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Chemical Name: | Methyleugenol |
---|---|
CASRN: | ="93-15-2" |
Study Number: | C60991D |
Study Length (Year Completed): | 6 month (N/A) |
Exposure Route: | GAV |
TDMS Number: | 0518712.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | BUN (mg_dL) | Creat (U per L) | ALT (IU_L) | SDH (IU_L) | AST (IU per L) | ALP (IU_L) | 5'Nuc (IU_L) | TBA (umol per g) |
Day 4 | 0091 | 0 | U | 18 | 0.6 | 46 | 8.2 | 74 | 297 | 36.6 | 12.7 |
Day 4 | 0092 | 0 | U | 18 | 0.5 | 49 | 8.1 | 73 | 345 | 34.3 | 12.9 |
Day 4 | 0093 | 0 | U | 15 | 0.6 | 46 | 4.9 | 74 | 312 | 33.4 | 11.6 |
Day 4 | 0094 | 0 | U | 14 | 0.6 | 38 | 7.9 | 69 | 252 | 31.6 | 16.3 |
Day 4 | 0095 | 0 | U | 15 | 0.6 | 39 | 4.8 | 64 | 213 | 31.2 | 12.6 |
Day 4 | 0096 | 0 | U | 17 | 0.5 | 38 | 4.8 | 66 | 233 | 31.9 | 17.0 |
Day 4 | 0098 | 30 | 15 | 0.6 | 38 | 5.7 | 63 | 237 | 35.4 | 11.2 | |
Day 4 | 0099 | 30 | 15 | 0.6 | 42 | 2.8 | 63 | 281 | 36.1 | 9.8 | |
Day 4 | 0100 | 30 | 14 | 0.6 | 44 | 14.4 | 66 | 291 | 35.7 | 21.6 | |
Day 4 | 0101 | 30 | 16 | 0.6 | 47 | 7.9 | 67 | 278 | 33.8 | 9.4 | |
Day 4 | 0102 | 30 | 12 | 0.6 | 44 | 9.8 | 56 | 254 | 34.7 | 12.1 | |
Day 4 | 0103 | 100 | 14 | 0.7 | 44 | 9.9 | 63 | 264 | 32.8 | 14.7 | |
Day 4 | 0104 | 100 | 18 | 0.6 | 47 | 7.1 | 71 | 233 | 31.7 | 26.7 | |
Day 4 | 0105 | 100 | 14 | 0.5 | 43 | 9.2 | 60 | 229 | 33.7 | 14.1 | |
Day 4 | 0106 | 100 | 14 | 0.6 | 48 | 8.6 | 66 | 232 | 34.4 | 21.6 | |
Day 4 | 0107 | 100 | 16 | 0.5 | 52 | 8.1 | 64 | 221 | 33.0 | 13.4 | |
Day 4 | 0108 | 100 | 13 | 0.5 | 46 | 7.1 | 68 | 244 | 32.6 | 9.5 | |
Day 4 | 0109 | 300 | 16 | 0.6 | 48 | 10.4 | 60 | 238 | 27.5 | 13.7 | |
Day 4 | 0110 | 300 | 15 | 0.6 | 58 | 9.3 | 71 | 222 | 27.0 | 12.5 | |
Day 4 | 0111 | 300 | 14 | 0.7 | 52 | 8.3 | 74 | 230 | 27.1 | 11.3 | |
Day 4 | 0112 | 300 | 15 | 0.4 | 48 | 8.4 | 64 | 247 | 27.8 | 19.3 | |
Day 4 | 0113 | 300 | 13 | 0.5 | 45 | 9.4 | 59 | 210 | 25.8 | 17.5 | |
Day 4 | 0114 | 300 | 13 | 0.6 | 49 | 6.1 | 64 | 238 | 25.6 | 20.2 | |
Day 4 | 0115 | 1000 | 11 | 0.8 | 63 | 6.3 | 85 | 135 | 17.2 | 15.4 | |
Day 4 | 0116 | 1000 | 14 | 0.8 | 75 | 8.1 | 97 | 127 | 17.9 | 21.7 | |
Day 4 | 0117 | 1000 | 14 | 0.7 | 71 | 6.3 | 107 | 191 | 23.7 | 40.0 | |
Day 4 | 0119 | 1000 | 10 | 0.8 | 167 | 5.2 | 177 | 202 | 27.9 | 26.8 | |
Day 4 | 0120 | 1000 | 17 | 0.7 | 75 | 7.4 | 81 | 156 | 18.2 | 24.7 | |
Day 8 | 0121 | 0 | U | 17 | 0.5 | 63 | 8.5 | 95 | 270 | 33.7 | 10.5 |
Day 8 | 0122 | 0 | U | 17 | 0.6 | 54 | 8.0 | 74 | 216 | 32.3 | 23.6 |
Day 8 | 0123 | 0 | U | 15 | 0.6 | 49 | 7.0 | 75 | 229 | 33.8 | 27.0 |
Day 8 | 0124 | 0 | U | 15 | 0.6 | 47 | 8.2 | 72 | 263 | 39.0 | 8.6 |
Day 8 | 0125 | 0 | U | 14 | 0.6 | 39 | 9.8 | 64 | 199 | 33.6 | 9.7 |
Day 8 | 0126 | 0 | U | 16 | 0.6 | 46 | 8.9 | 68 | 230 | 41.6 | 7.9 |
Day 8 | 0128 | 30 | 16 | 0.5 | 45 | 7.0 | 73 | 266 | 41.4 | 7.6 | |
Day 8 | 0129 | 30 | 18 | 0.5 | 45 | 7.0 | 71 | 286 | 38.9 | 9.3 | |
Day 8 | 0130 | 30 | 14 | 0.5 | 53 | 3.8 | 72 | 236 | 40.1 | 12.5 | |
Day 8 | 0131 | 30 | 13 | 0.5 | 46 | 7.2 | 74 | 198 | 37.7 | 18.3 | |
Day 8 | 0132 | 30 | 14 | 0.5 | 42 | 9.1 | 64 | 227 | 46.0 | 6.0 | |
Day 8 | 0133 | 100 | 15 | 0.5 | 42 | 7.1 | 64 | 220 | 35.3 | 9.0 | |
Day 8 | 0134 | 100 | 14 | 0.6 | 49 | 7.0 | 74 | 230 | 40.4 | 9.7 | |
Day 8 | 0135 | 100 | 15 | 0.5 | 52 | 6.7 | 78 | 216 | 41.2 | 10.6 | |
Day 8 | 0136 | 100 | 15 | 0.6 | 45 | 9.3 | 73 | 241 | 35.6 | 8.4 | |
Day 8 | 0137 | 100 | 16 | 0.5 | 48 | 8.8 | 73 | 226 | 37.7 | 15.4 | |
Day 8 | 0138 | 100 | 15 | 0.5 | 45 | 11.5 | 66 | 208 | 41.0 | 7.9 | |
Day 8 | 0139 | 300 | 15 | 0.5 | 42 | 10.7 | 59 | 223 | 33.5 | 29.6 | |
Day 8 | 0140 | 300 | 19 | 0.7 | 57 | 8.7 | 79 | 254 | 34.5 | 10.6 | |
Day 8 | 0141 | 300 | 16 | 0.4 | 49 | 9.2 | 67 | 226 | 29.9 | 15.0 | |
Day 8 | 0143 | 300 | 14 | 0.6 | 53 | 8.7 | 71 | 191 | 29.8 | 10.5 | |
Day 8 | 0144 | 300 | 16 | 0.5 | 44 | 9.0 | 61 | 176 | 30.6 | 13.0 | |
Day 8 | 0145 | 1000 | 14 | 0.7 | 66 | 9.5 | 80 | 105 | 21.8 | 21.4 | |
Day 8 | 0146 | 1000 | 13 | 0.5 | 58 | 6.3 | 72 | 113 | 27.1 | 14.2 | |
Day 8 | 0148 | 1000 | 17 | 0.7 | 91 | 7.2 | 102 | 119 | 25.9 | 67.1 | |
Day 8 | 0149 | 1000 | 16 | 0.6 | 60 | 8.3 | 69 | 139 | 26.7 | 13.9 | |
Day 8 | 0150 | 1000 | 12 | 0.7 | 73 | 8.8 | 85 | 164 | 27.2 | 16.3 | |
Day 15 | 0151 | 0 | U | 16 | 0.5 | 43 | 5.9 | 75 | 252 | 39.2 | 20.3 |
Day 15 | 0152 | 0 | U | 15 | 0.6 | 39 | 9.7 | 66 | 250 | 36.0 | 11.2 |
Day 15 | 0153 | 0 | U | 14 | 0.6 | 49 | 7.3 | 63 | 223 | 35.1 | 15.5 |
Day 15 | 0154 | 0 | U | 15 | 0.5 | 54 | 4.5 | 80 | 311 | 36.1 | 21.5 |
Day 15 | 0155 | 0 | U | 16 | 0.6 | 46 | 5.5 | 76 | 270 | 33.6 | 20.9 |
Day 15 | 0156 | 0 | U | 16 | 0.6 | 47 | 9.1 | 80 | 248 | 29.6 | 18.5 |
Day 15 | 0169 | 30 | 14 | 0.6 | 42 | 8.7 | 58 | 229 | 33.7 | 15.3 | |
Day 15 | 0170 | 30 | 16 | 0.5 | 42 | 10.1 | 67 | 252 | 35.3 | 11.1 | |
Day 15 | 0171 | 30 | 15 | 0.6 | 44 | 9.7 | 63 | 219 | 37.0 | 12.7 | |
Day 15 | 0172 | 30 | 18 | 0.6 | 49 | 5.9 | 78 | 292 | 39.7 | 18.8 | |
Day 15 | 0173 | 30 | 15 | 0.6 | 38 | 5.5 | 68 | 258 | 34.4 | 12.8 | |
Day 15 | 0174 | 30 | 14 | 0.6 | 34 | 2.5 | 63 | 224 | 30.2 | 11.9 | |
Day 15 | 0187 | 100 | 16 | 0.6 | 49 | 7.5 | 68 | 253 | 42.6 | 19.7 | |
Day 15 | 0188 | 100 | 14 | 0.6 | 47 | 7.1 | 67 | 241 | 38.2 | 12.4 | |
Day 15 | 0190 | 100 | 16 | 0.6 | 45 | 5.8 | 63 | 196 | 34.0 | 20.3 | |
Day 15 | 0191 | 100 | 18 | 0.5 | 48 | 7.1 | 69 | 182 | 32.5 | 13.8 | |
Day 15 | 0192 | 100 | 15 | 0.5 | 43 | 8.1 | 58 | 185 | 35.0 | 15.7 | |
Day 15 | 0205 | 300 | 13 | 0.6 | 43 | 10.8 | 67 | 197 | 27.5 | 19.7 | |
Day 15 | 0206 | 300 | 13 | 0.6 | 40 | 9.3 | 55 | 193 | 30.2 | 17.3 | |
Day 15 | 0207 | 300 | 14 | 0.5 | 44 | 6.6 | 69 | 182 | 25.9 | 25.9 | |
Day 15 | 0208 | 300 | 15 | 0.6 | 51 | 10.9 | 60 | 187 | 31.9 | 35.4 | |
Day 15 | 0209 | 300 | 14 | 0.6 | 53 | 9.2 | 71 | 179 | 26.3 | 26.6 | |
Day 15 | 0210 | 300 | 16 | 0.7 | 73 | 8.1 | 77 | 203 | 33.7 | 24.7 | |
Day 15 | 0223 | 1000 | 10 | 0.6 | 72 | 8.3 | 69 | 108 | 19.0 | 40.4 | |
Day 15 | 0224 | 1000 | 12 | 0.6 | 95 | 8.6 | 82 | 112 | 16.9 | 62.2 | |
Day 15 | 0226 | 1000 | 15 | 0.6 | 65 | 10.4 | 92 | 128 | 21.4 | 50.5 | |
Day 15 | 0227 | 1000 | 18 | 0.5 | 94 | 7.5 | 74 | 107 | 17.6 | 37.2 | |
Day 15 | 0228 | 1000 | 12 | 0.7 | 181 | 6.8 | 124 | 79 | 20.2 | 54.4 | |
Day 90 | 0158 | 0 | U | 16 | 0.7 | 63 | 10.2 | 73 | 189 | 45.3 | 17.3 |
Day 90 | 0159 | 0 | U | 18 | 0.6 | 64 | 8.6 | 82 | 169 | 35.9 | 18.3 |
Day 90 | 0161 | 0 | U | 15 | 0.5 | 48 | 7.4 | 70 | 154 | 35.6 | 16.6 |
Day 90 | 0162 | 0 | U | 18 | 0.6 | 91 | 7.9 | 118 | 179 | 41.8 | 25.4 |
Day 90 | 0175 | 30 | 18 | 0.6 | 60 | 8.6 | 89 | 197 | 43.2 | 24.5 | |
Day 90 | 0176 | 30 | 17 | 0.2 | 44 | 8.1 | 71 | 183 | 33.0 | 21.8 | |
Day 90 | 0177 | 30 | 18 | 0.6 | 51 | 5.6 | 83 | 194 | 37.4 | 19.4 | |
Day 90 | 0178 | 30 | 17 | 0.7 | 49 | 7.0 | 65 | 173 | 36.4 | 20.2 | |
Day 90 | 0244 | 30 | 19 | 0.5 | 58 | 9.5 | 76 | 171 | 40.4 | 24.3 | |
Day 90 | 0193 | 100 | 20 | 0.5 | 60 | 6.5 | 78 | 198 | 37.0 | 15.4 | |
Day 90 | 0194 | 100 | 18 | 0.6 | 58 | 10.5 | 85 | 214 | 34.4 | 21.1 | |
Day 90 | 0195 | 100 | 14 | 0.6 | 52 | 9.1 | 71 | 181 | 38.1 | 17.7 | |
Day 90 | 0196 | 100 | 20 | 0.6 | 72 | 6.8 | 94 | 204 | 42.5 | 19.0 | |
Day 90 | 0197 | 100 | 15 | 0.5 | 72 | 8.7 | 86 | 166 | 38.8 | 29.0 | |
Day 90 | 0198 | 100 | 16 | 0.6 | 50 | 7.6 | 86 | 177 | 36.5 | 17.0 | |
Day 90 | 0212 | 300 | 19 | 0.8 | 61 | 7.3 | 112 | 252 | 30.1 | 27.8 | |
Day 90 | 0213 | 300 | 18 | 0.7 | 63 | 14.1 | 89 | 225 | 36.2 | 27.1 | |
Day 90 | 0214 | 300 | 17 | 0.7 | 66 | 9.8 | 76 | 173 | 37.5 | 20.7 | |
Day 90 | 0215 | 300 | 18 | 0.7 | 58 | 8.1 | 80 | 198 | 39.5 | 19.5 | |
Day 90 | 0216 | 300 | 13 | 0.7 | 52 | 9.6 | 76 | 179 | 36.0 | 17.0 | |
Day 180 | 0163 | 0 | U | 19 | 0.6 | 166 | 15.5 | 189 | 50.8 | 29.7 | |
Day 180 | 0164 | 0 | U | 17 | 0.4 | 160 | 25.2 | 167 | 48.2 | 66.5 | |
Day 180 | 0165 | 0 | U | 16 | 0.6 | 173 | 38.0 | 149 | 45.4 | 53.0 | |
Day 180 | 0166 | 0 | U | 17 | 0.6 | 145 | 14.9 | 185 | 50.6 | 29.9 | |
Day 180 | 0167 | 0 | U | 18 | 0.5 | 110 | 12.3 | 176 | 50.8 | 24.8 | |
Day 180 | 0168 | 0 | U | 16 | 0.5 | 76 | 18.8 | 169 | 40.8 | 27.7 | |
Day 180 | 0181 | 30 | 17 | 0.6 | 107 | 36.8 | 173 | 41.0 | 31.6 | ||
Day 180 | 0182 | 30 | 17 | 0.5 | 105 | 12.7 | 158 | 44.6 | 32.3 | ||
Day 180 | 0183 | 30 | 15 | 0.5 | 74 | 10.5 | 140 | 39.8 | 32.8 | ||
Day 180 | 0184 | 30 | 18 | 0.4 | 96 | 7.3 | 131 | 51.8 | 19.7 | ||
Day 180 | 0185 | 30 | 17 | 0.5 | 169 | 8.1 | 201 | 51.8 | 49.3 | ||
Day 180 | 0186 | 30 | 14 | 0.5 | 111 | 7.6 | 162 | 50.7 | 61.8 | ||
Day 180 | 0199 | 100 | 16 | 0.6 | 140 | 17.8 | 143 | 46.6 | 29.7 | ||
Day 180 | 0200 | 100 | 13 | 0.6 | 126 | 14.8 | 180 | 48.5 | 50.5 | ||
Day 180 | 0201 | 100 | 16 | 0.6 | 86 | 13.2 | 147 | 46.2 | 23.1 | ||
Day 180 | 0202 | 100 | 15 | 0.5 | 92 | 16.7 | 151 | 45.0 | 18.9 | ||
Day 180 | 0203 | 100 | 14 | 0.6 | 94 | 20.2 | 128 | 38.8 | 29.1 | ||
Day 180 | 0204 | 100 | 15 | 0.6 | 109 | 10.6 | 185 | 42.8 | 34.9 | ||
Day 180 | 0217 | 300 | 14 | 0.5 | 135 | 18.3 | 189 | 45.5 | 45.5 | ||
Day 180 | 0218 | 300 | 13 | 0.5 | 86 | 9.5 | 154 | 40.3 | 27.9 | ||
Day 180 | 0219 | 300 | 16 | 0.6 | 96 | 13.8 | 153 | 41.0 | 30.4 | ||
Day 180 | 0220 | 300 | 15 | 0.6 | 179 | 20.6 | 159 | 45.1 | 34.5 | ||
Day 180 | 0221 | 300 | 13 | 0.6 | 41 | 14.8 | 130 | 36.9 | 23.8 | ||
Day 180 | 0222 | 300 | 14 | 0.5 | 133 | 11.8 | 164 | 43.2 | 32.8 | ||
Day 180 | 0230 | 1000 | 11 | 0.6 | 123 | 11.0 | 204 | 44.8 | 16.2 | ||
Day 180 | 0231 | 1000 | 15 | 0.6 | 115 | 14.3 | 154 | 43.0 | 20.1 | ||
Day 180 | 0233 | 1000 | 16 | 0.8 | 84 | 12.1 | 182 | 47.4 | 24.0 | ||
Day 180 | 0234 | 1000 | 15 | 0.8 | 200 | 21.8 | 163 | 47.6 | 44.9 | ||
Day 180 | 0235 | 1000 | 15 | 0.4 | 124 | 17.8 | 142 | 25.2 | 48.8 | ||
Day 180 | 0237 | 1000 | 12 | 0.6 | 85 | 16.0 | 130 | 37.8 | 28.9 | ||
Abbreviations: | |||||||||||
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, AST: Aspartate Aminotransferase, ALP: Alkaline Phosphatase, 5'Nuc: 5 Prime Nucleotidase, TBA: Bile Acids Per G Tissue |