Alimentary System |
Liver |
Bile Duct |
0.5 G/KG |
10 |
7 |
33 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.0 G/KG |
10 |
9 |
43 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
4 |
17 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
7 |
31 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
3 |
11 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
3 |
12 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
3 |
13 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
3 |
15 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
4 |
16 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
4 |
18 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
4 |
19 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
5 |
24 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
6 |
26 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
6 |
27 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
6 |
28 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
6 |
30 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
7 |
32 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
7 |
33 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
8 |
37 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
8 |
38 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
8 |
39 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
10 |
46 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
10 |
47 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
10 |
50 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
9 |
41 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
9 |
42 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
11 |
51 |
93 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
11 |
54 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
12 |
58 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
12 |
59 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
8 |
39 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
11 |
55 |
80 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
11 |
53 |
80 |
1 |
Mineralization |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
12 |
60 |
5 |
1 |
Ulcer |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
11 |
53 |
80 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
11 |
55 |
80 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
11 |
51 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
12 |
56 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
12 |
58 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
2.0 G/KG |
10 |
12 |
59 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
2.0 G/KG |
10 |
12 |
58 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
2.0 G/KG |
10 |
12 |
60 |
5 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
11 |
53 |
80 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
11 |
55 |
80 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Spleen |
|
2.0 G/KG |
10 |
12 |
60 |
5 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
1.0 G/KG |
10 |
9 |
45 |
93 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
12 |
60 |
5 |
1 |
Necrosis |
Mild |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
11 |
51 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
11 |
54 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
12 |
56 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
12 |
59 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
11 |
53 |
80 |
1 |
Inflammation |
Minimal, Granulomatous |
Natural Death |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
11 |
55 |
80 |
1 |
Inflammation |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
11 |
51 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
11 |
54 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Metaplasia, Osseous |
Minimal, Focal, Osseous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Metaplasia, Osseous |
Minimal, Osseous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
11 |
54 |
93 |
1 |
Metaplasia, Osseous |
Minimal, Osseous |
Terminal Sacrifice |
Respiratory System |
Nose |
Squam Epithel |
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Hyperplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Respiratory System |
Nose |
|
2.0 G/KG |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
56 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
58 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
11 |
53 |
80 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
11 |
55 |
80 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
11 |
52 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
56 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
57 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
58 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
12 |
59 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |