 | 3.7 | 2.03 | 61.00 | |
Week 13 | 0904 | 37 | 18 | 0.6 | 262 | 56 | 17 | 228 | 567 | 339 | 150 | 5.3 | 2.46 | 69.00 | |
Week 13 | 0905 | 37 | 19 | 0.6 | 229 | 36 | 15 | 282 | 552 | 270 | 119 | 5.7 | 3.06 | 257.00 | |
Week 13 | 0906 | 37 | 24 | 0.6 | 192 | 68 | 20 | 200 | 553 | 353 | 91 | 2.8 | 1.93 | 60.0 | |
Week 13 | 0907 | 37 | 22 | 0.5 | 91 | 46 | 17 | 205 | 509 | 304 | 123 | 4.8 | 2.56 | ||
Week 13 | 0908 | 37 | 21 | 0.7 | 140 | 62 | 22 | 187 | 539 | 352 | 132 | 3.9 | 2.32 | 107.00 | |
Week 13 | 0909 | 37 | 27 | 0.6 | 156 | 42 | 18 | 201 | 566 | 365 | 80 | 3 | 2.02 | 45.00 | |
Week 13 | 0910 | 37 | 15 | 0.5 | 124 | 43 | 18 | 239 | 542 | 303 | 147 | 5.2 | 2.85 | 141.00 | |
Week 13 | 1101 | 75 | 21 | 0.6 | 145 | 70 | 25 | 203 | 516 | 313 | 132 | 4.1 | 2.18 | 180.0 | |
Week 13 | 1102 | 75 | 19 | 0.6 | 378 | 61 | 22 | 158 | 518 | 360 | 139 | 4.2 | 2.35 | 91.00 | |
Week 13 | 1103 | 75 | 25 | 0.7 | 80 | 54 | 20 | 205 | 526 | 321 | 99 | 4.2 | 2.55 | 104.00 | |
Week 13 | 1104 | 75 | 21 | 0.6 | 111 | 72 | 21 | 225 | 527 | 302 | 132 | 2.3 | 1.37 | 122.00 | |
Week 13 | 1105 | 75 | 17 | 0.5 | 172 | 49 | 18 | 200 | 500 | 300 | 115 | 4.8 | 2.46 | 111.00 | |
Week 13 | 1106 | 75 | 19 | 0.7 | 107 | 74 | 21 | 213 | 518 | 305 | 122 | 4.7 | 2.41 | 144.00 | |
Week 13 | 1107 | 75 | 23 | 0.6 | 121 | 89 | 29 | 176 | 539 | 363 | |||||
Week 13 | 1108 | 75 | 20 | 0.6 | 89 | 49 | 19 | 174 | 490 | 316 | 118 | 4.9 | 2.53 | 81.00 | |
Week 13 | 1109 | 75 | 24 | 0.7 | 153 | 65 | 21 | 253 | 535 | 282 | 106 | 2.5 | 1.33 | 200 | |
Week 13 | 1110 | 75 | 22 | 0.6 | 137 | 47 | 20 | 233 | 514 | 281 | 108 | 3 | 62.00 | ||
Abbreviations: | |||||||||||||||
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, TIBC: Iron Binding Capacity Total, UIBC: Iron Unbound Binding Capacity, T3: Triiodothyronine, T4: Thyroxine, Free T4: Thyroxine Free, TSH: Thyroid Stimulating Hormone |