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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Kava kava extract |
CASRN: | ="9000-38-8" |
Study Number: | C20007 |
Exposure Route: | GAVAGE |
TDMS Number: | 2000702 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
5 |
52 |
52 |
18 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
5 |
54 |
54 |
18 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
5 |
55 |
55 |
18 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
5 |
51 |
51 |
2 |
1 |
Depletion Glycogen |
Marked |
Moribund Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
5 |
53 |
53 |
3 |
1 |
Depletion Glycogen |
Marked |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
3 |
3 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
4 |
4 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
5 |
5 |
5 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
5 |
41 |
41 |
18 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
5 |
42 |
42 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
5 |
44 |
44 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
5 |
53 |
53 |
3 |
1 |
Inflammation |
Minimal, Chronic |
Natural Death |
Alimentary System |
Liver |
|
2.0 G/KG |
5 |
54 |
54 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
5 |
55 |
55 |
18 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
Cortex, Renal Tubule |
2.0 G/KG |
5 |
52 |
52 |
18 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |