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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Kava kava extract |
CASRN: | ="9000-38-8" |
Study Number: | C20007 |
Exposure Route: | GAVAGE |
TDMS Number: | 2000703 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
Hepatocyte |
0.5 G/KG |
10 |
20 |
100 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.5 G/KG |
10 |
20 |
98 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.5 G/KG |
10 |
20 |
99 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.0 G/KG |
10 |
21 |
104 |
32 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1.0 G/KG |
10 |
22 |
109 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.0 G/KG |
10 |
22 |
110 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
23 |
113 |
4 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
24 |
116 |
44 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
24 |
117 |
2 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
24 |
118 |
4 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
23 |
111 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
23 |
112 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
23 |
114 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
23 |
115 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
24 |
119 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.0 G/KG |
10 |
24 |
120 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
21 |
104 |
32 |
1 |
Congestion |
Mild |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
16 |
77 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
93 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
66 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
67 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
15 |
71 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
15 |
72 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
15 |
74 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
15 |
75 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
16 |
77 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
16 |
78 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
16 |
79 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
16 |
80 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
17 |
83 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
18 |
87 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
18 |
88 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
18 |
90 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
91 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
92 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
93 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
94 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
19 |
95 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
20 |
96 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
20 |
98 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
21 |
104 |
32 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
21 |
101 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
21 |
103 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
21 |
105 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
22 |
106 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
22 |
107 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
22 |
108 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
22 |
110 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
23 |
111 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
23 |
114 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
22 |
108 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
Vehicle Control |
1 |
14 |
67 |
93 |
1 |
Necrosis |
Mild, Focal |
Terminal Sacrifice |
Alimentary System |
Mesentery |
|
0.5 G/KG |
1 |
20 |
98 |
93 |
1 |
Necrosis |
Mild, Fatty |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
2.0 G/KG |
10 |
24 |
116 |
44 |
1 |
Atrophy |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
24 |
119 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
24 |
118 |
4 |
1 |
Mineralization |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
24 |
118 |
4 |
1 |
Ulcer |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
66 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
24 |
116 |
44 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
23 |
114 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
13 |
65 |
18 |
1 |
Cyst |
|
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
2.0 G/KG |
10 |
23 |
112 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
10 |
13 |
65 |
18 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
23 |
113 |
4 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
24 |
117 |
2 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
24 |
118 |
4 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
10 |
13 |
65 |
18 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
23 |
113 |
4 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
24 |
117 |
2 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
24 |
118 |
4 |
1 |
Necrosis |
Mild |
Natural Death |
Nervous System |
Brain |
Cerebrum |
2.0 G/KG |
10 |
24 |
117 |
2 |
1 |
Hemorrhage |
Mild |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
2.0 G/KG |
10 |
24 |
116 |
44 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Respiratory System |
Lung |
Alveolus |
2.0 G/KG |
10 |
23 |
111 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
2.0 G/KG |
10 |
23 |
114 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
2.0 G/KG |
10 |
24 |
119 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
14 |
66 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
1.0 G/KG |
1 |
21 |
104 |
32 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
24 |
117 |
2 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
23 |
111 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
23 |
115 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
23 |
113 |
4 |
1 |
Congestion |
Mild, Diffuse, Acute |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
24 |
119 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Metaplasia, Osseous |
Minimal, Osseous |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
2.0 G/KG |
10 |
23 |
112 |
93 |
1 |
Neovascularization |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
2.0 G/KG |
10 |
24 |
120 |
93 |
1 |
Neovascularization |
Mild |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
2.0 G/KG |
10 |
23 |
113 |
4 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
66 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
67 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.0 G/KG |
1 |
21 |
104 |
32 |
1 |
Mineralization |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
23 |
111 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
23 |
112 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
24 |
120 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |