If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Chemical Name: | Kava Kava Extract |
---|---|
CASRN: | ="9000-38-8" |
Study Number: | C20007 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | GAV |
TDMS Number: | 2000799.ss |
Sex: | Female |
Strain and Species: | Fischer 344 Rats |
Hematology Individual Animal Data | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (g/kg) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Retics (million/uL) | Retics (%) | Platelet (1000/mL) | Leukocytes (1000/mL) | Neut (1000/mL) | Neut (%) | Lymph (1000/mL) | Lymph (%) | Mono (1000/mL) | Mono (%) | EOS (1000/mL) | EOS (%) | Basophils (1000/mL) | Baso (%) | LUC (1000/mL) | LUC (%) |
Day 23 | 0241 | 0 | V | 8.02 | 14.6 | 46.6 | 58.2 | 18.3 | 31.4 | 156.00 | 1.9 | 849 | 11.60 | 0.93 | 8.0 | 10.31 | 88.8 | 0.18 | 1.6 | 0.06 | 0.5 | 0.06 | 0.5 | 0.07 | 0.6 |
Day 23 | 0242 | 0 | V | 8.40 | 15.3 | 49.4 | 58.8 | 18.2 | 31.0 | 156.20 | 1.9 | 816 | 13.19 | 1.27 | 9.6 | 11.40 | 86.4 | 0.26 | 2.0 | 0.11 | 0.8 | 0.04 | 0.3 | 0.12 | 0.9 |
Day 23 | 0243 | 0 | V | 8.12 | 14.7 | 48.7 | 59.9 | 18.1 | 30.3 | 147.40 | 1.8 | 858 | 10.02 | 0.74 | 7.4 | 9.07 | 90.5 | 0.11 | 1.1 | 0.03 | 0.3 | 0.03 | 0.3 | 0.05 | 0.5 |
Day 23 | 0244 | 0 | V | 8.33 | 15.0 | 49.2 | 59.1 | 18.0 | 30.4 | 167.90 | 2.0 | 886 | 10.70 | 0.62 | 5.8 | 9.72 | 90.8 | 0.17 | 1.6 | 0.05 | 0.4 | 0.05 | 0.5 | 0.09 | 0.8 |
Day 23 | 0246 | 0 | V | 7.83 | 14.6 | 46.4 | 59.2 | 18.7 | 31.5 | 147.30 | 1.9 | 884 | 8.11 | 0.80 | 9.9 | 7.03 | 86.8 | 0.10 | 1.2 | 0.11 | 1.3 | 0.03 | 0.4 | 0.04 | 0.5 |
Day 23 | 0248 | 0 | V | 8.17 | 15.0 | 48.4 | 59.3 | 18.4 | 31.1 | 179.70 | 2.2 | 818 | 8.96 | 0.63 | 7.0 | 7.96 | 88.9 | 0.20 | 2.2 | 0.06 | 0.6 | 0.04 | 0.5 | 0.07 | 0.8 |
Day 23 | 0249 | 0 | V | 8.10 | 14.9 | 49.3 | 60.8 | 18.4 | 30.3 | 154.30 | 1.9 | 914 | 10.31 | 0.83 | 8.0 | 9.22 | 89.4 | 0.15 | 1.4 | 0.04 | 0.4 | 0.03 | 0.3 | 0.05 | 0.5 |
Day 23 | 0251 | 0.125 | 8.00 | 14.7 | 46.9 | 58.7 | 18.4 | 31.3 | 138.90 | 1.7 | 947 | 9.15 | 0.57 | 6.2 | 8.29 | 90.6 | 0.13 | 1.4 | 0.06 | 0.6 | 0.04 | 0.4 | 0.07 | 0.7 | |
Day 23 | 0252 | 0.125 | 8.33 | 15.0 | 49.4 | 59.4 | 18.0 | 30.4 | 171.60 | 2.1 | 843 | 10.88 | 0.66 | 6.1 | 9.75 | 89.6 | 0.31 | 2.9 | 0.04 | 0.4 | 0.04 | 0.4 | 0.07 | 0.6 | |
Day 23 | 0253 | 0.125 | 7.78 | 14.4 | 45.6 | 58.6 | 18.5 | 31.6 | 148.60 | 1.9 | 939 | 10.77 | 0.82 | 7.6 | 9.62 | 89.3 | 0.12 | 1.1 | 0.08 | 0.7 | 0.05 | 0.5 | 0.08 | 0.8 | |
Day 23 | 0254 | 0.125 | 8.02 | 14.4 | 47.5 | 59.3 | 17.9 | 30.2 | 161.60 | 2.0 | 840 | 9.05 | 0.68 | 7.5 | 8.13 | 89.8 | 0.12 | 1.4 | 0.06 | 0.6 | 0.02 | 0.2 | 0.04 | 0.5 | |
Day 23 | 0255 | 0.125 | 7.92 | 14.9 | 47.6 | 60.1 | 18.8 | 31.3 | 140.40 | 1.8 | 859 | 11.42 | 0.76 | 6.6 | 10.17 | 89.0 | 0.29 | 2.6 | 0.06 | 0.5 | 0.05 | 0.4 | 0.09 | 0.8 | |
Day 23 | 0256 | 0.125 | 8.56 | 15.5 | 50.9 | 59.4 | 18.1 | 30.5 | 152.40 | 1.8 | 814 | 7.70 | 0.53 | 6.9 | 6.98 | 90.6 | 0.09 | 1.2 | 0.04 | 0.5 | 0.02 | 0.3 | 0.04 | 0.5 | |
Day 23 | 0257 | 0.125 | 8.02 | 14.6 | 47.9 | 59.8 | 18.3 | 30.6 | 152.40 | 1.9 | 851 | 9.28 | 0.79 | 8.5 | 8.14 | 87.7 | 0.16 | 1.7 | 0.05 | 0.5 | 0.05 | 0.6 | 0.08 | 0.9 | |
Day 23 | 0258 | 0.125 | 7.81 | 14.8 | 45.4 | 58.1 | 18.9 | 32.6 | 151.90 | 1.9 | 671 | 6.97 | 0.84 | 12.0 | 5.77 | 82.7 | 0.12 | 1.8 | 0.17 | 2.4 | 0.02 | 0.3 | 0.05 | 0.8 | |
Day 23 | 0259 | 0.125 | 8.92 | 16.1 | 53.6 | 60.1 | 18.0 | 30.0 | 155.70 | 1.7 | 903 | 7.06 | 0.47 | 6.7 | 6.38 | 90.3 | 0.10 | 1.4 | 0.05 | 0.7 | 0.02 | 0.2 | 0.04 | 0.6 | |
Day 23 | 0260 | 0.125 | 8.71 | 15.7 | 50.9 | 58.5 | 18.0 | 30.8 | 155.30 | 1.8 | 794 | 12.03 | 1.24 | 10.3 | 10.25 | 85.2 | 0.23 | 1.9 | 0.15 | 1.3 | 0.08 | 0.7 | 0.09 | 0.7 | |
Day 23 | 0261 | 0.25 | 7.92 | 14.6 | 47.7 | 60.2 | 18.5 | 30.7 | 165.40 | 2.1 | 950 | 10.46 | 0.68 | 6.5 | 9.43 | 90.2 | 0.19 | 1.8 | 0.05 | 0.5 | 0.03 | 0.3 | 0.07 | 0.7 | |
Day 23 | 0262 | 0.25 | 7.98 | 14.7 | 45.6 | 57.1 | 18.4 | 32.3 | 145.20 | 1.8 | 827 | 7.28 | 0.46 | 6.3 | 6.50 | 89.3 | 0.20 | 2.8 | 0.05 | 0.7 | 0.02 | 0.2 | 0.04 | 0.6 | |
Day 23 | 0263 | 0.25 | 8.20 | 14.9 | 48.9 | 59.6 | 18.2 | 30.5 | 184.50 | 2.2 | 960 | 9.73 | 1.02 | 10.4 | 8.35 | 85.8 | 0.25 | 2.6 | 0.04 | 0.4 | 0.04 | 0.4 | 0.03 | 0.3 | |
Day 23 | 0264 | 0.25 | 8.22 | 15.2 | 48.5 | 59.0 | 18.5 | 31.3 | 137.90 | 1.7 | 926 | 8.36 | 0.52 | 6.3 | 7.56 | 90.4 | 0.14 | 1.7 | 0.08 | 0.9 | 0.02 | 0.2 | 0.04 | 0.5 | |
Day 23 | 0265 | 0.25 | 8.18 | 14.9 | 47.1 | 57.6 | 18.3 | 31.7 | 170.00 | 2.1 | 751 | 5.68 | 0.39 | 6.8 | 5.16 | 90.9 | 0.05 | 0.9 | 0.04 | 0.7 | 0.01 | 0.2 | 0.03 | 0.5 | |
Day 23 | 0266 | 0.25 | 8.36 | 15.5 | 50.2 | 60.1 | 18.6 | 30.9 | 175.90 | 2.1 | 857 | 11.36 | 0.95 | 8.4 | 9.97 | 87.8 | 0.26 | 2.3 | 0.05 | 0.4 | 0.04 | 0.4 | 0.09 | 0.8 | |
Day 23 | 0267 | 0.25 | 8.30 | 15.1 | 49.6 | 59.8 | 18.1 | 30.3 | 155.40 | 1.9 | 861 | 9.22 | 0.75 | 8.1 | 8.20 | 89.0 | 0.12 | 1.4 | 0.05 | 0.5 | 0.04 | 0.4 | 0.06 | 0.7 | |
Day 23 | 0268 | 0.25 | 8.16 | 14.7 | 48.6 | 59.6 | 18.0 | 30.3 | 167.70 | 2.1 | 813 | 12.22 | 1.20 | 9.8 | 10.61 | 86.9 | 0.23 | 1.9 | 0.05 | 0.4 | 0.04 | 0.3 | 0.08 | 0.6 | |
Day 23 | 0269 | 0.25 | 7.85 | 14.5 | 47.6 | 60.6 | 18.5 | 30.5 | 153.70 | 2.0 | 849 | 7.47 | 0.65 | 8.7 | 6.60 | 88.4 | 0.12 | 1.6 | 0.05 | 0.7 | 0.01 | 0.1 | 0.03 | 0.4 | |
Day 23 | 0270 | 0.25 | 8.08 | 14.9 | 49.0 | 60.6 | 18.4 | 30.3 | 161.80 | 2.0 | 980 | 10.54 | 0.90 | 8.5 | 9.34 | 88.6 | 0.18 | 1.7 | 0.04 | 0.4 | 0.03 | 0.3 | 0.06 | 0.5 | |
Day 23 | 0272 | 0.5 | 8.15 | 15.0 | 49.2 | 60.3 | 18.4 | 30.6 | 165.10 | 2.0 | 837 | 9.64 | 0.95 | 9.8 | 8.43 | 87.4 | 0.15 | 1.5 | 0.04 | 0.4 | 0.03 | 0.3 | 0.05 | 0.5 | |
Day 23 | 0273 | 0.5 | 8.49 | 15.5 | 50.6 | 59.7 | 18.3 | 30.7 | 158.40 | 1.9 | 848 | 10.45 | 0.75 | 7.2 | 9.38 | 89.7 | 0.15 | 1.5 | 0.06 | 0.6 | 0.03 | 0.3 | 0.07 | 0.7 | |
Day 23 | 0274 | 0.5 | 8.08 | 15.0 | 48.8 | 60.4 | 18.5 | 30.6 | 152.80 | 1.9 | 773 | 8.26 | 0.78 | 9.5 | 7.21 | 87.3 | 0.15 | 1.8 | 0.04 | 0.4 | 0.03 | 0.3 | 0.05 | 0.7 | |
Day 23 | 0275 | 0.5 | 8.39 | 15.4 | 49.4 | 58.9 | 18.4 | 31.2 | 156.00 | 1.9 | 981 | 4.92 | 0.66 | 13.4 | 4.04 | 82.1 | 0.05 | 1.1 | 0.14 | 2.9 | 0.01 | 0.2 | 0.02 | 0.3 | |
Day 23 | 0276 | 0.5 | 8.28 | 15.1 | 49.4 | 59.6 | 18.3 | 30.6 | 137.70 | 1.7 | 905 | 10.17 | 0.73 | 7.2 | 9.13 | 89.8 | 0.17 | 1.6 | 0.05 | 0.5 | 0.04 | 0.4 | 0.05 | 0.5 | |
Day 23 | 0277 | 0.5 | 8.39 | 15.3 | 49.7 | 59.2 | 18.3 | 30.9 | 159.30 | 1.9 | 744 | 11.36 | 1.47 | 12.9 | 9.49 | 83.6 | 0.19 | 1.7 | 0.10 | 0.9 | 0.04 | 0.3 | 0.07 | 0.6 | |
Day 23 | 0278 | 0.5 | 8.17 | 15.1 | 47.6 | 58.3 | 18.5 | 31.7 | 162.90 | 2.0 | 958 | 11.46 | 1.23 | 10.7 | 9.78 | 85.3 | 0.27 | 2.3 | 0.08 | 0.7 | 0.03 | 0.3 | 0.08 | 0.7 | |
Day 23 | 0279 | 0.5 | 8.56 | 15.2 | 49.2 | 57.4 | 17.7 | 30.9 | 172.10 | 2.0 | 754 | 7.69 | 0.49 | 6.3 | 7.02 | 91.3 | 0.11 | 1.4 | 0.02 | 0.3 | 0.01 | 0.1 | 0.04 | 0.5 | |
Day 23 | 0280 | 0.5 | 8.15 | 15.0 | 47.3 | 58.0 | 18.4 | 31.8 | 133.60 | 1.6 | 803 | 11.30 | 1.04 | 9.2 | 9.82 | 86.9 | 0.19 | 1.7 | 0.11 | 1.0 | 0.07 | 0.7 | 0.06 | 0.6 | |
Day 23 | 0281 | 1.0 | 8.29 | 15.5 | 49.7 | 60.0 | 18.7 | 31.2 | 167.20 | 2.0 | 874 | 11.77 | 1.23 | 10.5 | 10.16 | 86.3 | 0.20 | 1.7 | 0.06 | 0.5 | 0.04 | 0.4 | 0.08 | 0.7 | |
Day 23 | 0282 | 1.0 | 8.34 | 15.3 | 50.3 | 60.3 | 18.4 | 30.5 | 184.40 | 2.2 | 897 | 10.33 | 0.80 | 7.7 | 9.20 | 89.1 | 0.21 | 2.0 | 0.04 | 0.4 | 0.03 | 0.3 | 0.05 | 0.5 | |
Day 23 | 0283 | 1.0 | 8.23 | 14.9 | 49.7 | 60.3 | 18.1 | 30.0 | 182.40 | 2.2 | 757 | 8.59 | 1.02 | 11.9 | 7.21 | 83.9 | 0.20 | 2.3 | 0.08 | 0.9 | 0.03 | 0.3 | 0.06 | 0.7 | |
Day 23 | 0284 | 1.0 | 8.82 | 16.2 | 52.9 | 60.0 | 18.3 | 30.5 | 146.70 | 1.7 | 827 | 11.67 | 1.16 | 10.0 | 10.06 | 86.2 | 0.26 | 2.2 | 0.08 | 0.7 | 0.05 | 0.5 | 0.06 | 0.5 | |
Day 23 | 0285 | 1.0 | 8.24 | 15.0 | 48.9 | 59.4 | 18.2 | 30.6 | 182.40 | 2.2 | 887 | 11.19 | 1.12 | 10.0 | 9.57 | 85.5 | 0.29 | 2.6 | 0.07 | 0.7 | 0.05 | 0.5 | 0.09 | 0.8 | |
Day 23 | 0286 | 1.0 | 7.84 | 14.4 | 45.6 | 58.2 | 18.4 | 31.7 | 164.10 | 2.1 | 830 | 8.38 | 0.97 | 11.6 | 7.02 | 83.7 | 0.27 | 3.2 | 0.04 | 0.5 | 0.03 | 0.3 | 0.06 | 0.7 | |
Day 23 | 0287 | 1.0 | 7.70 | 14.1 | 45.6 | 59.3 | 18.3 | 30.8 | 162.70 | 2.1 | 809 | 10.17 | 0.76 | 7.4 | 9.12 | 89.7 | 0.13 | 1.3 | 0.05 | 0.5 | 0.04 | 0.4 | 0.07 | 0.7 | |
Day 23 | 0288 | 1.0 | 8.16 | 15.0 | 49.3 | 60.3 | 18.4 | 30.5 | 155.20 | 1.9 | 786 | 11.48 | 1.04 | 9.1 | 10.06 | 87.7 | 0.20 | 1.7 | 0.04 | 0.4 | 0.06 | 0.5 | 0.07 | 0.6 | |
Day 23 | 0289 | 1.0 | 8.50 | 15.7 | 50.9 | 59.9 | 18.4 | 30.8 | 151.00 | 1.8 | 865 | 11.64 | 1.02 | 8.8 | 10.19 | 87.5 | 0.27 | 2.3 | 0.03 | 0.3 | 0.03 | 0.3 | 0.10 | 0.8 | |
Day 23 | 0290 | 1.0 | 8.12 | 14.9 | 47.2 | 58.2 | 18.4 | 31.6 | 174.90 | 2.2 | 768 | 11.12 | 1.07 | 9.6 | 9.54 | 85.9 | 0.30 | 2.7 | 0.06 | 0.6 | 0.03 | 0.3 | 0.11 | 1.0 | |
Day 23 | 0291 | 2.0 | 8.11 | 14.7 | 48.4 | 59.6 | 18.2 | 30.5 | 183.30 | 2.3 | 931 | 9.47 | 0.75 | 7.9 | 8.40 | 88.7 | 0.17 | 1.8 | 0.04 | 0.4 | 0.03 | 0.3 | 0.08 | 0.9 | |
Day 23 | 0292 | 2.0 | 8.26 | 14.7 | 48.2 | 58.4 | 17.8 | 30.5 | 182.60 | 2.2 | 878 | 10.76 | 1.14 | 10.6 | 9.22 | 85.7 | 0.24 | 2.2 | 0.05 | 0.5 | 0.03 | 0.3 | 0.08 | 0.7 | |
Day 23 | 0293 | 2.0 | 8.66 | 15.3 | 51.4 | 59.4 | 17.7 | 29.8 | 212.30 | 2.5 | 956 | 7.30 | 0.68 | 9.3 | 6.45 | 88.4 | 0.10 | 1.4 | 0.01 | 0.2 | 0.02 | 0.2 | 0.04 | 0.6 | |
Day 23 | 0294 | 2.0 | 8.74 | 16.2 | 53.5 | 61.2 | 18.5 | 30.2 | 146.10 | 1.7 | 731 | 9.99 | 1.21 | 12.1 | 8.40 | 84.0 | 0.27 | 2.7 | 0.03 | 0.3 | 0.02 | 0.2 | 0.07 | 0.7 | |
Day 23 | 0295 | 2.0 | 8.42 | 14.9 | 49.5 | 58.7 | 17.7 | 30.2 | 196.20 | 2.3 | 849 | 8.99 | 0.83 | 9.3 | 7.79 | 86.6 | 0.24 | 2.6 | 0.06 | 0.7 | 0.03 | 0.3 | 0.05 | 0.5 | |
Day 23 | 0296 | 2.0 | 8.24 | 14.4 | 48.1 | 58.4 | 17.5 | 30.0 | 206.40 | 2.5 | 784 | 10.50 | 0.93 | 8.9 | 9.08 | 86.4 | 0.33 | 3.2 | 0.05 | 0.4 | 0.03 | 0.3 | 0.08 | 0.8 | |
Day 23 | 0297 | 2.0 | 8.11 | 14.5 | 48.9 | 60.3 | 17.8 | 29.6 | 225.20 | 2.8 | 630 | 7.20 | 0.91 | 12.6 | 5.96 | 82.8 | 0.21 | 3.0 | 0.05 | 0.7 | 0.02 | 0.3 | 0.04 | 0.6 | |
Day 23 | 0298 | 2.0 | 8.41 | 15.0 | 50.0 | 59.4 | 17.8 | 30.0 | 256.70 | 3.1 | 816 | 10.00 | 1.11 | 11.1 | 8.45 | 84.5 | 0.30 | 3.0 | 0.05 | 0.5 | 0.03 | 0.3 | 0.06 | 0.6 | |
Day 23 | 0299 | 2.0 | 8.73 | 15.5 | 51.7 | 59.2 | 17.7 | 29.9 | 212.30 | 2.4 | 909 | 11.08 | 1.03 | 9.3 | 9.65 | 87.0 | 0.21 | 1.9 | 0.06 | 0.6 | 0.05 | 0.5 | 0.08 | 0.8 | |
Day 23 | 0300 | 2.0 | 8.64 | 15.2 | 51.8 | 60.0 | 17.6 | 29.3 | 299.50 | 3.5 | 913 | 8.60 | 1.04 | 12.1 | 7.06 | 82.1 | 0.31 | 3.6 | 0.09 | 1.0 | 0.05 | 0.6 | 0.06 | 0.7 | |
Abbreviations: | |||||||||||||||||||||||||
NA: Not Available, V: Vehicle Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Retics: Reticulocyte Percentage, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Neut: Neutrophil Count, Neut: Neutrophil Percentage, Lymph: Lymphocyte Count, Lymph: Lymphocyte Percentage, Mono: Monocyte Count, Mono: Monocyte Percentage, EOS: Eosinophil Count, EOS: Eosinophil Percentage, Basophils: Basophil Count, Baso: Basophil Percentage, LUC: Large Unstained Cells Count, LUC: Large Unstained Cells Percentage |