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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Methylene blue trihydrate |
CASRN: | ="7220-79-3" |
Study Number: | C91005C |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | GAVAGE |
TDMS Number: | 9100507 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (MG/KG) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 131 |
296 |
5 |
|
180.2 |
|
Day 223 |
367 |
50 |
|
|
|
Day 239 |
373 |
50 |
|
|
|
Day 284 |
372 |
50 |
|
|
|
Day 312 |
388 |
50 |
|
|
|
Day 344 |
217 |
0 |
|
257 |
|
Day 349 |
364 |
50 |
|
|
|
Day 395 |
267 |
5 |
|
173.5 |
|
Day 480 |
386 |
50 |
|
|
|
Day 492 |
324 |
25 |
|
|
|
Day 509 |
384 |
50 |
|
301.6 |
|
Day 516 |
228 |
0 |
|
|
|
Day 521 |
314 |
25 |
|
|
|
Day 527 |
363 |
50 |
|
|
|
Day 540 |
338 |
25 |
|
|
|
Day 544 |
360 |
50 |
|
221.1 |
|
Day 557 |
335 |
25 |
|
|
|
Day 560 |
340 |
25 |
|
|
|
Day 563 |
236 |
0 |
|
340.2 |
|
Day 563 |
320 |
25 |
|
274.5 |
|
Day 568 |
277 |
5 |
|
403.8 |
|
Day 568 |
389 |
50 |
|
301.2 |
|
Day 573 |
368 |
50 |
|
|
|
Day 576 |
281 |
5 |
|
334.1 |
|
Day 585 |
288 |
5 |
|
|
|
Day 591 |
204 |
0 |
|
|
|
Day 593 |
322 |
25 |
|
|
|
Day 596 |
319 |
25 |
|
273.2 |
|
Day 596 |
339 |
25 |
|
|
|
Day 621 |
289 |
5 |
|
|
|
Day 628 |
265 |
5 |
|
271.5 |
|
Day 638 |
215 |
0 |
|
211.2 |
|
Day 640 |
214 |
0 |
|
|
|
Day 641 |
270 |
5 |
|
367.4 |
|
Day 644 |
253 |
5 |
|
|
|
Day 646 |
311 |
25 |
|
233.6 |
|
Day 648 |
206 |
0 |
|
261.1 |
|
Day 648 |
244 |
0 |
|
318.9 |
|
Day 648 |
279 |
5 |
|
317 |
|
Day 651 |
306 |
25 |
|
|
|
Day 652 |
209 |
0 |
|
344.9 |
|
Day 652 |
211 |
0 |
|
391.5 |
|
Day 652 |
235 |
0 |
|
406.7 |
|
Day 663 |
294 |
5 |
|
|
|
Day 668 |
242 |
0 |
|
|
|
Day 674 |
212 |
0 |
|
|
|
Day 677 |
258 |
5 |
|
371.3 |
|
Day 677 |
351 |
50 |
|
|
|
Day 677 |
385 |
50 |
|
|
|
Day 687 |
252 |
5 |
|
389.1 |
|
Day 687 |
344 |
25 |
|
|
|
Day 687 |
371 |
50 |
|
|
|
Day 694 |
284 |
5 |
|
211 |
|
Day 698 |
219 |
0 |
|
|
|
Day 702 |
254 |
5 |
|
301.4 |
|
Day 702 |
268 |
5 |
|
195.8 |
|
Day 702 |
290 |
5 |
|
219.3 |
|
Day 702 |
302 |
25 |
|
183.3 |
|
Day 710 |
225 |
0 |
|
382.9 |
|
Day 710 |
297 |
5 |
|
406.6 |
|
Day 723 |
349 |
25 |
|
369.7 |
|
Day 725 |
355 |
50 |
|
|
|
Day 729 |
346 |
25 |
|
|
|
Day 729 |
352 |
50 |
|
355.6 |
|
Day 729 |
353 |
50 |
|
290.8 |
|
Day 729 |
354 |
50 |
|
314.4 |
|
Day 729 |
381 |
50 |
|
324.6 |
|
Day 729 |
382 |
50 |
|
308.4 |
|
Day 729 |
383 |
50 |
|
304.6 |
|
Day 730 |
304 |
25 |
|
|
|
Day 733 |
246 |
0 |
|
249.9 |
|
Day 733 |
247 |
0 |
|
338.9 |
|
Day 733 |
248 |
0 |
|
345.7 |
|
Day 733 |
249 |
0 |
|
225 |
|
Day 733 |
250 |
0 |
|
325.7 |
|
Day 733 |
276 |
5 |
|
305 |
|
Day 733 |
278 |
5 |
|
346.6 |
|
Day 733 |
280 |
5 |
|
328.8 |
|
Day 733 |
291 |
5 |
|
350.5 |
|
Day 733 |
292 |
5 |
|
299.5 |
|
Day 733 |
293 |
5 |
|
316.8 |
|
Day 733 |
295 |
5 |
|
351.4 |
|
Day 733 |
301 |
25 |
|
303.5 |
|
Day 733 |
303 |
25 |
|
313.5 |
|
Day 733 |
305 |
25 |
|
294.8 |
|
Day 733 |
374 |
50 |
|
294.8 |
|
Day 733 |
375 |
50 |
|
279 |
|
Day 734 |
201 |
0 |
|
365 |
|
Day 734 |
202 |
0 |
|
296.8 |
|
Day 734 |
203 |
0 |
|
329.2 |
|
Day 734 |
205 |
0 |
|
297 |
|
Day 734 |
213 |
0 |
|
279.1 |
|
Day 734 |
216 |
0 |
|
379.6 |
|
Day 734 |
218 |
0 |
|
335.9 |
|
Day 734 |
220 |
0 |
|
353.2 |
|
Day 734 |
226 |
0 |
|
332.4 |
|
Day 734 |
227 |
0 |
|
349.7 |
|
Day 734 |
229 |
0 |
|
235.3 |
|
Day 734 |
230 |
0 |
|
348.2 |
|
Day 734 |
241 |
0 |
|
357.4 |
|
Day 734 |
243 |
0 |
|
349 |
|
Day 734 |
245 |
0 |
|
377.9 |
|
Day 734 |
271 |
5 |
|
358.4 |
|
Day 734 |
272 |
5 |
|
309.1 |
|
Day 734 |
273 |
5 |
|
364.6 |
|
Day 734 |
274 |
5 |
|
408.3 |
|
Day 734 |
275 |
5 |
|
312.8 |
|
Day 734 |
282 |
5 |
|
340.9 |
|
Day 734 |
283 |
5 |
|
382.2 |
|
Day 734 |
285 |
5 |
|
337.6 |
|
Day 734 |
286 |
5 |
|
356.6 |
|
Day 734 |
287 |
5 |
|
368.4 |
|
Day 734 |
331 |
25 |
|
270.5 |
|
Day 734 |
332 |
25 |
|
312 |
|
Day 734 |
333 |
25 |
|
355.3 |
|
Day 734 |
334 |
25 |
|
292 |
|
Day 734 |
366 |
50 |
|
311 |
|
Day 734 |
369 |
50 |
|
288.2 |
|
Day 734 |
370 |
50 |
|
299.3 |
|
Day 736 |
207 |
0 |
|
320.2 |
|
Day 736 |
208 |
0 |
|
327 |
|
Day 736 |
210 |
0 |
|
268 |
|
Day 736 |
221 |
0 |
|
305.5 |
|
Day 736 |
222 |
0 |
|
333.2 |
|
Day 736 |
223 |
0 |
|
301.7 |
|
Day 736 |
224 |
0 |
|
304.8 |
|
Day 736 |
251 |
5 |
|
280.9 |
|
Day 736 |
255 |
5 |
|
367.2 |
|
Day 736 |
261 |
5 |
|
347.1 |
|
Day 736 |
262 |
5 |
|
295.6 |
|
Day 736 |
263 |
5 |
|
370.7 |
|
Day 736 |
264 |
5 |
|
378 |
|
Day 736 |
298 |
5 |
|
403.2 |
|
Day 736 |
299 |
5 |
|
352.6 |
|
Day 736 |
300 |
5 |
|
305 |
|
Day 736 |
307 |
25 |
|
334.5 |
|
Day 736 |
308 |
25 |
|
323.1 |
|
Day 736 |
309 |
25 |
|
259.9 |
|
Day 736 |
310 |
25 |
|
292 |
|
Day 736 |
312 |
25 |
|
365.5 |
|
Day 736 |
313 |
25 |
|
295.9 |
|
Day 736 |
315 |
25 |
|
319.2 |
|
Day 736 |
316 |
25 |
|
327.4 |
|
Day 736 |
317 |
25 |
|
313.1 |
|
Day 736 |
318 |
25 |
|
210.8 |
|
Day 736 |
321 |
25 |
|
333.8 |
|
Day 736 |
323 |
25 |
|
302.5 |
|
Day 736 |
325 |
25 |
|
241.7 |
|
Day 736 |
336 |
25 |
|
324.8 |
|
Day 736 |
337 |
25 |
|
316.6 |
|
Day 736 |
341 |
25 |
|
300.9 |
|
Day 736 |
342 |
25 |
|
320.7 |
|
Day 736 |
343 |
25 |
|
272.3 |
|
Day 736 |
345 |
25 |
|
300.5 |
|
Day 736 |
347 |
25 |
|
289.6 |
|
Day 736 |
348 |
25 |
|
304.8 |
|
Day 736 |
350 |
25 |
|
354.9 |
|
Day 736 |
361 |
50 |
|
312.1 |
|
Day 736 |
362 |
50 |
|
308.7 |
|
Day 736 |
365 |
50 |
|
265.5 |
|
Day 737 |
231 |
0 |
|
324.7 |
|
Day 737 |
232 |
0 |
|
446.4 |
|
Day 737 |
233 |
0 |
|
338.7 |
|
Day 737 |
234 |
0 |
|
286.8 |
|
Day 737 |
237 |
0 |
|
347.3 |
|
Day 737 |
238 |
0 |
|
332.3 |
|
Day 737 |
239 |
0 |
|
332.5 |
|
Day 737 |
240 |
0 |
|
347.4 |
|
Day 737 |
256 |
5 |
|
346.3 |
|
Day 737 |
257 |
5 |
|
285.7 |
|
Day 737 |
259 |
5 |
|
260.5 |
|
Day 737 |
260 |
5 |
|
332 |
|
Day 737 |
266 |
5 |
|
291.1 |
|
Day 737 |
269 |
5 |
|
319 |
|
Day 737 |
326 |
25 |
|
335.9 |
|
Day 737 |
327 |
25 |
|
328.8 |
|
Day 737 |
328 |
25 |
|
284.3 |
|
Day 737 |
329 |
25 |
|
323.3 |
|
Day 737 |
330 |
25 |
|
264.6 |
|
Day 737 |
356 |
50 |
|
255.3 |
|
Day 737 |
357 |
50 |
|
263.8 |
|
Day 737 |
358 |
50 |
|
326.8 |
|
Day 737 |
359 |
50 |
|
348 |
|
Day 737 |
376 |
50 |
|
283 |
|
Day 737 |
377 |
50 |
|
277.9 |
|
Day 737 |
378 |
50 |
|
274.6 |
|
Day 737 |
379 |
50 |
|
312.3 |
|
Day 737 |
380 |
50 |
|
296.3 |
|
Day 737 |
387 |
50 |
|
239.9 |
|
Day 737 |
390 |
50 |
|
321.2 |
|
Day 737 |
391 |
50 |
|
265.4 |
|
Day 737 |
392 |
50 |
|
260.7 |
|
Day 737 |
393 |
50 |
|
303.5 |
|
Day 737 |
394 |
50 |
|
312.3 |
|
Day 737 |
395 |
50 |
|
243.7 |
|
Day 737 |
396 |
50 |
|
321.4 |
|
Day 737 |
397 |
50 |
|
304.5 |
|
Day 737 |
398 |
50 |
|
336.7 |
|
Day 737 |
399 |
50 |
|
288.5 |
|
Day 737 |
400 |
50 |
|
292.6 |
|
Abbreviations: |
NA: Not Available
|