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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Kava kava extract |
CASRN: | ="9000-38-8" |
Study Number: | C20007 |
Exposure Route: | GAVAGE |
TDMS Number: | 2000704 |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Esophagus |
|
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Alimentary System |
Esophagus |
|
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Alimentary System |
Liver |
Centrilobular |
0.5 G/KG |
10 |
68 |
100 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
0.5 G/KG |
10 |
68 |
97 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
1.0 G/KG |
10 |
69 |
102 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
1.0 G/KG |
10 |
69 |
104 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
1.0 G/KG |
10 |
70 |
106 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
1.0 G/KG |
10 |
70 |
109 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
1.0 G/KG |
10 |
70 |
110 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
2.0 G/KG |
10 |
71 |
111 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
2.0 G/KG |
10 |
71 |
113 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
2.0 G/KG |
10 |
71 |
115 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular |
2.0 G/KG |
10 |
72 |
118 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
61 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
62 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
64 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
65 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
66 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
67 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
68 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
69 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
70 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
63 |
71 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
63 |
72 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
63 |
73 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
63 |
74 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
63 |
75 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
76 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
77 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
78 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
79 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
80 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
81 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
82 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
83 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
84 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
85 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
66 |
86 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
66 |
87 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
66 |
88 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
66 |
89 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
66 |
90 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
67 |
91 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
67 |
93 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
67 |
94 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
67 |
95 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
100 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
96 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
97 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
98 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
99 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
69 |
101 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
69 |
102 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
69 |
103 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
69 |
104 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
69 |
105 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
70 |
106 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
70 |
107 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1.0 G/KG |
10 |
70 |
108 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
71 |
111 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
71 |
113 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
71 |
114 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.0 G/KG |
10 |
71 |
115 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.125 G/KG |
10 |
64 |
78 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.25 G/KG |
10 |
65 |
81 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
0.5 G/KG |
10 |
68 |
96 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
10 |
61 |
64 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
2.0 G/KG |
10 |
71 |
114 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
2.0 G/KG |
10 |
72 |
118 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Mineralization |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
61 |
63 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
2.0 G/KG |
10 |
72 |
117 |
2 |
1 |
Cyst |
|
Natural Death |
Alimentary System |
Stomach |
Glandular |
2.0 G/KG |
10 |
71 |
115 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Mineralization |
Mild |
Natural Death |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
61 |
61 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
61 |
62 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
61 |
63 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
61 |
64 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
61 |
65 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
62 |
66 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
62 |
67 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
62 |
68 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
62 |
69 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
62 |
70 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
72 |
120 |
37 |
1 |
Hyperplasia |
Minimal |
Dosing Accident |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
72 |
116 |
2 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
71 |
111 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
71 |
113 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
71 |
114 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
71 |
115 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
2.0 G/KG |
10 |
72 |
118 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
2.0 G/KG |
10 |
72 |
117 |
2 |
1 |
Cyst |
|
Natural Death |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
71 |
112 |
2 |
1 |
Necrosis |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
2.0 G/KG |
10 |
72 |
117 |
2 |
1 |
Necrosis |
Minimal |
Natural Death |
Integumentary System |
Skin |
|
2.0 G/KG |
10 |
71 |
111 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2.0 G/KG |
10 |
72 |
120 |
37 |
1 |
Congestion |
Moderate |
Dosing Accident |
Urinary System |
Kidney |
|
2.0 G/KG |
10 |
72 |
119 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |