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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Isobutyl nitrite |
CASRN: | ="542-56-3" |
Study Number: | C61052B |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | RESPIRATORY EXPOSURE WHOLE BODY |
TDMS Number: | 0518503 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group () |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 176 |
189 |
37.5 |
|
|
|
Day 234 |
413 |
150 |
|
198.7 |
|
Day 316 |
284 |
75 |
|
229.3 |
|
Day 377 |
301 |
75 |
|
201.2 |
|
Day 378 |
180 |
37.5 |
|
392.7 |
|
Day 394 |
407 |
150 |
|
385 |
|
Day 457 |
103 |
0 |
|
292.9 |
|
Day 457 |
104 |
0 |
|
327.3 |
|
Day 457 |
105 |
0 |
|
320.4 |
|
Day 457 |
106 |
0 |
|
315.9 |
|
Day 457 |
107 |
0 |
|
285.6 |
|
Day 457 |
108 |
0 |
|
303.8 |
|
Day 457 |
109 |
0 |
|
307.8 |
|
Day 457 |
110 |
0 |
|
304.1 |
|
Day 457 |
111 |
0 |
|
301 |
|
Day 457 |
112 |
0 |
|
330.7 |
|
Day 457 |
215 |
37.5 |
|
275.6 |
|
Day 457 |
216 |
37.5 |
|
306.4 |
|
Day 457 |
217 |
37.5 |
|
326.9 |
|
Day 457 |
218 |
37.5 |
|
277.4 |
|
Day 457 |
219 |
37.5 |
|
330.7 |
|
Day 457 |
220 |
37.5 |
|
254.7 |
|
Day 457 |
221 |
37.5 |
|
311.3 |
|
Day 457 |
222 |
37.5 |
|
284.3 |
|
Day 457 |
223 |
37.5 |
|
292.7 |
|
Day 457 |
224 |
37.5 |
|
288.4 |
|
Day 457 |
327 |
75 |
|
269.3 |
|
Day 457 |
328 |
75 |
|
278.4 |
|
Day 457 |
329 |
75 |
|
294.2 |
|
Day 457 |
330 |
75 |
|
294.8 |
|
Day 457 |
331 |
75 |
|
303.7 |
|
Day 457 |
332 |
75 |
|
269.2 |
|
Day 457 |
333 |
75 |
|
282.7 |
|
Day 457 |
334 |
75 |
|
274.6 |
|
Day 457 |
335 |
75 |
|
296.7 |
|
Day 457 |
336 |
75 |
|
279.2 |
|
Day 457 |
439 |
150 |
|
267 |
|
Day 457 |
440 |
150 |
|
281.2 |
|
Day 457 |
441 |
150 |
|
293 |
|
Day 457 |
442 |
150 |
|
275.2 |
|
Day 457 |
443 |
150 |
|
283.9 |
|
Day 457 |
444 |
150 |
|
231.7 |
|
Day 457 |
445 |
150 |
|
280.7 |
|
Day 457 |
446 |
150 |
|
258.6 |
|
Day 457 |
447 |
150 |
|
248 |
|
Day 457 |
448 |
150 |
|
245.1 |
|
Day 464 |
99 |
0 |
|
224.2 |
|
Day 477 |
183 |
37.5 |
|
257.8 |
|
Day 483 |
433 |
150 |
|
180 |
|
Day 500 |
419 |
150 |
|
186.3 |
|
Day 504 |
300 |
75 |
|
245.1 |
|
Day 516 |
70 |
0 |
|
133.8 |
|
Day 526 |
85 |
0 |
|
318.2 |
|
Day 533 |
426 |
150 |
|
166.1 |
|
Day 602 |
69 |
0 |
|
242.6 |
|
Day 604 |
82 |
0 |
|
177.7 |
|
Day 604 |
286 |
75 |
|
154.3 |
|
Day 608 |
403 |
150 |
|
254.7 |
|
Day 610 |
314 |
75 |
|
195.5 |
|
Day 617 |
427 |
150 |
|
176.7 |
|
Day 622 |
432 |
150 |
|
230.1 |
|
Day 624 |
190 |
37.5 |
|
262.8 |
|
Day 630 |
428 |
150 |
|
327.1 |
|
Day 636 |
308 |
75 |
|
277.8 |
|
Day 640 |
94 |
0 |
|
235.4 |
|
Day 640 |
96 |
0 |
|
196.1 |
|
Day 641 |
71 |
0 |
|
258.1 |
|
Day 645 |
181 |
37.5 |
|
369.3 |
|
Day 646 |
75 |
0 |
|
193 |
|
Day 647 |
297 |
75 |
|
268.7 |
|
Day 648 |
175 |
37.5 |
|
280.7 |
|
Day 650 |
315 |
75 |
|
209.2 |
|
Day 652 |
62 |
0 |
|
230 |
|
Day 653 |
282 |
75 |
|
376 |
|
Day 658 |
72 |
0 |
|
185 |
|
Day 659 |
173 |
37.5 |
|
205.8 |
|
Day 666 |
97 |
0 |
|
421.9 |
|
Day 668 |
63 |
0 |
|
166.3 |
|
Day 671 |
76 |
0 |
|
209 |
|
Day 672 |
185 |
37.5 |
|
410 |
|
Day 674 |
290 |
75 |
|
190.5 |
|
Day 674 |
414 |
150 |
|
382 |
|
Day 681 |
393 |
150 |
|
278 |
|
Day 686 |
194 |
37.5 |
|
171 |
|
Day 686 |
322 |
75 |
|
268 |
|
Day 696 |
434 |
150 |
|
154.2 |
|
Day 702 |
80 |
0 |
|
182.4 |
|
Day 705 |
316 |
75 |
|
232.9 |
|
Day 705 |
436 |
150 |
|
277.8 |
|
Day 708 |
305 |
75 |
|
233 |
|
Day 720 |
100 |
0 |
|
158.1 |
|
Day 720 |
174 |
37.5 |
|
346.9 |
|
Day 721 |
86 |
0 |
|
298 |
|
Day 726 |
285 |
75 |
|
378.3 |
|
Day 729 |
207 |
37.5 |
|
374.6 |
|
Day 730 |
292 |
75 |
|
266.4 |
|
Day 733 |
102 |
0 |
|
277.8 |
|
Day 733 |
57 |
0 |
|
317.7 |
|
Day 733 |
59 |
0 |
|
344.8 |
|
Day 733 |
60 |
0 |
|
339.7 |
|
Day 733 |
66 |
0 |
|
326 |
|
Day 733 |
84 |
0 |
|
306.5 |
|
Day 733 |
87 |
0 |
|
291.7 |
|
Day 733 |
90 |
0 |
|
283.1 |
|
Day 733 |
93 |
0 |
|
309.9 |
|
Day 733 |
95 |
0 |
|
308.4 |
|
Day 733 |
169 |
37.5 |
|
296.3 |
|
Day 733 |
171 |
37.5 |
|
373.2 |
|
Day 733 |
186 |
37.5 |
|
292.5 |
|
Day 733 |
187 |
37.5 |
|
304 |
|
Day 733 |
188 |
37.5 |
|
233.1 |
|
Day 733 |
191 |
37.5 |
|
304.2 |
|
Day 733 |
195 |
37.5 |
|
343.4 |
|
Day 733 |
196 |
37.5 |
|
320.8 |
|
Day 733 |
200 |
37.5 |
|
292.9 |
|
Day 733 |
204 |
37.5 |
|
348.1 |
|
Day 733 |
205 |
37.5 |
|
292.6 |
|
Day 733 |
213 |
37.5 |
|
259.7 |
|
Day 733 |
283 |
75 |
|
288 |
|
Day 733 |
295 |
75 |
|
270.4 |
|
Day 733 |
299 |
75 |
|
298.3 |
|
Day 733 |
302 |
75 |
|
253.1 |
|
Day 733 |
303 |
75 |
|
321.6 |
|
Day 733 |
306 |
75 |
|
228.1 |
|
Day 733 |
309 |
75 |
|
324 |
|
Day 733 |
321 |
75 |
|
283.9 |
|
Day 733 |
323 |
75 |
|
280.8 |
|
Day 733 |
324 |
75 |
|
250.1 |
|
Day 733 |
396 |
150 |
|
314.1 |
|
Day 733 |
399 |
150 |
|
341.7 |
|
Day 733 |
400 |
150 |
|
327.8 |
|
Day 733 |
401 |
150 |
|
284.4 |
|
Day 733 |
408 |
150 |
|
296.9 |
|
Day 733 |
409 |
150 |
|
319.5 |
|
Day 733 |
418 |
150 |
|
299.6 |
|
Day 733 |
422 |
150 |
|
271.7 |
|
Day 733 |
423 |
150 |
|
293.4 |
|
Day 733 |
430 |
150 |
|
268.2 |
|
Day 733 |
431 |
150 |
|
274.9 |
|
Day 733 |
437 |
150 |
|
278.9 |
|
Day 733 |
438 |
150 |
|
296.6 |
|
Day 734 |
101 |
0 |
|
317.9 |
|
Day 734 |
58 |
0 |
|
216.7 |
|
Day 734 |
61 |
0 |
|
345.3 |
|
Day 734 |
64 |
0 |
|
298.2 |
|
Day 734 |
68 |
0 |
|
294 |
|
Day 734 |
74 |
0 |
|
312.2 |
|
Day 734 |
81 |
0 |
|
338.3 |
|
Day 734 |
88 |
0 |
|
294.7 |
|
Day 734 |
89 |
0 |
|
308.7 |
|
Day 734 |
92 |
0 |
|
234.1 |
|
Day 734 |
170 |
37.5 |
|
296.3 |
|
Day 734 |
176 |
37.5 |
|
248.4 |
|
Day 734 |
177 |
37.5 |
|
287.6 |
|
Day 734 |
178 |
37.5 |
|
365.3 |
|
Day 734 |
182 |
37.5 |
|
318.5 |
|
Day 734 |
184 |
37.5 |
|
334.8 |
|
Day 734 |
197 |
37.5 |
|
268.8 |
|
Day 734 |
198 |
37.5 |
|
324.2 |
|
Day 734 |
203 |
37.5 |
|
314.3 |
|
Day 734 |
206 |
37.5 |
|
290.8 |
|
Day 734 |
209 |
37.5 |
|
298.5 |
|
Day 734 |
211 |
37.5 |
|
264.1 |
|
Day 734 |
212 |
37.5 |
|
245.8 |
|
Day 734 |
287 |
75 |
|
297.5 |
|
Day 734 |
288 |
75 |
|
287.4 |
|
Day 734 |
291 |
75 |
|
299.3 |
|
Day 734 |
293 |
75 |
|
312.4 |
|
Day 734 |
296 |
75 |
|
218 |
|
Day 734 |
304 |
75 |
|
299.2 |
|
Day 734 |
307 |
75 |
|
311.9 |
|
Day 734 |
310 |
75 |
|
339 |
|
Day 734 |
318 |
75 |
|
315.3 |
|
Day 734 |
319 |
75 |
|
355.6 |
|
Day 734 |
320 |
75 |
|
270.5 |
|
Day 734 |
325 |
75 |
|
346.6 |
|
Day 734 |
326 |
75 |
|
332.9 |
|
Day 734 |
394 |
150 |
|
289.4 |
|
Day 734 |
397 |
150 |
|
260.5 |
|
Day 734 |
402 |
150 |
|
259.8 |
|
Day 734 |
404 |
150 |
|
338.3 |
|
Day 734 |
410 |
150 |
|
291.9 |
|
Day 734 |
412 |
150 |
|
322.1 |
|
Day 734 |
420 |
150 |
|
265.7 |
|
Day 734 |
421 |
150 |
|
272.7 |
|
Day 734 |
429 |
150 |
|
340.7 |
|
Day 734 |
435 |
150 |
|
248.6 |
|
Day 735 |
65 |
0 |
|
244.7 |
|
Day 735 |
67 |
0 |
|
353.5 |
|
Day 735 |
73 |
0 |
|
231.5 |
|
Day 735 |
77 |
0 |
|
289.6 |
|
Day 735 |
78 |
0 |
|
279.1 |
|
Day 735 |
79 |
0 |
|
315.6 |
|
Day 735 |
83 |
0 |
|
312.2 |
|
Day 735 |
91 |
0 |
|
282.4 |
|
Day 735 |
98 |
0 |
|
335.7 |
|
Day 735 |
172 |
37.5 |
|
319.1 |
|
Day 735 |
179 |
37.5 |
|
365.2 |
|
Day 735 |
192 |
37.5 |
|
384.1 |
|
Day 735 |
193 |
37.5 |
|
310.8 |
|
Day 735 |
199 |
37.5 |
|
310.3 |
|
Day 735 |
201 |
37.5 |
|
301.7 |
|
Day 735 |
202 |
37.5 |
|
317.2 |
|
Day 735 |
208 |
37.5 |
|
264.7 |
|
Day 735 |
210 |
37.5 |
|
309.9 |
|
Day 735 |
214 |
37.5 |
|
337.5 |
|
Day 735 |
281 |
75 |
|
272.7 |
|
Day 735 |
289 |
75 |
|
311.8 |
|
Day 735 |
294 |
75 |
|
301.8 |
|
Day 735 |
298 |
75 |
|
284.4 |
|
Day 735 |
311 |
75 |
|
311 |
|
Day 735 |
312 |
75 |
|
313.5 |
|
Day 735 |
313 |
75 |
|
299.3 |
|
Day 735 |
317 |
75 |
|
291 |
|
Day 735 |
395 |
150 |
|
282.9 |
|
Day 735 |
398 |
150 |
|
296.9 |
|
Day 735 |
405 |
150 |
|
318 |
|
Day 735 |
406 |
150 |
|
273.6 |
|
Day 735 |
411 |
150 |
|
295.9 |
|
Day 735 |
415 |
150 |
|
306.2 |
|
Day 735 |
416 |
150 |
|
293.4 |
|
Day 735 |
417 |
150 |
|
344.2 |
|
Day 735 |
424 |
150 |
|
302.9 |
|
Day 735 |
425 |
150 |
|
277.3 |
|
Abbreviations: |
NA: Not Available
|