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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Isobutyl nitrite |
CASRN: | ="542-56-3" |
Study Number: | C61052B |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | RESPIRATORY EXPOSURE WHOLE BODY |
TDMS Number: | 0518504 |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight (g) |
Day 65 |
457 |
150 |
|
17 |
Day 71 |
80 |
0 |
|
19.8 |
Day 71 |
460 |
150 |
|
18.6 |
Day 91 |
115 |
0 |
|
17.4 |
Day 114 |
466 |
150 |
|
22.9 |
Day 183 |
240 |
37.5 |
|
19.8 |
Day 210 |
355 |
75 |
|
49.1 |
Day 415 |
331 |
75 |
|
28.4 |
Day 434 |
306 |
75 |
|
35.5 |
Day 458 |
111 |
0 |
|
45.2 |
Day 458 |
112 |
0 |
|
52.8 |
Day 458 |
113 |
0 |
|
49.2 |
Day 458 |
114 |
0 |
|
48.4 |
Day 458 |
116 |
0 |
|
46.8 |
Day 458 |
117 |
0 |
|
37.5 |
Day 458 |
118 |
0 |
|
50.6 |
Day 458 |
119 |
0 |
|
39 |
Day 458 |
120 |
0 |
|
47.3 |
Day 458 |
231 |
37.5 |
|
48.1 |
Day 458 |
232 |
37.5 |
|
44.2 |
Day 458 |
233 |
37.5 |
|
50.7 |
Day 458 |
234 |
37.5 |
|
42.7 |
Day 458 |
235 |
37.5 |
|
33.6 |
Day 458 |
236 |
37.5 |
|
50.5 |
Day 458 |
237 |
37.5 |
|
43.9 |
Day 458 |
238 |
37.5 |
|
35.2 |
Day 458 |
239 |
37.5 |
|
43.9 |
Day 458 |
351 |
75 |
|
38.5 |
Day 458 |
352 |
75 |
|
46 |
Day 458 |
353 |
75 |
|
34.1 |
Day 458 |
354 |
75 |
|
45 |
Day 458 |
356 |
75 |
|
38.4 |
Day 458 |
357 |
75 |
|
45.4 |
Day 458 |
358 |
75 |
|
43.9 |
Day 458 |
359 |
75 |
|
37.2 |
Day 458 |
360 |
75 |
|
53.9 |
Day 458 |
471 |
150 |
|
35.9 |
Day 458 |
472 |
150 |
|
36.9 |
Day 458 |
473 |
150 |
|
31.7 |
Day 458 |
474 |
150 |
|
37.1 |
Day 458 |
475 |
150 |
|
36 |
Day 458 |
476 |
150 |
|
30.2 |
Day 458 |
477 |
150 |
|
31.7 |
Day 458 |
478 |
150 |
|
33.7 |
Day 458 |
479 |
150 |
|
34.3 |
Day 458 |
480 |
150 |
|
32.7 |
Day 460 |
308 |
75 |
|
30 |
Day 485 |
441 |
150 |
|
34.3 |
Day 494 |
426 |
150 |
|
17.6 |
Day 505 |
349 |
75 |
|
28.7 |
Day 512 |
219 |
37.5 |
|
40.4 |
Day 520 |
189 |
37.5 |
|
58.6 |
Day 558 |
319 |
75 |
|
35.2 |
Day 558 |
350 |
75 |
|
29.7 |
Day 572 |
64 |
0 |
|
34.6 |
Day 576 |
90 |
0 |
|
45.5 |
Day 583 |
422 |
150 |
|
30.5 |
Day 585 |
76 |
0 |
|
33.3 |
Day 585 |
335 |
75 |
|
24 |
Day 586 |
218 |
37.5 |
|
33 |
Day 589 |
83 |
0 |
|
32.1 |
Day 595 |
103 |
0 |
|
28.5 |
Day 603 |
440 |
150 |
|
44.7 |
Day 613 |
78 |
0 |
|
45.1 |
Day 614 |
198 |
37.5 |
|
47.8 |
Day 625 |
428 |
150 |
|
20.1 |
Day 628 |
309 |
75 |
|
42.7 |
Day 635 |
95 |
0 |
|
26 |
Day 636 |
327 |
75 |
|
30.2 |
Day 638 |
89 |
0 |
|
24.4 |
Day 639 |
334 |
75 |
|
38.3 |
Day 643 |
109 |
0 |
|
34.6 |
Day 645 |
199 |
37.5 |
|
35.8 |
Day 646 |
468 |
150 |
|
24.2 |
Day 649 |
105 |
0 |
|
37.8 |
Day 660 |
321 |
75 |
|
37.2 |
Day 663 |
317 |
75 |
|
25.2 |
Day 689 |
68 |
0 |
|
44 |
Day 690 |
74 |
0 |
|
25.5 |
Day 691 |
75 |
0 |
|
47.2 |
Day 691 |
82 |
0 |
|
27.2 |
Day 692 |
445 |
150 |
|
47.1 |
Day 696 |
108 |
0 |
|
22.8 |
Day 697 |
183 |
37.5 |
|
35.4 |
Day 706 |
323 |
75 |
|
37.4 |
Day 707 |
194 |
37.5 |
|
45.6 |
Day 709 |
62 |
0 |
|
42 |
Day 709 |
91 |
0 |
|
43.1 |
Day 716 |
462 |
150 |
|
23.8 |
Day 719 |
310 |
75 |
|
47.8 |
Day 721 |
446 |
150 |
|
21.3 |
Day 724 |
435 |
150 |
|
25.7 |
Day 728 |
192 |
37.5 |
|
35.6 |
Day 729 |
101 |
0 |
|
45.5 |
Day 729 |
106 |
0 |
|
49.8 |
Day 729 |
63 |
0 |
|
48.6 |
Day 729 |
66 |
0 |
|
39.3 |
Day 729 |
69 |
0 |
|
43.7 |
Day 729 |
70 |
0 |
|
36.1 |
Day 729 |
71 |
0 |
|
57.7 |
Day 729 |
79 |
0 |
|
48.8 |
Day 729 |
84 |
0 |
|
40.2 |
Day 729 |
85 |
0 |
|
50.6 |
Day 729 |
88 |
0 |
|
58 |
Day 729 |
92 |
0 |
|
47.3 |
Day 729 |
96 |
0 |
|
58 |
Day 729 |
182 |
37.5 |
|
48.3 |
Day 729 |
188 |
37.5 |
|
52.5 |
Day 729 |
191 |
37.5 |
|
42.7 |
Day 729 |
195 |
37.5 |
|
47.2 |
Day 729 |
200 |
37.5 |
|
40.5 |
Day 729 |
202 |
37.5 |
|
39.1 |
Day 729 |
206 |
37.5 |
|
42.8 |
Day 729 |
207 |
37.5 |
|
33.3 |
Day 729 |
209 |
37.5 |
|
46.8 |
Day 729 |
210 |
37.5 |
|
44.8 |
Day 729 |
212 |
37.5 |
|
41.3 |
Day 729 |
213 |
37.5 |
|
41.7 |
Day 729 |
216 |
37.5 |
|
48.6 |
Day 729 |
220 |
37.5 |
|
45.5 |
Day 729 |
225 |
37.5 |
|
42.1 |
Day 729 |
226 |
37.5 |
|
61.4 |
Day 729 |
228 |
37.5 |
|
47.5 |
Day 729 |
229 |
37.5 |
|
51.8 |
Day 729 |
230 |
37.5 |
|
35.8 |
Day 729 |
301 |
75 |
|
43.4 |
Day 729 |
302 |
75 |
|
38.7 |
Day 729 |
305 |
75 |
|
51.7 |
Day 729 |
314 |
75 |
|
37.2 |
Day 729 |
316 |
75 |
|
46.4 |
Day 729 |
322 |
75 |
|
42.2 |
Day 729 |
329 |
75 |
|
42 |
Day 729 |
339 |
75 |
|
38.8 |
Day 729 |
340 |
75 |
|
50.5 |
Day 729 |
341 |
75 |
|
46.8 |
Day 729 |
342 |
75 |
|
55 |
Day 729 |
344 |
75 |
|
45.5 |
Day 729 |
345 |
75 |
|
53.9 |
Day 729 |
346 |
75 |
|
49.7 |
Day 729 |
348 |
75 |
|
51.7 |
Day 729 |
421 |
150 |
|
42.7 |
Day 729 |
423 |
150 |
|
33.5 |
Day 729 |
424 |
150 |
|
47.1 |
Day 729 |
427 |
150 |
|
39.2 |
Day 729 |
430 |
150 |
|
29.5 |
Day 729 |
432 |
150 |
|
35.8 |
Day 729 |
433 |
150 |
|
44.7 |
Day 729 |
434 |
150 |
|
21.3 |
Day 729 |
437 |
150 |
|
37.9 |
Day 729 |
439 |
150 |
|
33.9 |
Day 729 |
442 |
150 |
|
25.9 |
Day 729 |
450 |
150 |
|
34.6 |
Day 729 |
453 |
150 |
|
18.1 |
Day 729 |
456 |
150 |
|
48.8 |
Day 729 |
459 |
150 |
|
36.2 |
Day 729 |
463 |
150 |
|
34.2 |
Day 729 |
464 |
150 |
|
38.6 |
Day 729 |
465 |
150 |
|
50.9 |
Day 729 |
467 |
150 |
|
35 |
Day 729 |
469 |
150 |
|
35.4 |
Day 730 |
104 |
0 |
|
39.7 |
Day 730 |
107 |
0 |
|
52.5 |
Day 730 |
67 |
0 |
|
46.1 |
Day 730 |
81 |
0 |
|
46.3 |
Day 730 |
86 |
0 |
|
40.6 |
Day 730 |
93 |
0 |
|
48 |
Day 730 |
94 |
0 |
|
53.4 |
Day 730 |
97 |
0 |
|
31.5 |
Day 730 |
98 |
0 |
|
48.4 |
Day 730 |
99 |
0 |
|
45.2 |
Day 730 |
184 |
37.5 |
|
52.9 |
Day 730 |
193 |
37.5 |
|
35.2 |
Day 730 |
196 |
37.5 |
|
60.3 |
Day 730 |
197 |
37.5 |
|
50.7 |
Day 730 |
203 |
37.5 |
|
45.2 |
Day 730 |
205 |
37.5 |
|
41 |
Day 730 |
208 |
37.5 |
|
53.7 |
Day 730 |
215 |
37.5 |
|
37.2 |
Day 730 |
217 |
37.5 |
|
49.9 |
Day 730 |
221 |
37.5 |
|
53.3 |
Day 730 |
222 |
37.5 |
|
37.2 |
Day 730 |
223 |
37.5 |
|
51.1 |
Day 730 |
227 |
37.5 |
|
41.2 |
Day 730 |
303 |
75 |
|
63.7 |
Day 730 |
312 |
75 |
|
51.8 |
Day 730 |
313 |
75 |
|
47.4 |
Day 730 |
315 |
75 |
|
57.5 |
Day 730 |
318 |
75 |
|
55.2 |
Day 730 |
320 |
75 |
|
52.9 |
Day 730 |
324 |
75 |
|
58.9 |
Day 730 |
325 |
75 |
|
43.8 |
Day 730 |
326 |
75 |
|
52.1 |
Day 730 |
328 |
75 |
|
35.7 |
Day 730 |
332 |
75 |
|
38.8 |
Day 730 |
333 |
75 |
|
47.7 |
Day 730 |
336 |
75 |
|
47 |
Day 730 |
338 |
75 |
|
55.2 |
Day 730 |
343 |
75 |
|
33 |
Day 730 |
347 |
75 |
|
59.1 |
Day 730 |
425 |
150 |
|
32.8 |
Day 730 |
429 |
150 |
|
41.7 |
Day 730 |
431 |
150 |
|
24.8 |
Day 730 |
436 |
150 |
|
37.3 |
Day 730 |
438 |
150 |
|
37 |
Day 730 |
448 |
150 |
|
41.8 |
Day 730 |
449 |
150 |
|
35.2 |
Day 730 |
451 |
150 |
|
36.4 |
Day 730 |
452 |
150 |
|
58.5 |
Day 730 |
454 |
150 |
|
40.8 |
Day 730 |
470 |
150 |
|
40.8 |
Day 731 |
100 |
0 |
|
39.3 |
Day 731 |
102 |
0 |
|
52.4 |
Day 731 |
110 |
0 |
|
42.2 |
Day 731 |
61 |
0 |
|
42.7 |
Day 731 |
65 |
0 |
|
26.1 |
Day 731 |
72 |
0 |
|
36.3 |
Day 731 |
73 |
0 |
|
64.7 |
Day 731 |
77 |
0 |
|
57.8 |
Day 731 |
87 |
0 |
|
45.4 |
Day 731 |
181 |
37.5 |
|
41.9 |
Day 731 |
185 |
37.5 |
|
61.9 |
Day 731 |
186 |
37.5 |
|
47 |
Day 731 |
187 |
37.5 |
|
53.9 |
Day 731 |
190 |
37.5 |
|
41.7 |
Day 731 |
201 |
37.5 |
|
45.7 |
Day 731 |
204 |
37.5 |
|
48.4 |
Day 731 |
211 |
37.5 |
|
48.6 |
Day 731 |
214 |
37.5 |
|
35.3 |
Day 731 |
224 |
37.5 |
|
44.7 |
Day 731 |
304 |
75 |
|
49.6 |
Day 731 |
307 |
75 |
|
36.3 |
Day 731 |
311 |
75 |
|
62.2 |
Day 731 |
330 |
75 |
|
40.3 |
Day 731 |
337 |
75 |
|
41.9 |
Day 731 |
443 |
150 |
|
53 |
Day 731 |
444 |
150 |
|
34.9 |
Day 731 |
447 |
150 |
|
35.9 |
Day 731 |
455 |
150 |
|
43.2 |
Day 731 |
458 |
150 |
|
52.5 |
Day 731 |
461 |
150 |
|
42.1 |
Abbreviations: |
NA: Not Available
|