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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Methylphenidate hydrochloride |
CASRN: | ="298-59-9" |
Study Number: | C56280B |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | DOSED FEED |
TDMS Number: | 0515002 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 274 |
46 |
0 |
|
49 |
|
Day 274 |
56 |
0 |
|
51 |
|
Day 274 |
70 |
0 |
|
49 |
|
Day 274 |
8 |
0 |
|
41.4 |
|
Day 274 |
100 |
50 |
|
44.6 |
|
Day 274 |
119 |
50 |
|
47.8 |
|
Day 274 |
120 |
50 |
|
44.8 |
|
Day 274 |
129 |
50 |
|
45.6 |
|
Day 274 |
96 |
50 |
|
44.4 |
|
Day 274 |
97 |
50 |
|
46.8 |
|
Day 274 |
98 |
50 |
|
47.2 |
|
Day 274 |
99 |
50 |
|
49.8 |
|
Day 274 |
142 |
250 |
|
48.4 |
|
Day 274 |
144 |
250 |
|
44.6 |
|
Day 274 |
148 |
250 |
|
41.2 |
|
Day 274 |
158 |
250 |
|
45 |
|
Day 274 |
202 |
250 |
|
45.2 |
|
Day 274 |
206 |
250 |
|
36 |
|
Day 274 |
221 |
500 |
|
48.4 |
|
Day 274 |
248 |
500 |
|
33.6 |
|
Day 275 |
26 |
0 |
|
45.6 |
|
Day 275 |
28 |
0 |
|
40.6 |
|
Day 275 |
31 |
0 |
|
44.6 |
|
Day 275 |
34 |
0 |
|
50.8 |
|
Day 275 |
41 |
0 |
|
48.4 |
|
Day 275 |
65 |
0 |
|
49.4 |
|
Day 275 |
75 |
50 |
|
44.4 |
|
Day 275 |
93 |
50 |
|
47.2 |
|
Day 275 |
143 |
250 |
|
45.2 |
|
Day 275 |
156 |
250 |
|
43.4 |
|
Day 275 |
187 |
250 |
|
41.4 |
|
Day 275 |
193 |
250 |
|
33 |
|
Day 275 |
213 |
500 |
|
33.8 |
|
Day 275 |
230 |
500 |
|
45.4 |
|
Day 275 |
236 |
500 |
|
37.2 |
|
Day 275 |
237 |
500 |
|
44.2 |
|
Day 275 |
246 |
500 |
|
44.2 |
|
Day 275 |
250 |
500 |
|
37.2 |
|
Day 275 |
257 |
500 |
|
39.6 |
|
Day 275 |
263 |
500 |
|
46.6 |
|
Day 454 |
11 |
0 |
|
43.8 |
|
Day 454 |
35 |
0 |
|
46.6 |
|
Day 454 |
37 |
0 |
|
45.2 |
|
Day 454 |
4 |
0 |
|
41.6 |
|
Day 454 |
50 |
0 |
|
43.4 |
|
Day 454 |
52 |
0 |
|
46.4 |
|
Day 454 |
117 |
50 |
|
44.8 |
|
Day 454 |
126 |
50 |
|
41.2 |
|
Day 454 |
86 |
50 |
|
48.8 |
|
Day 454 |
161 |
250 |
|
46.2 |
|
Day 454 |
163 |
250 |
|
38.6 |
|
Day 454 |
172 |
250 |
|
44.8 |
|
Day 454 |
174 |
250 |
|
43.6 |
|
Day 454 |
190 |
250 |
|
38.6 |
|
Day 454 |
191 |
250 |
|
40.6 |
|
Day 454 |
222 |
500 |
|
33.6 |
|
Day 454 |
232 |
500 |
|
44.4 |
|
Day 454 |
244 |
500 |
|
35 |
|
Day 454 |
251 |
500 |
|
41.4 |
|
Day 454 |
267 |
500 |
|
33.6 |
|
Day 455 |
12 |
0 |
|
39.2 |
|
Day 455 |
13 |
0 |
|
39.4 |
|
Day 455 |
30 |
0 |
|
40.4 |
|
Day 455 |
6 |
0 |
|
51 |
|
Day 455 |
104 |
50 |
|
52.4 |
|
Day 455 |
127 |
50 |
|
38.2 |
|
Day 455 |
71 |
50 |
|
50.8 |
|
Day 455 |
77 |
50 |
|
50.4 |
|
Day 455 |
80 |
50 |
|
40.6 |
|
Day 455 |
91 |
50 |
|
37.6 |
|
Day 455 |
92 |
50 |
|
41.1 |
|
Day 455 |
150 |
250 |
|
46.4 |
|
Day 455 |
157 |
250 |
|
41.6 |
|
Day 455 |
164 |
250 |
|
38 |
|
Day 455 |
181 |
250 |
|
48.6 |
|
Day 455 |
219 |
500 |
|
40.2 |
|
Day 455 |
234 |
500 |
|
47.4 |
|
Day 455 |
253 |
500 |
|
41.4 |
|
Day 455 |
254 |
500 |
|
36.2 |
|
Day 455 |
265 |
500 |
|
49.8 |
|
Day 537 |
16 |
0 |
|
44.8 |
|
Day 541 |
167 |
250 |
|
32 |
|
Day 574 |
211 |
500 |
|
36 |
|
Day 585 |
155 |
250 |
|
22.2 |
|
Day 601 |
201 |
250 |
|
33.2 |
|
Day 610 |
209 |
250 |
|
27 |
|
Day 617 |
60 |
0 |
|
47 |
|
Day 618 |
241 |
500 |
|
36 |
|
Day 626 |
204 |
250 |
|
23 |
|
Day 626 |
275 |
500 |
|
24 |
|
Day 628 |
76 |
50 |
|
31.8 |
|
Day 639 |
7 |
0 |
|
31.8 |
|
Day 640 |
67 |
0 |
|
30.6 |
|
Day 647 |
270 |
500 |
|
23 |
|
Day 654 |
220 |
500 |
|
40 |
|
Day 674 |
81 |
50 |
|
40.8 |
|
Day 679 |
10 |
0 |
|
24 |
|
Day 684 |
261 |
500 |
|
31.2 |
|
Day 687 |
217 |
500 |
|
35.6 |
|
Day 700 |
273 |
500 |
|
29.4 |
|
Day 707 |
79 |
50 |
|
35.4 |
|
Day 707 |
279 |
500 |
|
25.6 |
|
Day 708 |
115 |
50 |
|
33.6 |
|
Day 710 |
207 |
250 |
|
27.8 |
|
Day 720 |
128 |
50 |
|
28.4 |
|
Day 730 |
212 |
500 |
|
44.5 |
|
Day 730 |
214 |
500 |
|
48.6 |
|
Day 730 |
216 |
500 |
|
40.9 |
|
Day 731 |
173 |
250 |
|
26.6 |
|
Day 733 |
215 |
500 |
|
43 |
|
Day 733 |
225 |
500 |
|
29.4 |
|
Day 733 |
226 |
500 |
|
48.7 |
|
Day 733 |
227 |
500 |
|
41 |
|
Day 733 |
228 |
500 |
|
41.7 |
|
Day 733 |
229 |
500 |
|
41.6 |
|
Day 733 |
231 |
500 |
|
38.1 |
|
Day 733 |
233 |
500 |
|
42.2 |
|
Day 733 |
238 |
500 |
|
40.1 |
|
Day 733 |
255 |
500 |
|
40.5 |
|
Day 733 |
256 |
500 |
|
35.4 |
|
Day 733 |
258 |
500 |
|
35.3 |
|
Day 733 |
259 |
500 |
|
38.5 |
|
Day 733 |
260 |
500 |
|
39.2 |
|
Day 733 |
264 |
500 |
|
48.1 |
|
Day 733 |
266 |
500 |
|
50.2 |
|
Day 733 |
268 |
500 |
|
46.2 |
|
Day 733 |
274 |
500 |
|
39 |
|
Day 733 |
278 |
500 |
|
52.3 |
|
Day 733 |
280 |
500 |
|
37.5 |
|
Day 734 |
235 |
500 |
|
31.6 |
|
Day 734 |
269 |
500 |
|
43.2 |
|
Day 734 |
271 |
500 |
|
37.4 |
|
Day 734 |
272 |
500 |
|
43.6 |
|
Day 734 |
276 |
500 |
|
48.4 |
|
Day 734 |
277 |
500 |
|
44.6 |
|
Day 735 |
242 |
500 |
|
44.6 |
|
Day 735 |
243 |
500 |
|
36.6 |
|
Day 735 |
249 |
500 |
|
27.4 |
|
Day 735 |
252 |
500 |
|
45 |
|
Day 736 |
159 |
250 |
|
|
|
Day 736 |
162 |
250 |
|
35.2 |
|
Day 736 |
165 |
250 |
|
|
|
Day 736 |
166 |
250 |
|
|
|
Day 736 |
168 |
250 |
|
42.6 |
|
Day 736 |
169 |
250 |
|
35 |
|
Day 736 |
218 |
500 |
|
42.4 |
|
Day 736 |
223 |
500 |
|
52.2 |
|
Day 736 |
224 |
500 |
|
43.4 |
|
Day 736 |
239 |
500 |
|
|
|
Day 736 |
240 |
500 |
|
46.6 |
|
Day 736 |
245 |
500 |
|
39.6 |
|
Day 736 |
247 |
500 |
|
33.6 |
|
Day 736 |
262 |
500 |
|
42.8 |
|
Day 737 |
141 |
250 |
|
34.2 |
|
Day 737 |
145 |
250 |
|
43 |
|
Day 737 |
146 |
250 |
|
37.4 |
|
Day 737 |
147 |
250 |
|
33.2 |
|
Day 737 |
149 |
250 |
|
32.4 |
|
Day 737 |
151 |
250 |
|
41.8 |
|
Day 737 |
152 |
250 |
|
40.6 |
|
Day 737 |
153 |
250 |
|
42.8 |
|
Day 737 |
154 |
250 |
|
30.2 |
|
Day 737 |
160 |
250 |
|
47.8 |
|
Day 740 |
101 |
50 |
|
42.2 |
|
Day 740 |
102 |
50 |
|
33 |
|
Day 740 |
103 |
50 |
|
40.8 |
|
Day 740 |
105 |
50 |
|
50.2 |
|
Day 740 |
106 |
50 |
|
38.6 |
|
Day 740 |
114 |
50 |
|
41.6 |
|
Day 740 |
116 |
50 |
|
44.6 |
|
Day 740 |
118 |
50 |
|
49 |
|
Day 740 |
72 |
50 |
|
41.6 |
|
Day 740 |
73 |
50 |
|
33.8 |
|
Day 740 |
74 |
50 |
|
33.8 |
|
Day 740 |
78 |
50 |
|
50.6 |
|
Day 740 |
82 |
50 |
|
45.2 |
|
Day 740 |
83 |
50 |
|
31.6 |
|
Day 740 |
84 |
50 |
|
46.4 |
|
Day 740 |
85 |
50 |
|
49 |
|
Day 740 |
87 |
50 |
|
44.4 |
|
Day 740 |
88 |
50 |
|
33.6 |
|
Day 740 |
89 |
50 |
|
44 |
|
Day 740 |
90 |
50 |
|
40.6 |
|
Day 740 |
94 |
50 |
|
44.4 |
|
Day 740 |
95 |
50 |
|
50.6 |
|
Day 740 |
170 |
250 |
|
42.6 |
|
Day 740 |
171 |
250 |
|
44.2 |
|
Day 740 |
175 |
250 |
|
37.8 |
|
Day 740 |
176 |
250 |
|
41.4 |
|
Day 740 |
177 |
250 |
|
35 |
|
Day 740 |
178 |
250 |
|
39 |
|
Day 740 |
179 |
250 |
|
34.8 |
|
Day 740 |
180 |
250 |
|
49.8 |
|
Day 740 |
182 |
250 |
|
39.2 |
|
Day 740 |
183 |
250 |
|
|
|
Day 740 |
184 |
250 |
|
42 |
|
Day 740 |
185 |
250 |
|
48.4 |
|
Day 740 |
186 |
250 |
|
43.6 |
|
Day 740 |
188 |
250 |
|
39.8 |
|
Day 740 |
189 |
250 |
|
42.6 |
|
Day 740 |
192 |
250 |
|
46.6 |
|
Day 740 |
194 |
250 |
|
36 |
|
Day 740 |
195 |
250 |
|
34.2 |
|
Day 740 |
196 |
250 |
|
53.8 |
|
Day 740 |
197 |
250 |
|
36.4 |
|
Day 740 |
198 |
250 |
|
45.4 |
|
Day 740 |
199 |
250 |
|
40.2 |
|
Day 740 |
200 |
250 |
|
39.4 |
|
Day 740 |
203 |
250 |
|
50 |
|
Day 740 |
205 |
250 |
|
36.4 |
|
Day 740 |
208 |
250 |
|
35 |
|
Day 740 |
210 |
250 |
|
42.8 |
|
Day 741 |
1 |
0 |
|
38.8 |
|
Day 741 |
14 |
0 |
|
46.2 |
|
Day 741 |
15 |
0 |
|
50.4 |
|
Day 741 |
17 |
0 |
|
40 |
|
Day 741 |
18 |
0 |
|
45.2 |
|
Day 741 |
19 |
0 |
|
30.6 |
|
Day 741 |
2 |
0 |
|
51.8 |
|
Day 741 |
20 |
0 |
|
48.4 |
|
Day 741 |
21 |
0 |
|
50.8 |
|
Day 741 |
22 |
0 |
|
43.2 |
|
Day 741 |
23 |
0 |
|
37.6 |
|
Day 741 |
24 |
0 |
|
39.6 |
|
Day 741 |
25 |
0 |
|
47 |
|
Day 741 |
27 |
0 |
|
41.6 |
|
Day 741 |
29 |
0 |
|
48.6 |
|
Day 741 |
3 |
0 |
|
46.6 |
|
Day 741 |
32 |
0 |
|
49.2 |
|
Day 741 |
33 |
0 |
|
51.2 |
|
Day 741 |
36 |
0 |
|
45 |
|
Day 741 |
38 |
0 |
|
31.6 |
|
Day 741 |
39 |
0 |
|
|
|
Day 741 |
40 |
0 |
|
38.4 |
|
Day 741 |
42 |
0 |
|
49.4 |
|
Day 741 |
43 |
0 |
|
30 |
|
Day 741 |
44 |
0 |
|
43.4 |
|
Day 741 |
45 |
0 |
|
49.8 |
|
Day 741 |
47 |
0 |
|
47.4 |
|
Day 741 |
48 |
0 |
|
48.4 |
|
Day 741 |
49 |
0 |
|
32 |
|
Day 741 |
5 |
0 |
|
43 |
|
Day 741 |
51 |
0 |
|
41.8 |
|
Day 741 |
53 |
0 |
|
45.4 |
|
Day 741 |
54 |
0 |
|
37.8 |
|
Day 741 |
55 |
0 |
|
41 |
|
Day 741 |
57 |
0 |
|
45 |
|
Day 741 |
58 |
0 |
|
32.6 |
|
Day 741 |
59 |
0 |
|
47.4 |
|
Day 741 |
61 |
0 |
|
41 |
|
Day 741 |
62 |
0 |
|
50.8 |
|
Day 741 |
63 |
0 |
|
51.4 |
|
Day 741 |
64 |
0 |
|
40.8 |
|
Day 741 |
66 |
0 |
|
27.4 |
|
Day 741 |
68 |
0 |
|
43.4 |
|
Day 741 |
69 |
0 |
|
46.4 |
|
Day 741 |
9 |
0 |
|
44.2 |
|
Day 741 |
107 |
50 |
|
49.8 |
|
Day 741 |
108 |
50 |
|
24.8 |
|
Day 741 |
109 |
50 |
|
50 |
|
Day 741 |
110 |
50 |
|
44.2 |
|
Day 741 |
111 |
50 |
|
45.2 |
|
Day 741 |
112 |
50 |
|
44.4 |
|
Day 741 |
113 |
50 |
|
42.8 |
|
Day 741 |
121 |
50 |
|
41.8 |
|
Day 741 |
122 |
50 |
|
45.8 |
|
Day 741 |
123 |
50 |
|
47.2 |
|
Day 741 |
124 |
50 |
|
|
|
Day 741 |
125 |
50 |
|
51.2 |
|
Day 741 |
130 |
50 |
|
39.2 |
|
Day 741 |
131 |
50 |
|
39.6 |
|
Day 741 |
132 |
50 |
|
29 |
|
Day 741 |
133 |
50 |
|
48.8 |
|
Day 741 |
134 |
50 |
|
52 |
|
Day 741 |
135 |
50 |
|
34.4 |
|
Day 741 |
136 |
50 |
|
25.4 |
|
Day 741 |
137 |
50 |
|
40 |
|
Day 741 |
138 |
50 |
|
40.8 |
|
Day 741 |
139 |
50 |
|
51 |
|
Day 741 |
140 |
50 |
|
38 |
|
Abbreviations: |
NA: Not Available
|