Alimentary System |
Esophagus |
Muscularis |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Degeneration |
Minimal |
Moribund Sacrifice |
Alimentary System |
Esophagus |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Esophagus |
|
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Perforation |
|
Dosing Accident |
Alimentary System |
Esophagus |
|
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Perforation |
|
Dosing Accident |
Alimentary System |
Intestine Large |
Cecum |
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Cecum |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Cecum |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Intestine Large |
Cecum |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Cecum |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Cecum, Epithelium |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Hyperplasia |
Mild |
Scheduled Sacrifice |
Alimentary System |
Intestine Large |
Colon |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon, Epithelium |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon, Epithelium |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Large |
Rectum |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Intestine Large |
Rectum |
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Parasite Metazoan |
|
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Rectum, Muscularis |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Epithelium |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Regeneration |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Mucosa |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Ileum, Mucosa |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Mucosa |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Muscularis |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Hyperplasia |
Marked |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Hyperplasia |
Moderate, Cystic |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Regeneration |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Oval Cell |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Liver |
Oval Cell |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Portal |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Fibrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Portal |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Liver |
Portal |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Angiectasis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Angiectasis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
20 |
59 |
525 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
20 |
59 |
525 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
30 |
88 |
513 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Deformity |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Fatty Change |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Fatty Change |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Fatty Change |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
3 |
92 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Scheduled Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hematopoietic Cell Proliferation, Granulocytic |
Mild, Granulocytic |
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Pigmentation |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Vacuolization Cytoplasmic |
Focal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Vacuolization Cytoplasmic |
Focal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Vacuolization Cytoplasmic |
Focal |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Vacuolization Cytoplasmic |
Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Vacuolization Cytoplasmic |
Focal |
Natural Death |
Alimentary System |
Mesentery |
|
100 mg/kg |
2 |
29 |
87 |
668 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Alimentary System |
Mesentery |
|
Vehicle Control |
3 |
18 |
52 |
727 |
1 |
Necrosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
Vehicle Control |
3 |
6 |
18 |
729 |
1 |
Necrosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
100 mg/kg |
2 |
27 |
80 |
728 |
1 |
Necrosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
1000 mg/kg |
1 |
70 |
208 |
727 |
1 |
Necrosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Pancreas |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Pancreas |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Lipomatosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Pigmentation |
Minimal, Hemosiderin |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Duct |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Cyst |
Marked |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Amyloid Deposition |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
|
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Alimentary System |
Salivary Glands |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Erosion |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Degeneration |
Mild, Hydropic |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Hyperkeratosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Hyperkeratosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Cyst |
Squamous |
Natural Death |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Hyalinization |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Necrosis |
Mild |
Dosing Accident |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Mucosa |
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Pigmentation |
Minimal |
Natural Death |
Alimentary System |
Tooth |
|
Vehicle Control |
1 |
5 |
14 |
728 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
Adventitia, Aorta |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
Adventitia, Aorta |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
Endocardium |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
Epicardium |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Epicardium |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Inflammation |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Epicardium |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Inflammation |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
Epicardium |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
Epicardium |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Inflammation |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
Epicardium |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Inflammation |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Myocardium |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Necrosis |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Myocardium |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Myocardium |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Pericardium |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Marked |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
19 |
56 |
631 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
10 |
30 |
92 |
1 |
Cardiomyopathy |
Minimal |
Scheduled Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
15 |
45 |
92 |
1 |
Cardiomyopathy |
Minimal |
Scheduled Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
30 |
88 |
513 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Inflammation |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Inflammation |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Hematopoietic Cell Proliferation, Granulocytic |
Moderate, Granulocytic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Infiltration Cellular |
Marked, Lipocyte |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Necrosis |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Necrosis |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Necrosis |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Intermed |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
20 |
59 |
525 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Cyst |
Marked |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Amyloid Deposition |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Granuloma Sperm |
Moderate |
Terminal Sacrifice |
Genital System |
Epididymis |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Granuloma Sperm |
Moderate |
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Spermatocele |
Marked |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
60 |
15 |
45 |
92 |
1 |
Inflammation |
Minimal |
Scheduled Sacrifice |
Genital System |
Preputial Gland |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Inflammation |
Mild |
Scheduled Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
Epithelium |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
60 |
1 |
3 |
92 |
1 |
Inflammation |
Moderate |
Scheduled Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
60 |
15 |
45 |
92 |
1 |
Inflammation |
Moderate |
Scheduled Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Prostate |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Genital System |
Prostate |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Genital System |
Prostate |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Prostate |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Prostate |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Genital System |
Prostate |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Inflammation |
Marked |
Natural Death |
Genital System |
Seminal Vesicle |
Epithelium |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
Epithelium |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
Epithelium |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Inflammation |
Mild |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Testes |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Degeneration |
Marked, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
20 |
59 |
525 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Moderate, Histiocytic |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Hyperplasia |
Minimal |
Dosing Accident |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Degeneration |
Mild, Cystic |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Degeneration |
Moderate, Cystic |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Degeneration |
Moderate, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Hemorrhage |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
1 |
3 |
92 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
12 |
34 |
92 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
13 |
38 |
92 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
15 |
45 |
92 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
60 |
16 |
48 |
92 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
57 |
167 |
92 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
59 |
175 |
92 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
65 |
192 |
92 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
69 |
204 |
92 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
70 |
207 |
92 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Scheduled Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Degeneration |
Moderate, Cystic |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Hemorrhage |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Hyperplasia |
Marked, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Hyperplasia |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Degeneration |
Marked, Cystic |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Hemorrhage |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Depletion Lymphoid |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Depletion Lymphoid |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Depletion Lymphoid |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Depletion Lymphoid |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Depletion Lymphoid |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Depletion Lymphoid |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Depletion Lymphoid |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Hyperplasia |
Mild, Lymphoid |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Hemorrhage |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Moderate |
Natural Death |
Integumentary System |
Mammary Gland |
Duct |
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
Hair Follicle |
100 mg/kg |
50 |
34 |
101 |
729 |
Multiple |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Musculoskeletal System |
Skeletal Muscle |
|
1000 mg/kg |
1 |
57 |
169 |
727 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Nervous System |
Brain |
Ventricle |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Nervous System |
Spinal Cord |
|
100 mg/kg |
1 |
29 |
87 |
668 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
13 |
38 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Scheduled Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
9 |
26 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Scheduled Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Scheduled Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Scheduled Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
9 |
26 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Scheduled Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Inflammation |
Marked, Suppurative |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Inflammation |
Mild, Suppurative |
Dosing Accident |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Scheduled Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
67 |
197 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Scheduled Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Inflammation |
Mild, Chronic Active |
Scheduled Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Goblet Cell, Nasopharyn Dct |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Goblet Cell, Nasopharyn Dct |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Epithelium, Goblet Cell, Nasopharyn Dct |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Degeneration |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Hyperplasia |
Moderate |
Scheduled Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Metaplasia |
Mild, Squamous |
Moribund Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Metaplasia |
Mild, Squamous |
Moribund Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Necrosis |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Pigmentation |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Regeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Regeneration |
Moderate |
Dosing Accident |
Respiratory System |
Nose |
Epithelium, Nasopharyn Dct |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Regeneration |
Marked |
Natural Death |
Respiratory System |
Nose |
Goblet Cell |
Vehicle Control |
60 |
10 |
30 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Goblet Cell |
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Goblet Cell |
1000 mg/kg |
60 |
59 |
175 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Goblet Cell, Nasopharyn Dct |
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Mineralization |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Pigmentation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Pigmentation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Pigmentation |
Mild |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Pigmentation |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Pigmentation |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Pigmentation |
Moderate |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Pigmentation |
Marked |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Pigmentation |
Marked |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Pigmentation |
Marked |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Pigmentation |
Marked |
Natural Death |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Lumen |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Pigmentation |
Moderate, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Foreign Body |
|
Scheduled Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Inflammation |
Mild, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Inflammation |
Marked, Suppurative |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Inflammation |
Moderate, Suppurative |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Mineralization |
Minimal |
Natural Death |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Atrophy |
Minimal |
Natural Death |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Atrophy |
Minimal |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Atrophy |
Minimal |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
59 |
175 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
67 |
197 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
69 |
203 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Accumulation, Hyaline Droplet |
Marked |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
19 |
56 |
631 |
1 |
Accumulation, Hyaline Droplet |
Marked |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Accumulation, Hyaline Droplet |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Accumulation, Hyaline Droplet |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Accumulation, Hyaline Droplet |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Atrophy |
Moderate |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Atrophy |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Atrophy |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Atrophy |
Moderate |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
59 |
175 |
92 |
1 |
Atrophy |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
197 |
92 |
1 |
Atrophy |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Atrophy |
Moderate |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
69 |
203 |
92 |
1 |
Atrophy |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Hyperplasia, Basal Cell |
Moderate, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Hyperplasia, Basal Cell |
Moderate, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Hyperplasia, Basal Cell |
Moderate, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Hyperplasia, Basal Cell |
Mild, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
31 |
91 |
344 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
59 |
175 |
92 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
197 |
92 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
69 |
203 |
92 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Metaplasia, Respiratory |
Mild, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Metaplasia, Respiratory |
Minimal, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Metaplasia, Respiratory |
Moderate, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Metaplasia, Respiratory |
Marked, Respiratory |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Necrosis |
Minimal |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Necrosis |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
64 |
190 |
53 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Necrosis |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Necrosis |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
27 |
79 |
661 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Pigmentation |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Pigmentation |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Pigmentation |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Pigmentation |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
197 |
92 |
1 |
Pigmentation |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Pigmentation |
Mild |
Scheduled Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Squamous Metaplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Squamous Metaplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Squamous Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Squamous Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Squamous Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
7 |
20 |
519 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
19 |
56 |
631 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
24 |
71 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
62 |
183 |
352 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
60 |
177 |
728 |
1 |
Accumulation, Hyaline Droplet |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Atrophy |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Atrophy |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Degeneration |
Minimal |
Dosing Accident |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Degeneration |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
10 |
30 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
12 |
34 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Hyperplasia |
Minimal |
Dosing Accident |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
57 |
167 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Hyperplasia |
Minimal |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Metaplasia |
Mild, Squamous |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Metaplasia |
Minimal, Squamous |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Metaplasia |
Minimal, Squamous |
Dosing Accident |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Metaplasia |
Mild, Squamous |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Metaplasia |
Moderate, Squamous |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Metaplasia |
Minimal, Squamous |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Metaplasia |
Minimal, Squamous |
Scheduled Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Metaplasia |
Mild, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Pigmentation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Pigmentation |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Pigmentation |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Deformity |
|
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Deformity |
|
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Deformity |
|
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Hyperostosis |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
26 |
77 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
34 |
102 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
37 |
109 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Hyperostosis |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Hyperostosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
46 |
136 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Hyperostosis |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
62 |
182 |
699 |
1 |
Hyperostosis |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Hyperostosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Hyperostosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Hyperostosis |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Hyperostosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Hyperostosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Hyperostosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Hyperostosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperostosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Hyperostosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Hyperostosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Hyperostosis |
Mild |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Hyperostosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
57 |
169 |
727 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Hyperostosis |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Hyperostosis |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Hyperostosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Hyperostosis |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Turbinate |
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Hyperostosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Foreign Body |
|
Scheduled Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
29 |
85 |
541 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
28 |
84 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Inflammation |
Mild, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
44 |
130 |
643 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
159 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
55 |
163 |
109 |
1 |
Inflammation |
Minimal, Suppurative |
Dosing Accident |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
61 |
180 |
109 |
1 |
Inflammation |
Moderate, Suppurative |
Dosing Accident |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Inflammation |
Marked, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
57 |
168 |
615 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
58 |
172 |
594 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
63 |
187 |
462 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
64 |
189 |
340 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
66 |
195 |
554 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
73 |
215 |
580 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
73 |
217 |
584 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
56 |
164 |
92 |
1 |
Inflammation |
Moderate, Suppurative |
Scheduled Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
57 |
167 |
92 |
1 |
Inflammation |
Minimal, Acute |
Scheduled Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
68 |
201 |
92 |
1 |
Inflammation |
Moderate, Suppurative |
Scheduled Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Inflammation |
Marked, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Inflammation |
Marked, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Trachea |
Epithelium |
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
60 |
60 |
178 |
336 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
60 |
65 |
191 |
697 |
1 |
Inflammation |
Mild |
Natural Death |
Special Senses System |
Eye |
Ciliary Body |
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Special Senses System |
Eye |
Retina |
Vehicle Control |
60 |
18 |
53 |
671 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Special Senses System |
Eye |
Retina |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Hyperplasia, Reticulum Cell |
Mild, Reticulum Cell |
Terminal Sacrifice |
Special Senses System |
Eye |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Cataract |
Minimal |
Terminal Sacrifice |
Special Senses System |
Eye |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Cataract |
Moderate |
Terminal Sacrifice |
Special Senses System |
Eye |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Synechia |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Synechia |
Marked |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Necrosis |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
300 mg/kg |
50 |
42 |
123 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Transit Epithe |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Urinary System |
Kidney |
Transit Epithe |
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
55 |
162 |
668 |
1 |
Casts Granular |
Mild |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Cyst |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Hydronephrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Hydronephrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Hydronephrosis |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Hydronephrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Hydronephrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Hydronephrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
66 |
194 |
350 |
1 |
Hydronephrosis |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
71 |
211 |
463 |
1 |
Hydronephrosis |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Hydronephrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Hydronephrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Infarct |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Infarct |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Infiltration Cellular |
Minimal, Lipocyte |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
20 |
59 |
525 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
15 |
45 |
92 |
1 |
Inflammation |
Mild |
Scheduled Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
24 |
72 |
692 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Inflammation |
Mild |
Natural Death |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
47 |
138 |
608 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
47 |
140 |
596 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Inflammation |
Marked |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
72 |
213 |
665 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
56 |
165 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
1 |
1 |
538 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
10 |
28 |
505 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
13 |
37 |
604 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
14 |
42 |
674 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
15 |
43 |
629 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
15 |
44 |
668 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
17 |
49 |
539 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
17 |
51 |
645 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
3 |
8 |
519 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
14 |
41 |
519 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
18 |
54 |
709 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
19 |
56 |
631 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
1 |
2 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
10 |
29 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
11 |
32 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
11 |
33 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
12 |
35 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
12 |
36 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
13 |
39 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
14 |
40 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
16 |
46 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
16 |
47 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
17 |
50 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
18 |
52 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
19 |
55 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
19 |
57 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
2 |
4 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
2 |
5 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
2 |
6 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
20 |
58 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
3 |
7 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
3 |
9 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
4 |
10 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
4 |
11 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
4 |
12 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
5 |
13 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
5 |
14 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
5 |
15 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
6 |
16 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
6 |
17 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
6 |
18 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
7 |
19 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
7 |
21 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
8 |
22 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
8 |
24 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
9 |
25 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
60 |
9 |
27 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
28 |
83 |
645 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
29 |
87 |
668 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
30 |
90 |
636 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
32 |
95 |
706 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
35 |
105 |
604 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
36 |
106 |
650 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
32 |
94 |
584 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
36 |
107 |
608 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
21 |
61 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
21 |
62 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
21 |
63 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
22 |
64 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
22 |
65 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
22 |
66 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
23 |
67 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
23 |
68 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
23 |
69 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
24 |
70 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
25 |
73 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
25 |
74 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
25 |
75 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
26 |
76 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
26 |
78 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
27 |
80 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
27 |
81 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
28 |
82 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
29 |
86 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
30 |
89 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
31 |
92 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
31 |
93 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
32 |
96 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
33 |
97 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
33 |
98 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
33 |
99 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
34 |
100 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
34 |
101 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
35 |
103 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
35 |
104 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
36 |
108 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
50 |
37 |
110 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
38 |
113 |
646 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
41 |
121 |
585 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
49 |
146 |
224 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
155 |
701 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
40 |
119 |
727 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
38 |
111 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
38 |
112 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
114 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
115 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
39 |
116 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
40 |
117 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
40 |
118 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
41 |
120 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
41 |
122 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
42 |
124 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
42 |
125 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
43 |
126 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
43 |
127 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
43 |
128 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
44 |
129 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
44 |
131 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
45 |
132 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
45 |
133 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
45 |
134 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
46 |
135 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
46 |
137 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
47 |
139 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
48 |
141 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
48 |
142 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
48 |
143 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
49 |
144 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
49 |
145 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
50 |
147 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
50 |
148 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
50 |
149 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
51 |
150 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
51 |
151 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
51 |
152 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
153 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
154 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
156 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
157 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
158 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
54 |
160 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
64 |
188 |
611 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
72 |
214 |
525 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
63 |
185 |
588 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
68 |
200 |
216 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
68 |
202 |
513 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
70 |
206 |
625 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
74 |
219 |
192 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
55 |
161 |
92 |
1 |
Nephropathy |
Minimal |
Scheduled Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
56 |
166 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
58 |
170 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
58 |
171 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
59 |
173 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
59 |
174 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
60 |
176 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
61 |
179 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
61 |
181 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
62 |
184 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
63 |
186 |
728 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
65 |
193 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
66 |
196 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
67 |
198 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
67 |
199 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
69 |
205 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
70 |
208 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
71 |
210 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
72 |
212 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
73 |
216 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
74 |
218 |
729 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
60 |
74 |
220 |
727 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
Transit Epithe |
1000 mg/kg |
60 |
71 |
209 |
578 |
1 |
Hyperplasia |
Mild |
Natural Death |