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Chemical Name: | Isobutyl Nitrite |
---|---|
CASRN: | ="542-56-3" |
Study Number: | C61052B |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | INHAL |
TDMS Number: | 0518501.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Hematology Individual Animal Data | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Leukocytes (1000/mL) | Seg Neut | Seg Neut (1000/mL) | Lymph (1000/mL) | Mono (1000/mL) | EOS (1000/mL) | NRBC (1000/uL) |
Week 13 | 0001 | 0 | U | 8.66 | 15.7 | 44.5 | 18.1 | 35.3 | 6.6 | |||||||
Week 13 | 0002 | 0 | U | 7.92 | 15.5 | 40.3 | 51 | 19.6 | 38.5 | 8.3 | 1.2 | 1.4 | 6.7 | 0.2 | 0.1 | 0 |
Week 13 | 0003 | 0 | U | 7.91 | 14.8 | 41.2 | 52 | 18.7 | 36 | 9.5 | 1.7 | 7.5 | 0.3 | 0 | 0 | |
Week 13 | 0004 | 0 | U | 8 | 15.1 | 40.6 | 51 | 18.9 | 37.2 | 7.1 | 0.7 | 6.2 | 0.2 | 0 | 1 | |
Week 13 | 0005 | 0 | U | 8.16 | 15.6 | 41.4 | 51 | 19.1 | 37.7 | 8.6 | 1.7 | 6.5 | 0.3 | 0.1 | 0 | |
Week 13 | 0006 | 0 | U | 7.84 | 15.5 | 43.6 | 56 | 19.8 | 35.6 | 6.1 | 0.7 | 5.1 | 0.2 | 0 | 1 | |
Week 13 | 0007 | 0 | U | 8.29 | 15.8 | 44 | 53 | 19.1 | 35.9 | 6.9 | 1.4 | 5.4 | 0.1 | 0 | 1 | |
Week 13 | 0008 | 0 | U | 8.16 | 16.1 | 42.5 | 52 | 19.7 | 37.9 | 10.9 | 1.3 | 9.2 | 0.4 | 0 | 0 | |
Week 13 | 0009 | 0 | U | 8.47 | 15.7 | 43.5 | 52 | 18.6 | 36.1 | 6.2 | 0.7 | 5.1 | 0.2 | 0.1 | 0 | |
Week 13 | 0010 | 0 | U | 8.55 | 15.7 | 43.2 | 51 | 18.4 | 36.4 | 6 | 1.3 | 4.5 | 0.2 | 0 | 1 | |
Week 13 | 0021 | 10 | 8.34 | 15.4 | 42.8 | 52 | 18.5 | 36 | 7.3 | 0.9 | 6.3 | 0.1 | 0 | 0 | ||
Week 13 | 0022 | 10 | 8.69 | 16.6 | 44.5 | 51 | 19.1 | 37.3 | 9.4 | 1.4 | 7.4 | 0.6 | 0 | 0 | ||
Week 13 | 0023 | 10 | 8.56 | 15.8 | 44.9 | 53 | 18.5 | 35.2 | 7.5 | 0.9 | 5.9 | 0.6 | 0.1 | 0 | ||
Week 13 | 0024 | 10 | 8.04 | 15.2 | 42.3 | 53 | 18.9 | 36 | 8.2 | 1.6 | 6.1 | 0.3 | 0.2 | 0 | ||
Week 13 | 0025 | 10 | 7.6 | 14.2 | 38.9 | 52 | 18.7 | 36.5 | 13.5 | 5.4* | 7.6 | 0.4 | 0.1 | 2 | ||
Week 13 | 0026 | 10 | 8.22 | 15.6 | 41.9 | 51 | 19 | 37.3 | 8.7 | 1.2 | 7.1 | 0.3 | 0.1 | 0 | ||
Week 13 | 0027 | 10 | 8.01 | 15.3 | 41 | 51 | 19.1 | 37.4 | 5.9 | 0.6 | 5.2 | 0.1 | 0.1 | 0 | ||
Week 13 | 0028 | 10 | 8.09 | 15.5 | 43.5 | 54 | 19.2 | 35.6 | 6.8 | 0.9 | 5.5 | 0.3 | 0.1 | 0 | ||
Week 13 | 0029 | 10 | 7.88 | 15.2 | 40.6 | 52 | 19.3 | 37.5 | 6.6 | 0.6 | 5.9 | 0.1 | 0 | 1 | ||
Week 13 | 0030 | 10 | 8.17 | 15.6 | 41.2 | 50 | 19.1 | 37.9 | 7.1 | 1.3 | 5.8 | 0.1 | 0 | 0 | ||
Week 13 | 0041 | 25 | 8.57 | 15.8 | 43.9 | 51 | 18.5 | 36 | 10 | 1.6 | 7.9 | 0.5 | 0 | 0 | ||
Week 13 | 0042 | 25 | 8.08 | 15.5 | 41.7 | 52 | 19.2 | 37.2 | 8.5 | 0.5 | 7.7 | 0.2 | 0.1 | 0 | ||
Week 13 | 0043 | 25 | 8.51 | 15.9 | 42.8 | 50 | 18.7 | 37.2 | 6.6 | 0.6 | 5.7 | 0.2 | 0.1 | 1 | ||
Week 13 | 0044 | 25 | 8.07 | 15.4 | 41.4 | 52 | 19.1 | 37.2 | 7.4 | 1 | 6.2 | 0.2 | 0 | 0 | ||
Week 13 | 0045 | 25 | 7.69 | 15 | 39.9 | 52 | 19.5 | 37.6 | 7.3 | 1.8 | 5.3 | 0.3 | 0 | 0 | ||
Week 13 | 0046 | 25 | 7.76 | 15.6 | 38.5 | 50 | 20.1 | 40.6 | 6.1 | 1.2 | 4.7 | 0.2 | 0.1 | 1 | ||
Week 13 | 0047 | 25 | 8.74 | 16.2 | 44.7 | 51 | 18.6 | 36.2 | 7 | 1.3 | 5.5 | 0.3 | 0 | 0 | ||
Week 13 | 0048 | 25 | 8.74 | 16.1 | 45.1 | 52 | 18.4 | 35.7 | 9.7 | 1.6 | 7.6 | 0.2 | 0.2 | 0 | ||
Week 13 | 0049 | 25 | 7.67 | 14.7 | 41.6 | 54 | 19.2 | 35.4 | 7.2 | 1.8 | 4.8 | 0.4 | 0.2 | 5 | ||
Week 13 | 0050 | 25 | 8.71 | 16.1 | 44 | 51 | 18.5 | 36.6 | 8.7 | 1 | 7.4 | 0.3 | 0.1 | 0 | ||
Week 13 | 0061 | 75 | 8.14 | 14.8 | 42.1 | 52 | 18.2 | 35.2 | 6.9 | 0.9 | 5.7 | 0.2 | 0.1 | 0 | ||
Week 13 | 0062 | 75 | 8.24 | 15.4 | 42.5 | 52 | 18.7 | 36.3 | 8.5 | 1.3 | 7 | 0.3 | 0 | 1 | ||
Week 13 | 0063 | 75 | 7.83 | 14.6 | 41.1 | 53 | 18.7 | 35.5 | 9.6 | 0.9 | 8.3 | 0.5 | 0 | 0 | ||
Week 13 | 0064 | 75 | 7.91 | 14.9 | 41.8 | 53 | 18.8 | 35.6 | 8.5 | 1.8 | 6.2 | 0.4 | 0.1 | 1 | ||
Week 13 | 0065 | 75 | 7.78 | 14.6 | 41.6 | 54 | 18.8 | 35.1 | 10.7 | 1.9 | 8.1 | 0.2 | 0.1 | 1 | ||
Week 13 | 0066 | 75 | 8.05 | 15.2 | 41.1 | 51 | 18.9 | 37 | 7.5 | 1.4 | 5.9 | 0.2 | 0.1 | 2 | ||
Week 13 | 0067 | 75 | 8.12 | 15.1 | 42.7 | 53 | 18.6 | 35.4 | 8.4 | 0.5 | 7.7 | 0.2 | 0 | 0 | ||
Week 13 | 0068 | 75 | 6.71 | 13.6 | 36 | 54 | 20.3 | 37.8 | 9.4 | 1.6 | 7.4 | 0.2 | 0 | 0 | ||
Week 13 | 0069 | 75 | 7.07 | 13.8 | 37.2 | 53 | 19.5 | 37.1 | 12.1 | 5.7* | 4.1 | 0.4 | 0 | 1 | ||
Week 13 | 0070 | 75 | 7.73 | 14.6 | 40.2 | 52 | 18.9 | 36.4 | 9.4 | 1.4 | 7.5 | 0.3 | 0.2 | 2 | ||
Week 13 | 0081 | 150 | 8.07 | 15.5 | 43.7 | 54 | 19.2 | 35.5 | 12 | 2.5 | 8.8 | 0.5 | 0.1 | 0 | ||
Week 13 | 0082 | 150 | 7.77 | 15 | 42 | 54 | 19.3 | 35.7 | 10.3 | 1.2 | 8.5 | 0.5 | 0 | 0 | ||
Week 13 | 0083 | 150 | 7.75 | 14.9 | 41.5 | 54 | 19.3 | 35.9 | 11 | 1.3 | 9.5 | 0.2 | 0 | 0 | ||
Week 13 | 0084 | 150 | 7.66 | 15 | 41.3 | 54 | 19.6 | 36.3 | 9.5 | 1.2 | 8 | 0.3 | 0 | 1 | ||
Week 13 | 0085 | 150 | 7.77 | 15.3 | 42.4 | 55 | 19.7 | 36.1 | 9.8 | 1.9 | 7.2 | 0.8 | 0 | 1 | ||
Week 13 | 0086 | 150 | 7.86 | 15.2 | 43 | 55 | 19.3 | 35.4 | 9.6 | 1.3 | 8.1 | 0.1 | 0.1 | 0 | ||
Week 13 | 0087 | 150 | 7.85 | 15.2 | 42.3 | 54 | 19.4 | 35.9 | 9.7 | 1.4 | 7.9 | 0.4 | 0 | 1 | ||
Week 13 | 0088 | 150 | 7.87 | 15.4 | 42.6 | 54 | 19.6 | 36.2 | 7.3 | 1.7 | 5.5 | 0.1 | 0 | 0 | ||
Week 13 | 0089 | 150 | 8.19 | 15.7 | 43.9 | 54 | 19.2 | 35.8 | 7.3 | 1.5 | 5.6 | 0.2 | 0 | 0 | ||
Week 13 | 0090 | 150 | 7.65 | 15.2 | 40.3 | 53 | 19.9 | 37.8 | 9.8 | 1.3 | 8 | 0.5 | 0 | 3 | ||
Week 13 | 0101 | 300 | 7.75 | 15.8 | 45 | 58 | 20.4 | 35.1 | 9.7 | 0.9 | 8.2 | 0.2 | 0 | 0 | ||
Week 13 | 0102 | 300 | 7.71 | 15.8 | 44.7 | 58 | 20.5 | 35.3 | 11.2 | 1.3 | 9.6 | 0.1 | 0 | 1 | ||
Week 13 | 0103 | 300 | 7.92 | 15.9 | 46.5 | 59 | 20.1 | 34.2 | 11.7 | 1.3 | 10.1 | 0.2 | 0.1 | 0 | ||
Week 13 | 0104 | 300 | 7.96 | 16.8 | 46.6 | 59 | 21.1 | 36 | 10.7 | 1.7 | 8.2 | 0.5 | 0.1 | 3 | ||
Week 13 | 0105 | 300 | 7.78 | 16 | 45.3 | 58 | 20.6 | 35.3 | 11 | 1.8 | 8 | 0.7 | 0.1 | 1 | ||
Week 13 | 0106 | 300 | 7.73 | 15.8 | 44.2 | 57 | 20.5 | 35.8 | 11.7 | 1.8 | 9.5 | 0.4 | 0.1 | 0 | ||
Week 13 | 0107 | 300 | 7.88 | 16.3 | 45.8 | 59 | 20.7 | 35.6 | 8.5 | 0.9 | 7.3 | 0.2 | 0.1 | 1 | ||
Week 13 | 0108 | 300 | 8.07 | 16.7 | 47.3 | 59 | 20.7 | 35.3 | 11.6 | 2.1 | 8.9 | 0.3 | 0.1 | 2 | ||
Week 13 | 0109 | 300 | 7.83 | 16 | 45 | 58 | 20.5 | 35.6 | 10 | 1.7 | 7.6 | 0.2 | 0 | 0 | ||
Week 13 | 0110 | 300 | 7.71 | 15.8 | 44.9 | 58 | 20.5 | 35.2 | 7.8 | 1.1 | 6.6 | 0.2 | 0 | 2 | ||
Abbreviations: | ||||||||||||||||
NA: Not Available, U: Untreated Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Leukocytes: White Blood Cell Count, Seg Neut: Segmented Neutrophil Count, Seg Neut: Segmented Neutrophil Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, NRBC: Nucleated Rbc Count |