Alimentary System |
Esophagus |
Epithelium |
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Esophagus |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Cecum |
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Cecum |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Intestine Large |
Cecum |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Colon |
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Erosion |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Large |
Rectum |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Ectasia |
Minimal |
Dosing Accident |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Ectasia |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Ectasia |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Ectasia |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Duodenum, Lymphatic |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Ectasia |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Ectasia |
Marked |
Dosing Accident |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Ectasia |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Ectasia |
Moderate |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Ectasia |
Minimal |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Ectasia |
Mild |
Natural Death |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Ectasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Lymphatic |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Artery |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
40 |
117 |
709 |
Multiple |
Cyst |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Cyst |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Cyst |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Fibrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Fibrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Liver |
Oval Cell |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Periportal |
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Angiectasis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Cholangiofibrosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Cholangiofibrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Cholangiofibrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Cholangiofibrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Cholangiofibrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Degeneration |
Moderate, Cystic |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Hepatodiaphragmatic Nodule |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Hepatodiaphragmatic Nodule |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
3 |
634 |
1 |
Mixed Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Mesentery |
Artery |
Vehicle Control |
2 |
5 |
15 |
685 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Artery |
75 mg/kg |
2 |
29 |
86 |
505 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
2 |
2 |
5 |
727 |
1 |
Necrosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Oral Mucosa |
Sebaceous Gl |
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Ectopic Tissue |
|
Moribund Sacrifice |
Alimentary System |
Oral Mucosa |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Alimentary System |
Oral Mucosa |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Hyperplasia |
Mild, Squamous |
Moribund Sacrifice |
Alimentary System |
Oral Mucosa |
|
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Hyperplasia |
Mild, Squamous |
Natural Death |
Alimentary System |
Oral Mucosa |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Hyperplasia |
Moderate, Squamous |
Terminal Sacrifice |
Alimentary System |
Oral Mucosa |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hyperplasia |
Moderate, Squamous |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Atrophy |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Artery |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Angiectasis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Pancreas |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Thrombosis |
Moderate |
Natural Death |
Alimentary System |
Salivary Glands |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Metaplasia |
Mild |
Natural Death |
Alimentary System |
Salivary Glands |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Erosion |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
1 |
3 |
634 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
21 |
60 |
357 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Ulcer |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Ulcer |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Amyloid Deposition |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Mineralization |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Mineralization |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Mineralization |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Mineralization |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium, Muscularis |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Hyperplasia |
Mild, Focal |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
150 mg/kg |
1 |
42 |
123 |
367 |
1 |
Malformation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
1 |
8 |
24 |
720 |
1 |
Necrosis |
Moderate |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Dilatation |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Blood Vessel |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Mineralization |
Moderate |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Mineralization |
Moderate |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Mineralization |
Moderate |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Thrombosis |
|
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Thrombosis |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Thrombosis |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Thrombosis |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Thrombosis |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
Atrium |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Thrombosis |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Thrombosis |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Epicardium |
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Epicardium |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
Pericardium |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Inflammation |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
12 |
36 |
421 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
1 |
3 |
634 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
11 |
32 |
188 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
5 |
13 |
438 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
21 |
60 |
357 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
25 |
73 |
191 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Cardiomyopathy |
Minimal |
Dosing Accident |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Cardiomyopathy |
Moderate |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Cardiomyopathy |
Moderate |
Natural Death |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Cardiomyopathy |
Moderate |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Degeneration |
Mild, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Degeneration |
Moderate, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Degeneration |
Moderate, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Degeneration |
Moderate, Cystic |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Degeneration |
Moderate, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Degeneration |
Mild, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Degeneration |
Mild, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Degeneration |
Mild, Cystic |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Degeneration |
Mild, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Degeneration |
Mild, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Degeneration |
Moderate, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Degeneration |
Moderate, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Degeneration |
Moderate, Cystic |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Degeneration |
Mild, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Degeneration |
Mild, Cystic |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Degeneration |
Minimal, Cystic |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Degeneration |
Minimal, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Degeneration |
Minimal, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Degeneration |
Minimal, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Degeneration |
Mild, Fatty |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Necrosis |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Necrosis |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Thrombosis |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Angiectasis |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
25 |
73 |
191 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Hyperplasia |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
C Cell |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Hyperplasia |
Marked |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
12 |
36 |
421 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
5 |
13 |
438 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
21 |
60 |
357 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
25 |
73 |
191 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hypertrophy |
Marked |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Hypertrophy |
Moderate |
Dosing Accident |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Hypertrophy |
Marked |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Hypertrophy |
Mild |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Thrombosis |
Mild |
Natural Death |
Genital System |
Epididymis |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Cyst |
Mild |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Cyst |
Mild |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Cyst |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Cyst |
Marked |
Natural Death |
Genital System |
Preputial Gland |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Cyst |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Cyst |
Mild |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Cyst |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Cyst |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Prostate |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Prostate |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Fibrosis |
Minimal |
Natural Death |
Genital System |
Prostate |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Genital System |
Prostate |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Genital System |
Prostate |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Genital System |
Prostate |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Genital System |
Prostate |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Genital System |
Prostate |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Genital System |
Prostate |
|
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Genital System |
Prostate |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Genital System |
Prostate |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Necrosis |
Moderate |
Natural Death |
Genital System |
Seminal Vesicle |
|
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Hypoplasia |
Mild |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Marked, Acute |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Marked, Acute |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Inflammation |
Marked, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Inflammation |
Marked, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Inflammation |
Marked, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Artery |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
Interstit Cell |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Atrophy |
Marked |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Atrophy |
Marked |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Atrophy |
Mild |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Atrophy |
Minimal |
Natural Death |
Genital System |
Testes |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Pigmentation |
Minimal, Hemosiderin |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Hyperplasia |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Bronchial |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Deep Cervical |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Deep Cervical |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Deep Cervical |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Iliac |
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Hematopoietic System |
Lymph Node |
Lumbar |
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Lumbar |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Ectasia |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Ectasia |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mediastinal |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hyperplasia |
Marked, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mediastinal |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Infiltration Cellular |
Moderate, Lipocyte |
Natural Death |
Hematopoietic System |
Lymph Node |
Mediastinal |
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Ectasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Hemorrhage |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hyperplasia |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Ectasia |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Ectasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Ectasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Ectasia |
Minimal |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric, Lymphatic |
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Ectasia |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Pancreatic |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Hemorrhage |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Pancreatic |
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Renal |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Ectasia |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Renal |
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Renal |
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Renal |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Renal |
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hemorrhage |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Renal |
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Angiectasis |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
12 |
36 |
421 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
25 |
73 |
191 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
Epithel Cell |
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
12 |
36 |
421 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
1 |
3 |
634 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
5 |
13 |
438 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
21 |
60 |
357 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Integumentary System |
Mammary Gland |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Integumentary System |
Mammary Gland |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Inflammation |
Moderate |
Natural Death |
Integumentary System |
Skin |
Epidermis |
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Ulcer |
Moderate |
Natural Death |
Integumentary System |
Skin |
Sebaceous Gl |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Cyst Epithelial Inclusion |
|
Natural Death |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Cyst Epithelial Inclusion |
|
Natural Death |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Integumentary System |
Skin |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Cyst Epithelial Inclusion |
|
Natural Death |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Cyst Epithelial Inclusion |
|
Natural Death |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Inflammation |
Minimal |
Natural Death |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
Maxilla |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Fracture |
Mild |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Fibrous Osteodystrophy |
Moderate |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Fibrous Osteodystrophy |
Moderate |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Fibrous Osteodystrophy |
Moderate |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Fibrous Osteodystrophy |
Moderate |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Fibrous Osteodystrophy |
Marked |
Natural Death |
Musculoskeletal System |
Bone |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Fibrous Osteodystrophy |
Marked |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Fibrous Osteodystrophy |
Moderate |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Fibrous Osteodystrophy |
Moderate |
Natural Death |
Nervous System |
Brain |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Nervous System |
Brain |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Gliosis |
Minimal |
Moribund Sacrifice |
Nervous System |
Brain |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Gliosis |
Minimal |
Moribund Sacrifice |
Nervous System |
Brain |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Nervous System |
Brain |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Nervous System |
Spinal Cord |
|
75 mg/kg |
2 |
18 |
53 |
637 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Nervous System |
Spinal Cord |
|
75 mg/kg |
2 |
23 |
66 |
671 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Nervous System |
Spinal Cord |
|
150 mg/kg |
1 |
49 |
143 |
711 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
11 |
31 |
684 |
1 |
Hyperplasia |
Marked |
Natural Death |
Respiratory System |
Lung |
Alveolar Epith |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
15 |
45 |
539 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
4 |
11 |
666 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
6 |
16 |
599 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
1 |
3 |
634 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
11 |
31 |
684 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
11 |
33 |
669 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
4 |
10 |
631 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
5 |
13 |
438 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
5 |
14 |
685 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
7 |
19 |
575 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
7 |
21 |
505 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
9 |
25 |
681 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
10 |
29 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
12 |
34 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
12 |
35 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
13 |
37 |
727 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
13 |
39 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
3 |
7 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
9 |
26 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Dosing Accident |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
49 |
16 |
47 |
726 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Mineralization |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Lung |
Alveolus |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Mineralization |
Moderate |
Natural Death |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Mineralization |
Mild |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Edema |
Moderate |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Edema |
Mild |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
8 |
23 |
645 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
1 |
3 |
634 |
1 |
Hemorrhage |
Minimal, Multifocal |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
10 |
28 |
729 |
1 |
Hemorrhage |
Minimal, Multifocal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Hemorrhage |
Minimal, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Hemorrhage |
Minimal, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Hemorrhage |
Minimal, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Hemorrhage |
Minimal, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Hemorrhage |
Minimal, Multifocal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Hemorrhage |
Minimal, Multifocal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Hemorrhage |
Minimal |
Dosing Accident |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Hemorrhage |
Moderate, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Hemorrhage |
Minimal, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Hemorrhage |
Mild, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Hemorrhage |
Moderate, Multifocal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Hemorrhage |
Minimal, Multifocal |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Hemorrhage |
Minimal, Multifocal |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Hemorrhage |
Mild, Multifocal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
10 |
30 |
685 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
17 |
50 |
444 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
3 |
9 |
689 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
8 |
23 |
645 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
1 |
3 |
634 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
16 |
47 |
726 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
4 |
10 |
631 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
7 |
21 |
505 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
9 |
25 |
681 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
1 |
1 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
10 |
28 |
729 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
12 |
35 |
728 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
13 |
37 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
15 |
43 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
15 |
44 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
2 |
5 |
727 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
3 |
7 |
728 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Moderate, Chronic |
Natural Death |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Inflammation |
Moderate, Chronic |
Natural Death |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Mild, Granulomatous |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Inflammation |
Moderate, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Inflammation |
Moderate, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Inflammation |
Mild, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Inflammation |
Moderate, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Inflammation |
Moderate, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Inflammation |
Mild, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Inflammation |
Mild, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Mineralization |
Marked |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
8 |
24 |
720 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Metaplasia |
Minimal, Squamous |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Foreign Body |
|
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Fungus |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
42 |
123 |
367 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Thrombosis |
Minimal |
Natural Death |
Respiratory System |
Trachea |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Trachea |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Inflammation |
Mild |
Natural Death |
Respiratory System |
Trachea |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Special Senses System |
Ear |
External Ear |
150 mg/kg |
1 |
36 |
105 |
727 |
1 |
Hyperplasia |
Moderate, Squamous |
Terminal Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Antr Chamber |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Antr Chamber |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Antr Chamber |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Inflammation |
Marked, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
11 |
32 |
188 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
5 |
13 |
438 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Inflammation |
Moderate, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
19 |
56 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Inflammation |
Moderate, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Inflammation |
Minimal, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Inflammation |
Mild, Acute |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Inflammation |
Moderate, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Fibrosis |
Moderate |
Natural Death |
Special Senses System |
Eye |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Cataract |
Mild |
Natural Death |
Special Senses System |
Harderian Gland |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Angiectasis |
Mild |
Natural Death |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Pigmentation |
Moderate, Porphyrin |
Terminal Sacrifice |
Special Senses System |
Lacrimal Gland |
|
Vehicle Control |
1 |
8 |
22 |
575 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Special Senses System |
Lacrimal Gland |
|
75 mg/kg |
2 |
29 |
86 |
505 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Special Senses System |
Lacrimal Gland |
|
75 mg/kg |
2 |
34 |
100 |
729 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Special Senses System |
Lacrimal Gland |
|
150 mg/kg |
4 |
35 |
103 |
587 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Special Senses System |
Lacrimal Gland |
|
150 mg/kg |
4 |
36 |
104 |
709 |
1 |
Degeneration |
Mild |
Natural Death |
Special Senses System |
Lacrimal Gland |
|
150 mg/kg |
4 |
44 |
129 |
593 |
1 |
Degeneration |
Mild |
Natural Death |
Special Senses System |
Lacrimal Gland |
|
150 mg/kg |
4 |
43 |
127 |
729 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Dilatation |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Cyst |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Metaplasia, Osseous |
Mild, Osseous |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
30 |
685 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
12 |
36 |
421 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
14 |
41 |
716 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
15 |
45 |
539 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
17 |
50 |
444 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
4 |
197 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
9 |
689 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
11 |
666 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
15 |
685 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
16 |
599 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
17 |
695 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
8 |
22 |
575 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
8 |
23 |
645 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
27 |
693 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
3 |
634 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
11 |
31 |
684 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
11 |
32 |
188 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
11 |
33 |
669 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
16 |
47 |
726 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
17 |
49 |
485 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
8 |
450 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
10 |
631 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
12 |
682 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
13 |
438 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
14 |
685 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
18 |
635 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
19 |
575 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
21 |
505 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
8 |
24 |
720 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
25 |
681 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
1 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
2 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
28 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
29 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
12 |
34 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
12 |
35 |
728 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
13 |
37 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
13 |
38 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
13 |
39 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
14 |
40 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
14 |
42 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
15 |
43 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
15 |
44 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
16 |
46 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
16 |
48 |
729 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
5 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
6 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
7 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
20 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
26 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
18 |
53 |
637 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
19 |
55 |
441 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
20 |
59 |
569 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
21 |
60 |
357 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
21 |
61 |
695 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
21 |
62 |
617 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
23 |
66 |
671 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
23 |
67 |
648 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
23 |
68 |
454 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
24 |
70 |
571 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
24 |
71 |
703 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
25 |
72 |
650 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
25 |
74 |
559 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
26 |
76 |
637 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
26 |
77 |
617 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
28 |
83 |
448 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
29 |
86 |
505 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
30 |
88 |
533 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
30 |
89 |
651 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
31 |
90 |
597 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
31 |
92 |
489 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
32 |
93 |
661 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
32 |
94 |
679 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
18 |
51 |
692 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
19 |
54 |
382 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
20 |
57 |
689 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
20 |
58 |
680 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
25 |
73 |
191 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
26 |
75 |
602 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
27 |
78 |
623 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
27 |
79 |
516 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
29 |
84 |
616 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
29 |
85 |
456 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
30 |
87 |
655 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
32 |
95 |
582 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
33 |
96 |
685 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
33 |
98 |
614 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
18 |
52 |
729 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
22 |
63 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
22 |
64 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
22 |
65 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
24 |
69 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
27 |
80 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
28 |
81 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
28 |
82 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
31 |
91 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
33 |
97 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
34 |
100 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
75 mg/kg |
50 |
34 |
99 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
35 |
101 |
693 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
35 |
103 |
587 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
36 |
106 |
500 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
37 |
107 |
657 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
38 |
111 |
713 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
40 |
117 |
709 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
41 |
119 |
616 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
41 |
121 |
423 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
44 |
128 |
482 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
46 |
134 |
499 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
48 |
141 |
549 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
49 |
143 |
711 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
50 |
146 |
666 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
50 |
148 |
611 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
36 |
104 |
709 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
37 |
108 |
594 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
37 |
109 |
503 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
38 |
110 |
624 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
39 |
114 |
486 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
42 |
124 |
570 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
43 |
125 |
706 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
44 |
129 |
593 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
45 |
131 |
558 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
45 |
132 |
583 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
45 |
133 |
623 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
46 |
136 |
690 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
47 |
137 |
664 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
47 |
138 |
468 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
47 |
139 |
546 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
48 |
140 |
697 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
49 |
145 |
531 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
50 |
147 |
712 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
35 |
102 |
728 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
36 |
105 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
38 |
112 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
39 |
113 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
39 |
115 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
40 |
116 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
40 |
118 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
41 |
120 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
42 |
122 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
43 |
126 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
43 |
127 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
44 |
130 |
728 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
46 |
135 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
48 |
142 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
49 |
144 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
51 |
149 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
150 mg/kg |
50 |
51 |
150 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
61 |
180 |
190 |
1 |
Nephropathy |
Mild |
Dosing Accident |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
151 |
673 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
153 |
629 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
154 |
477 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
156 |
498 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
54 |
157 |
597 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
54 |
159 |
617 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
55 |
160 |
589 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
57 |
166 |
412 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
59 |
173 |
401 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
60 |
176 |
462 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
62 |
182 |
611 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
62 |
183 |
722 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
63 |
184 |
720 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
64 |
187 |
645 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
65 |
191 |
701 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
65 |
192 |
661 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
66 |
193 |
496 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
67 |
196 |
612 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
68 |
200 |
531 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
53 |
155 |
575 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
54 |
158 |
615 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
56 |
165 |
640 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
57 |
167 |
658 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
57 |
168 |
306 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
58 |
169 |
683 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
58 |
170 |
659 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
59 |
172 |
658 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
59 |
174 |
651 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
60 |
175 |
712 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
61 |
178 |
710 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
62 |
181 |
258 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
64 |
189 |
706 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
66 |
194 |
534 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
66 |
195 |
719 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
67 |
197 |
532 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
68 |
199 |
621 |
1 |
Nephropathy |
Marked |
Natural Death |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
52 |
152 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
55 |
161 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
55 |
162 |
727 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
56 |
163 |
727 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
56 |
164 |
728 |
1 |
Nephropathy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
58 |
171 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
60 |
177 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
61 |
179 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
63 |
185 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
63 |
186 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
65 |
190 |
729 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
300 mg/kg |
50 |
67 |
198 |
727 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Hemorrhage |
Mild |
Moribund Sacrifice |
Urinary System |
Urinary Bladder |
|
300 mg/kg |
50 |
64 |
188 |
519 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |